Reviewed, UniProtKB/Swiss-Prot O60232 (SSA27_HUMAN)

Names and origin

Protein names

Recommended name:
    Sjoegren syndrome/scleroderma autoantigen 1
Alternative name(s):
    Autoantigen p27

Gene names

Name:

SSSCA1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.3

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q65ZQ1	1	EBI-741415,EBI-1054063
DOK2	O60496	1	EBI-741415,EBI-1046024
DSG1	Q02413	1	EBI-741415,EBI-1045757
LRRC7	Q96NW7	1	EBI-741415,EBI-524275
PRMT1	Q99873	1	EBI-741415,EBI-78738
QRICH2	Q9H0J4	1	EBI-741415,EBI-1053637
RUVBL2	Q9Y230	1	EBI-741415,EBI-352939

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Sjoegren syndrome/scleroderma autoantigen 1		PRO_0000072201
Regions
	Compositional bias	75 – 83	9	Asp/Glu-rich (acidic)
	Compositional bias	113 – 122	10	Pro-rich
	Compositional bias	138 – 145	8	Pro-rich
	Compositional bias	170 – 177	8	Ser/Thr-rich
Amino acid modifications
	Modified residue	94	1	Phosphoserine Ref.3
Natural variations
	Natural variant	21	1	T → M: dbSNP rs35971725.		VAR_051383

Sequences

	Sequence		Length	Mass (Da)
	O60232-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: EF08439FDFFA1DAB	FASTA	199	21,474
	10 20 30 40 50 60 MALNGAEVDD FSWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG ETCADCGTIL 70 80 90 100 110 120 LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ LASASELPLG SRPAPQPPVP 130 140 150 160 170 180 RPEHCEGAAA GLKAAQGPPA PAVPPNTDVM ACTQTALLQK LTWASAELGS STSLETSIQL 190 CGLIRACAEA LRSLQQLQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies." Muro Y., Yamada T., Himeno M., Sugimoto K. Clin. Exp. Immunol. 111:372-376(1998) [PubMed: 9486406] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[3]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB001740 mRNA. Translation: BAA25263.1. BC014791 mRNA. Translation: AAH14791.1.
IPI	IPI00028412.
RefSeq	NP_006387.1.
UniGene	Hs.654840
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O60232. 26 interactions.
PTM databases
PhosphoSite	O60232.
Proteomic databases
PeptideAtlas	O60232.
PRIDE	O60232.
Genome annotation databases
Ensembl	ENSG00000173465. Homo sapiens. [Contig view]
GeneID	10534.
KEGG	hsa:10534.
UCSC	uc001oek.1. human.
Organism-specific databases
GeneCards	GC11P065094.
H-InvDB	HIX0009799.
HGNC	HGNC:11328. SSSCA1.
MIM	606044. gene.
PharmGKB	PA36152.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O60232.
HOVERGEN	O60232.
OMA	O60232. SIQLCSL.
Gene expression databases
ArrayExpress	O60232.
Bgee	O60232.
CleanEx	HS_SSSCA1.
GermOnline	ENSG00000173465. Homo sapiens.
Family and domain databases
InterPro	IPR009563. Auto_anti-p27. [Graphical view]
Pfam	PF06677. Auto_anti-p27. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	39965.
PMAP-CutDB	O60232.
SOURCE	Search...

Entry information

Entry name

SSA27_HUMAN

Accession

Primary (citable) accession number: O60232

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	July 7, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)