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Protein

Kalirin

Gene

KALRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei2712ATP1
Active sitei2802Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2689 – 2697ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08448-MONOMER.
ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-5687128. MAPK6/MAPK4 signaling.
SignaLinkiO60229.

Names & Taxonomyi

Protein namesi
Recommended name:
KalirinBy similarity (EC:2.7.11.1)
Alternative name(s):
Huntingtin-associated protein-interacting protein
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Gene namesi
Name:KALRNImported
Synonyms:DUET, DUO, HAPIP, TRAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4814. KALRN.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Associated with the cytoskeleton.

GO - Cellular componenti

  • actin cytoskeleton Source: ProtInc
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Coronary heart disease 5 (CHDS5)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
See also OMIM:608901

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2712K → A: Loss of autophosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi8997.
MalaCardsiKALRN.
MIMi608901. phenotype.
OpenTargetsiENSG00000160145.
PharmGKBiPA29189.

Polymorphism and mutation databases

BioMutaiKALRN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809551 – 2985KalirinAdd BLAST2985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1750PhosphoserineCombined sources1
Modified residuei1753PhosphoserineCombined sources1
Modified residuei1799PhosphoserineCombined sources1
Modified residuei1812PhosphothreonineBy similarity1
Modified residuei1817PhosphoserineCombined sources1
Modified residuei1912PhosphothreonineBy similarity1
Modified residuei2261PhosphoserineCombined sources1
Disulfide bondi2491 ↔ 2547PROSITE-ProRule annotation

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiO60229.
PeptideAtlasiO60229.
PRIDEiO60229.

PTM databases

iPTMnetiO60229.
PhosphoSitePlusiO60229.
SwissPalmiO60229.

Expressioni

Tissue specificityi

Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000160145.
CleanExiHS_KALRN.
ExpressionAtlasiO60229. baseline and differential.
GenevisibleiO60229. HS.

Organism-specific databases

HPAiCAB026456.
HPA011913.

Interactioni

Subunit structurei

Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNCAIPQ9Y6H5-13EBI-9075360,EBI-9075374

Protein-protein interaction databases

BioGridi114478. 15 interactors.
IntActiO60229. 12 interactors.
MINTiMINT-2865643.

Structurei

3D structure databases

ProteinModelPortaliO60229.
SMRiO60229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 180CRAL-TRIOPROSITE-ProRule annotationAdd BLAST146
Repeati167 – 308Spectrin 1Sequence analysisAdd BLAST142
Repeati310 – 417Spectrin 2Sequence analysisAdd BLAST108
Repeati418 – 535Spectrin 3Sequence analysisAdd BLAST118
Repeati536 – 639Spectrin 4Sequence analysisAdd BLAST104
Repeati640 – 770Spectrin 5Sequence analysisAdd BLAST131
Repeati771 – 888Spectrin 6Sequence analysisAdd BLAST118
Repeati889 – 1004Spectrin 7Sequence analysisAdd BLAST116
Repeati1005 – 1128Spectrin 8Sequence analysisAdd BLAST124
Repeati1129 – 1234Spectrin 9Sequence analysisAdd BLAST106
Domaini1281 – 1456DH 1PROSITE-ProRule annotationAdd BLAST176
Domaini1468 – 1580PH 1PROSITE-ProRule annotationAdd BLAST113
Domaini1646 – 1711SH3 1PROSITE-ProRule annotationAdd BLAST66
Domaini1928 – 2103DH 2PROSITE-ProRule annotationAdd BLAST176
Domaini2115 – 2225PH 2PROSITE-ProRule annotationAdd BLAST111
Domaini2320 – 2385SH3 2PROSITE-ProRule annotationAdd BLAST66
Domaini2470 – 2563Ig-like C2-typeAdd BLAST94
Domaini2570 – 2664Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95
Domaini2683 – 2937Protein kinasePROSITE-ProRule annotationAdd BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi682 – 687Poly-Gln6

Domaini

The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity).By similarity

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 2 DH (DBL-homology) domains.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation
Contains 9 spectrin repeats.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

