O60229 (KALRN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kalirin
EC=2.7.11.1

Alternative name(s):
Huntingtin-associated protein-interacting protein
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain

Gene names

Name:	KALRN
Synonyms:	DUET, DUO, HAPIP, TRAD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2985 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Ref.2
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium.
Subunit structure	Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) By similarity. Interacts with FASLG. Ref.10
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton. Note: Associated with the cytoskeleton. Ref.2
Tissue specificity	Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. Ref.2
Domain	The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity By similarity.
Post-translational modification	Autophosphorylated. Ref.2
Involvement in disease	Coronary heart disease 5 (CHDS5) [MIM:608901]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.7
Miscellaneous	Called DUO because the encoded protein is closely related to but shorter than TRIO.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 CRAL-TRIO domain. Contains 2 DH (DBL-homology) domains. Contains 1 fibronectin type-III domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 PH domains. Contains 1 protein kinase domain. Contains 2 SH3 domains. Contains 5 spectrin repeats.
Sequence caution	The sequence AAH58015.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative initiation Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat SH3 domain
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Guanine-nucleotide releasing factor Kinase Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic signaling pathway Traceable author statement. Source: Reactome nervous system development Inferred from sequence or structural similarity. Source: HGNC neurotrophin TRK receptor signaling pathway Traceable author statement. Source: Reactome regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome vesicle-mediated transport Traceable author statement Ref.1. Source: ProtInc
Cellular_component	actin cytoskeleton Traceable author statement Ref.2. Source: ProtInc cytosol Traceable author statement. Source: Reactome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro guanyl-nucleotide exchange factor activity Traceable author statement Ref.1. Source: ProtInc metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing and alternative initiation. [Align] [Select]

Isoform 1 (identifier: O60229-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Produced by alternative splicing.

Isoform 2 (identifier: O60229-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1644-1663: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1664-2985: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Isoform 3 (identifier: O60229-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-641: Missing.
     709-721: Missing.
     1465-1505: FDENLDVQGE...RHLFLFEISL → SCPPSTGEAS...ARLEERRNDK
     1506-2985: Missing.

Note: Produced by alternative initiation at Met-624 of isoform 1. Inferred by similarity.

Isoform 4 (identifier: O60229-4)

Also known as: DUET; TRAD;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1697: Missing.
     1698-1725: EGLVPSSALCISHSRSSVEMDCFFPLVK → MKGGDRAYTRGPSLGWLFAKCCCCFPCR

Note: Produced by alternative splicing.

Isoform 5 (identifier: O60229-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1627: Missing.
     1628-1643: ISIASRTSQNTVDSDK → MLKWISWRQSKANKAQ
     1857-1887: Missing.
     2313-2313: Missing.
     2398-2985: Missing.

Note: Produced by alternative splicing.

