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Protein

Transmembrane protease serine 11D

Gene

TMPRSS11D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.2 Publications

Enzyme regulationi

Strongly inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, and soybean trypsin inhibitor, but hardly inhibited by secretory leukocyte protease inhibitor at 10 microM.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227Charge relay systemBy similarity1
Active sitei272Charge relay systemBy similarity1
Active sitei368Charge relay systemBy similarity1

GO - Molecular functioni

  • peptidase activity Source: ProtInc
  • serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  • proteolysis Source: UniProtKB
  • respiratory gaseous exchange Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.047

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11D (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease
Cleaved into the following 2 chains:
Gene namesi
Name:TMPRSS11D
Synonyms:HAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000153802.11
HGNCiHGNC:24059 TMPRSS11D
MIMi605369 gene
neXtProtiNX_O60235

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini42 – 418ExtracellularSequence analysisAdd BLAST377

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9407
OpenTargetsiENSG00000153802
PharmGKBiPA142670728

Chemistry databases

ChEMBLiCHEMBL1795138
GuidetoPHARMACOLOGYi2420

Polymorphism and mutation databases

BioMutaiTMPRSS11D

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000278851 – 186Transmembrane protease serine 11D non-catalytic chainAdd BLAST186
ChainiPRO_0000027886187 – 418Transmembrane protease serine 11D catalytic chainAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 292Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotation
Disulfide bondi212 ↔ 228PROSITE-ProRule annotation
Disulfide bondi337 ↔ 353PROSITE-ProRule annotation
Disulfide bondi364 ↔ 393PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiO60235
PaxDbiO60235
PeptideAtlasiO60235
PRIDEiO60235

Expressioni

Tissue specificityi

Located in the cells of the submucosal serous glands of the bronchi and trachea.

Gene expression databases

BgeeiENSG00000153802
CleanExiHS_TMPRSS11D
ExpressionAtlasiO60235 baseline and differential
GenevisibleiO60235 HS

Organism-specific databases

HPAiHPA052834

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiO60235, 2 interactors
MINTiO60235
STRINGi9606.ENSP00000283916

Chemistry databases

BindingDBiO60235

Structurei

3D structure databases

ProteinModelPortaliO60235
SMRiO60235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 163SEAPROSITE-ProRule annotationAdd BLAST118
Domaini187 – 417Peptidase S1PROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140784
HOGENOMiHOG000251823
HOVERGENiHBG013304
InParanoidiO60235
KOiK09641
OMAiAFDQKSY
OrthoDBiEOG091G0AH5
PhylomeDBiO60235
TreeFamiTF351684

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00200 SEA, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRPARVTST SRFLNPYVVC FIVVAGVVIL AVTIALLVYF LAFDQKSYFY
60 70 80 90 100
RSSFQLLNVE YNSQLNSPAT QEYRTLSGRI ESLITKTFKE SNLRNQFIRA
110 120 130 140 150
HVAKLRQDGS GVRADVVMKF QFTRNNNGAS MKSRIESVLR QMLNNSGNLE
160 170 180 190 200
INPSTEITSL TDQAAANWLI NECGAGPDLI TLSEQRILGG TEAEEGSWPW
210 220 230 240 250
QVSLRLNNAH HCGGSLINNM WILTAAHCFR SNSNPRDWIA TSGISTTFPK
260 270 280 290 300
LRMRVRNILI HNNYKSATHE NDIALVRLEN SVTFTKDIHS VCLPAATQNI
310 320 330 340 350
PPGSTAYVTG WGAQEYAGHT VPELRQGQVR IISNDVCNAP HSYNGAILSG
360 370 380 390 400
MLCAGVPQGG VDACQGDSGG PLVQEDSRRL WFIVGIVSWG DQCGLPDKPG
410
VYTRVTAYLD WIRQQTGI
Length:418
Mass (Da):46,263
Last modified:August 1, 1998 - v1
Checksum:iF4BC1DB020CFBBD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002134 mRNA Translation: BAA28691.1
BC125195 mRNA Translation: AAI25196.1
BC125196 mRNA Translation: AAI25197.1
CCDSiCCDS3518.1
RefSeqiNP_004253.1, NM_004262.2
UniGeneiHs.132195

Genome annotation databases

EnsembliENST00000283916; ENSP00000283916; ENSG00000153802
GeneIDi9407
KEGGihsa:9407
UCSCiuc003hdq.4 human

Similar proteinsi

Entry informationi

Entry nameiTM11D_HUMAN
AccessioniPrimary (citable) accession number: O60235
Secondary accession number(s): Q08AF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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