O60241 (BAI2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-specific angiogenesis inhibitor 2

Gene names

Name:

BAI2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1585 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Might be involved in angiogenesis inhibition.
Subunit structure	Interacts with GABPB2 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 4 TSP type-1 domains.
Sequence caution	The sequence BAA25362.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI16890.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of angiogenesis Inferred from electronic annotation. Source: InterPro neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Traceable author statement. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Traceable author statement. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60241-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60241-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1473-1473: Missing.

Isoform 3 (identifier: O60241-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Isoform 4 (identifier: O60241-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1119-1151: Missing.
     1473-1473: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 1585	1553	Brain-specific angiogenesis inhibitor 2		PRO_0000012864
Regions
	Topological domain	33 – 936	904	Extracellular Potential
	Transmembrane	937 – 957	21	Helical; Name=1; Potential
	Topological domain	958 – 965	8	Cytoplasmic Potential
	Transmembrane	966 – 986	21	Helical; Name=2; Potential
	Topological domain	987 – 994	8	Extracellular Potential
	Transmembrane	995 – 1015	21	Helical; Name=3; Potential
	Topological domain	1016 – 1036	21	Cytoplasmic Potential
	Transmembrane	1037 – 1057	21	Helical; Name=4; Potential
	Topological domain	1058 – 1078	21	Extracellular Potential
	Transmembrane	1079 – 1099	21	Helical; Name=5; Potential
	Topological domain	1100 – 1121	22	Cytoplasmic Potential
	Transmembrane	1122 – 1142	21	Helical; Name=6; Potential
	Topological domain	1143 – 1153	11	Extracellular Potential
	Transmembrane	1154 – 1174	21	Helical; Name=7; Potential
	Topological domain	1175 – 1584	410	Cytoplasmic Potential
	Domain	309 – 362	54	TSP type-1 1
	Domain	364 – 417	54	TSP type-1 2
	Domain	419 – 472	54	TSP type-1 3
	Domain	475 – 528	54	TSP type-1 4
	Domain	871 – 923	53	GPS
	Compositional bias	129 – 134	6	Poly-Glu
	Compositional bias	189 – 192	4	Poly-Asn
	Compositional bias	234 – 237	4	Poly-Thr
	Compositional bias	1315 – 1318	4	Poly-Pro
	Compositional bias	1364 – 1370	7	Poly-Gly
	Compositional bias	1425 – 1430	6	Poly-Pro
Amino acid modifications
	Modified residue	1351	1	Phosphotyrosine By similarity
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	191	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Glycosylation	356	1	N-linked (GlcNAc...) Potential
	Glycosylation	437	1	N-linked (GlcNAc...) Potential
	Glycosylation	560	1	N-linked (GlcNAc...) Potential
	Glycosylation	645	1	N-linked (GlcNAc...) Potential
	Glycosylation	867	1	N-linked (GlcNAc...) Potential
	Disulfide bond	321 ↔ 355		By similarity
	Disulfide bond	325 ↔ 361		By similarity
	Disulfide bond	336 ↔ 345		By similarity
	Disulfide bond	376 ↔ 411		By similarity
	Disulfide bond	380 ↔ 416		By similarity
	Disulfide bond	391 ↔ 401		By similarity
	Disulfide bond	431 ↔ 466		By similarity
	Disulfide bond	435 ↔ 471		By similarity
	Disulfide bond	446 ↔ 456		By similarity
	Disulfide bond	487 ↔ 522		By similarity
	Disulfide bond	491 ↔ 527		By similarity
	Disulfide bond	502 ↔ 512		By similarity
Natural variations
	Alternative sequence	1 – 12	12	Missing in isoform 3.		VSP_037045
	Alternative sequence	1119 – 1151	33	Missing in isoform 4.		VSP_037046
	Alternative sequence	1473	1	Missing in isoform 2 and isoform 4.		VSP_037047
Experimental info
	Sequence conflict	325	1	C → R in AAI36534. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 56D253AE0AB1552D	FASTA	1,585	172,656
	10 20 30 40 50 60 MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG AFSLQDLFPT 70 80 90 100 110 120 IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL DHYLVNFTCL RPSPEEAVAQ 130 140 150 160 170 180 AESEVGRPEE EEAEAAAGLE LCSGSGPFTF LHFDKNFVQL CLSAEPSEAP RLLAPAALAF 190 200 210 220 230 240 RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG 250 260 270 280 290 300 PPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP 310 320 330 340 350 360 GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR ETRPCNNSAT 370 380 390 400 410 420 CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA CEGPELQTKL CSMAACPVEG 430 440 450 460 470 480 QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG PAWATCTGAL TDTRECSNLE CPATDSKWGP 490 500 510 520 530 540 WNAWSLCSKT CDTGWQRRFR MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM 550 560 570 580 590 600 LMTWKKAAAG EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR 610 620 630 640 650 660 EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF KRATYVPSAD 670 680 690 700 710 720 DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED FIHLVGDALK AFQSSLIVTD 730 740 750 760 770 780 NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRHSEDRLF LPKEVLSLSS PGKPATSGAA 790 800 810 820 830 840 GSPGRGRGPG TVPPGPGHSH QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR 850 860 870 880 890 900 VMTVTVRPPT QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ 910 920 930 940 950 960 AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL LAIYAAFWRF 970 980 990 1000 1010 1020 IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA AFLHFFFLSS FCWVLTEAWQ 1030 1040 1050 1060 1070 1080 SYLAVIGRMR TRLVRKRFLC LGWGLPALVV AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF 1090 1100 1110 1120 1130 1140 VGPAAVIVLV NMLIGIIVFN KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP 1150 1160 1170 1180 1190 1200 LLSSASARNA MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA 1210 1220 1230 1240 1250 1260 VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA CQTVLFKEVN 1270 1280 1290 1300 1310 1320 TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG NILVPMAASP GLGEPPPPQE 1330 1340 1350 1360 1370 1380 ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS LQPGGGGGGG EDAPRARPEG 1390 1400 1410 1420 1430 1440 TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE 1450 1460 1470 1480 1490 1500 RSRTMPRTVP GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS 1510 1520 1530 1540 1550 1560 QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM TLGSLPPKPR 1570 1580 ERLTLHRAAA WEPTEPPDGD FQTEV
	Isoform 2 [UniParc]. Checksum: A22E0B77267D56B4	FASTA	1,584	172,528
	10 20 30 40 50 60 MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG AFSLQDLFPT 70 80 90 100 110 120 IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL DHYLVNFTCL RPSPEEAVAQ 130 140 150 160 170 180 AESEVGRPEE EEAEAAAGLE LCSGSGPFTF LHFDKNFVQL CLSAEPSEAP RLLAPAALAF 190 200 210 220 230 240 RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG 250 260 270 280 290 300 PPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP 310 320 330 340 350 360 GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR ETRPCNNSAT 370 380 390 400 410 420 CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA CEGPELQTKL CSMAACPVEG 430 440 450 460 470 480 QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG PAWATCTGAL TDTRECSNLE CPATDSKWGP 490 500 510 520 530 540 WNAWSLCSKT CDTGWQRRFR MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM 550 560 570 580 590 600 LMTWKKAAAG EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR 610 620 630 640 650 660 EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF KRATYVPSAD 670 680 690 700 710 720 DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED FIHLVGDALK AFQSSLIVTD 730 740 750 760 770 780 NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRHSEDRLF LPKEVLSLSS PGKPATSGAA 790 800 810 820 830 840 GSPGRGRGPG TVPPGPGHSH QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR 850 860 870 880 890 900 VMTVTVRPPT QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ 910 920 930 940 950 960 AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL LAIYAAFWRF 970 980 990 1000 1010 1020 IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA AFLHFFFLSS FCWVLTEAWQ 1030 1040 1050 1060 1070 1080 SYLAVIGRMR TRLVRKRFLC LGWGLPALVV AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF 1090 1100 1110 1120 1130 1140 VGPAAVIVLV NMLIGIIVFN KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP 1150 1160 1170 1180 1190 1200 LLSSASARNA MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA 1210 1220 1230 1240 1250 1260 VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA CQTVLFKEVN 1270 1280 1290 1300 1310 1320 TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG NILVPMAASP GLGEPPPPQE 1330 1340 1350 1360 1370 1380 ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS LQPGGGGGGG EDAPRARPEG 1390 1400 1410 1420 1430 1440 TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE 1450 1460 1470 1480 1490 1500 RSRTMPRTVP GSTMKMGSLE RKKLRYSDLD FEVMHTRKRH SELYHELNQK FHTFDRYRSQ 1510 1520 1530 1540 1550 1560 STAKREKRWS VSSGGAAERS VCTDKPSPGE RPSLSQHRRH QSWSTFKSMT LGSLPPKPRE 1570 1580 RLTLHRAAAW EPTEPPDGDF QTEV
	Isoform 3 [UniParc]. Checksum: 7A690AF3382053B9	FASTA	1,573	171,270
	10 20 30 40 50 60 MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP 70 80 90 100 110 120 DPTKYSLYLR FNRQEQVCAH FAPRLLPLDH YLVNFTCLRP SPEEAVAQAE SEVGRPEEEE 130 140 150 160 170 180 AEAAAGLELC SGSGPFTFLH FDKNFVQLCL SAEPSEAPRL LAPAALAFRF VEVLLINNNN 190 200 210 220 230 240 SSQFTCGVLC RWSEECGRAA GRACGFAQPG CSCPGEAGAG STTTTSPGPP AAHTLSNALV 250 260 270 280 290 300 PGGPAPPAEA DLHSGSSNDL FTTEMRYGEE PEEEPKVKTQ WPRSADEPGL YMAQTGDPAA 310 320 330 340 350 360 EEWSPWSVCS LTCGQGLQVR TRSCVSSPYG TLCSGPLRET RPCNNSATCP VHGVWEEWGS 370 380 390 400 410 420 WSLCSRSCGR GSRSRMRTCV PPQHGGKACE GPELQTKLCS MAACPVEGQW LEWGPWGPCS 430 440 450 460 470 480 TSCANGTQQR SRKCSVAGPA WATCTGALTD TRECSNLECP ATDSKWGPWN AWSLCSKTCD 490 500 510 520 530 540 TGWQRRFRMC QATGTQGYPC EGTGEEVKPC SEKRCPAFHE MCRDEYVMLM TWKKAAAGEI 550 560 570 580 590 600 IYNKCPPNAS GSASRRCLLS AQGVAYWGLP SFARCISHEY RYLYLSLREH LAKGQRMLAG 610 620 630 640 650 660 EGMSQVVRSL QELLARRTYY SGDLLFSVDI LRNVTDTFKR ATYVPSADDV QRFFQVVSFM 670 680 690 700 710 720 VDAENKEKWD DAQQVSPGSV HLLRVVEDFI HLVGDALKAF QSSLIVTDNL VISIQREPVS 730 740 750 760 770 780 AVSSDITFPM RGRRGMKDWV RHSEDRLFLP KEVLSLSSPG KPATSGAAGS PGRGRGPGTV 790 800 810 820 830 840 PPGPGHSHQR LLPADPDESS YFVIGAVLYR TLGLILPPPR PPLAVTSRVM TVTVRPPTQP 850 860 870 880 890 900 PAEPLITVEL SYIINGTTDP HCASWDYSRA DASSGDWDTE NCQTLETQAA HTRCQCQHLS 910 920 930 940 950 960 TFAVLAQPPK DLTLELAGSP SVPLVIGCAV SCMALLTLLA IYAAFWRFIK SERSIILLNF 970 980 990 1000 1010 1020 CLSILASNIL ILVGQSRVLS KGVCTMTAAF LHFFFLSSFC WVLTEAWQSY LAVIGRMRTR 1030 1040 1050 1060 1070 1080 LVRKRFLCLG WGLPALVVAV SVGFTRTKGY GTSSYCWLSL EGGLLYAFVG PAAVIVLVNM 1090 1100 1110 1120 1130 1140 LIGIIVFNKL MARDGISDKS KKQRAGSERC PWASLLLPCS ACGAVPSPLL SSASARNAMA 1150 1160 1170 1180 1190 1200 SLWSSCVVLP LLALTWMSAV LAMTDRRSVL FQALFAVFNS AQGFVITAVH CFLRREVQDV 1210 1220 1230 1240 1250 1260 VKCQMGVCRA DESEDSPDSC KNGQLQILSD FEKDVDLACQ TVLFKEVNTC NPSTITGTLS 1270 1280 1290 1300 1310 1320 RLSLDEDEEP KSCLVGPEGS LSFSPLPGNI LVPMAASPGL GEPPPPQEAN PVYMCGEGGL 1330 1340 1350 1360 1370 1380 RQLDLTWLRP TEPGSEGDYM VLPRRTLSLQ PGGGGGGGED APRARPEGTP RRAAKTVAHT 1390 1400 1410 1420 1430 1440 EGYPSFLSVD HSGLGLGPAY GSLQNPYGMT FQPPPPTPSA RQVPEPGERS RTMPRTVPGS 1450 1460 1470 1480 1490 1500 TMKMGSLERK KLRYSDLDFE KVMHTRKRHS ELYHELNQKF HTFDRYRSQS TAKREKRWSV 1510 1520 1530 1540 1550 1560 SSGGAAERSV CTDKPSPGER PSLSQHRRHQ SWSTFKSMTL GSLPPKPRER LTLHRAAAWE 1570 PTEPPDGDFQ TEV
	Isoform 4 [UniParc]. Checksum: EA1685A0E11C2592	FASTA	1,551	169,199
	10 20 30 40 50 60 MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG AFSLQDLFPT 70 80 90 100 110 120 IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL DHYLVNFTCL RPSPEEAVAQ 130 140 150 160 170 180 AESEVGRPEE EEAEAAAGLE LCSGSGPFTF LHFDKNFVQL CLSAEPSEAP RLLAPAALAF 190 200 210 220 230 240 RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG 250 260 270 280 290 300 PPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP 310 320 330 340 350 360 GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR ETRPCNNSAT 370 380 390 400 410 420 CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA CEGPELQTKL CSMAACPVEG 430 440 450 460 470 480 QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG PAWATCTGAL TDTRECSNLE CPATDSKWGP 490 500 510 520 530 540 WNAWSLCSKT CDTGWQRRFR MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM 550 560 570 580 590 600 LMTWKKAAAG EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR 610 620 630 640 650 660 EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF KRATYVPSAD 670 680 690 700 710 720 DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED FIHLVGDALK AFQSSLIVTD 730 740 750 760 770 780 NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRHSEDRLF LPKEVLSLSS PGKPATSGAA 790 800 810 820 830 840 GSPGRGRGPG TVPPGPGHSH QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR 850 860 870 880 890 900 VMTVTVRPPT QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ 910 920 930 940 950 960 AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL LAIYAAFWRF 970 980 990 1000 1010 1020 IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA AFLHFFFLSS FCWVLTEAWQ 1030 1040 1050 1060 1070 1080 SYLAVIGRMR TRLVRKRFLC LGWGLPALVV AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF 1090 1100 1110 1120 1130 1140 VGPAAVIVLV NMLIGIIVFN KLMARDGISD KSKKQRAGAS LWSSCVVLPL LALTWMSAVL 1150 1160 1170 1180 1190 1200 AMTDRRSVLF QALFAVFNSA QGFVITAVHC FLRREVQDVV KCQMGVCRAD ESEDSPDSCK 1210 1220 1230 1240 1250 1260 NGQLQILSDF EKDVDLACQT VLFKEVNTCN PSTITGTLSR LSLDEDEEPK SCLVGPEGSL 1270 1280 1290 1300 1310 1320 SFSPLPGNIL VPMAASPGLG EPPPPQEANP VYMCGEGGLR QLDLTWLRPT EPGSEGDYMV 1330 1340 1350 1360 1370 1380 LPRRTLSLQP GGGGGGGEDA PRARPEGTPR RAAKTVAHTE GYPSFLSVDH SGLGLGPAYG 1390 1400 1410 1420 1430 1440 SLQNPYGMTF QPPPPTPSAR QVPEPGERSR TMPRTVPGST MKMGSLERKK LRYSDLDFEV 1450 1460 1470 1480 1490 1500 MHTRKRHSEL YHELNQKFHT FDRYRSQSTA KREKRWSVSS GGAAERSVCT DKPSPGERPS 1510 1520 1530 1540 1550 LSQHRRHQSW STFKSMTLGS LPPKPRERLT LHRAAAWEPT EPPDGDFQTE V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)." Shiratsuchi T., Nishimori H., Ichise H., Nakamura Y., Tokino T. Cytogenet. Cell Genet. 79:103-108(1997) [PubMed: 9533023] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Fetal brain.
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1293-1585 (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB005298 mRNA. Translation: BAA25362.1. Different initiation. AB065648 Genomic DNA. Translation: BAC05874.1. AL354919, AC114488 Genomic DNA. Translation: CAI16890.1. Sequence problems. BC009035 mRNA. Translation: AAH09035.1. BC136533 mRNA. Translation: AAI36534.1.
IPI	IPI00297188. IPI00746807. IPI00929479. IPI00929545.
PIR	T00027.
RefSeq	NP_001694.2. NM_001703.2.
UniGene	Hs.524138.
3D structure databases
ProteinModelPortal	O60241.
SMR	O60241. Positions 253-571.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60241. 1 interaction.
MINT	MINT-143677.
STRING	O60241.
Protein family/group databases
MEROPS	S63.032.
GPCRDB	Search...
PTM databases
PhosphoSite	O60241.
Proteomic databases
PRIDE	O60241.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373658; ENSP00000362762; ENSG00000121753.
GeneID	576.
KEGG	hsa:576.
UCSC	uc001btn.1. human.
Organism-specific databases
CTD	576.
GeneCards	GC01M032192.
H-InvDB	HIX0023509.
HGNC	HGNC:944. BAI2.
MIM	602683. gene.
neXtProt	NX_O60241.
PharmGKB	PA25248.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084332.
HOGENOM	HBG714232.
HOVERGEN	HBG004813.
OMA	ARNAMAS.
PhylomeDB	O60241.
Gene expression databases
ArrayExpress	O60241.
Bgee	O60241.
CleanEx	HS_BAI2.
Genevestigator	O60241.
GermOnline	ENSG00000121753. Homo sapiens.
Family and domain databases
InterPro	IPR022624. DUF3497. IPR017981. GPCR_2-like. IPR008077. GPCR_2_brain-spec_angio_inhib. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR000203. GPS_dom. IPR000884. Thrombospondin_1_rpt. [Graphical view]
KO	K04597.
Pfam	PF00002. 7tm_2. 1 hit. PF12003. DUF3497. 1 hit. PF01825. GPS. 1 hit. PF00090. TSP_1. 4 hits. [Graphical view]
PRINTS	PR01694. BAIPRECURSOR. PR00249. GPCRSECRETIN.
SMART	SM00303. GPS. 1 hit. SM00008. HormR. 1 hit. SM00209. TSP1. 4 hits. [Graphical view]
SUPFAM	SSF82895. TSP1. 4 hits.
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS50092. TSP1. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	2351.
SOURCE	Search...

Entry information

Entry name

BAI2_HUMAN

Accession

Primary (citable) accession number: O60241
Secondary accession number(s): B9EGK9 , Q5T6K0, Q8NGW8, Q96GZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.