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Protein

Sjoegren syndrome/scleroderma autoantigen 1

Gene

SSSCA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic cell cycle Source: ProtInc

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sjoegren syndrome/scleroderma autoantigen 1
Alternative name(s):
Autoantigen p27
Gene namesi
Name:SSSCA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173465.7
HGNCiHGNC:11328 SSSCA1
MIMi606044 gene
neXtProtiNX_O60232

Pathology & Biotechi

Organism-specific databases

DisGeNETi10534
OpenTargetsiENSG00000173465
PharmGKBiPA36152

Polymorphism and mutation databases

BioMutaiSSSCA1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000722012 – 199Sjoegren syndrome/scleroderma autoantigen 1Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei94PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60232
MaxQBiO60232
PaxDbiO60232
PeptideAtlasiO60232
PRIDEiO60232

PTM databases

iPTMnetiO60232
PhosphoSitePlusiO60232

Miscellaneous databases

PMAP-CutDBO60232

Expressioni

Gene expression databases

BgeeiENSG00000173465
CleanExiHS_SSSCA1
ExpressionAtlasiO60232 baseline and differential
GenevisibleiO60232 HS

Organism-specific databases

HPAiHPA039789

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115788, 176 interactors
IntActiO60232, 35 interactors
STRINGi9606.ENSP00000312318

Structurei

3D structure databases

ProteinModelPortaliO60232
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 83Asp/Glu-rich (acidic)9
Compositional biasi113 – 122Pro-rich10
Compositional biasi138 – 145Pro-rich8
Compositional biasi170 – 177Ser/Thr-rich8

Phylogenomic databases

eggNOGiKOG4537 Eukaryota
ENOG4111RNZ LUCA
GeneTreeiENSGT00390000013169
HOGENOMiHOG000007383
HOVERGENiHBG054236
InParanoidiO60232
OMAiMKVIQAR
OrthoDBiEOG091G0MMO
PhylomeDBiO60232
TreeFamiTF320182

Family and domain databases

InterProiView protein in InterPro
IPR009563 SSSCA1
PfamiView protein in Pfam
PF06677 Auto_anti-p27, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNGAEVDD FSWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG
60 70 80 90 100
ETCADCGTIL LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ
110 120 130 140 150
LASASELPLG SRPAPQPPVP RPEHCEGAAA GLKAAQGPPA PAVPPNTDVM
160 170 180 190
ACTQTALLQK LTWASAELGS STSLETSIQL CGLIRACAEA LRSLQQLQH
Length:199
Mass (Da):21,474
Last modified:August 1, 1998 - v1
Checksum:iEF08439FDFFA1DAB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05138321T → M. Corresponds to variant dbSNP:rs35971725Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001740 mRNA Translation: BAA25263.1
BC014791 mRNA Translation: AAH14791.1
CCDSiCCDS8104.1
RefSeqiNP_006387.1, NM_006396.2
UniGeneiHs.25723

Genome annotation databases

EnsembliENST00000309328; ENSP00000312318; ENSG00000173465
GeneIDi10534
KEGGihsa:10534
UCSCiuc001oek.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSSA27_HUMAN
AccessioniPrimary (citable) accession number: O60232
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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