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O60234

- GMFG_HUMAN

UniProt

O60234 - GMFG_HUMAN

Protein

Glia maturation factor gamma

Gene

GMFG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. enzyme activator activity Source: ProtInc
    2. protein kinase inhibitor activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of protein kinase activity Source: GOC
    2. positive regulation of catalytic activity Source: GOC
    3. protein phosphorylation Source: ProtInc

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glia maturation factor gamma
    Short name:
    GMF-gamma
    Gene namesi
    Name:GMFG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4374. GMFG.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28759.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 142142Glia maturation factor gammaPRO_0000214947Add
    BLAST

    Proteomic databases

    MaxQBiO60234.
    PaxDbiO60234.
    PRIDEiO60234.

    2D gel databases

    OGPiO60234.

    PTM databases

    PhosphoSiteiO60234.

    Expressioni

    Tissue specificityi

    Expressed predominantly in lung, heart and placenta.

    Gene expression databases

    ArrayExpressiO60234.
    BgeeiO60234.
    CleanExiHS_GMFG.
    GenevestigatoriO60234.

    Organism-specific databases

    HPAiHPA002954.

    Interactioni

    Protein-protein interaction databases

    BioGridi114911. 3 interactions.
    IntActiO60234. 4 interactions.
    MINTiMINT-1430865.
    STRINGi9606.ENSP00000253054.

    Structurei

    Secondary structure

    1
    142
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 2110
    Beta strandi31 – 377
    Turni38 – 414
    Beta strandi42 – 5110
    Helixi54 – 607
    Beta strandi63 – 653
    Beta strandi67 – 726
    Beta strandi86 – 916
    Helixi98 – 11518
    Beta strandi120 – 1256
    Helixi126 – 1283
    Helixi131 – 1388

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3L50X-ray1.90A/B7-140[»]
    ProteinModelPortaliO60234.
    SMRiO60234. Positions 6-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60234.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 139136ADF-HPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ADF-H domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG268251.
    HOGENOMiHOG000175654.
    HOVERGENiHBG003045.
    InParanoidiO60234.
    OMAiDLTETWL.
    PhylomeDBiO60234.
    TreeFamiTF315147.

    Family and domain databases

    Gene3Di3.40.20.10. 1 hit.
    InterProiIPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR011171. GMF-beta.
    [Graphical view]
    PANTHERiPTHR11249. PTHR11249. 1 hit.
    PfamiPF00241. Cofilin_ADF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001788. GMF-beta. 1 hit.
    SMARTiSM00102. ADF. 1 hit.
    [Graphical view]
    PROSITEiPS51263. ADF_H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60234-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDSLVVCEV DPELTEKLRK FRFRKETDNA AIIMKVDKDR QMVVLEEEFQ    50
    NISPEELKME LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ 100
    QMMYAGSKNR LVQTAELTKV FEIRTTDDLT EAWLQEKLSF FR 142
    Length:142
    Mass (Da):16,801
    Last modified:August 1, 1998 - v1
    Checksum:iDB64BD8DE4F88170
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti122 – 1221E → K.
    Corresponds to variant rs36110047 [ dbSNP | Ensembl ].
    VAR_048196
    Natural varianti136 – 1361E → K.
    Corresponds to variant rs34035414 [ dbSNP | Ensembl ].
    VAR_048197

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001993 mRNA. Translation: BAA25572.1.
    AF108027
    , AF108022, AF108023, AF108024, AF108025, AF108026 Genomic DNA. Translation: AAD27807.1.
    AF038956 mRNA. Translation: AAC39870.1.
    CR456967 mRNA. Translation: CAG33248.1.
    CR542114 mRNA. Translation: CAG46911.1.
    CH471126 Genomic DNA. Translation: EAW56874.1.
    BC032819 mRNA. Translation: AAH32819.2.
    BC080180 mRNA. Translation: AAH80180.1.
    BC093799 mRNA. Translation: AAH93799.1.
    BC101818 mRNA. Translation: AAI01819.1.
    BC143543 mRNA. Translation: AAI43544.1.
    BC143546 mRNA. Translation: AAI43547.1.
    BC143548 mRNA. Translation: AAI43549.1.
    CCDSiCCDS12532.1.
    RefSeqiNP_004868.1. NM_004877.2.
    UniGeneiHs.5210.

    Genome annotation databases

    EnsembliENST00000597595; ENSP00000472249; ENSG00000130755.
    GeneIDi9535.
    KEGGihsa:9535.
    UCSCiuc002okx.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001993 mRNA. Translation: BAA25572.1 .
    AF108027
    , AF108022 , AF108023 , AF108024 , AF108025 , AF108026 Genomic DNA. Translation: AAD27807.1 .
    AF038956 mRNA. Translation: AAC39870.1 .
    CR456967 mRNA. Translation: CAG33248.1 .
    CR542114 mRNA. Translation: CAG46911.1 .
    CH471126 Genomic DNA. Translation: EAW56874.1 .
    BC032819 mRNA. Translation: AAH32819.2 .
    BC080180 mRNA. Translation: AAH80180.1 .
    BC093799 mRNA. Translation: AAH93799.1 .
    BC101818 mRNA. Translation: AAI01819.1 .
    BC143543 mRNA. Translation: AAI43544.1 .
    BC143546 mRNA. Translation: AAI43547.1 .
    BC143548 mRNA. Translation: AAI43549.1 .
    CCDSi CCDS12532.1.
    RefSeqi NP_004868.1. NM_004877.2.
    UniGenei Hs.5210.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3L50 X-ray 1.90 A/B 7-140 [» ]
    ProteinModelPortali O60234.
    SMRi O60234. Positions 6-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114911. 3 interactions.
    IntActi O60234. 4 interactions.
    MINTi MINT-1430865.
    STRINGi 9606.ENSP00000253054.

    PTM databases

    PhosphoSitei O60234.

    2D gel databases

    OGPi O60234.

    Proteomic databases

    MaxQBi O60234.
    PaxDbi O60234.
    PRIDEi O60234.

    Protocols and materials databases

    DNASUi 9535.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000597595 ; ENSP00000472249 ; ENSG00000130755 .
    GeneIDi 9535.
    KEGGi hsa:9535.
    UCSCi uc002okx.4. human.

    Organism-specific databases

    CTDi 9535.
    GeneCardsi GC19M039821.
    HGNCi HGNC:4374. GMFG.
    HPAi HPA002954.
    MIMi 604104. gene.
    neXtProti NX_O60234.
    PharmGKBi PA28759.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268251.
    HOGENOMi HOG000175654.
    HOVERGENi HBG003045.
    InParanoidi O60234.
    OMAi DLTETWL.
    PhylomeDBi O60234.
    TreeFami TF315147.

    Miscellaneous databases

    EvolutionaryTracei O60234.
    GenomeRNAii 9535.
    NextBioi 35750.
    PROi O60234.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60234.
    Bgeei O60234.
    CleanExi HS_GMFG.
    Genevestigatori O60234.

    Family and domain databases

    Gene3Di 3.40.20.10. 1 hit.
    InterProi IPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR011171. GMF-beta.
    [Graphical view ]
    PANTHERi PTHR11249. PTHR11249. 1 hit.
    Pfami PF00241. Cofilin_ADF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001788. GMF-beta. 1 hit.
    SMARTi SM00102. ADF. 1 hit.
    [Graphical view ]
    PROSITEi PS51263. ADF_H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of novel human cDNA (hGMF-gamma) homologous to glia maturation factor-beta gene."
      Asai K., Fujita K., Yamamoto M., Hotta T., Morikawa M., Kokubo M., Moriyama A., Kato T.
      Biochim. Biophys. Acta 1396:242-244(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The human glia maturation factor-gamma gene: genomic structure and mutation analysis in gliomas with chromosome 19q loss."
      Peters N., Smith J.S., Tachibana I., Lee H.K., Pohl U., Portier B.P., Louis D.N., Jenkins R.B.
      Neurogenetics 2:163-166(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
      Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Lymph.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "The crystal structure of human glia maturation factor, gamma (GMFG)."
      Structural genomics consortium (SGC)
      Submitted (FEB-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 7-140.

    Entry informationi

    Entry nameiGMFG_HUMAN
    AccessioniPrimary (citable) accession number: O60234
    Secondary accession number(s): Q6IB37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3