Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O60234

- GMFG_HUMAN

UniProt

O60234 - GMFG_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glia maturation factor gamma

Gene

GMFG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. enzyme activator activity Source: ProtInc
  2. protein kinase inhibitor activity Source: ProtInc

GO - Biological processi

  1. negative regulation of protein kinase activity Source: GOC
  2. positive regulation of catalytic activity Source: GOC
  3. protein phosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor gamma
Short name:
GMF-gamma
Gene namesi
Name:GMFG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4374. GMFG.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28759.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Glia maturation factor gammaPRO_0000214947Add
BLAST

Proteomic databases

MaxQBiO60234.
PaxDbiO60234.
PRIDEiO60234.

2D gel databases

OGPiO60234.

PTM databases

PhosphoSiteiO60234.

Expressioni

Tissue specificityi

Expressed predominantly in lung, heart and placenta.

Gene expression databases

BgeeiO60234.
CleanExiHS_GMFG.
ExpressionAtlasiO60234. baseline and differential.
GenevestigatoriO60234.

Organism-specific databases

HPAiHPA002954.

Interactioni

Protein-protein interaction databases

BioGridi114911. 3 interactions.
IntActiO60234. 4 interactions.
MINTiMINT-1430865.
STRINGi9606.ENSP00000253054.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 2110
Beta strandi31 – 377
Turni38 – 414
Beta strandi42 – 5110
Helixi54 – 607
Beta strandi63 – 653
Beta strandi67 – 726
Beta strandi86 – 916
Helixi98 – 11518
Beta strandi120 – 1256
Helixi126 – 1283
Helixi131 – 1388

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3L50X-ray1.90A/B7-140[»]
ProteinModelPortaliO60234.
SMRiO60234. Positions 6-140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60234.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 139136ADF-HPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG268251.
GeneTreeiENSGT00390000008920.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiO60234.
OMAiDLTETWL.
PhylomeDBiO60234.
TreeFamiTF315147.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF-beta.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60234-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSLVVCEV DPELTEKLRK FRFRKETDNA AIIMKVDKDR QMVVLEEEFQ
60 70 80 90 100
NISPEELKME LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNR LVQTAELTKV FEIRTTDDLT EAWLQEKLSF FR
Length:142
Mass (Da):16,801
Last modified:August 1, 1998 - v1
Checksum:iDB64BD8DE4F88170
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221E → K.
Corresponds to variant rs36110047 [ dbSNP | Ensembl ].
VAR_048196
Natural varianti136 – 1361E → K.
Corresponds to variant rs34035414 [ dbSNP | Ensembl ].
VAR_048197

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001993 mRNA. Translation: BAA25572.1.
AF108027
, AF108022, AF108023, AF108024, AF108025, AF108026 Genomic DNA. Translation: AAD27807.1.
AF038956 mRNA. Translation: AAC39870.1.
CR456967 mRNA. Translation: CAG33248.1.
CR542114 mRNA. Translation: CAG46911.1.
CH471126 Genomic DNA. Translation: EAW56874.1.
BC032819 mRNA. Translation: AAH32819.2.
BC080180 mRNA. Translation: AAH80180.1.
BC093799 mRNA. Translation: AAH93799.1.
BC101818 mRNA. Translation: AAI01819.1.
BC143543 mRNA. Translation: AAI43544.1.
BC143546 mRNA. Translation: AAI43547.1.
BC143548 mRNA. Translation: AAI43549.1.
CCDSiCCDS12532.1.
RefSeqiNP_004868.1. NM_004877.3.
UniGeneiHs.5210.

Genome annotation databases

EnsembliENST00000597595; ENSP00000472249; ENSG00000130755.
GeneIDi9535.
KEGGihsa:9535.
UCSCiuc002okx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001993 mRNA. Translation: BAA25572.1 .
AF108027
, AF108022 , AF108023 , AF108024 , AF108025 , AF108026 Genomic DNA. Translation: AAD27807.1 .
AF038956 mRNA. Translation: AAC39870.1 .
CR456967 mRNA. Translation: CAG33248.1 .
CR542114 mRNA. Translation: CAG46911.1 .
CH471126 Genomic DNA. Translation: EAW56874.1 .
BC032819 mRNA. Translation: AAH32819.2 .
BC080180 mRNA. Translation: AAH80180.1 .
BC093799 mRNA. Translation: AAH93799.1 .
BC101818 mRNA. Translation: AAI01819.1 .
BC143543 mRNA. Translation: AAI43544.1 .
BC143546 mRNA. Translation: AAI43547.1 .
BC143548 mRNA. Translation: AAI43549.1 .
CCDSi CCDS12532.1.
RefSeqi NP_004868.1. NM_004877.3.
UniGenei Hs.5210.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3L50 X-ray 1.90 A/B 7-140 [» ]
ProteinModelPortali O60234.
SMRi O60234. Positions 6-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114911. 3 interactions.
IntActi O60234. 4 interactions.
MINTi MINT-1430865.
STRINGi 9606.ENSP00000253054.

PTM databases

PhosphoSitei O60234.

2D gel databases

OGPi O60234.

Proteomic databases

MaxQBi O60234.
PaxDbi O60234.
PRIDEi O60234.

Protocols and materials databases

DNASUi 9535.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000597595 ; ENSP00000472249 ; ENSG00000130755 .
GeneIDi 9535.
KEGGi hsa:9535.
UCSCi uc002okx.4. human.

Organism-specific databases

CTDi 9535.
GeneCardsi GC19M039821.
HGNCi HGNC:4374. GMFG.
HPAi HPA002954.
MIMi 604104. gene.
neXtProti NX_O60234.
PharmGKBi PA28759.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG268251.
GeneTreei ENSGT00390000008920.
HOGENOMi HOG000175654.
HOVERGENi HBG003045.
InParanoidi O60234.
OMAi DLTETWL.
PhylomeDBi O60234.
TreeFami TF315147.

Miscellaneous databases

EvolutionaryTracei O60234.
GenomeRNAii 9535.
NextBioi 35750.
PROi O60234.
SOURCEi Search...

Gene expression databases

Bgeei O60234.
CleanExi HS_GMFG.
ExpressionAtlasi O60234. baseline and differential.
Genevestigatori O60234.

Family and domain databases

Gene3Di 3.40.20.10. 1 hit.
InterProi IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF-beta.
[Graphical view ]
PANTHERi PTHR11249. PTHR11249. 1 hit.
Pfami PF00241. Cofilin_ADF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001788. GMF-beta. 1 hit.
SMARTi SM00102. ADF. 1 hit.
[Graphical view ]
PROSITEi PS51263. ADF_H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of novel human cDNA (hGMF-gamma) homologous to glia maturation factor-beta gene."
    Asai K., Fujita K., Yamamoto M., Hotta T., Morikawa M., Kokubo M., Moriyama A., Kato T.
    Biochim. Biophys. Acta 1396:242-244(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The human glia maturation factor-gamma gene: genomic structure and mutation analysis in gliomas with chromosome 19q loss."
    Peters N., Smith J.S., Tachibana I., Lee H.K., Pohl U., Portier B.P., Louis D.N., Jenkins R.B.
    Neurogenetics 2:163-166(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
    Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
    Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Lymph.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "The crystal structure of human glia maturation factor, gamma (GMFG)."
    Structural genomics consortium (SGC)
    Submitted (FEB-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 7-140.

Entry informationi

Entry nameiGMFG_HUMAN
AccessioniPrimary (citable) accession number: O60234
Secondary accession number(s): Q6IB37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3