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Reviewed, UniProtKB/Swiss-Prot O60240 (PLIN_HUMAN)

Last modified November 25, 2008. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Perilipin
      Short name=PERI
Alternative name(s):
    Lipid droplet-associated protein
Gene names
Name: PLIN
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Modulator of adipocyte lipid metabolism, it coats lipid storage droplets to protect them to be broken down by hormone-sensitive lipase (HSL). Its absence may result in leanness.

Subunit structure

Interacts with ABHD5 By similarity.

Subcellular location

Lipid dropletBy similarity. Note= Lipid droplet surface-associated By similarity.

Tissue specificity

Adipocytes.

Post-translational modification

Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet By similarity.

Sequence similarities

Belongs to the perilipin family.

Ontologies

Keywords

   Biological processLipid metabolism
   Cellular componentLipid droplet
   PTMPhosphoprotein

Gene Ontology (GO)

   Cellular componentmonolayer-surrounded lipid storage body

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionlipid binding Ref.1

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Perilipin
PRO_0000099884

Regions

Compositional bias307 – 31610Poly-Glu

Experimental info

Sequence conflict2101K → E in AAH31084. Ref.2
Sequence conflict5101V → L in AAH31084. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O60240-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 7D42B5479C6C55B5

FASTA52255,950
        10         20         30         40         50         60 
MAVNKGLTLL DGDLPEQENV LQRVLQLPVV SGTCECFQKT YTSTKEAHPL VASVCNAYEK 

        70         80         90        100        110        120 
GVQSASSLAA WSMEPVVRRL STQFTAANEL ACRGLDHLEE KIPALQYPPE KIASELKDTI 

       130        140        150        160        170        180 
STRLRSARNS ISVPIASTSD KVLGAALAGC ELAWGVARDT AEFAANTRAG RLASGGADLA 

       190        200        210        220        230        240 
LGSIEKVVEY LLPADKEESA PAPGHQQAQK SPKAKPSLLS RVGALTNTLS RYTVQTMARA 

       250        260        270        280        290        300 
LEQGHTVAMW IPGVVPLSSL AQWGASVAMQ AVSRRRSEVR VPWLHSLAAA QEEDHEDQTD 

       310        320        330        340        350        360 
TEGEDTEEEE ELETEENKFS EVAALPGPRG LLGGVAHTLQ KTLQTTISAV TWAPAAVLGM 

       370        380        390        400        410        420 
AGRVLHLTPA PAVSSTKGRA MSLSDALKGV TDNVVDTVVH YVPLPRLSLM EPESEFRDID 

       430        440        450        460        470        480 
NPPAEVERRE AERRASGAPS AGPEPAPRLA QPRRSLRSAQ SPGAPPGPGL EDEVATPAAP 

       490        500        510        520 
RPGFPAVPRE KPKRRVSDSF FRPSVMEPIV GRTHYSQLRK KS 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method."
Nishiu J., Tanaka T., Nakamura Y.
Genomics 48:254-257(1998) [PubMed: 9521880] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Adipocyte.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Fat, wonderful fat - Issue 10 of May 2001

Cross-references

Sequence databases

AB005293 mRNA. Translation: BAA25420.1.
BC031084 mRNA. Translation: AAH31084.1.
RefSeqNP_002657.2.
UniGeneHs.103253

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteO60240.

Genome annotation databases

EnsemblENSG00000166819. Homo sapiens. [Contig view]
GeneID5346.
KEGGhsa:5346.

Organism-specific databases

H-InvDBHIX0012568.
HGNCHGNC:9076. PLIN.
MIM170290. gene.
PharmGKBPA33409.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMO60240.
HOVERGENO60240.

Enzyme and pathway databases

ReactomeREACT_602. Lipid and lipoprotein metabolism.

Gene expression databases

ArrayExpressO60240.
CleanExHS_PLIN.
GermOnlineENSG00000166819. Homo sapiens.

Family and domain databases

InterProIPR004279. Perilipin.
[Graphical view]
PANTHERPTHR14024. Perilipin. 1 hit.
PfamPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFPIRSF036881. PAT. 1 hit.
ProtoNetSearch...

Other Resources

NextBio20718.
SOURCESearch...

Entry information

Entry namePLIN_HUMAN
AccessionPrimary (citable) accession number: O60240
Secondary accession number(s): Q8N5Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 25, 2008
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents