Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sjoegren syndrome/scleroderma autoantigen 1

Gene

SSSCA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic nuclear division Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sjoegren syndrome/scleroderma autoantigen 1
Alternative name(s):
Autoantigen p27
Gene namesi
Name:SSSCA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11328. SSSCA1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36152.

Polymorphism and mutation databases

BioMutaiSSSCA1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 199198Sjoegren syndrome/scleroderma autoantigen 1PRO_0000072201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei94 – 941Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO60232.
PaxDbiO60232.
PeptideAtlasiO60232.
PRIDEiO60232.

PTM databases

PhosphoSiteiO60232.

Miscellaneous databases

PMAP-CutDBO60232.

Expressioni

Gene expression databases

BgeeiO60232.
CleanExiHS_SSSCA1.
ExpressionAtlasiO60232. baseline and differential.
GenevisibleiO60232. HS.

Organism-specific databases

HPAiHPA039789.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-741415,EBI-10175576
CCNHP519464EBI-741415,EBI-741406
CCT2P783713EBI-741415,EBI-357407
CCT7Q998323EBI-741415,EBI-357046
HEL-S-100nV9HW963EBI-741415,EBI-10330207
HEL-S-69V9HW373EBI-741415,EBI-10186233
ORFQ9Q2G44EBI-741415,EBI-6248094From a different organism.
SNAPC5O759713EBI-741415,EBI-749483
TRAF3IP3Q9Y2283EBI-741415,EBI-765817

Protein-protein interaction databases

BioGridi115788. 93 interactions.
IntActiO60232. 22 interactions.
MINTiMINT-1434192.
STRINGi9606.ENSP00000312318.

Structurei

3D structure databases

ProteinModelPortaliO60232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 839Asp/Glu-rich (acidic)
Compositional biasi113 – 12210Pro-rich
Compositional biasi138 – 1458Pro-rich
Compositional biasi170 – 1778Ser/Thr-rich

Phylogenomic databases

eggNOGiNOG303301.
GeneTreeiENSGT00390000013169.
HOGENOMiHOG000007383.
HOVERGENiHBG054236.
InParanoidiO60232.
OMAiMKVIQAR.
PhylomeDBiO60232.
TreeFamiTF320182.

Family and domain databases

InterProiIPR009563. SSSCA1.
[Graphical view]
PfamiPF06677. Auto_anti-p27. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNGAEVDD FSWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG
60 70 80 90 100
ETCADCGTIL LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ
110 120 130 140 150
LASASELPLG SRPAPQPPVP RPEHCEGAAA GLKAAQGPPA PAVPPNTDVM
160 170 180 190
ACTQTALLQK LTWASAELGS STSLETSIQL CGLIRACAEA LRSLQQLQH
Length:199
Mass (Da):21,474
Last modified:August 1, 1998 - v1
Checksum:iEF08439FDFFA1DAB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211T → M.
Corresponds to variant rs35971725 [ dbSNP | Ensembl ].
VAR_051383

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001740 mRNA. Translation: BAA25263.1.
BC014791 mRNA. Translation: AAH14791.1.
CCDSiCCDS8104.1.
RefSeqiNP_006387.1. NM_006396.2.
UniGeneiHs.25723.

Genome annotation databases

EnsembliENST00000309328; ENSP00000312318; ENSG00000173465.
GeneIDi10534.
UCSCiuc001oek.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001740 mRNA. Translation: BAA25263.1.
BC014791 mRNA. Translation: AAH14791.1.
CCDSiCCDS8104.1.
RefSeqiNP_006387.1. NM_006396.2.
UniGeneiHs.25723.

3D structure databases

ProteinModelPortaliO60232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115788. 93 interactions.
IntActiO60232. 22 interactions.
MINTiMINT-1434192.
STRINGi9606.ENSP00000312318.

PTM databases

PhosphoSiteiO60232.

Polymorphism and mutation databases

BioMutaiSSSCA1.

Proteomic databases

MaxQBiO60232.
PaxDbiO60232.
PeptideAtlasiO60232.
PRIDEiO60232.

Protocols and materials databases

DNASUi10534.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309328; ENSP00000312318; ENSG00000173465.
GeneIDi10534.
UCSCiuc001oek.3. human.

Organism-specific databases

CTDi10534.
GeneCardsiGC11P065337.
HGNCiHGNC:11328. SSSCA1.
HPAiHPA039789.
MIMi606044. gene.
neXtProtiNX_O60232.
PharmGKBiPA36152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG303301.
GeneTreeiENSGT00390000013169.
HOGENOMiHOG000007383.
HOVERGENiHBG054236.
InParanoidiO60232.
OMAiMKVIQAR.
PhylomeDBiO60232.
TreeFamiTF320182.

Miscellaneous databases

ChiTaRSiSSSCA1. human.
GenomeRNAii10534.
NextBioi39965.
PMAP-CutDBO60232.
PROiO60232.
SOURCEiSearch...

Gene expression databases

BgeeiO60232.
CleanExiHS_SSSCA1.
ExpressionAtlasiO60232. baseline and differential.
GenevisibleiO60232. HS.

Family and domain databases

InterProiIPR009563. SSSCA1.
[Graphical view]
PfamiPF06677. Auto_anti-p27. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies."
    Muro Y., Yamada T., Himeno M., Sugimoto K.
    Clin. Exp. Immunol. 111:372-376(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSSA27_HUMAN
AccessioniPrimary (citable) accession number: O60232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: July 22, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.