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O60234 (GMFG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glia maturation factor gamma

Short name=GMF-gamma
Gene names
Name:GMFG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed predominantly in lung, heart and placenta.

Sequence similarities

Belongs to the actin-binding proteins ADF family. GMF subfamily.

Contains 1 ADF-H domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 142142Glia maturation factor gamma
PRO_0000214947

Regions

Domain4 – 139136ADF-H

Natural variations

Natural variant1221E → K.
Corresponds to variant rs36110047 [ dbSNP | Ensembl ].
VAR_048196
Natural variant1361E → K.
Corresponds to variant rs34035414 [ dbSNP | Ensembl ].
VAR_048197

Secondary structure

...................... 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O60234 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: DB64BD8DE4F88170

FASTA14216,801
        10         20         30         40         50         60 
MSDSLVVCEV DPELTEKLRK FRFRKETDNA AIIMKVDKDR QMVVLEEEFQ NISPEELKME 

        70         80         90        100        110        120 
LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNR LVQTAELTKV 

       130        140 
FEIRTTDDLT EAWLQEKLSF FR 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of novel human cDNA (hGMF-gamma) homologous to glia maturation factor-beta gene."
Asai K., Fujita K., Yamamoto M., Hotta T., Morikawa M., Kokubo M., Moriyama A., Kato T.
Biochim. Biophys. Acta 1396:242-244(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The human glia maturation factor-gamma gene: genomic structure and mutation analysis in gliomas with chromosome 19q loss."
Peters N., Smith J.S., Tachibana I., Lee H.K., Pohl U., Portier B.P., Louis D.N., Jenkins R.B.
Neurogenetics 2:163-166(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Lymph.
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"The crystal structure of human glia maturation factor, gamma (GMFG)."
Structural genomics consortium (SGC)
Submitted (FEB-2010) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 7-140.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB001993 mRNA. Translation: BAA25572.1.
AF108027 expand/collapse EMBL AC list , AF108022, AF108023, AF108024, AF108025, AF108026 Genomic DNA. Translation: AAD27807.1.
AF038956 mRNA. Translation: AAC39870.1.
CR456967 mRNA. Translation: CAG33248.1.
CR542114 mRNA. Translation: CAG46911.1.
CH471126 Genomic DNA. Translation: EAW56874.1.
BC032819 mRNA. Translation: AAH32819.2.
BC080180 mRNA. Translation: AAH80180.1.
BC093799 mRNA. Translation: AAH93799.1.
BC101818 mRNA. Translation: AAI01819.1.
BC143543 mRNA. Translation: AAI43544.1.
BC143546 mRNA. Translation: AAI43547.1.
BC143548 mRNA. Translation: AAI43549.1.
CCDSCCDS12532.1.
RefSeqNP_004868.1. NM_004877.2.
UniGeneHs.5210.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3L50X-ray1.90A/B7-140[»]
ProteinModelPortalO60234.
SMRO60234. Positions 6-140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114911. 3 interactions.
IntActO60234. 4 interactions.
MINTMINT-1430865.
STRING9606.ENSP00000253054.

PTM databases

PhosphoSiteO60234.

2D gel databases

OGPO60234.

Proteomic databases

MaxQBO60234.
PaxDbO60234.
PRIDEO60234.

Protocols and materials databases

DNASU9535.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000597595; ENSP00000472249; ENSG00000130755.
GeneID9535.
KEGGhsa:9535.
UCSCuc002okx.4. human.

Organism-specific databases

CTD9535.
GeneCardsGC19M039821.
HGNCHGNC:4374. GMFG.
HPAHPA002954.
MIM604104. gene.
neXtProtNX_O60234.
PharmGKBPA28759.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG268251.
HOGENOMHOG000175654.
HOVERGENHBG003045.
InParanoidO60234.
OMADLTETWL.
PhylomeDBO60234.
TreeFamTF315147.

Gene expression databases

ArrayExpressO60234.
BgeeO60234.
CleanExHS_GMFG.
GenevestigatorO60234.

Family and domain databases

Gene3D3.40.20.10. 1 hit.
InterProIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF-beta.
[Graphical view]
PANTHERPTHR11249. PTHR11249. 1 hit.
PfamPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFPIRSF001788. GMF-beta. 1 hit.
SMARTSM00102. ADF. 1 hit.
[Graphical view]
PROSITEPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO60234.
GenomeRNAi9535.
NextBio35750.
PROO60234.
SOURCESearch...

Entry information

Entry nameGMFG_HUMAN
AccessionPrimary (citable) accession number: O60234
Secondary accession number(s): Q6IB37
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM