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Protein

Adhesion G protein-coupled receptor B3

Gene

ADGRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).By similarity1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB
  • GTPase activator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor B31 Publication
Alternative name(s):
Brain-specific angiogenesis inhibitor 3
Gene namesi
Name:ADGRB3Imported
Synonyms:BAI3, KIAA0550
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:945. ADGRB3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 880ExtracellularCuratedAdd BLAST856
Transmembranei881 – 901Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini902 – 910CytoplasmicCurated9
Transmembranei911 – 931Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini932 – 939ExtracellularCurated8
Transmembranei940 – 960Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini961 – 981CytoplasmicCuratedAdd BLAST21
Transmembranei982 – 1002Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1003 – 1023ExtracellularCuratedAdd BLAST21
Transmembranei1024 – 1044Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1045 – 1098CytoplasmicCuratedAdd BLAST54
Transmembranei1099 – 1119Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1120 – 1125ExtracellularCurated6
Transmembranei1126 – 1146Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1147 – 1522CytoplasmicCuratedAdd BLAST376

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB
  • postsynapse Source: Ensembl
  • synaptic cleft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi577.
OpenTargetsiENSG00000135298.
PharmGKBiPA25249.

Polymorphism and mutation databases

BioMutaiBAI3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001286525 – 1522Adhesion G protein-coupled receptor B3Add BLAST1498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 55PROSITE-ProRule annotation
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi303 ↔ 336PROSITE-ProRule annotation
Disulfide bondi307 ↔ 342PROSITE-ProRule annotation
Disulfide bondi318 ↔ 326PROSITE-ProRule annotation
Glycosylationi337N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi357 ↔ 392PROSITE-ProRule annotation
Disulfide bondi361 ↔ 397PROSITE-ProRule annotation
Disulfide bondi372 ↔ 382PROSITE-ProRule annotation
Disulfide bondi412 ↔ 447PROSITE-ProRule annotation
Disulfide bondi416 ↔ 452PROSITE-ProRule annotation
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi427 ↔ 437PROSITE-ProRule annotation
Disulfide bondi467 ↔ 502PROSITE-ProRule annotation
Disulfide bondi471 ↔ 507PROSITE-ProRule annotation
Disulfide bondi482 ↔ 492PROSITE-ProRule annotation
Disulfide bondi514 ↔ 5491 Publication
Disulfide bondi537 ↔ 5671 Publication
Glycosylationi540N-linked (GlcNAc...)1 Publication1
Modified residuei619PhosphoserineCombined sources1
Glycosylationi625N-linked (GlcNAc...)1 Publication1
Glycosylationi779N-linked (GlcNAc...)Sequence analysis1
Glycosylationi812N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi819 ↔ 8511 Publication
Glycosylationi828N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi839 ↔ 8531 Publication
Glycosylationi937N-linked (GlcNAc...)Sequence analysis1
Modified residuei1220PhosphoserineBy similarity1
Modified residuei1411PhosphoserineBy similarity1

Post-translational modificationi

The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO60242.
PeptideAtlasiO60242.
PRIDEiO60242.

PTM databases

iPTMnetiO60242.
PhosphoSitePlusiO60242.

Expressioni

Tissue specificityi

Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines.1 Publication

Gene expression databases

BgeeiENSG00000135298.
CleanExiHS_BAI3.
ExpressionAtlasiO60242. baseline and differential.
GenevisibleiO60242. HS.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts (via TSP N-terminal domains) with C1QL1, C1QL2, C1QL3 and C1QL4 (PubMed:21262840). Interacts with ELMO1, ELMO2 AND ELMO3 (PubMed:24567399).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GPATCH11Q8N9543EBI-2682765,EBI-2555378

Protein-protein interaction databases

BioGridi107053. 2 interactors.
DIPiDIP-56121N.
IntActiO60242. 2 interactors.
STRINGi9606.ENSP00000359630.

Structurei

Secondary structure

11522
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni502 – 504Combined sources3
Turni519 – 521Combined sources3
Beta strandi532 – 535Combined sources4
Beta strandi541 – 551Combined sources11
Beta strandi557 – 559Combined sources3
Beta strandi563 – 569Combined sources7
Helixi570 – 583Combined sources14
Helixi589 – 608Combined sources20
Helixi613 – 632Combined sources20
Helixi639 – 652Combined sources14
Helixi655 – 657Combined sources3
Helixi658 – 664Combined sources7
Turni665 – 667Combined sources3
Helixi670 – 687Combined sources18
Beta strandi694 – 698Combined sources5
Beta strandi700 – 710Combined sources11
Beta strandi718 – 721Combined sources4
Helixi730 – 734Combined sources5
Beta strandi738 – 741Combined sources4
Helixi743 – 746Combined sources4
Beta strandi759 – 769Combined sources11
Helixi770 – 772Combined sources3
Beta strandi781 – 783Combined sources3
Beta strandi787 – 794Combined sources8
Beta strandi803 – 808Combined sources6
Beta strandi815 – 823Combined sources9
Beta strandi833 – 835Combined sources3
Beta strandi839 – 845Combined sources7
Beta strandi848 – 855Combined sources8
Beta strandi857 – 864Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DLOX-ray2.30A/B498-868[»]
ProteinModelPortaliO60242.
SMRiO60242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 159CUBPROSITE-ProRule annotationAdd BLAST130
Domaini291 – 343TSP type-1 1PROSITE-ProRule annotationAdd BLAST53
Domaini345 – 398TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini400 – 453TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini455 – 508TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini816 – 868GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi942 – 945Poly-Thr4
Compositional biasi1173 – 1176Poly-Ser4