Isoform 6 (identifier: O60229-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1697: Missing.
     1698-1725: EGLVPSSALCISHSRSSVEMDCFFPLVK → MKGGDRAYTRGPSLGWLFAKCCCCFPCR
     1857-1887: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2985	2985	Kalirin		PRO_0000080955
Regions
	Domain	35 – 180	146	CRAL-TRIO
	Repeat	188 – 308	121	Spectrin 1
	Repeat	310 – 416	107	Spectrin 2
	Repeat	536 – 642	107	Spectrin 3
	Repeat	890 – 1004	115	Spectrin 4
	Repeat	1130 – 1222	93	Spectrin 5
	Domain	1281 – 1456	176	DH 1
	Domain	1468 – 1580	113	PH 1
	Domain	1646 – 1711	66	SH3 1
	Domain	1928 – 2103	176	DH 2
	Domain	2115 – 2225	111	PH 2
	Domain	2320 – 2385	66	SH3 2
	Domain	2470 – 2563	94	Ig-like C2-type
	Domain	2568 – 2659	92	Fibronectin type-III
	Domain	2683 – 2937	255	Protein kinase
	Nucleotide binding	2689 – 2697	9	ATP By similarity
	Compositional bias	682 – 687	6	Poly-Gln
Sites
	Active site	2802	1	Proton acceptor By similarity
	Binding site	2712	1	ATP
Amino acid modifications
	Modified residue	1750	1	Phosphoserine Ref.8
	Modified residue	1753	1	Phosphoserine Ref.8
	Modified residue	1799	1	Phosphoserine Ref.8 Ref.9
	Modified residue	1817	1	Phosphoserine Ref.8
	Modified residue	2261	1	Phosphoserine Ref.8
	Disulfide bond	2491 ↔ 2547		By similarity
Natural variations
	Alternative sequence	1 – 1697	1697	Missing in isoform 4 and isoform 6.		VSP_028903
	Alternative sequence	1 – 1627	1627	Missing in isoform 5.		VSP_028904
	Alternative sequence	1 – 641	641	Missing in isoform 3.		VSP_028905
	Alternative sequence	709 – 721	13	Missing in isoform 3.		VSP_028906
	Alternative sequence	1465 – 1505	41	FDENL…FEISL → SCPPSTGEASSLPRHGGACI MGGKWHEVRQGARLEERRND K in isoform 3.		VSP_028907
	Alternative sequence	1506 – 2985	1480	Missing in isoform 3.		VSP_028908
	Alternative sequence	1628 – 1643	16	ISIAS…VDSDK → MLKWISWRQSKANKAQ in isoform 5.		VSP_028909
	Alternative sequence	1644 – 1663	20	LSGGC…AGHSS → DGNLVPRWHLGPGDPFSTYV in isoform 2.		VSP_028910
	Alternative sequence	1664 – 2985	1322	Missing in isoform 2.		VSP_028911
	Alternative sequence	1698 – 1725	28	EGLVP…FPLVK → MKGGDRAYTRGPSLGWLFAK CCCCFPCR in isoform 4 and isoform 6.		VSP_028912
	Alternative sequence	1857 – 1887	31	Missing in isoform 5 and isoform 6.		VSP_028913
	Alternative sequence	2313	1	Missing in isoform 5.		VSP_028914
	Alternative sequence	2398 – 2985	588	Missing in isoform 5.		VSP_028915
	Natural variant	196	1	S → L. Ref.12		VAR_041898
	Natural variant	213	1	R → W in a colorectal cancer sample; somatic mutation. Ref.11		VAR_035976
	Natural variant	1326	1	E → D. Corresponds to variant rs2289838 [ dbSNP | Ensembl ].		VAR_020192
	Natural variant	1896	1	S → C in a breast cancer sample; somatic mutation. Ref.11		VAR_035625
	Natural variant	1929	1	R → M. Corresponds to variant rs35298864 [ dbSNP | Ensembl ].		VAR_057190
Experimental info
	Mutagenesis	2712	1	K → A: Loss of autophosphorylation. Ref.2
	Sequence conflict	1857	1	S → SS in BAA76314. Ref.2
	Sequence conflict	2458	1	E → G in BAA76314. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: F4C01D0F2422A92F	FASTA	2,985	340,174
