Reviewed,
UniProtKB/Swiss-Prot O60238 (BNI3L_HUMAN)
Last modified
November 25, 2008.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Alternative name(s): NIP3-like protein X Short name=NIP3L BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A Adenovirus E1B19K-binding protein B5 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 219 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3. |
| Subunit structure | Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein. |
| Subcellular location | Nucleus envelope. Endoplasmic reticulum. Mitochondrion. Membrane; Single-pass membrane proteinPotential. |
| Post-translational modification | Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin. |
| Sequence similarities | Belongs to the NIP3 family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| itself | 1 | EBI-849893,EBI-849893 | ||
| BAD | Q92934 | 1 | EBI-849893,EBI-700771 | |
| BCL2 | P10415 | 1 | EBI-849893,EBI-77694 | |
| BNIP3 | Q12983 | 1 | EBI-849893,EBI-749464 | |
| E1B | P03247 | 3 | EBI-849893,EBI-849856 | From a different organism. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 219 | 219 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like | PRO_0000064957 | |||||
Regions | |||||||||
| Transmembrane | 188 – 208 | 21 | Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 62 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 63 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 117 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 120 | 1 | Phosphoserine | ||||||
Experimental info | |||||||||
| Sequence conflict | 107 | 1 | D → E in AAN04051. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3." Matsushima M., Fujiwara T., Takahashi E., Minaguchi T., Eguchi Y., Tsujimoto Y., Suzumori K., Nakamura Y. Genes Chromosomes Cancer 21:230-235(1998) [PubMed: 9523198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "BNIP3a, a human homolog of pro-apoptotic protein BNIP3, promotes apoptosis and interacts with viral and cellular anti-apoptosis proteins." Yasuda M., Han J.-W., Dionne C.A., Boyd J.M., Chinnadurai G. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins." Chen G., Cizeau J., Vande Velde C., Park J.H., Bozek G., Bolton J., Shi L., Dubik D., Greenberg A. J. Biol. Chem. 274:7-10(1999) [PubMed: 9867803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver. |
| [4] | "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region." Ohi N., Tokunaga A., Tsunoda H., Nakano K., Haraguchi K., Oda K., Motoyama N., Nakajima T. Cell Death Differ. 6:314-325(1999) [PubMed: 10381623] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, SELF-ASSOCIATION, INTERACTION WITH BNIP3 AND HUMAN ADENOVIRUS-2 E1B 19 KDA PROTEIN. |
| [5] | "The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation." Aerbajinai W., Giattina M., Lee Y.T., Raffeld M., Miller J.L. Blood 102:712-717(2003) [PubMed: 12663450] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [6] | "A catalog of genes in the human dermal papilla cells as identified by expressed sequence tags." Farooq M., Kim M.K., Kim Y.H., Seo J.M., Lee H.M., Sohn M.Y., Hwang S.Y., Chung H.J., Im S.U., Jung E.J., Kim J.C. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Hair follicle dermal papilla. |
| [7] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow and Cervix. |
| [9] | "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase." Passer B.J., Nancy-Portebois V., Amzallag N., Prieur S., Cans C., Roborel de Climens A., Fiucci G., Bouvard V., Tuynder M., Susini L., Morchoisne S., Crible V., Lespagnol A., Dausset J., Oren M., Amson R., Telerman A. Proc. Natl. Acad. Sci. U.S.A. 100:2284-2289(2003) [PubMed: 12606722] [Abstract] Cited for: INTERACTION WITH STEAP3. |
| [10] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, MASS SPECTROMETRY. Tissue: Epithelium. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB004788 mRNA. Translation: BAA28692.1. AF079221 mRNA. Translation: AAC27723.1. AF067396 mRNA. Translation: AAD03589.1. AF536326 mRNA. Translation: AAN04051.1. AF452712 mRNA. Translation: AAL50978.1. AF255051 Genomic DNA. Translation: AAF70290.1. BT019501 mRNA. Translation: AAV38308.1. BC001559 mRNA. Translation: AAH01559.1. BC009603 mRNA. Translation: AAH09603.1. | |
| PIR | T34523. |
| RefSeq | NP_004322.1. |
| UniGene | Hs.131226 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O60238. |
PTM databases | |
| PhosphoSite | O60238. |
Genome annotation databases | |
| Ensembl | ENSG00000104765. Homo sapiens. [Contig view] |
| GeneID | 665. |
| KEGG | hsa:665. |
Organism-specific databases | |
| H-InvDB | HIX0007401. |
| HGNC | HGNC:1085. BNIP3L. |
| HPA | HPA015652. |
| MIM | 605368. gene. |
| PharmGKB | PA25395. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | O60238. |
Gene expression databases | |
| ArrayExpress | O60238. |
| CleanEx | HS_BNIP3L. |
| GermOnline | ENSG00000104765. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR010548. BNIP3. [Graphical view] |
| Pfam | PF06553. BNIP3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 2712. |
| SOURCE | Search... |
Entry information
| Entry name | BNI3L_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O60238 Secondary accession number(s): Q8NF87 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


