Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O60241 (BAI2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-specific angiogenesis inhibitor 2
Gene names
Name:BAI2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1585 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Might be involved in angiogenesis inhibition.

Subunit structure

Interacts with GABPB2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Contains 4 TSP type-1 domains.

Sequence caution

The sequence BAA25362.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI16890.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60241-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60241-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1473-1473: Missing.
Isoform 3 (identifier: O60241-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.
Isoform 4 (identifier: O60241-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1119-1151: Missing.
     1473-1473: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 15851553Brain-specific angiogenesis inhibitor 2
PRO_0000012864

Regions

Topological domain33 – 936904Extracellular Potential
Transmembrane937 – 95721Helical; Name=1; Potential
Topological domain958 – 9658Cytoplasmic Potential
Transmembrane966 – 98621Helical; Name=2; Potential
Topological domain987 – 9948Extracellular Potential
Transmembrane995 – 101521Helical; Name=3; Potential
Topological domain1016 – 103621Cytoplasmic Potential
Transmembrane1037 – 105721Helical; Name=4; Potential
Topological domain1058 – 107821Extracellular Potential
Transmembrane1079 – 109921Helical; Name=5; Potential
Topological domain1100 – 112122Cytoplasmic Potential
Transmembrane1122 – 114221Helical; Name=6; Potential
Topological domain1143 – 115311Extracellular Potential
Transmembrane1154 – 117421Helical; Name=7; Potential
Topological domain1175 – 1584410Cytoplasmic Potential
Domain309 – 36254TSP type-1 1
Domain364 – 41754TSP type-1 2
Domain419 – 47254TSP type-1 3
Domain475 – 52854TSP type-1 4
Domain871 – 92353GPS
Compositional bias129 – 1346Poly-Glu
Compositional bias189 – 1924Poly-Asn
Compositional bias234 – 2374Poly-Thr
Compositional bias1315 – 13184Poly-Pro
Compositional bias1364 – 13707Poly-Gly
Compositional bias1425 – 14306Poly-Pro

Amino acid modifications

Modified residue13511Phosphotyrosine By similarity
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation3561N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation5601N-linked (GlcNAc...) Potential
Glycosylation6451N-linked (GlcNAc...) Potential
Glycosylation8671N-linked (GlcNAc...) Potential
Disulfide bond321 ↔ 355 By similarity
Disulfide bond325 ↔ 361 By similarity
Disulfide bond336 ↔ 345 By similarity
Disulfide bond376 ↔ 411 By similarity
Disulfide bond380 ↔ 416 By similarity
Disulfide bond391 ↔ 401 By similarity
Disulfide bond431 ↔ 466 By similarity
Disulfide bond435 ↔ 471 By similarity
Disulfide bond446 ↔ 456 By similarity
Disulfide bond487 ↔ 522 By similarity
Disulfide bond491 ↔ 527 By similarity
Disulfide bond502 ↔ 512 By similarity
Disulfide bond534 ↔ 569 By similarity
Disulfide bond557 ↔ 587 By similarity
Disulfide bond874 ↔ 906 By similarity
Disulfide bond894 ↔ 908 By similarity

Natural variations

Alternative sequence1 – 1212Missing in isoform 3.
VSP_037045
Alternative sequence1119 – 115133Missing in isoform 4.
VSP_037046
Alternative sequence14731Missing in isoform 2 and isoform 4.
VSP_037047

Experimental info

Sequence conflict3251C → R in AAI36534. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 56D253AE0AB1552D

FASTA1,585172,656
        10         20         30         40         50         60 
MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG AFSLQDLFPT 

        70         80         90        100        110        120 
IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL DHYLVNFTCL RPSPEEAVAQ 

       130        140        150        160        170        180 
AESEVGRPEE EEAEAAAGLE LCSGSGPFTF LHFDKNFVQL CLSAEPSEAP RLLAPAALAF 

       190        200        210        220        230        240 
RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG 

       250        260        270        280        290        300 
PPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP 

       310        320        330        340        350        360 
GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR ETRPCNNSAT 

       370        380        390        400        410        420 
CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA CEGPELQTKL CSMAACPVEG 

       430        440        450        460        470        480 
QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG PAWATCTGAL TDTRECSNLE CPATDSKWGP 

       490        500        510        520        530        540 
WNAWSLCSKT CDTGWQRRFR MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM 

       550        560        570        580        590        600 
LMTWKKAAAG EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR 

       610        620        630        640        650        660 
EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF KRATYVPSAD 

       670        680        690        700        710        720 
DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED FIHLVGDALK AFQSSLIVTD 

       730        740        750        760        770        780 
NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRHSEDRLF LPKEVLSLSS PGKPATSGAA 

       790        800        810        820        830        840 
GSPGRGRGPG TVPPGPGHSH QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR 

       850        860        870        880        890        900 
VMTVTVRPPT QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ 

       910        920        930        940        950        960 
AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL LAIYAAFWRF 

       970        980        990       1000       1010       1020 
IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA AFLHFFFLSS FCWVLTEAWQ 

      1030       1040       1050       1060       1070       1080 
SYLAVIGRMR TRLVRKRFLC LGWGLPALVV AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF 

      1090       1100       1110       1120       1130       1140 
VGPAAVIVLV NMLIGIIVFN KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP 

      1150       1160       1170       1180       1190       1200 
LLSSASARNA MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA 

      1210       1220       1230       1240       1250       1260 
VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA CQTVLFKEVN 

      1270       1280       1290       1300       1310       1320 
TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG NILVPMAASP GLGEPPPPQE 

      1330       1340       1350       1360       1370       1380 
ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS LQPGGGGGGG EDAPRARPEG 

      1390       1400       1410       1420       1430       1440 
TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE 

      1450       1460       1470       1480       1490       1500 
RSRTMPRTVP GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS 

      1510       1520       1530       1540       1550       1560 
QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM TLGSLPPKPR 

      1570       1580 
ERLTLHRAAA WEPTEPPDGD FQTEV 

« Hide

Isoform 2 [UniParc].

Checksum: A22E0B77267D56B4
Show »

FASTA1,584172,528
Isoform 3 [UniParc].

Checksum: 7A690AF3382053B9
Show »

FASTA1,573171,270
Isoform 4 [UniParc].

Checksum: EA1685A0E11C2592
Show »

FASTA1,551169,199

References

« Hide 'large scale' references
[1]"Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)."
Shiratsuchi T., Nishimori H., Ichise H., Nakamura Y., Tokino T.
Cytogenet. Cell Genet. 79:103-108(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Fetal brain.
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1293-1585 (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB005298 mRNA. Translation: BAA25362.1. Different initiation.
AB065648 Genomic DNA. Translation: BAC05874.1.
AL354919, AC114488 Genomic DNA. Translation: CAI16890.1. Sequence problems.
BC009035 mRNA. Translation: AAH09035.1.
BC136533 mRNA. Translation: AAI36534.1.
PIRT00027.
RefSeqNP_001694.2. NM_001703.2.
XP_005271124.1. XM_005271067.2.
UniGeneHs.524138.

3D structure databases

ProteinModelPortalO60241.
SMRO60241. Positions 253-921, 944-1205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107052. 3 interactions.
IntActO60241. 4 interactions.
MINTMINT-143677.
STRING9606.ENSP00000362762.

Protein family/group databases

MEROPSS63.032.
TCDB9.A.14.6.6. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteO60241.

Proteomic databases

PaxDbO60241.
PRIDEO60241.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257070; ENSP00000257070; ENSG00000121753. [O60241-4]
ENST00000373655; ENSP00000362759; ENSG00000121753. [O60241-2]
ENST00000373658; ENSP00000362762; ENSG00000121753. [O60241-1]
ENST00000527361; ENSP00000435397; ENSG00000121753. [O60241-4]
GeneID576.
KEGGhsa:576.
UCSCuc001btn.3. human. [O60241-1]
uc001bto.3. human. [O60241-2]
uc010ogq.2. human. [O60241-4]

Organism-specific databases

CTD576.
GeneCardsGC01M032192.
H-InvDBHIX0023509.
HGNCHGNC:944. BAI2.
HPAHPA052612.
HPA054617.
MIM602683. gene.
neXtProtNX_O60241.
PharmGKBPA25248.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146816.
HOGENOMHOG000230916.
HOVERGENHBG004813.
KOK04597.
OMAEQVCAHF.
PhylomeDBO60241.
TreeFamTF331634.

Gene expression databases

ArrayExpressO60241.
BgeeO60241.
CleanExHS_BAI2.
GenevestigatorO60241.

Family and domain databases

InterProIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain-spec_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF01825. GPS. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMSSF82895. SSF82895. 4 hits.
PROSITEPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBAI2. human.
GeneWikiBrain-specific_angiogenesis_inhibitor_2.
GenomeRNAi576.
NextBio2351.
PROO60241.
SOURCESearch...

Entry information

Entry nameBAI2_HUMAN
AccessionPrimary (citable) accession number: O60241
Secondary accession number(s): B9EGK9 expand/collapse secondary AC list , Q5T6K0, Q8NGW8, Q96GZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries