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O60232

- SSA27_HUMAN

UniProt

O60232 - SSA27_HUMAN

Protein

Sjoegren syndrome/scleroderma autoantigen 1

Gene

SSSCA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. mitotic nuclear division Source: ProtInc

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sjoegren syndrome/scleroderma autoantigen 1
    Alternative name(s):
    Autoantigen p27
    Gene namesi
    Name:SSSCA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11328. SSSCA1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36152.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 199198Sjoegren syndrome/scleroderma autoantigen 1PRO_0000072201Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei94 – 941Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO60232.
    PaxDbiO60232.
    PeptideAtlasiO60232.
    PRIDEiO60232.

    PTM databases

    PhosphoSiteiO60232.

    Miscellaneous databases

    PMAP-CutDBO60232.

    Expressioni

    Gene expression databases

    ArrayExpressiO60232.
    BgeeiO60232.
    CleanExiHS_SSSCA1.
    GenevestigatoriO60232.

    Organism-specific databases

    HPAiHPA039789.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ORFQ9Q2G44EBI-741415,EBI-6248094From a different organism.

    Protein-protein interaction databases

    BioGridi115788. 87 interactions.
    IntActiO60232. 15 interactions.
    MINTiMINT-1434192.
    STRINGi9606.ENSP00000312318.

    Structurei

    3D structure databases

    ProteinModelPortaliO60232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi75 – 839Asp/Glu-rich (acidic)
    Compositional biasi113 – 12210Pro-rich
    Compositional biasi138 – 1458Pro-rich
    Compositional biasi170 – 1778Ser/Thr-rich

    Phylogenomic databases

    eggNOGiNOG303301.
    HOGENOMiHOG000007383.
    HOVERGENiHBG054236.
    InParanoidiO60232.
    OMAiMKVIQAR.
    PhylomeDBiO60232.
    TreeFamiTF320182.

    Family and domain databases

    InterProiIPR009563. SSSCA1.
    [Graphical view]
    PfamiPF06677. Auto_anti-p27. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60232-1 [UniParc]FASTAAdd to Basket

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    MALNGAEVDD FSWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG    50
    ETCADCGTIL LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ 100
    LASASELPLG SRPAPQPPVP RPEHCEGAAA GLKAAQGPPA PAVPPNTDVM 150
    ACTQTALLQK LTWASAELGS STSLETSIQL CGLIRACAEA LRSLQQLQH 199
    Length:199
    Mass (Da):21,474
    Last modified:August 1, 1998 - v1
    Checksum:iEF08439FDFFA1DAB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211T → M.
    Corresponds to variant rs35971725 [ dbSNP | Ensembl ].
    VAR_051383

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001740 mRNA. Translation: BAA25263.1.
    BC014791 mRNA. Translation: AAH14791.1.
    CCDSiCCDS8104.1.
    RefSeqiNP_006387.1. NM_006396.1.
    UniGeneiHs.25723.

    Genome annotation databases

    EnsembliENST00000309328; ENSP00000312318; ENSG00000173465.
    GeneIDi10534.
    KEGGihsa:10534.
    UCSCiuc001oek.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001740 mRNA. Translation: BAA25263.1 .
    BC014791 mRNA. Translation: AAH14791.1 .
    CCDSi CCDS8104.1.
    RefSeqi NP_006387.1. NM_006396.1.
    UniGenei Hs.25723.

    3D structure databases

    ProteinModelPortali O60232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115788. 87 interactions.
    IntActi O60232. 15 interactions.
    MINTi MINT-1434192.
    STRINGi 9606.ENSP00000312318.

    PTM databases

    PhosphoSitei O60232.

    Proteomic databases

    MaxQBi O60232.
    PaxDbi O60232.
    PeptideAtlasi O60232.
    PRIDEi O60232.

    Protocols and materials databases

    DNASUi 10534.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309328 ; ENSP00000312318 ; ENSG00000173465 .
    GeneIDi 10534.
    KEGGi hsa:10534.
    UCSCi uc001oek.3. human.

    Organism-specific databases

    CTDi 10534.
    GeneCardsi GC11P065337.
    HGNCi HGNC:11328. SSSCA1.
    HPAi HPA039789.
    MIMi 606044. gene.
    neXtProti NX_O60232.
    PharmGKBi PA36152.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303301.
    HOGENOMi HOG000007383.
    HOVERGENi HBG054236.
    InParanoidi O60232.
    OMAi MKVIQAR.
    PhylomeDBi O60232.
    TreeFami TF320182.

    Miscellaneous databases

    ChiTaRSi SSSCA1. human.
    GenomeRNAii 10534.
    NextBioi 39965.
    PMAP-CutDB O60232.
    PROi O60232.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60232.
    Bgeei O60232.
    CleanExi HS_SSSCA1.
    Genevestigatori O60232.

    Family and domain databases

    InterProi IPR009563. SSSCA1.
    [Graphical view ]
    Pfami PF06677. Auto_anti-p27. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies."
      Muro Y., Yamada T., Himeno M., Sugimoto K.
      Clin. Exp. Immunol. 111:372-376(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSSA27_HUMAN
    AccessioniPrimary (citable) accession number: O60232
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3