O60242 (BAI3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-specific angiogenesis inhibitor 3

Gene names

Name:	BAI3
Synonyms:	KIAA0550

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1522 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma.
Subunit structure	Interacts with C1QL1, C1QL2, C1QL3 and C1QL4. Ref.8
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.8 Ref.9.
Tissue specificity	Strongly expressed in brain. Also detected in heart. Reduced expression is observed in some glioblastoma cell lines.
Post-translational modification	The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Does not undergo autocatalytic cleavage (in vitro). Ref.9
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 CUB domain. Contains 1 GPS domain. Contains 4 TSP type-1 domains.
Sequence caution	The sequence BAA25476.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of angiogenesis Inferred from electronic annotation. Source: InterPro neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement PubMed 15203201. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15203201. Source: GDB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Potential

Chain

25 – 1522

1498

Brain-specific angiogenesis inhibitor 3

PRO_0000012865

Regions

Topological domain

25 – 880

856

Extracellular Potential

Transmembrane

881 – 901

21

Helical; Name=1; Potential

Topological domain

902 – 910

9

Cytoplasmic Potential

Transmembrane

911 – 931

21

Helical; Name=2; Potential

Topological domain

932 – 939

8

Extracellular Potential

Transmembrane

940 – 960

21

Helical; Name=3; Potential

Topological domain

961 – 981

21

Cytoplasmic Potential

Transmembrane

982 – 1002

21

Helical; Name=4; Potential

Topological domain

1003 – 1023

21

Extracellular Potential

Transmembrane

1024 – 1044

21

Helical; Name=5; Potential

Topological domain

1045 – 1098

54

Cytoplasmic Potential

Transmembrane

1099 – 1119

21

Helical; Name=6; Potential

Topological domain

1120 – 1125

6

Extracellular Potential

Transmembrane

1126 – 1146

21

Helical; Name=7; Potential

Topological domain

1147 – 1522

376

Cytoplasmic Potential

Domain

30 – 159

130

CUB

Domain

291 – 343

53

TSP type-1 1

Domain

345 – 398

54

TSP type-1 2

Domain

400 – 453

54

TSP type-1 3

Domain

455 – 508

54

TSP type-1 4

Domain

816 – 868

53

GPS

Compositional bias

942 – 945

4

Poly-Thr

Compositional bias

1173 – 1176

4

Poly-Ser

Amino acid modifications

Modified residue

619

1

Phosphoserine Ref.7

Modified residue

1220

1

Phosphoserine By similarity

Modified residue

1411

1

Phosphoserine By similarity

Glycosylation

51

1

N-linked (GlcNAc...) Potential

Glycosylation

54

1

N-linked (GlcNAc...) Potential

Glycosylation

82

1

N-linked (GlcNAc...) Potential

Glycosylation

105

1

N-linked (GlcNAc...) Potential

Glycosylation

241

1

N-linked (GlcNAc...) Potential

Glycosylation

337

1

N-linked (GlcNAc...) Potential

Glycosylation

418

1

N-linked (GlcNAc...) Potential

Glycosylation

540

1

N-linked (GlcNAc...) Ref.9

Glycosylation

625

1

N-linked (GlcNAc...) Ref.9

Glycosylation

779

1

N-linked (GlcNAc...) Potential

Glycosylation

812

1

N-linked (GlcNAc...) Potential

Glycosylation

828

1

N-linked (GlcNAc...) Potential

Glycosylation

937

1

N-linked (GlcNAc...) Potential

Disulfide bond

30 ↔ 55

By similarity

Disulfide bond

303 ↔ 336

By similarity

Disulfide bond

307 ↔ 342

By similarity

Disulfide bond

318 ↔ 326

By similarity

Disulfide bond

357 ↔ 392

By similarity

Disulfide bond

361 ↔ 397

By similarity

Disulfide bond

372 ↔ 382

By similarity

Disulfide bond

412 ↔ 447

By similarity

Disulfide bond

416 ↔ 452

By similarity

Disulfide bond

427 ↔ 437

By similarity

Disulfide bond

467 ↔ 502

By similarity

Disulfide bond

471 ↔ 507

By similarity

Disulfide bond

482 ↔ 492

By similarity

Disulfide bond

514 ↔ 549

Ref.9

Disulfide bond

537 ↔ 567

Ref.9

Disulfide bond

819 ↔ 851

Ref.9

Disulfide bond

839 ↔ 853

Ref.9

Natural variations

Natural variant

503

1

N → S. Ref.1 Ref.2 Ref.6
Corresponds to variant rs1932618 [ dbSNP | Ensembl ].

VAR_046525

Secondary structure

1

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1522

Helix Strand Turn

Details...

Turn

519 – 521

3

Beta strand

532 – 535

4

Beta strand

541 – 551

11

Beta strand

557 – 559

3

Beta strand

563 – 569

7

Helix

570 – 583

14

Helix

589 – 608

20

Helix

613 – 632

20

Helix

639 – 652

14

Helix

655 – 657

3

Helix

658 – 664

7

Turn

665 – 667

3

Helix

670 – 687

18

Beta strand

694 – 698

5

Beta strand

700 – 710

11

Beta strand

718 – 721

4

Helix

730 – 734

5

Beta strand

738 – 741

4

Helix

743 – 746

4

Beta strand

759 – 769

11

Helix

770 – 772

3

Beta strand

781 – 783

3

Beta strand

787 – 794

8

Beta strand

803 – 808

6

Beta strand

815 – 823

9

Beta strand

833 – 835

3

Beta strand

839 – 845

7

Beta strand

848 – 855

8

Beta strand

857 – 864

8

Sequences

	Sequence		Length	Mass (Da)
	O60242 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: D22D0A5CF59E811F	FASTA	1,522	171,518
	10 20 30 40 50 60 MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK NFTNCTWTLE 70 80 90 100 110 120 NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD LLRKNHSIMQ LCNSKNAFVF 130 140 150 160 170 180 LQYDKNFIQI RRVFPTNFPG LQKKGEEDQK SFFEFLVLNK VSPSQFGCHV LCTWLESCLK 190 200 210 220 230 240 SENGRTESCG IMYTKCTCPQ HLGEWGIDDQ SLILLNNVVL PLNEQTEGCL TQELQTTQVC 250 260 270 280 290 300 NLTREAKRPP KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW 310 320 330 340 350 360 STCSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE WSPWSLCSFT 370 380 390 400 410 420 CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD GQWQEWSSWS QCSVTCSNGT 430 440 450 460 470 480 QQRSRQCTAA AHGGSECRGP WAESRECYNP ECTANGQWNQ WGHWSGCSKS CDGGWERRIR 490 500 510 520 530 540 TCQGAVITGQ QCEGTGEEVR RCNEQRCPAP YEICPEDYLM SMVWKRTPAG DLAFNQCPLN 550 560 570 580 590 600 ATGTTSRRCS LSLHGVAFWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK 610 620 630 640 650 660 TLLDLTQRKN FYAGDLLMSV EILRNVTDTF KRASYIPASD GVQNFFQIVS NLLDEENKEK 670 680 690 700 710 720 WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG NVVASIQKLP AASVLTDINF 730 740 750 760 770 780 PMKGRKGMVD WARNSEDRVV IPKSIFTPVS SKELDESSVF VLGAVLYKNL DLILPTLRNY 790 800 810 820 830 840 TVINSKIIVV TIRPEPKTTD SFLEIELAHL ANGTLNPYCV LWDDSKTNES LGTWSTQGCK 850 860 870 880 890 900 TVLTDASHTK CLCDRLSTFA ILAQQPREII MESSGTPSVT LIVGSGLSCL ALITLAVVYA 910 920 930 940 950 960 ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF FFLASFCWVL 970 980 990 1000 1010 1020 TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG FTRTKGYGTD HYCWLSLEGG 1030 1040 1050 1060 1070 1080 LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR DGILDKKLKH RAGQMSEPHS GLTLKCAKCG 1090 1100 1110 1120 1130 1140 VVSTTALSAT TASNAMASLW SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG 1150 1160 1170 1180 1190 1200 FVIVMVHCIL RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL 1210 1220 1230 1240 1250 1260 HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII QQPTGLHMPM 1270 1280 1290 1300 1310 1320 SMNELSNPCL KKENSELRRT VYLCTDDNLR GADMDIVHPQ ERMMESDYIV MPRSSVNNQP 1330 1340 1350 1360 1370 1380 SMKEESKMNI GMETLPHERL LHYKVNPEFN MNPPVMDQFN MNLEQHLAPQ EHMQNLPFEP 1390 1400 1410 1420 1430 1440 RTAVKNFMAS ELDDNAGLSR SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE 1450 1460 1470 1480 1490 1500 LNQKFQTLDR FRDIPNTSSM ENPAPNKNPW DTFKNPSEYP HYTTINVLDT EAKDALELRP 1510 1520 AEWEKCLNLP LDVQEGDFQT EV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)." Shiratsuchi T., Nishimori H., Ichise H., Nakamura Y., Tokino T. Cytogenet. Cell Genet. 79:103-108(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-503. Tissue: Fetal brain.
[2]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-503. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO 643-665 AND C-TERMINUS.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-503.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-619, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins." Bolliger M.F., Martinelli D.C., Sudhof T.C. Proc. Natl. Acad. Sci. U.S.A. 108:2534-2539(2011) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH C1QL1; C1QL2; C1QL3 AND C1QL4.
[9]	"A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis." Arac D., Boucard A.A., Bolliger M.F., Nguyen J., Soltis S.M., Sudhof T.C., Brunger A.T. EMBO J. 31:1364-1378(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 498-868, PROTEOLYTIC PROCESSING, GLYCOSYLATION AT ASN-540 AND ASN-625, DISULFIDE BONDS, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB005299 mRNA. Translation: BAA25363.1.
AB011122 mRNA. Translation: BAA25476.2. Different initiation.
AL133378 , AL158051, AL160401, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAC34969.2.
AL359714 , AL133378, AL158051, AL160401, AL356117, AL391807 Genomic DNA. Translation: CAH71522.1.
AL356117 , AL133378, AL158051, AL160401, AL359714, AL391807 Genomic DNA. Translation: CAH71772.1.
AL160401 , AL133378, AL158051, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAH73864.1.
AL158051 , AL133378, AL160401, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAI19625.1.
AL391807 , AL133378, AL158051, AL160401, AL356117, AL359714 Genomic DNA. Translation: CAI21673.1.
CH471051 Genomic DNA. Translation: EAW48837.1.
BC111720 mRNA. Translation: AAI11721.1.

IPI

IPI00028448.

PIR

T00028.
T00326.

RefSeq

NP_001695.1. NM_001704.2.

UniGene

Hs.13261.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DLO	X-ray	2.30	A/B	498-868	[»]

ProteinModelPortal

O60242.

SMR

O60242. Positions 508-866.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-56121N.

IntAct

O60242. 1 interaction.

STRING

9606.ENSP00000238918.

Protein family/group databases

MEROPS

S63.030.

GPCRDB

Search...

PTM databases

PhosphoSite

O60242.

Proteomic databases

PaxDb

O60242.

PRIDE

O60242.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000370598; ENSP00000359630; ENSG00000135298.

GeneID

577.

KEGG

hsa:577.

UCSC

uc003pev.4. human.

Organism-specific databases

CTD

577.

GeneCards

GC06P069404.

HGNC

HGNC:945. BAI3.

HPA

HPA015963.

MIM

602684. gene.

neXtProt

NX_O60242.

PharmGKB

PA25249.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG146816.

HOGENOM

HOG000230916.

HOVERGEN

HBG004813.

InParanoid

O60242.

KO

K04598.

OMA

LTDINFP.

OrthoDB

EOG4H462V.

PhylomeDB

O60242.

Gene expression databases

ArrayExpress

O60242.

Bgee

O60242.

CleanEx

HS_BAI3.

Genevestigator

O60242.

GermOnline

ENSG00000135298. Homo sapiens.

Family and domain databases

InterPro

IPR000859. CUB_dom.
IPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain-spec_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS_dom.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]

Pfam

PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]

PRINTS

PR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.

SMART

SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view]

SUPFAM

SSF82895. TSP1. 4 hits.

PROSITE

PS01180. CUB. 1 hit.
PS00649. G_PROTEIN_RECEP_F2_1. False negative.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

BAI3. human.

GenomeRNAi

577.

NextBio

2355.

SOURCE

Search...

Entry information

Entry name

BAI3_HUMAN

Accession

Primary (citable) accession number: O60242
Secondary accession number(s): O60297 , Q2NKN6, Q5VY37, Q9BX54

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.