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Protein

Adhesion G protein-coupled receptor B2

Gene

ADGRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT signaling pathway probably via a G-protein dependent pathway (PubMed:20367554). Might be involved in angiogenesis inhibition (By similarity).By similarity1 Publication

Enzyme regulationi

Displays increased activity following removal of N-terminal regions (mimicking the situation after proteolytic cleavage in the GPS domain and N-terminal fragment release).1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121753-MONOMER.

Protein family/group databases

MEROPSiP02.029.
TCDBi9.A.14.6.6. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor B21 Publication
Alternative name(s):
Brain-specific angiogenesis inhibitor 2
Gene namesi
Name:ADGRB2Imported
Synonyms:BAI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:944. ADGRB2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 936ExtracellularCuratedAdd BLAST904
Transmembranei937 – 957Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini958 – 965CytoplasmicCurated8
Transmembranei966 – 986Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini987 – 994ExtracellularCurated8
Transmembranei995 – 1015Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini1016 – 1036CytoplasmicCuratedAdd BLAST21
Transmembranei1037 – 1057Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1058 – 1078ExtracellularCuratedAdd BLAST21
Transmembranei1079 – 1099Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1100 – 1121CytoplasmicCuratedAdd BLAST22
Transmembranei1122 – 1142Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1143 – 1153ExtracellularCuratedAdd BLAST11
Transmembranei1154 – 1174Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1175 – 1585CytoplasmicCuratedAdd BLAST411

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi889W → S: Inhibits autoproteolytic cleavage. 1 Publication1
Mutagenesisi908C → W: Inhibits autoproteolytic cleavage. 1 Publication1
Mutagenesisi912S → P: Inhibits autoproteolytic cleavage. 1 Publication1

Organism-specific databases

DisGeNETi576.
OpenTargetsiENSG00000121753.
PharmGKBiPA25248.

Polymorphism and mutation databases

BioMutaiBAI2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001286433 – 1585Adhesion G protein-coupled receptor B2Add BLAST1553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi321 ↔ 355PROSITE-ProRule annotation
Disulfide bondi325 ↔ 361PROSITE-ProRule annotation
Disulfide bondi336 ↔ 345PROSITE-ProRule annotation
Glycosylationi356N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi376 ↔ 411PROSITE-ProRule annotation
Disulfide bondi380 ↔ 416PROSITE-ProRule annotation
Disulfide bondi391 ↔ 401PROSITE-ProRule annotation
Disulfide bondi431 ↔ 466PROSITE-ProRule annotation
Disulfide bondi435 ↔ 471PROSITE-ProRule annotation
Glycosylationi437N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi446 ↔ 456PROSITE-ProRule annotation
Disulfide bondi487 ↔ 522PROSITE-ProRule annotation
Disulfide bondi491 ↔ 527PROSITE-ProRule annotation
Disulfide bondi502 ↔ 512PROSITE-ProRule annotation
Disulfide bondi534 ↔ 569PROSITE-ProRule annotation
Disulfide bondi557 ↔ 587PROSITE-ProRule annotation
Glycosylationi560N-linked (GlcNAc...)Sequence analysis1
Glycosylationi645N-linked (GlcNAc...)Sequence analysis1
Glycosylationi867N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi874 ↔ 906PROSITE-ProRule annotation
Disulfide bondi894 ↔ 908PROSITE-ProRule annotation
Modified residuei1351PhosphotyrosineBy similarity1

Post-translational modificationi

Proteolytically cleaved at 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment.1 Publication
Glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei296 – 297Cleavage; by furin1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO60241.
PeptideAtlasiO60241.
PRIDEiO60241.

PTM databases

iPTMnetiO60241.
PhosphoSitePlusiO60241.

Expressioni

Tissue specificityi

Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

Gene expression databases

BgeeiENSG00000121753.
CleanExiHS_BAI2.
ExpressionAtlasiO60241. baseline and differential.
GenevisibleiO60241. HS.

Organism-specific databases

HPAiHPA052612.
HPA054617.

Interactioni

Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with GABPB2 (By similarity). Interacts (via carboxy-terminus) with TAX1BP3 (PubMed:21787750).By similarity1 Publication

Protein-protein interaction databases

BioGridi107052. 3 interactors.
IntActiO60241. 4 interactors.
MINTiMINT-143677.
STRINGi9606.ENSP00000362762.

Structurei

3D structure databases

ProteinModelPortaliO60241.
SMRiO60241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 362TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini364 – 417TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini419 – 472TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini475 – 528TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini871 – 923GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 134Poly-Glu6
Compositional biasi189 – 192Poly-Asn4
Compositional biasi234 – 237Poly-Thr4
Compositional biasi1315 – 1318Poly-Pro4
Compositional biasi1364 – 1370Poly-Gly7
Compositional biasi1425 – 1430Poly-Pro6

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 4 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEA0. Eukaryota.
ENOG4111FBM. LUCA.
GeneTreeiENSGT00850000132260.
HOGENOMiHOG000230916.
HOVERGENiHBG004813.
InParanoidiO60241.
KOiK04597.
OMAiEQVCAHF.
OrthoDBiEOG091G00C7.
PhylomeDBiO60241.
TreeFamiTF331634.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSiPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 4 hits.
PROSITEiPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG
60 70 80 90 100
AFSLQDLFPT IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL
110 120 130 140 150
DHYLVNFTCL RPSPEEAVAQ AESEVGRPEE EEAEAAAGLE LCSGSGPFTF
160 170 180 190 200
LHFDKNFVQL CLSAEPSEAP RLLAPAALAF RFVEVLLINN NNSSQFTCGV
210 220 230 240 250
LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG PPAAHTLSNA
260 270 280 290 300
LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP
310 320 330 340 350
GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR
360 370 380 390 400
ETRPCNNSAT CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA
410 420 430 440 450
CEGPELQTKL CSMAACPVEG QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG
460 470 480 490 500
PAWATCTGAL TDTRECSNLE CPATDSKWGP WNAWSLCSKT CDTGWQRRFR
510 520 530 540 550
MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM LMTWKKAAAG
560 570 580 590 600
EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR
610 620 630 640 650
EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF
660 670 680 690 700
KRATYVPSAD DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED
710 720 730 740 750
FIHLVGDALK AFQSSLIVTD NLVISIQREP VSAVSSDITF PMRGRRGMKD
760 770 780 790 800
WVRHSEDRLF LPKEVLSLSS PGKPATSGAA GSPGRGRGPG TVPPGPGHSH
810 820 830 840 850
QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR VMTVTVRPPT
860 870 880 890 900
QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ
910 920 930 940 950
AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL
960 970 980 990 1000
LAIYAAFWRF IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA
1010 1020 1030 1040 1050
AFLHFFFLSS FCWVLTEAWQ SYLAVIGRMR TRLVRKRFLC LGWGLPALVV
1060 1070 1080 1090 1100
AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF VGPAAVIVLV NMLIGIIVFN
1110 1120 1130 1140 1150
KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP LLSSASARNA
1160 1170 1180 1190 1200
MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA
1210 1220 1230 1240 1250
VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA
1260 1270 1280 1290 1300
CQTVLFKEVN TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG
1310 1320 1330 1340 1350
NILVPMAASP GLGEPPPPQE ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD
1360 1370 1380 1390 1400
YMVLPRRTLS LQPGGGGGGG EDAPRARPEG TPRRAAKTVA HTEGYPSFLS
1410 1420 1430 1440 1450
VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE RSRTMPRTVP
1460 1470 1480 1490 1500
GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS
1510 1520 1530 1540 1550
QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM
1560 1570 1580
TLGSLPPKPR ERLTLHRAAA WEPTEPPDGD FQTEV
Length:1,585
Mass (Da):172,656
Last modified:May 5, 2009 - v2
Checksum:i56D253AE0AB1552D
GO
Isoform 2 (identifier: O60241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1473-1473: Missing.

Show »
Length:1,584
Mass (Da):172,528
Checksum:iA22E0B77267D56B4
GO
Isoform 3 (identifier: O60241-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:1,573
Mass (Da):171,270
Checksum:i7A690AF3382053B9
GO
Isoform 4 (identifier: O60241-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1119-1151: Missing.
     1473-1473: Missing.

Show »
Length:1,551
Mass (Da):169,199
Checksum:iEA1685A0E11C2592
GO

Sequence cautioni

The sequence BAA25362 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI16890 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti325C → R in AAI36534 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0370451 – 12Missing in isoform 3. CuratedAdd BLAST12
Alternative sequenceiVSP_0370461119 – 1151Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0370471473Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005298 mRNA. Translation: BAA25362.1. Different initiation.
AB065648 Genomic DNA. Translation: BAC05874.1.
AL354919, AC114488 Genomic DNA. Translation: CAI16890.1. Sequence problems.
BC009035 mRNA. Translation: AAH09035.1.
BC136533 mRNA. Translation: AAI36534.1.
CCDSiCCDS72746.1. [O60241-4]
CCDS72747.1. [O60241-2]
PIRiT00027.
RefSeqiNP_001281264.1. NM_001294335.1. [O60241-2]
NP_001281265.1. NM_001294336.1. [O60241-4]
XP_011540150.1. XM_011541848.2. [O60241-1]
XP_011540151.1. XM_011541849.2. [O60241-3]
XP_016857388.1. XM_017001899.1. [O60241-1]
XP_016857389.1. XM_017001900.1. [O60241-2]
XP_016857394.1. XM_017001905.1. [O60241-4]
UniGeneiHs.524138.

Genome annotation databases

EnsembliENST00000373655; ENSP00000362759; ENSG00000121753. [O60241-2]
ENST00000373658; ENSP00000362762; ENSG00000121753. [O60241-1]
ENST00000527361; ENSP00000435397; ENSG00000121753. [O60241-4]
GeneIDi576.
KEGGihsa:576.
UCSCiuc001btn.4. human. [O60241-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005298 mRNA. Translation: BAA25362.1. Different initiation.
AB065648 Genomic DNA. Translation: BAC05874.1.
AL354919, AC114488 Genomic DNA. Translation: CAI16890.1. Sequence problems.
BC009035 mRNA. Translation: AAH09035.1.
BC136533 mRNA. Translation: AAI36534.1.
CCDSiCCDS72746.1. [O60241-4]
CCDS72747.1. [O60241-2]
PIRiT00027.
RefSeqiNP_001281264.1. NM_001294335.1. [O60241-2]
NP_001281265.1. NM_001294336.1. [O60241-4]
XP_011540150.1. XM_011541848.2. [O60241-1]
XP_011540151.1. XM_011541849.2. [O60241-3]
XP_016857388.1. XM_017001899.1. [O60241-1]
XP_016857389.1. XM_017001900.1. [O60241-2]
XP_016857394.1. XM_017001905.1. [O60241-4]
UniGeneiHs.524138.

3D structure databases

ProteinModelPortaliO60241.
SMRiO60241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107052. 3 interactors.
IntActiO60241. 4 interactors.
MINTiMINT-143677.
STRINGi9606.ENSP00000362762.

Protein family/group databases

MEROPSiP02.029.
TCDBi9.A.14.6.6. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiO60241.
PhosphoSitePlusiO60241.

Polymorphism and mutation databases

BioMutaiBAI2.

Proteomic databases

PaxDbiO60241.
PeptideAtlasiO60241.
PRIDEiO60241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373655; ENSP00000362759; ENSG00000121753. [O60241-2]
ENST00000373658; ENSP00000362762; ENSG00000121753. [O60241-1]
ENST00000527361; ENSP00000435397; ENSG00000121753. [O60241-4]
GeneIDi576.
KEGGihsa:576.
UCSCiuc001btn.4. human. [O60241-1]

Organism-specific databases

CTDi576.
DisGeNETi576.
GeneCardsiADGRB2.
H-InvDBHIX0023509.
HGNCiHGNC:944. ADGRB2.
HPAiHPA052612.
HPA054617.
MIMi602683. gene.
neXtProtiNX_O60241.
OpenTargetsiENSG00000121753.
PharmGKBiPA25248.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEA0. Eukaryota.
ENOG4111FBM. LUCA.
GeneTreeiENSGT00850000132260.
HOGENOMiHOG000230916.
HOVERGENiHBG004813.
InParanoidiO60241.
KOiK04597.
OMAiEQVCAHF.
OrthoDBiEOG091G00C7.
PhylomeDBiO60241.
TreeFamiTF331634.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121753-MONOMER.

Miscellaneous databases

ChiTaRSiBAI2. human.
GeneWikiiBrain-specific_angiogenesis_inhibitor_2.
GenomeRNAii576.
PROiO60241.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121753.
CleanExiHS_BAI2.
ExpressionAtlasiO60241. baseline and differential.
GenevisibleiO60241. HS.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSiPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 4 hits.
PROSITEiPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRB2_HUMAN
AccessioniPrimary (citable) accession number: O60241
Secondary accession number(s): B9EGK9
, Q5T6K0, Q8NGW8, Q96GZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.