	10 20 30 40 50 60 MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR DKRGGPILTF 70 80 90 100 110 120 PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM RGSKWDLIKP LLKTLQEAFP 130 140 150 160 170 180 AEIHVALIIK PDNFWQKQKT NFGSSKFIFE TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH 190 200 210 220 230 240 EEWIELRLSL EEFFNSAVHL LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA 250 260 270 280 290 300 PVEELDREGQ RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH 310 320 330 340 350 360 VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL QTQHNHFAMN 370 380 390 400 410 420 SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW KSFAAALDER STILAMSAVF 430 440 450 460 470 480 HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL ELAIHHHQTL YEQVTQAYTE VSQDGKALLD 490 500 510 520 530 540 VLQRPLSPGN SESLTATANY SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV 550 560 570 580 590 600 FQQDVQQVLD WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA 610 620 630 640 650 660 AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT KELWTWMEDL 670 680 690 700 710 720 QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE GEDLIQQLRS APPSLGEPSE 730 740 750 760 770 780 ARDSAVSNNK TPHSSSISHI ESVLQQLDDA QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE 790 800 810 820 830 840 VTAELDAWNE DLLRQMNDFN TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT 850 860 870 880 890 900 EVQASGIELI CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK 910 920 930 940 950 960 QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI ESLFHATSLQ KTHQSALQVQ 970 980 990 1000 1010 1020 QKAEVLLQAG HYDADAIREC AEKVALHWQQ LMLKMEDRLK LVNASVAFYK TSEQVCSVLE 1030 1040 1050 1060 1070 1080 SLEQEYRRDE DWCGGRDKLG PAAEIDHVIP LISKHLEQKE AFLKACTLAR RNAEVFLKYI 1090 1100 1110 1120 1130 1140 HRNNVSMPSV ASHTRGPEQQ VKAILSELLQ RENRVLHFWT LKKRRLDQCQ QYVVFERSAK 1150 1160 1170 1180 1190 1200 QALDWIQETG EFYLSTHTST GETTEETQEL LKEYGEFRVP AKQTKEKVKL LIQLADSFVE 1210 1220 1230 1240 1250 1260 KGHIHATEIR KWVTTVDKHY RDFSLRMGKY RYSLEKALGV NTEDNKDLEL DIIPASLSDR 1270 1280 1290 1300 1310 1320 EVKLRDANHE VNEEKRKSAR KKEFIMAELL QTEKAYVRDL HECLETYLWE MTSGVEEIPP 1330 1340 1350 1360 1370 1380 GILNKEHIIF GNIQEIYDFH NNIFLKELEK YEQLPEDVGH CFVTWADKFQ MYVTYCKNKP 1390 1400 1410 1420 1430 1440 DSNQLILEHA GTFFDEIQQR HGLANSISSY LIKPVQRITK YQLLLKELLT CCEEGKGELK 1450 1460 1470 1480 1490 1500 DGLEVMLSVP KKANDAMHVS MLEGFDENLD VQGELILQDA FQVWDPKSLI RKGRERHLFL 1510 1520 1530 1540 1550 1560 FEISLVFSKE IKDSSGHTKY VYKNKLLTSE LGVTEHVEGD PCKFALWSGR TPSSDNKTVL 1570 1580 1590 1600 1610 1620 KASNIETKQE WIKNIREVIQ ERIIHLKGAL KEPLQLPKTP AKQRNNSKRD GVEDIDSQGD 1630 1640 1650 1660 1670 1680 GSSQPDTISI ASRTSQNTVD SDKLSGGCEL TVVLQDFSAG HSSELTIQVG QTVELLERPS 1690 1700 1710 1720 1730 1740 ERPGWCLVRT TERSPPLEGL VPSSALCISH SRSSVEMDCF FPLVKDAYSH SSSENGGKSE 1750 1760 1770 1780 1790 1800 SVANLQAQPS LNSIHSSPGP KRSTNTLKKW LTSPVRRLNS GKADGNIKKQ KKVRDGRKSF 1810 1820 1830 1840 1850 1860 DLGSPKPGDE TTPQGDSADE KSKKGWGEDE PDEESHTPLP PPMKIFDNDP TQDEMSSLLA 1870 1880 1890 1900 1910 1920 ARQASTEVPT AADLVNAIEK LVKNKLSLEG SSYRGSLKDP AGCLNEGMAP PTPPKNPEEE 1930 1940 1950 1960 1970 1980 QKAKALRGRM FVLNELVQTE KDYVKDLGIV VEGFMKRIEE KGVPEDMRGK DKIVFGNIHQ 1990 2000 2010 2020 2030 2040 IYDWHKDFFL AELEKCIQEQ DRLAQLFIKH ERKLHIYVWY CQNKPRSEYI VAEYDAYFEE 2050 2060 2070 2080 2090 2100 VKQEINQRLT LSDFLIKPIQ RITKYQLLLK DFLRYSEKAG LECSDIEKAV ELMCLVPKRC 2110 2120 2130 2140 2150 2160 NDMMNLGRLQ GFEGTLTAQG KLLQQDTFYV IELDAGMQSR TKERRVFLFE QIVIFSELLR 2170 2180 2190 2200 2210 2220 KGSLTPGYMF KRSIKMNYLV LEENVDNDPC KFALMNRETS ERVVLQAANA DIQQAWVQDI 2230 2240 2250 2260 2270 2280 NQVLETQRDF LNALQSPIEY QRKERSTAVM RSQPARLPQA SPRPYSSVPA GSEKPPKGSS 2290 2300 2310 2320 2330 2340 YNPPLPPLKI STSNGSPGFE YHQPGDKFEA SKQNDLGGCN GTSSMAVIKD YYALKENEIC 2350 2360 2370 2380 2390 2400 VSQGEVVQVL AVNQQNMCLV YQPASDHSPA AEGWVPGSIL APLTKATAAE SSDGSIKKSC 2410 2420 2430 2440 2450 2460 SWHTLRMRKR AEVENTGKNE ATGPRKPKDI LGNKVSVKET NSSEESECDD LDPNTSMEIL 2470 2480 2490 2500 2510 2520 NPNFIQEVAP EFLVPLVDVT CLLGDTVILQ CKVCGRPKPT ITWKGPDQNI LDTDNSSATY 2530 2540 2550 2560 2570 2580 TVSSCDSGEI TLKICNLMPQ DSGIYTCIAT NDHGTTSTSA TVKVQGVPAA PNRPIAQERS 2590 2600 2610 2620 2630 2640 CTSVILRWLP PSSTGNCTIS GYTVEYREEG SQIWQQSVAS TLDTYLVIED LSPGCPYQFR 2650 2660 2670 2680 2690 2700 VSASNPWGIS LPSEPSEFVR LPEYDAAADG ATISWKENFD SAYTELNEIG RGRFSIVKKC 2710 2720 2730 2740 2750 2760 IHKATRKDVA VKFVSKKMKK KEQAAHEAAL LQHLQHPQYI TLHDTYESPT SYILILELMD 2770 2780 2790 2800 2810 2820 DGRLLDYLMN HDELMEEKVA FYIRDIMEAL QYLHNCRVAH LDIKPENLLI DLRIPVPRVK 2830 2840 2850 2860 2870 2880 LIDLEDAVQI SGHFHIHHLL GNPEFAAPEV IQGIPVSLGT DIWSIGVLTY VMLSGVSPFL 2890 2900 2910 2920 2930 2940 DESKEETCIN VCRVDFSFPH EYFCGVSNAA RDFINVILQE DFRRRPTAAT CLQHPWLQPH 2950 2960 2970 2980 NGSYSKIPLD TSRLACFIER RKHQNDVRPI PNVKSYIVNR VNQGT
	Isoform 2 [UniParc]. Checksum: FAE683734C83417C	FASTA	1,663	192,229
	10 20 30 40 50 60 MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR DKRGGPILTF 70 80 90 100 110 120 PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM RGSKWDLIKP LLKTLQEAFP 130 140 150 160 170 180 AEIHVALIIK PDNFWQKQKT NFGSSKFIFE TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH 190 200 210 220 230 240 EEWIELRLSL EEFFNSAVHL LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA 250 260 270 280 290 300 PVEELDREGQ RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH 310 320 330 340 350 360 VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL QTQHNHFAMN 370 380 390 400 410 420 SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW KSFAAALDER STILAMSAVF 430 440 450 460 470 480 HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL ELAIHHHQTL YEQVTQAYTE VSQDGKALLD 490 500 510 520 530 540 VLQRPLSPGN SESLTATANY SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV 550 560 570 580 590 600 FQQDVQQVLD WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA 610 620 630 640 650 660 AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT KELWTWMEDL 670 680 690 700 710 720 QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE GEDLIQQLRS APPSLGEPSE 730 740 750 760 770 780 ARDSAVSNNK TPHSSSISHI ESVLQQLDDA QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE 790 800 810 820 830 840 VTAELDAWNE DLLRQMNDFN TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT 850 860 870 880 890 900 EVQASGIELI CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK 910 920 930 940 950 960 QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI ESLFHATSLQ KTHQSALQVQ 970 980 990 1000 1010 1020 QKAEVLLQAG HYDADAIREC AEKVALHWQQ LMLKMEDRLK LVNASVAFYK TSEQVCSVLE 1030 1040 1050 1060 1070 1080 SLEQEYRRDE DWCGGRDKLG PAAEIDHVIP LISKHLEQKE AFLKACTLAR RNAEVFLKYI 1090 1100 1110 1120 1130 1140 HRNNVSMPSV ASHTRGPEQQ VKAILSELLQ RENRVLHFWT LKKRRLDQCQ QYVVFERSAK 1150 1160 1170 1180 1190 1200 QALDWIQETG EFYLSTHTST GETTEETQEL LKEYGEFRVP AKQTKEKVKL LIQLADSFVE 1210 1220 1230 1240 1250 1260 KGHIHATEIR KWVTTVDKHY RDFSLRMGKY RYSLEKALGV NTEDNKDLEL DIIPASLSDR 1270 1280 1290 1300 1310 1320 EVKLRDANHE VNEEKRKSAR KKEFIMAELL QTEKAYVRDL HECLETYLWE MTSGVEEIPP 1330 1340 1350 1360 1370 1380 GILNKEHIIF GNIQEIYDFH NNIFLKELEK YEQLPEDVGH CFVTWADKFQ MYVTYCKNKP 1390 1400 1410 1420 1430 1440 DSNQLILEHA GTFFDEIQQR HGLANSISSY LIKPVQRITK YQLLLKELLT CCEEGKGELK 1450 1460 1470 1480 1490 1500 DGLEVMLSVP KKANDAMHVS MLEGFDENLD VQGELILQDA FQVWDPKSLI RKGRERHLFL 1510 1520 1530 1540 1550 1560 FEISLVFSKE IKDSSGHTKY VYKNKLLTSE LGVTEHVEGD PCKFALWSGR TPSSDNKTVL 1570 1580 1590 1600 1610 1620 KASNIETKQE WIKNIREVIQ ERIIHLKGAL KEPLQLPKTP AKQRNNSKRD GVEDIDSQGD 1630 1640 1650 1660 GSSQPDTISI ASRTSQNTVD SDKDGNLVPR WHLGPGDPFS TYV
	Isoform 3 [UniParc]. Checksum: 3F611F4EF00D376C	FASTA	851	98,659
	10 20 30 40 50 60 MSVSFHTHTK ELWTWMEDLQ KEMLEDVCAD SVDAVQELIK QFQQQQTATL DATLNVIKEG 70 80 90 100 110 120 EDLIQQLRDS AVSNNKTPHS SSISHIESVL QQLDDAQVQM EELFHERKIK LDIFLQLRIF 130 140 150 160 170 180 EQYTIEVTAE LDAWNEDLLR QMNDFNTEDL TLAEQRLQRH TERKLAMNNM TFEVIQQGQD 190 200 210 220 230 240 LHQYITEVQA SGIELICEKD IDLAAQVQEL LEFLHEKQHE LELNAEQTHK RLEQCLQLRH 250 260 270 280 290 300 LQAEVKQVLG WIRNGESMLN ASLVNASSLS EAEQLQREHE QFQLAIESLF HATSLQKTHQ 310 320 330 340 350 360 SALQVQQKAE VLLQAGHYDA DAIRECAEKV ALHWQQLMLK MEDRLKLVNA SVAFYKTSEQ 370 380 390 400 410 420 VCSVLESLEQ EYRRDEDWCG GRDKLGPAAE IDHVIPLISK HLEQKEAFLK ACTLARRNAE 430 440 450 460 470 480 VFLKYIHRNN VSMPSVASHT RGPEQQVKAI LSELLQRENR VLHFWTLKKR RLDQCQQYVV 490 500 510 520 530 540 FERSAKQALD WIQETGEFYL STHTSTGETT EETQELLKEY GEFRVPAKQT KEKVKLLIQL 550 560 570 580 590 600 ADSFVEKGHI HATEIRKWVT TVDKHYRDFS LRMGKYRYSL EKALGVNTED NKDLELDIIP 610 620 630 640 650 660 ASLSDREVKL RDANHEVNEE KRKSARKKEF IMAELLQTEK AYVRDLHECL ETYLWEMTSG 670 680 690 700 710 720 VEEIPPGILN KEHIIFGNIQ EIYDFHNNIF LKELEKYEQL PEDVGHCFVT WADKFQMYVT 730 740 750 760 770 780 YCKNKPDSNQ LILEHAGTFF DEIQQRHGLA NSISSYLIKP VQRITKYQLL LKELLTCCEE 790 800 810 820 830 840 GKGELKDGLE VMLSVPKKAN DAMHVSMLEG SCPPSTGEAS SLPRHGGACI MGGKWHEVRQ 850 GARLEERRND K
	Isoform 4 (DUET) (TRAD) [UniParc]. Checksum: 3D665C59AC6E431A	FASTA	1,288	144,398
	10 20 30 40 50 60 MKGGDRAYTR GPSLGWLFAK CCCCFPCRDA YSHSSSENGG KSESVANLQA QPSLNSIHSS 70 80 90 100 110 120 PGPKRSTNTL KKWLTSPVRR LNSGKADGNI KKQKKVRDGR KSFDLGSPKP GDETTPQGDS 130 140 150 160 170 180 ADEKSKKGWG EDEPDEESHT PLPPPMKIFD NDPTQDEMSS LLAARQASTE VPTAADLVNA 190 200 210 220 230 240 IEKLVKNKLS LEGSSYRGSL KDPAGCLNEG MAPPTPPKNP EEEQKAKALR GRMFVLNELV 250 260 270 280 290 300 QTEKDYVKDL GIVVEGFMKR IEEKGVPEDM RGKDKIVFGN IHQIYDWHKD FFLAELEKCI 310 320 330 340 350 360 QEQDRLAQLF IKHERKLHIY VWYCQNKPRS EYIVAEYDAY FEEVKQEINQ RLTLSDFLIK 370 380 390 400 410 420 PIQRITKYQL LLKDFLRYSE KAGLECSDIE KAVELMCLVP KRCNDMMNLG RLQGFEGTLT 430 440 450 460 470 480 AQGKLLQQDT FYVIELDAGM QSRTKERRVF LFEQIVIFSE LLRKGSLTPG YMFKRSIKMN 490 500 510 520 530 540 YLVLEENVDN DPCKFALMNR ETSERVVLQA ANADIQQAWV QDINQVLETQ RDFLNALQSP 550 560 570 580 590 600 IEYQRKERST AVMRSQPARL PQASPRPYSS VPAGSEKPPK GSSYNPPLPP LKISTSNGSP 610 620 630 640 650 660 GFEYHQPGDK FEASKQNDLG GCNGTSSMAV IKDYYALKEN EICVSQGEVV QVLAVNQQNM 670 680 690 700 710 720 CLVYQPASDH SPAAEGWVPG SILAPLTKAT AAESSDGSIK KSCSWHTLRM RKRAEVENTG 730 740 750 760 770 780 KNEATGPRKP KDILGNKVSV KETNSSEESE CDDLDPNTSM EILNPNFIQE VAPEFLVPLV 790 800 810 820 830 840 DVTCLLGDTV ILQCKVCGRP KPTITWKGPD QNILDTDNSS ATYTVSSCDS GEITLKICNL 850 860 870 880 890 900 MPQDSGIYTC IATNDHGTTS TSATVKVQGV PAAPNRPIAQ ERSCTSVILR WLPPSSTGNC 910 920 930 940 950 960 TISGYTVEYR EEGSQIWQQS VASTLDTYLV IEDLSPGCPY QFRVSASNPW GISLPSEPSE 970 980 990 1000 1010 1020 FVRLPEYDAA ADGATISWKE NFDSAYTELN EIGRGRFSIV KKCIHKATRK DVAVKFVSKK 1030 1040 1050 1060 1070 1080 MKKKEQAAHE AALLQHLQHP QYITLHDTYE SPTSYILILE LMDDGRLLDY LMNHDELMEE 1090 1100 1110 1120 1130 1140 KVAFYIRDIM EALQYLHNCR VAHLDIKPEN LLIDLRIPVP RVKLIDLEDA VQISGHFHIH 1150 1160 1170 1180 1190 1200 HLLGNPEFAA PEVIQGIPVS LGTDIWSIGV LTYVMLSGVS PFLDESKEET CINVCRVDFS 1210 1220 1230 1240 1250 1260 FPHEYFCGVS NAARDFINVI LQEDFRRRPT AATCLQHPWL QPHNGSYSKI PLDTSRLACF 1270 1280 IERRKHQNDV RPIPNVKSYI VNRVNQGT
	Isoform 5 [UniParc]. Checksum: 1C9AC959DC07903E	FASTA	738	82,806
	10 20 30 40 50 60 MLKWISWRQS KANKAQLSGG CELTVVLQDF SAGHSSELTI QVGQTVELLE RPSERPGWCL 70 80 90 100 110 120 VRTTERSPPL EGLVPSSALC ISHSRSSVEM DCFFPLVKDA YSHSSSENGG KSESVANLQA 130 140 150 160 170 180 QPSLNSIHSS PGPKRSTNTL KKWLTSPVRR LNSGKADGNI KKQKKVRDGR KSFDLGSPKP 190 200 210 220 230 240 GDETTPQGDS ADEKSKKGWG EDEPDEESHT PLPPPMKIFD NDPTQDEMSL EGSSYRGSLK 250 260 270 280 290 300 DPAGCLNEGM APPTPPKNPE EEQKAKALRG RMFVLNELVQ TEKDYVKDLG IVVEGFMKRI 310 320 330 340 350 360 EEKGVPEDMR GKDKIVFGNI HQIYDWHKDF FLAELEKCIQ EQDRLAQLFI KHERKLHIYV 370 380 390 400 410 420 WYCQNKPRSE YIVAEYDAYF EEVKQEINQR LTLSDFLIKP IQRITKYQLL LKDFLRYSEK 430 440 450 460 470 480 AGLECSDIEK AVELMCLVPK RCNDMMNLGR LQGFEGTLTA QGKLLQQDTF YVIELDAGMQ 490 500 510 520 530 540 SRTKERRVFL FEQIVIFSEL LRKGSLTPGY MFKRSIKMNY LVLEENVDND PCKFALMNRE 550 560 570 580 590 600 TSERVVLQAA NADIQQAWVQ DINQVLETQR DFLNALQSPI EYQRKERSTA VMRSQPARLP 610 620 630 640 650 660 QASPRPYSSV PAGSEKPPKG SSYNPPLPPL KISTSNGSPG FEYHQPGDKF EASKNDLGGC 670 680 690 700 710 720 NGTSSMAVIK DYYALKENEI CVSQGEVVQV LAVNQQNMCL VYQPASDHSP AAEGWVPGSI 730 LAPLTKATAA ESSDGSIK
	Isoform 6 [UniParc]. Checksum: A45112D100678192	FASTA	1,257	141,164
	10 20 30 40 50 60 MKGGDRAYTR GPSLGWLFAK CCCCFPCRDA YSHSSSENGG KSESVANLQA QPSLNSIHSS 70 80 90 100 110 120 PGPKRSTNTL KKWLTSPVRR LNSGKADGNI KKQKKVRDGR KSFDLGSPKP GDETTPQGDS 130 140 150 160 170 180 ADEKSKKGWG EDEPDEESHT PLPPPMKIFD NDPTQDEMSL EGSSYRGSLK DPAGCLNEGM 190 200 210 220 230 240 APPTPPKNPE EEQKAKALRG RMFVLNELVQ TEKDYVKDLG IVVEGFMKRI EEKGVPEDMR 250 260 270 280 290 300 GKDKIVFGNI HQIYDWHKDF FLAELEKCIQ EQDRLAQLFI KHERKLHIYV WYCQNKPRSE 310 320 330 340 350 360 YIVAEYDAYF EEVKQEINQR LTLSDFLIKP IQRITKYQLL LKDFLRYSEK AGLECSDIEK 370 380 390 400 410 420 AVELMCLVPK RCNDMMNLGR LQGFEGTLTA QGKLLQQDTF YVIELDAGMQ SRTKERRVFL 430 440 450 460 470 480 FEQIVIFSEL LRKGSLTPGY MFKRSIKMNY LVLEENVDND PCKFALMNRE TSERVVLQAA 490 500 510 520 530 540 NADIQQAWVQ DINQVLETQR DFLNALQSPI EYQRKERSTA VMRSQPARLP QASPRPYSSV 550 560 570 580 590 600 PAGSEKPPKG SSYNPPLPPL KISTSNGSPG FEYHQPGDKF EASKQNDLGG CNGTSSMAVI 610 620 630 640 650 660 KDYYALKENE ICVSQGEVVQ VLAVNQQNMC LVYQPASDHS PAAEGWVPGS ILAPLTKATA 670 680 690 700 710 720 AESSDGSIKK SCSWHTLRMR KRAEVENTGK NEATGPRKPK DILGNKVSVK ETNSSEESEC 730 740 750 760 770 780 DDLDPNTSME ILNPNFIQEV APEFLVPLVD VTCLLGDTVI LQCKVCGRPK PTITWKGPDQ 790 800 810 820 830 840 NILDTDNSSA TYTVSSCDSG EITLKICNLM PQDSGIYTCI ATNDHGTTST SATVKVQGVP 850 860 870 880 890 900 AAPNRPIAQE RSCTSVILRW LPPSSTGNCT ISGYTVEYRE EGSQIWQQSV ASTLDTYLVI 910 920 930 940 950 960 EDLSPGCPYQ FRVSASNPWG ISLPSEPSEF VRLPEYDAAA DGATISWKEN FDSAYTELNE 970 980 990 1000 1010 1020 IGRGRFSIVK KCIHKATRKD VAVKFVSKKM KKKEQAAHEA ALLQHLQHPQ YITLHDTYES 1030 1040 1050 1060 1070 1080 PTSYILILEL MDDGRLLDYL MNHDELMEEK VAFYIRDIME ALQYLHNCRV AHLDIKPENL 1090 1100 1110 1120 1130 1140 LIDLRIPVPR VKLIDLEDAV QISGHFHIHH LLGNPEFAAP EVIQGIPVSL GTDIWSIGVL 1150 1160 1170 1180 1190 1200 TYVMLSGVSP FLDESKEETC INVCRVDFSF PHEYFCGVSN AARDFINVIL QEDFRRRPTA 1210 1220 1230 1240 1250 ATCLQHPWLQ PHNGSYSKIP LDTSRLACFI ERRKHQNDVR PIPNVKSYIV NRVNQGT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain." Colomer V., Engelender S., Sharp A.H., Duan K., Cooper J.K., Lanahan A., Lyford G., Worley P., Ross C.A. Hum. Mol. Genet. 6:1519-1525(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Frontal cortex.
[2]	"Duet is a novel serine/threonine kinase with Dbl-homology (DH) and pleckstrin-homology (PH) domains." Kawai T., Sanjo H., Akira S. Gene 227:249-255(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, MUTAGENESIS OF LYS-2712, AUTOPHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Skeletal muscle.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5). Tissue: Amygdala and Testis.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1917 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2104-2985 (ISOFORM 5). Tissue: Kidney.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2016-2985 (ISOFORM 5). Tissue: Testis.
[7]	"Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease." Wang L., Hauser E.R., Shah S.H., Pericak-Vance M.A., Haynes C., Crosslin D., Harris M. II, Nelson S., Hale A.B., Granger C.B., Haines J.L., Jones C.J.H., Crossman D., Seo D., Gregory S.G., Kraus W.E., Goldschmidt-Clermont P.J., Vance J.M. Am. J. Hum. Genet. 80:650-663(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CHDS5.
[8]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1750; SER-1753; SER-1799; SER-1817 AND SER-2261, MASS SPECTROMETRY. Tissue: Platelet.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1799, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening." Voss M., Lettau M., Janssen O. BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FASLG.
[11]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-213 AND CYS-1896.
[12]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-196.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U94190 mRNA. Translation: AAC15791.1. AB011422 mRNA. Translation: BAA76314.1. AK125979 mRNA. Translation: BAC86373.1. AK131379 mRNA. Translation: BAD18530.1. AC022336 Genomic DNA. No translation available. AC069233 Genomic DNA. No translation available. AC080008 Genomic DNA. No translation available. AC112129 Genomic DNA. No translation available. AC117401 Genomic DNA. No translation available. BC026865 mRNA. Translation: AAH26865.1. BC058015 mRNA. Translation: AAH58015.1. Sequence problems. AL137629 mRNA. Translation: CAB70850.1.
IPI	IPI00021156. IPI00028382. IPI00410727. IPI00410728. IPI00607777. IPI00794432.
PIR	T46482.
RefSeq	NP_001019831.2. NM_001024660.3. NP_003938.1. NM_003947.4. NP_008995.2. NM_007064.3.
UniGene	Hs.8004.
3D structure databases
ProteinModelPortal	O60229.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60229. 7 interactions.
MINT	MINT-2865643.
STRING	9606.ENSP00000240874.
PTM databases
PhosphoSite	O60229.
Proteomic databases
PaxDb	O60229.
PRIDE	O60229.
Protocols and materials databases
DNASU	8997.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000240874; ENSP00000240874; ENSG00000160145. ENST00000393496; ENSP00000377134; ENSG00000160145. ENST00000428018; ENSP00000402419; ENSG00000160145.
GeneID	8997.
KEGG	hsa:8997.
UCSC	uc003ehf.1. human. uc003ehg.3. human. uc003ehi.3. human.
Organism-specific databases
CTD	8997.
GeneCards	GC03P123798.
HGNC	HGNC:4814. KALRN.
HPA	CAB026456. HPA011913.
MIM	604605. gene. 608901. phenotype.
neXtProt	NX_O60229.
PharmGKB	PA29189.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG331990.
HOGENOM	HOG000044462.
HOVERGEN	HBG108598.
InParanoid	O60229.
KO	K15048.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6downstreampathway. Arf6 downstream pathway. ephbfwdpathway. EPHB forward signaling.
Reactome	REACT_111102. Signal Transduction.
SignaLink	O60229.
Gene expression databases
ArrayExpress	O60229.
Bgee	O60229.
CleanEx	HS_KALRN.
Genevestigator	O60229.
GermOnline	ENSG00000160145. Homo sapiens.
Family and domain databases
Gene3D	1.20.900.10. 2 hits. 2.30.29.30. 2 hits. 2.60.40.10. 2 hits. 3.40.525.10. 1 hit.
InterPro	IPR001251. CRAL-TRIO_dom. IPR000219. DH-domain. IPR003961. Fibronectin_type3. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. IPR001452. SH3_domain. IPR018159. Spectrin/alpha-actinin. IPR002017. Spectrin_repeat. [Graphical view]
Pfam	PF00041. fn3. 1 hit. PF07679. I-set. 1 hit. PF00069. Pkinase. 1 hit. PF00621. RhoGEF. 2 hits. PF00435. Spectrin. 4 hits. [Graphical view]
SMART	SM00060. FN3. 1 hit. SM00408. IGc2. 1 hit. SM00233. PH. 2 hits. SM00325. RhoGEF. 2 hits. SM00220. S_TKc. 1 hit. SM00516. SEC14. 1 hit. SM00326. SH3. 2 hits. SM00150. SPEC. 7 hits. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit. SSF48065. DH-domain. 2 hits. SSF49265. FN_III-like. 1 hit. SSF56112. Kinase_like. 1 hit. SSF50044. SH3. 2 hits.
PROSITE	PS50191. CRAL_TRIO. 1 hit. PS00741. DH_1. False negative. PS50010. DH_2. 2 hits. PS50853. FN3. 1 hit. PS50835. IG_LIKE. 1 hit. PS50003. PH_DOMAIN. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KALRN. human.
GenomeRNAi	8997.
NextBio	33739.
SOURCE	Search...

Entry information

Entry name

KALRN_HUMAN

Accession

Primary (citable) accession number: O60229
Secondary accession number(s): A8MSI4 , Q6ZN45, Q8TBQ5, Q9NSZ4, Q9Y2A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	October 23, 2007
Last modified:	May 29, 2013
This is version 133 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.