O60234 (GMFG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glia maturation factor gamma
Short name=GMF-gamma

Gene names

Name:

GMFG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed predominantly in lung, heart and placenta.
Sequence similarities	Belongs to the actin-binding proteins ADF family. GMF subfamily. Contains 1 ADF-H domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Growth factor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein phosphorylation Traceable author statement PubMed 7598724. Source: ProtInc
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	enzyme activator activity Traceable author statement PubMed 8798479. Source: ProtInc protein kinase inhibitor activity Traceable author statement PubMed 8639570. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 142

142

Glia maturation factor gamma

PRO_0000214947

Regions

Domain

4 – 139

136

ADF-H

Natural variations

Natural variant

122

1

E → K.
Corresponds to variant rs36110047 [ dbSNP | Ensembl ].

VAR_048196

Natural variant

136

1

E → K.
Corresponds to variant rs34035414 [ dbSNP | Ensembl ].

VAR_048197

Secondary structure

1

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142

Helix Strand Turn

Details...

Helix

12 – 21

10

Beta strand

31 – 37

7

Turn

38 – 41

4

Beta strand

42 – 51

10

Helix

54 – 60

7

Beta strand

63 – 65

3

Beta strand

67 – 72

6

Beta strand

86 – 91

6

Helix

98 – 115

18

Beta strand

120 – 125

6

Helix

126 – 128

3

Helix

131 – 138

8

Sequences

	Sequence		Length	Mass (Da)
	O60234 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: DB64BD8DE4F88170	FASTA	142	16,801
	10 20 30 40 50 60 MSDSLVVCEV DPELTEKLRK FRFRKETDNA AIIMKVDKDR QMVVLEEEFQ NISPEELKME 70 80 90 100 110 120 LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNR LVQTAELTKV 130 140 FEIRTTDDLT EAWLQEKLSF FR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of novel human cDNA (hGMF-gamma) homologous to glia maturation factor-beta gene." Asai K., Fujita K., Yamamoto M., Hotta T., Morikawa M., Kokubo M., Moriyama A., Kato T. Biochim. Biophys. Acta 1396:242-244(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The human glia maturation factor-gamma gene: genomic structure and mutation analysis in gliomas with chromosome 19q loss." Peters N., Smith J.S., Tachibana I., Lee H.K., Pohl U., Portier B.P., Louis D.N., Jenkins R.B. Neurogenetics 2:163-166(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"The crystal structure of human glia maturation factor, gamma (GMFG)." Structural genomics consortium (SGC) Submitted (FEB-2010) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 7-140.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB001993 mRNA. Translation: BAA25572.1.
AF108027 , AF108022, AF108023, AF108024, AF108025, AF108026 Genomic DNA. Translation: AAD27807.1.
AF038956 mRNA. Translation: AAC39870.1.
BC032819 mRNA. Translation: AAH32819.2.
BC080180 mRNA. Translation: AAH80180.1.

IPI

IPI00028414.

RefSeq

NP_004868.1. NM_004877.2.

UniGene

Hs.5210.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3L50	X-ray	1.90	A/B	7-140	[»]

ProteinModelPortal

O60234.

ModBase

Search...

Protein-protein interaction databases

IntAct

O60234. 4 interactions.

MINT

MINT-1430865.

STRING

9606.ENSP00000253054.

PTM databases

PhosphoSite

O60234.

2D gel databases

OGP

O60234.

Proteomic databases

PaxDb

O60234.

PRIDE

O60234.

Protocols and materials databases

DNASU

9535.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000597595; ENSP00000472249; ENSG00000130755.

GeneID

9535.

KEGG

hsa:9535.

UCSC

uc002okx.4. human.

Organism-specific databases

CTD

9535.

GeneCards

GC19M039821.

HGNC

HGNC:4374. GMFG.

HPA

HPA002954.

MIM

604104. gene.

neXtProt

NX_O60234.

PharmGKB

PA28759.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG268251.

HOGENOM

HOG000175654.

HOVERGEN

HBG003045.

InParanoid

O60234.

OMA

DLTETWL.

OrthoDB

EOG441QCP.

PhylomeDB

O60234.

Gene expression databases

ArrayExpress

O60234.

Bgee

O60234.

CleanEx

HS_GMFG.

Genevestigator

O60234.

GermOnline

ENSG00000130755. Homo sapiens.

Family and domain databases

InterPro

IPR002108. Actin-bd_cofilin/tropomyosin.
IPR011171. GMF-beta.
[Graphical view]

PANTHER

PTHR11249. PTHR11249. 1 hit.

Pfam

PF00241. Cofilin_ADF. 1 hit.
[Graphical view]

PIRSF

PIRSF001788. GMF-beta. 1 hit.

SMART

SM00102. ADF. 1 hit.
[Graphical view]

PROSITE

PS51263. ADF_H. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O60234.

GenomeRNAi

9535.

NextBio

35750.

SOURCE

Search...

Entry information

Entry name

GMFG_HUMAN

Accession

Primary (citable) accession number: O60234

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.