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O60232

- SSA27_HUMAN

UniProt

O60232 - SSA27_HUMAN

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Protein

Sjoegren syndrome/scleroderma autoantigen 1

Gene

SSSCA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

GO - Biological processi

  1. mitotic nuclear division Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sjoegren syndrome/scleroderma autoantigen 1
Alternative name(s):
Autoantigen p27
Gene namesi
Name:SSSCA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:11328. SSSCA1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 199198Sjoegren syndrome/scleroderma autoantigen 1PRO_0000072201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei94 – 941Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO60232.
PaxDbiO60232.
PeptideAtlasiO60232.
PRIDEiO60232.

PTM databases

PhosphoSiteiO60232.

Miscellaneous databases

PMAP-CutDBO60232.

Expressioni

Gene expression databases

BgeeiO60232.
CleanExiHS_SSSCA1.
ExpressionAtlasiO60232. baseline and differential.
GenevestigatoriO60232.

Organism-specific databases

HPAiHPA039789.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ORFQ9Q2G44EBI-741415,EBI-6248094From a different organism.

Protein-protein interaction databases

BioGridi115788. 89 interactions.
IntActiO60232. 15 interactions.
MINTiMINT-1434192.
STRINGi9606.ENSP00000312318.

Structurei

3D structure databases

ProteinModelPortaliO60232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 839Asp/Glu-rich (acidic)
Compositional biasi113 – 12210Pro-rich
Compositional biasi138 – 1458Pro-rich
Compositional biasi170 – 1778Ser/Thr-rich

Phylogenomic databases

eggNOGiNOG303301.
GeneTreeiENSGT00390000013169.
HOGENOMiHOG000007383.
HOVERGENiHBG054236.
InParanoidiO60232.
OMAiMKVIQAR.
PhylomeDBiO60232.
TreeFamiTF320182.

Family and domain databases

InterProiIPR009563. SSSCA1.
[Graphical view]
PfamiPF06677. Auto_anti-p27. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60232-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALNGAEVDD FSWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG
60 70 80 90 100
ETCADCGTIL LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ
110 120 130 140 150
LASASELPLG SRPAPQPPVP RPEHCEGAAA GLKAAQGPPA PAVPPNTDVM
160 170 180 190
ACTQTALLQK LTWASAELGS STSLETSIQL CGLIRACAEA LRSLQQLQH
Length:199
Mass (Da):21,474
Last modified:August 1, 1998 - v1
Checksum:iEF08439FDFFA1DAB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211T → M.
Corresponds to variant rs35971725 [ dbSNP | Ensembl ].
VAR_051383

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001740 mRNA. Translation: BAA25263.1.
BC014791 mRNA. Translation: AAH14791.1.
CCDSiCCDS8104.1.
RefSeqiNP_006387.1. NM_006396.1.
UniGeneiHs.25723.

Genome annotation databases

EnsembliENST00000309328; ENSP00000312318; ENSG00000173465.
GeneIDi10534.
KEGGihsa:10534.
UCSCiuc001oek.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001740 mRNA. Translation: BAA25263.1 .
BC014791 mRNA. Translation: AAH14791.1 .
CCDSi CCDS8104.1.
RefSeqi NP_006387.1. NM_006396.1.
UniGenei Hs.25723.

3D structure databases

ProteinModelPortali O60232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115788. 89 interactions.
IntActi O60232. 15 interactions.
MINTi MINT-1434192.
STRINGi 9606.ENSP00000312318.

PTM databases

PhosphoSitei O60232.

Proteomic databases

MaxQBi O60232.
PaxDbi O60232.
PeptideAtlasi O60232.
PRIDEi O60232.

Protocols and materials databases

DNASUi 10534.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309328 ; ENSP00000312318 ; ENSG00000173465 .
GeneIDi 10534.
KEGGi hsa:10534.
UCSCi uc001oek.3. human.

Organism-specific databases

CTDi 10534.
GeneCardsi GC11P065337.
HGNCi HGNC:11328. SSSCA1.
HPAi HPA039789.
MIMi 606044. gene.
neXtProti NX_O60232.
PharmGKBi PA36152.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303301.
GeneTreei ENSGT00390000013169.
HOGENOMi HOG000007383.
HOVERGENi HBG054236.
InParanoidi O60232.
OMAi MKVIQAR.
PhylomeDBi O60232.
TreeFami TF320182.

Miscellaneous databases

ChiTaRSi SSSCA1. human.
GenomeRNAii 10534.
NextBioi 39965.
PMAP-CutDB O60232.
PROi O60232.
SOURCEi Search...

Gene expression databases

Bgeei O60232.
CleanExi HS_SSSCA1.
ExpressionAtlasi O60232. baseline and differential.
Genevestigatori O60232.

Family and domain databases

InterProi IPR009563. SSSCA1.
[Graphical view ]
Pfami PF06677. Auto_anti-p27. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies."
    Muro Y., Yamada T., Himeno M., Sugimoto K.
    Clin. Exp. Immunol. 111:372-376(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSSA27_HUMAN
AccessioniPrimary (citable) accession number: O60232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3