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Protein

Sjoegren syndrome/scleroderma autoantigen 1

Gene

SSSCA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic nuclear division Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173465-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sjoegren syndrome/scleroderma autoantigen 1
Alternative name(s):
Autoantigen p27
Gene namesi
Name:SSSCA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11328. SSSCA1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi10534.
OpenTargetsiENSG00000173465.
PharmGKBiPA36152.

Polymorphism and mutation databases

BioMutaiSSSCA1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000722012 – 199Sjoegren syndrome/scleroderma autoantigen 1Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei94PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60232.
MaxQBiO60232.
PaxDbiO60232.
PeptideAtlasiO60232.
PRIDEiO60232.

PTM databases

iPTMnetiO60232.
PhosphoSitePlusiO60232.

Miscellaneous databases

PMAP-CutDBO60232.

Expressioni

Gene expression databases

BgeeiENSG00000173465.
CleanExiHS_SSSCA1.
ExpressionAtlasiO60232. baseline and differential.
GenevisibleiO60232. HS.

Organism-specific databases

HPAiHPA039789.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ05EBI-741415,EBI-10175576
CCNHP519464EBI-741415,EBI-741406
CCT2P783713EBI-741415,EBI-357407
CCT5P486433EBI-741415,EBI-355710
CCT7Q998325EBI-741415,EBI-357046
HEL-S-100nV9HW963EBI-741415,EBI-10330207
HEL-S-69V9HW373EBI-741415,EBI-10186233
ORFQ9Q2G44EBI-741415,EBI-6248094From a different organism.
SNAPC5O759713EBI-741415,EBI-749483
TRAF3IP3Q9Y2283EBI-741415,EBI-765817

Protein-protein interaction databases

BioGridi115788. 169 interactors.
IntActiO60232. 31 interactors.
MINTiMINT-1434192.
STRINGi9606.ENSP00000312318.

Structurei

3D structure databases

ProteinModelPortaliO60232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 83Asp/Glu-rich (acidic)9
Compositional biasi113 – 122Pro-rich10
Compositional biasi138 – 145Pro-rich8
Compositional biasi170 – 177Ser/Thr-rich8

Phylogenomic databases

eggNOGiKOG4537. Eukaryota.
ENOG4111RNZ. LUCA.
GeneTreeiENSGT00390000013169.
HOGENOMiHOG000007383.
HOVERGENiHBG054236.
InParanoidiO60232.
OMAiGECCELC.
OrthoDBiEOG091G0MMO.
PhylomeDBiO60232.
TreeFamiTF320182.

Family and domain databases

InterProiIPR009563. SSSCA1.
[Graphical view]
PfamiPF06677. Auto_anti-p27. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNGAEVDD FSWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG
60 70 80 90 100
ETCADCGTIL LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ
110 120 130 140 150
LASASELPLG SRPAPQPPVP RPEHCEGAAA GLKAAQGPPA PAVPPNTDVM
160 170 180 190
ACTQTALLQK LTWASAELGS STSLETSIQL CGLIRACAEA LRSLQQLQH
Length:199
Mass (Da):21,474
Last modified:August 1, 1998 - v1
Checksum:iEF08439FDFFA1DAB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05138321T → M.Corresponds to variant rs35971725dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001740 mRNA. Translation: BAA25263.1.
BC014791 mRNA. Translation: AAH14791.1.
CCDSiCCDS8104.1.
RefSeqiNP_006387.1. NM_006396.2.
UniGeneiHs.25723.

Genome annotation databases

EnsembliENST00000309328; ENSP00000312318; ENSG00000173465.
GeneIDi10534.
KEGGihsa:10534.
UCSCiuc001oek.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001740 mRNA. Translation: BAA25263.1.
BC014791 mRNA. Translation: AAH14791.1.
CCDSiCCDS8104.1.
RefSeqiNP_006387.1. NM_006396.2.
UniGeneiHs.25723.

3D structure databases

ProteinModelPortaliO60232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115788. 169 interactors.
IntActiO60232. 31 interactors.
MINTiMINT-1434192.
STRINGi9606.ENSP00000312318.

PTM databases

iPTMnetiO60232.
PhosphoSitePlusiO60232.

Polymorphism and mutation databases

BioMutaiSSSCA1.

Proteomic databases

EPDiO60232.
MaxQBiO60232.
PaxDbiO60232.
PeptideAtlasiO60232.
PRIDEiO60232.

Protocols and materials databases

DNASUi10534.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309328; ENSP00000312318; ENSG00000173465.
GeneIDi10534.
KEGGihsa:10534.
UCSCiuc001oek.4. human.

Organism-specific databases

CTDi10534.
DisGeNETi10534.
GeneCardsiSSSCA1.
HGNCiHGNC:11328. SSSCA1.
HPAiHPA039789.
MIMi606044. gene.
neXtProtiNX_O60232.
OpenTargetsiENSG00000173465.
PharmGKBiPA36152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4537. Eukaryota.
ENOG4111RNZ. LUCA.
GeneTreeiENSGT00390000013169.
HOGENOMiHOG000007383.
HOVERGENiHBG054236.
InParanoidiO60232.
OMAiGECCELC.
OrthoDBiEOG091G0MMO.
PhylomeDBiO60232.
TreeFamiTF320182.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173465-MONOMER.

Miscellaneous databases

ChiTaRSiSSSCA1. human.
GenomeRNAii10534.
PMAP-CutDBO60232.
PROiO60232.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173465.
CleanExiHS_SSSCA1.
ExpressionAtlasiO60232. baseline and differential.
GenevisibleiO60232. HS.

Family and domain databases

InterProiIPR009563. SSSCA1.
[Graphical view]
PfamiPF06677. Auto_anti-p27. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSA27_HUMAN
AccessioniPrimary (citable) accession number: O60232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.