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 4 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEA0. Eukaryota.
ENOG4111FBM. LUCA.
GeneTreeiENSGT00850000132260.
HOGENOMiHOG000230916.
HOVERGENiHBG004813.
InParanoidiO60242.
KOiK04598.
OMAiWDDSKTN.
OrthoDBiEOG091G00C7.
PhylomeDBiO60242.
TreeFamiTF331634.

Family and domain databases

InterProiIPR000859. CUB_dom.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSiPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 4 hits.
PROSITEiPS01180. CUB. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60242-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK
60 70 80 90 100
NFTNCTWTLE NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD
110 120 130 140 150
LLRKNHSIMQ LCNSKNAFVF LQYDKNFIQI RRVFPTNFPG LQKKGEEDQK
160 170 180 190 200
SFFEFLVLNK VSPSQFGCHV LCTWLESCLK SENGRTESCG IMYTKCTCPQ
210 220 230 240 250
HLGEWGIDDQ SLILLNNVVL PLNEQTEGCL TQELQTTQVC NLTREAKRPP
260 270 280 290 300
KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW
310 320 330 340 350
STCSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE
360 370 380 390 400
WSPWSLCSFT CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD
410 420 430 440 450
GQWQEWSSWS QCSVTCSNGT QQRSRQCTAA AHGGSECRGP WAESRECYNP
460 470 480 490 500
ECTANGQWNQ WGHWSGCSKS CDGGWERRIR TCQGAVITGQ QCEGTGEEVR
510 520 530 540 550
RCNEQRCPAP YEICPEDYLM SMVWKRTPAG DLAFNQCPLN ATGTTSRRCS
560 570 580 590 600
LSLHGVAFWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK
610 620 630 640 650
TLLDLTQRKN FYAGDLLMSV EILRNVTDTF KRASYIPASD GVQNFFQIVS
660 670 680 690 700
NLLDEENKEK WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG
710 720 730 740 750
NVVASIQKLP AASVLTDINF PMKGRKGMVD WARNSEDRVV IPKSIFTPVS
760 770 780 790 800
SKELDESSVF VLGAVLYKNL DLILPTLRNY TVINSKIIVV TIRPEPKTTD
810 820 830 840 850
SFLEIELAHL ANGTLNPYCV LWDDSKTNES LGTWSTQGCK TVLTDASHTK
860 870 880 890 900
CLCDRLSTFA ILAQQPREII MESSGTPSVT LIVGSGLSCL ALITLAVVYA
910 920 930 940 950
ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF
960 970 980 990 1000
FFLASFCWVL TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG
1010 1020 1030 1040 1050
FTRTKGYGTD HYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR
1060 1070 1080 1090 1100
DGILDKKLKH RAGQMSEPHS GLTLKCAKCG VVSTTALSAT TASNAMASLW
1110 1120 1130 1140 1150
SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG FVIVMVHCIL
1160 1170 1180 1190 1200
RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL
1210 1220 1230 1240 1250
HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII
1260 1270 1280 1290 1300
QQPTGLHMPM SMNELSNPCL KKENSELRRT VYLCTDDNLR GADMDIVHPQ
1310 1320 1330 1340 1350
ERMMESDYIV MPRSSVNNQP SMKEESKMNI GMETLPHERL LHYKVNPEFN
1360 1370 1380 1390 1400
MNPPVMDQFN MNLEQHLAPQ EHMQNLPFEP RTAVKNFMAS ELDDNAGLSR
1410 1420 1430 1440 1450
SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE LNQKFQTLDR
1460 1470 1480 1490 1500
FRDIPNTSSM ENPAPNKNPW DTFKNPSEYP HYTTINVLDT EAKDALELRP
1510 1520
AEWEKCLNLP LDVQEGDFQT EV
Length:1,522
Mass (Da):171,518
Last modified:November 2, 2010 - v2
Checksum:iD22D0A5CF59E811F
GO
Isoform 2 (identifier: O60242-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1036: Missing.

Note: No experimental confirmation available.
Show »
Length:486
Mass (Da):55,035
Checksum:i361BC76A2B85A843
GO

Sequence cautioni

The sequence BAA25476 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046525503N → S.3 PublicationsCorresponds to variant rs1932618dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569391 – 1036Missing in isoform 2. 1 PublicationAdd BLAST1036

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005299 mRNA. Translation: BAA25363.1.
AB011122 mRNA. Translation: BAA25476.2. Different initiation.
AK293560 mRNA. Translation: BAH11536.1.
AL035469 Genomic DNA. No translation available.
AL078598 Genomic DNA. No translation available.
AL589875 Genomic DNA. No translation available.
AL133378
, AL158051, AL160401, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAC34969.2.
AL359714
, AL133378, AL158051, AL160401, AL356117, AL391807 Genomic DNA. Translation: CAH71522.1.
AL356117
, AL133378, AL158051, AL160401, AL359714, AL391807 Genomic DNA. Translation: CAH71772.1.
AL160401
, AL133378, AL158051, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAH73864.1.
AL158051
, AL133378, AL160401, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAI19625.1.
AL391807
, AL133378, AL158051, AL160401, AL356117, AL359714 Genomic DNA. Translation: CAI21673.1.
CH471051 Genomic DNA. Translation: EAW48837.1.
BC111720 mRNA. Translation: AAI11721.1.
CCDSiCCDS4968.1. [O60242-1]
PIRiT00028.
T00326.
RefSeqiNP_001695.1. NM_001704.2.
XP_005248809.1. XM_005248752.2. [O60242-1]
UniGeneiHs.13261.

Genome annotation databases

EnsembliENST00000370598; ENSP00000359630; ENSG00000135298. [O60242-1]
ENST00000546190; ENSP00000441821; ENSG00000135298. [O60242-1]
GeneIDi577.
KEGGihsa:577.
UCSCiuc003pev.5. human. [O60242-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005299 mRNA. Translation: BAA25363.1.
AB011122 mRNA. Translation: BAA25476.2. Different initiation.
AK293560 mRNA. Translation: BAH11536.1.
AL035469 Genomic DNA. No translation available.
AL078598 Genomic DNA. No translation available.
AL589875 Genomic DNA. No translation available.
AL133378
, AL158051, AL160401, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAC34969.2.
AL359714
, AL133378, AL158051, AL160401, AL356117, AL391807 Genomic DNA. Translation: CAH71522.1.
AL356117
, AL133378, AL158051, AL160401, AL359714, AL391807 Genomic DNA. Translation: CAH71772.1.
AL160401
, AL133378, AL158051, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAH73864.1.
AL158051
, AL133378, AL160401, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAI19625.1.
AL391807
, AL133378, AL158051, AL160401, AL356117, AL359714 Genomic DNA. Translation: CAI21673.1.
CH471051 Genomic DNA. Translation: EAW48837.1.
BC111720 mRNA. Translation: AAI11721.1.
CCDSiCCDS4968.1. [O60242-1]
PIRiT00028.
T00326.
RefSeqiNP_001695.1. NM_001704.2.
XP_005248809.1. XM_005248752.2. [O60242-1]
UniGeneiHs.13261.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DLOX-ray2.30A/B498-868[»]
ProteinModelPortaliO60242.
SMRiO60242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107053. 2 interactors.
DIPiDIP-56121N.
IntActiO60242. 2 interactors.
STRINGi9606.ENSP00000359630.

Protein family/group databases

MEROPSiP02.027.
GPCRDBiSearch...

PTM databases

iPTMnetiO60242.
PhosphoSitePlusiO60242.

Polymorphism and mutation databases

BioMutaiBAI3.

Proteomic databases

PaxDbiO60242.
PeptideAtlasiO60242.
PRIDEiO60242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370598; ENSP00000359630; ENSG00000135298. [O60242-1]
ENST00000546190; ENSP00000441821; ENSG00000135298. [O60242-1]
GeneIDi577.
KEGGihsa:577.
UCSCiuc003pev.5. human. [O60242-1]

Organism-specific databases

CTDi577.
DisGeNETi577.
GeneCardsiADGRB3.
HGNCiHGNC:945. ADGRB3.
MIMi602684. gene.
neXtProtiNX_O60242.
OpenTargetsiENSG00000135298.
PharmGKBiPA25249.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEA0. Eukaryota.
ENOG4111FBM. LUCA.
GeneTreeiENSGT00850000132260.
HOGENOMiHOG000230916.
HOVERGENiHBG004813.
InParanoidiO60242.
KOiK04598.
OMAiWDDSKTN.
OrthoDBiEOG091G00C7.
PhylomeDBiO60242.
TreeFamiTF331634.

Miscellaneous databases

ChiTaRSiBAI3. human.
GeneWikiiBrain-specific_angiogenesis_inhibitor_3.
GenomeRNAii577.
PROiO60242.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135298.
CleanExiHS_BAI3.
ExpressionAtlasiO60242. baseline and differential.
GenevisibleiO60242. HS.

Family and domain databases

InterProiIPR000859. CUB_dom.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSiPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 4 hits.
PROSITEiPS01180. CUB. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRB3_HUMAN
AccessioniPrimary (citable) accession number: O60242
Secondary accession number(s): B7Z1K0
, O60297, Q2NKN6, Q5VY37, Q9BX54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Autoproteolysis appears to be cell specific, does not readily undergo proteolytic cleavage in HEK293T cells.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.