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O60232 (SSA27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sjoegren syndrome/scleroderma autoantigen 1
Alternative name(s):
Autoantigen p27
Gene names
Name:SSSCA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Coding sequence diversityPolymorphism
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 22190034. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ORFQ9Q2G44EBI-741415,EBI-6248094From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 199198Sjoegren syndrome/scleroderma autoantigen 1
PRO_0000072201

Regions

Compositional bias75 – 839Asp/Glu-rich (acidic)
Compositional bias113 – 12210Pro-rich
Compositional bias138 – 1458Pro-rich
Compositional bias170 – 1778Ser/Thr-rich

Amino acid modifications

Modified residue21N-acetylalanine Ref.4 Ref.6
Modified residue941Phosphoserine Ref.3

Natural variations

Natural variant211T → M.
Corresponds to variant rs35971725 [ dbSNP | Ensembl ].
VAR_051383

Sequences

Sequence LengthMass (Da)Tools
O60232 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: EF08439FDFFA1DAB

FASTA19921,474
        10         20         30         40         50         60 
MALNGAEVDD FSWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG ETCADCGTIL 

        70         80         90        100        110        120 
LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ LASASELPLG SRPAPQPPVP 

       130        140        150        160        170        180 
RPEHCEGAAA GLKAAQGPPA PAVPPNTDVM ACTQTALLQK LTWASAELGS STSLETSIQL 

       190 
CGLIRACAEA LRSLQQLQH 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies."
Muro Y., Yamada T., Himeno M., Sugimoto K.
Clin. Exp. Immunol. 111:372-376(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[3]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB001740 mRNA. Translation: BAA25263.1.
BC014791 mRNA. Translation: AAH14791.1.
CCDSCCDS8104.1.
RefSeqNP_006387.1. NM_006396.1.
UniGeneHs.25723.

3D structure databases

ProteinModelPortalO60232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115788. 87 interactions.
IntActO60232. 15 interactions.
MINTMINT-1434192.
STRING9606.ENSP00000312318.

PTM databases

PhosphoSiteO60232.

Proteomic databases

MaxQBO60232.
PaxDbO60232.
PeptideAtlasO60232.
PRIDEO60232.

Protocols and materials databases

DNASU10534.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309328; ENSP00000312318; ENSG00000173465.
GeneID10534.
KEGGhsa:10534.
UCSCuc001oek.3. human.

Organism-specific databases

CTD10534.
GeneCardsGC11P065337.
HGNCHGNC:11328. SSSCA1.
HPAHPA039789.
MIM606044. gene.
neXtProtNX_O60232.
PharmGKBPA36152.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303301.
HOGENOMHOG000007383.
HOVERGENHBG054236.
InParanoidO60232.
OMAMKVIQAR.
PhylomeDBO60232.
TreeFamTF320182.

Gene expression databases

ArrayExpressO60232.
BgeeO60232.
CleanExHS_SSSCA1.
GenevestigatorO60232.

Family and domain databases

InterProIPR009563. SSSCA1.
[Graphical view]
PfamPF06677. Auto_anti-p27. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSSSCA1. human.
GenomeRNAi10534.
NextBio39965.
PMAP-CutDBO60232.
PROO60232.
SOURCESearch...

Entry information

Entry nameSSA27_HUMAN
AccessionPrimary (citable) accession number: O60232
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM