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O60242

- BAI3_HUMAN

UniProt

O60242 - BAI3_HUMAN

Protein

Brain-specific angiogenesis inhibitor 3

Gene

BAI3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. negative regulation of angiogenesis Source: InterPro
    3. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Protein family/group databases

    MEROPSiS63.030.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific angiogenesis inhibitor 3
    Gene namesi
    Name:BAI3
    Synonyms:KIAA0550
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:945. BAI3.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25249.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 15221498Brain-specific angiogenesis inhibitor 3PRO_0000012865Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 55By similarity
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi303 ↔ 336By similarity
    Disulfide bondi307 ↔ 342By similarity
    Disulfide bondi318 ↔ 326By similarity
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi357 ↔ 392By similarity
    Disulfide bondi361 ↔ 397By similarity
    Disulfide bondi372 ↔ 382By similarity
    Disulfide bondi412 ↔ 447By similarity
    Disulfide bondi416 ↔ 452By similarity
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi427 ↔ 437By similarity
    Disulfide bondi467 ↔ 502By similarity
    Disulfide bondi471 ↔ 507By similarity
    Disulfide bondi482 ↔ 492By similarity
    Disulfide bondi514 ↔ 5491 Publication
    Disulfide bondi537 ↔ 5671 Publication
    Glycosylationi540 – 5401N-linked (GlcNAc...)1 Publication
    Modified residuei619 – 6191Phosphoserine1 Publication
    Glycosylationi625 – 6251N-linked (GlcNAc...)1 Publication
    Glycosylationi779 – 7791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi812 – 8121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi819 ↔ 8511 Publication
    Glycosylationi828 – 8281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi839 ↔ 8531 Publication
    Glycosylationi937 – 9371N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Does not undergo autocatalytic cleavage (in vitro).1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO60242.
    PRIDEiO60242.

    PTM databases

    PhosphoSiteiO60242.

    Expressioni

    Tissue specificityi

    Strongly expressed in brain. Also detected in heart. Reduced expression is observed in some glioblastoma cell lines.

    Gene expression databases

    ArrayExpressiO60242.
    BgeeiO60242.
    CleanExiHS_BAI3.
    GenevestigatoriO60242.

    Organism-specific databases

    HPAiHPA015963.

    Interactioni

    Subunit structurei

    Interacts with C1QL1, C1QL2, C1QL3 and C1QL4.1 Publication

    Protein-protein interaction databases

    BioGridi107053. 1 interaction.
    DIPiDIP-56121N.
    IntActiO60242. 1 interaction.
    STRINGi9606.ENSP00000238918.

    Structurei

    Secondary structure

    1
    1522
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni519 – 5213
    Beta strandi532 – 5354
    Beta strandi541 – 55111
    Beta strandi557 – 5593
    Beta strandi563 – 5697
    Helixi570 – 58314
    Helixi589 – 60820
    Helixi613 – 63220
    Helixi639 – 65214
    Helixi655 – 6573
    Helixi658 – 6647
    Turni665 – 6673
    Helixi670 – 68718
    Beta strandi694 – 6985
    Beta strandi700 – 71011
    Beta strandi718 – 7214
    Helixi730 – 7345
    Beta strandi738 – 7414
    Helixi743 – 7464
    Beta strandi759 – 76911
    Helixi770 – 7723
    Beta strandi781 – 7833
    Beta strandi787 – 7948
    Beta strandi803 – 8086
    Beta strandi815 – 8239
    Beta strandi833 – 8353
    Beta strandi839 – 8457
    Beta strandi848 – 8558
    Beta strandi857 – 8648

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DLOX-ray2.30A/B498-868[»]
    ProteinModelPortaliO60242.
    SMRiO60242. Positions 508-866.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 880856ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini902 – 9109CytoplasmicSequence Analysis
    Topological domaini932 – 9398ExtracellularSequence Analysis
    Topological domaini961 – 98121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1003 – 102321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1045 – 109854CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1120 – 11256ExtracellularSequence Analysis
    Topological domaini1147 – 1522376CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei881 – 90121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei911 – 93121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei940 – 96021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei982 – 100221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei1024 – 104421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1099 – 111921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1126 – 114621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 159130CUBPROSITE-ProRule annotationAdd
    BLAST
    Domaini291 – 34353TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini345 – 39854TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 45354TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini455 – 50854TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini816 – 86853GPSPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi942 – 9454Poly-Thr
    Compositional biasi1173 – 11764Poly-Ser

    Sequence similaritiesi

    Contains 1 CUB domain.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 4 TSP type-1 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146816.
    HOGENOMiHOG000230916.
    HOVERGENiHBG004813.
    InParanoidiO60242.
    KOiK04598.
    OMAiWDDSKTN.
    OrthoDBiEOG7KDF90.
    PhylomeDBiO60242.
    TreeFamiTF331634.

    Family and domain databases

    InterProiIPR000859. CUB_dom.
    IPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR008077. GPCR_2_brain-spec_angio_inhib.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF00090. TSP_1. 4 hits.
    [Graphical view]
    PRINTSiPR01694. BAIPRECURSOR.
    PR00249. GPCRSECRETIN.
    SMARTiSM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00209. TSP1. 4 hits.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 4 hits.
    PROSITEiPS01180. CUB. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50092. TSP1. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60242-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK     50
    NFTNCTWTLE NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD 100
    LLRKNHSIMQ LCNSKNAFVF LQYDKNFIQI RRVFPTNFPG LQKKGEEDQK 150
    SFFEFLVLNK VSPSQFGCHV LCTWLESCLK SENGRTESCG IMYTKCTCPQ 200
    HLGEWGIDDQ SLILLNNVVL PLNEQTEGCL TQELQTTQVC NLTREAKRPP 250
    KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW 300
    STCSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE 350
    WSPWSLCSFT CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD 400
    GQWQEWSSWS QCSVTCSNGT QQRSRQCTAA AHGGSECRGP WAESRECYNP 450
    ECTANGQWNQ WGHWSGCSKS CDGGWERRIR TCQGAVITGQ QCEGTGEEVR 500
    RCNEQRCPAP YEICPEDYLM SMVWKRTPAG DLAFNQCPLN ATGTTSRRCS 550
    LSLHGVAFWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK 600
    TLLDLTQRKN FYAGDLLMSV EILRNVTDTF KRASYIPASD GVQNFFQIVS 650
    NLLDEENKEK WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG 700
    NVVASIQKLP AASVLTDINF PMKGRKGMVD WARNSEDRVV IPKSIFTPVS 750
    SKELDESSVF VLGAVLYKNL DLILPTLRNY TVINSKIIVV TIRPEPKTTD 800
    SFLEIELAHL ANGTLNPYCV LWDDSKTNES LGTWSTQGCK TVLTDASHTK 850
    CLCDRLSTFA ILAQQPREII MESSGTPSVT LIVGSGLSCL ALITLAVVYA 900
    ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF 950
    FFLASFCWVL TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG 1000
    FTRTKGYGTD HYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR 1050
    DGILDKKLKH RAGQMSEPHS GLTLKCAKCG VVSTTALSAT TASNAMASLW 1100
    SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG FVIVMVHCIL 1150
    RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL 1200
    HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII 1250
    QQPTGLHMPM SMNELSNPCL KKENSELRRT VYLCTDDNLR GADMDIVHPQ 1300
    ERMMESDYIV MPRSSVNNQP SMKEESKMNI GMETLPHERL LHYKVNPEFN 1350
    MNPPVMDQFN MNLEQHLAPQ EHMQNLPFEP RTAVKNFMAS ELDDNAGLSR 1400
    SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE LNQKFQTLDR 1450
    FRDIPNTSSM ENPAPNKNPW DTFKNPSEYP HYTTINVLDT EAKDALELRP 1500
    AEWEKCLNLP LDVQEGDFQT EV 1522
    Length:1,522
    Mass (Da):171,518
    Last modified:November 2, 2010 - v2
    Checksum:iD22D0A5CF59E811F
    GO

    Sequence cautioni

    The sequence BAA25476.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti503 – 5031N → S.3 Publications
    Corresponds to variant rs1932618 [ dbSNP | Ensembl ].
    VAR_046525

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005299 mRNA. Translation: BAA25363.1.
    AB011122 mRNA. Translation: BAA25476.2. Different initiation.
    AL133378
    , AL158051, AL160401, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAC34969.2.
    AL359714
    , AL133378, AL158051, AL160401, AL356117, AL391807 Genomic DNA. Translation: CAH71522.1.
    AL356117
    , AL133378, AL158051, AL160401, AL359714, AL391807 Genomic DNA. Translation: CAH71772.1.
    AL160401
    , AL133378, AL158051, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAH73864.1.
    AL158051
    , AL133378, AL160401, AL356117, AL359714, AL391807 Genomic DNA. Translation: CAI19625.1.
    AL391807
    , AL133378, AL158051, AL160401, AL356117, AL359714 Genomic DNA. Translation: CAI21673.1.
    CH471051 Genomic DNA. Translation: EAW48837.1.
    BC111720 mRNA. Translation: AAI11721.1.
    CCDSiCCDS4968.1.
    PIRiT00028.
    T00326.
    RefSeqiNP_001695.1. NM_001704.2.
    XP_005248809.1. XM_005248752.1.
    UniGeneiHs.13261.

    Genome annotation databases

    EnsembliENST00000370598; ENSP00000359630; ENSG00000135298.
    GeneIDi577.
    KEGGihsa:577.
    UCSCiuc003pev.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005299 mRNA. Translation: BAA25363.1 .
    AB011122 mRNA. Translation: BAA25476.2 . Different initiation.
    AL133378
    , AL158051 , AL160401 , AL356117 , AL359714 , AL391807 Genomic DNA. Translation: CAC34969.2 .
    AL359714
    , AL133378 , AL158051 , AL160401 , AL356117 , AL391807 Genomic DNA. Translation: CAH71522.1 .
    AL356117
    , AL133378 , AL158051 , AL160401 , AL359714 , AL391807 Genomic DNA. Translation: CAH71772.1 .
    AL160401
    , AL133378 , AL158051 , AL356117 , AL359714 , AL391807 Genomic DNA. Translation: CAH73864.1 .
    AL158051
    , AL133378 , AL160401 , AL356117 , AL359714 , AL391807 Genomic DNA. Translation: CAI19625.1 .
    AL391807
    , AL133378 , AL158051 , AL160401 , AL356117 , AL359714 Genomic DNA. Translation: CAI21673.1 .
    CH471051 Genomic DNA. Translation: EAW48837.1 .
    BC111720 mRNA. Translation: AAI11721.1 .
    CCDSi CCDS4968.1.
    PIRi T00028.
    T00326.
    RefSeqi NP_001695.1. NM_001704.2.
    XP_005248809.1. XM_005248752.1.
    UniGenei Hs.13261.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DLO X-ray 2.30 A/B 498-868 [» ]
    ProteinModelPortali O60242.
    SMRi O60242. Positions 508-866.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107053. 1 interaction.
    DIPi DIP-56121N.
    IntActi O60242. 1 interaction.
    STRINGi 9606.ENSP00000238918.

    Protein family/group databases

    MEROPSi S63.030.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei O60242.

    Proteomic databases

    PaxDbi O60242.
    PRIDEi O60242.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370598 ; ENSP00000359630 ; ENSG00000135298 .
    GeneIDi 577.
    KEGGi hsa:577.
    UCSCi uc003pev.4. human.

    Organism-specific databases

    CTDi 577.
    GeneCardsi GC06P069404.
    HGNCi HGNC:945. BAI3.
    HPAi HPA015963.
    MIMi 602684. gene.
    neXtProti NX_O60242.
    PharmGKBi PA25249.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146816.
    HOGENOMi HOG000230916.
    HOVERGENi HBG004813.
    InParanoidi O60242.
    KOi K04598.
    OMAi WDDSKTN.
    OrthoDBi EOG7KDF90.
    PhylomeDBi O60242.
    TreeFami TF331634.

    Miscellaneous databases

    ChiTaRSi BAI3. human.
    GeneWikii Brain-specific_angiogenesis_inhibitor_3.
    GenomeRNAii 577.
    NextBioi 2355.
    PROi O60242.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60242.
    Bgeei O60242.
    CleanExi HS_BAI3.
    Genevestigatori O60242.

    Family and domain databases

    InterProi IPR000859. CUB_dom.
    IPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR008077. GPCR_2_brain-spec_angio_inhib.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF00090. TSP_1. 4 hits.
    [Graphical view ]
    PRINTSi PR01694. BAIPRECURSOR.
    PR00249. GPCRSECRETIN.
    SMARTi SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00209. TSP1. 4 hits.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 4 hits.
    PROSITEi PS01180. CUB. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50092. TSP1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)."
      Shiratsuchi T., Nishimori H., Ichise H., Nakamura Y., Tokino T.
      Cytogenet. Cell Genet. 79:103-108(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-503.
      Tissue: Fetal brain.
    2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-503.
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 643-665 AND C-TERMINUS.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-503.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-619, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins."
      Bolliger M.F., Martinelli D.C., Sudhof T.C.
      Proc. Natl. Acad. Sci. U.S.A. 108:2534-2539(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH C1QL1; C1QL2; C1QL3 AND C1QL4.
    9. "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis."
      Arac D., Boucard A.A., Bolliger M.F., Nguyen J., Soltis S.M., Sudhof T.C., Brunger A.T.
      EMBO J. 31:1364-1378(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 498-868, PROTEOLYTIC PROCESSING, GLYCOSYLATION AT ASN-540 AND ASN-625, DISULFIDE BONDS, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiBAI3_HUMAN
    AccessioniPrimary (citable) accession number: O60242
    Secondary accession number(s): O60297
    , Q2NKN6, Q5VY37, Q9BX54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3