GeneTreeiENSGT00760000119030.
HOGENOMiHOG000294214.
HOVERGENiHBG108598.
InParanoidiO60229.
KOiK15048.
PhylomeDBiO60229.
TreeFamiTF318080.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 3 hits.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF50729. SSF50729. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform 1 (identifier: O60229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR
60 70 80 90 100
DKRGGPILTF PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM
110 120 130 140 150
RGSKWDLIKP LLKTLQEAFP AEIHVALIIK PDNFWQKQKT NFGSSKFIFE
160 170 180 190 200
TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH EEWIELRLSL EEFFNSAVHL
210 220 230 240 250
LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA PVEELDREGQ
260 270 280 290 300
RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH
310 320 330 340 350
VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL
360 370 380 390 400
QTQHNHFAMN SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW
410 420 430 440 450
KSFAAALDER STILAMSAVF HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL
460 470 480 490 500
ELAIHHHQTL YEQVTQAYTE VSQDGKALLD VLQRPLSPGN SESLTATANY
510 520 530 540 550
SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV FQQDVQQVLD
560 570 580 590 600
WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA
610 620 630 640 650
AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT
660 670 680 690 700
KELWTWMEDL QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE
710 720 730 740 750
GEDLIQQLRS APPSLGEPSE ARDSAVSNNK TPHSSSISHI ESVLQQLDDA
760 770 780 790 800
QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE VTAELDAWNE DLLRQMNDFN
810 820 830 840 850
TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT EVQASGIELI
860 870 880 890 900
CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK
910 920 930 940 950
QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI ESLFHATSLQ
960 970 980 990 1000
KTHQSALQVQ QKAEVLLQAG HYDADAIREC AEKVALHWQQ LMLKMEDRLK
1010 1020 1030 1040 1050
LVNASVAFYK TSEQVCSVLE SLEQEYRRDE DWCGGRDKLG PAAEIDHVIP
1060 1070 1080 1090 1100
LISKHLEQKE AFLKACTLAR RNAEVFLKYI HRNNVSMPSV ASHTRGPEQQ
1110 1120 1130 1140 1150
VKAILSELLQ RENRVLHFWT LKKRRLDQCQ QYVVFERSAK QALDWIQETG
1160 1170 1180 1190 1200
EFYLSTHTST GETTEETQEL LKEYGEFRVP AKQTKEKVKL LIQLADSFVE
1210 1220 1230 1240 1250
KGHIHATEIR KWVTTVDKHY RDFSLRMGKY RYSLEKALGV NTEDNKDLEL
1260 1270 1280 1290 1300
DIIPASLSDR EVKLRDANHE VNEEKRKSAR KKEFIMAELL QTEKAYVRDL
1310 1320 1330 1340 1350
HECLETYLWE MTSGVEEIPP GILNKEHIIF GNIQEIYDFH NNIFLKELEK
1360 1370 1380 1390 1400
YEQLPEDVGH CFVTWADKFQ MYVTYCKNKP DSNQLILEHA GTFFDEIQQR
1410 1420 1430 1440 1450
HGLANSISSY LIKPVQRITK YQLLLKELLT CCEEGKGELK DGLEVMLSVP
1460 1470 1480 1490 1500
KKANDAMHVS MLEGFDENLD VQGELILQDA FQVWDPKSLI RKGRERHLFL
1510 1520 1530 1540 1550
FEISLVFSKE IKDSSGHTKY VYKNKLLTSE LGVTEHVEGD PCKFALWSGR
1560 1570 1580 1590 1600
TPSSDNKTVL KASNIETKQE WIKNIREVIQ ERIIHLKGAL KEPLQLPKTP
1610 1620 1630 1640 1650
AKQRNNSKRD GVEDIDSQGD GSSQPDTISI ASRTSQNTVD SDKLSGGCEL
1660 1670 1680 1690 1700
TVVLQDFSAG HSSELTIQVG QTVELLERPS ERPGWCLVRT TERSPPLEGL
1710 1720 1730 1740 1750
VPSSALCISH SRSSVEMDCF FPLVKDAYSH SSSENGGKSE SVANLQAQPS
1760 1770 1780 1790 1800
LNSIHSSPGP KRSTNTLKKW LTSPVRRLNS GKADGNIKKQ KKVRDGRKSF
1810 1820 1830 1840 1850
DLGSPKPGDE TTPQGDSADE KSKKGWGEDE PDEESHTPLP PPMKIFDNDP
1860 1870 1880 1890 1900
TQDEMSSLLA ARQASTEVPT AADLVNAIEK LVKNKLSLEG SSYRGSLKDP
1910 1920 1930 1940 1950
AGCLNEGMAP PTPPKNPEEE QKAKALRGRM FVLNELVQTE KDYVKDLGIV
1960 1970 1980 1990 2000
VEGFMKRIEE KGVPEDMRGK DKIVFGNIHQ IYDWHKDFFL AELEKCIQEQ
2010 2020 2030 2040 2050
DRLAQLFIKH ERKLHIYVWY CQNKPRSEYI VAEYDAYFEE VKQEINQRLT
2060 2070 2080 2090 2100
LSDFLIKPIQ RITKYQLLLK DFLRYSEKAG LECSDIEKAV ELMCLVPKRC
2110 2120 2130 2140 2150
NDMMNLGRLQ GFEGTLTAQG KLLQQDTFYV IELDAGMQSR TKERRVFLFE
2160 2170 2180 2190 2200
QIVIFSELLR KGSLTPGYMF KRSIKMNYLV LEENVDNDPC KFALMNRETS
2210 2220 2230 2240 2250
ERVVLQAANA DIQQAWVQDI NQVLETQRDF LNALQSPIEY QRKERSTAVM
2260 2270 2280 2290 2300
RSQPARLPQA SPRPYSSVPA GSEKPPKGSS YNPPLPPLKI STSNGSPGFE
2310 2320 2330 2340 2350
YHQPGDKFEA SKQNDLGGCN GTSSMAVIKD YYALKENEIC VSQGEVVQVL
2360 2370 2380 2390 2400
AVNQQNMCLV YQPASDHSPA AEGWVPGSIL APLTKATAAE SSDGSIKKSC
2410 2420 2430 2440 2450
SWHTLRMRKR AEVENTGKNE ATGPRKPKDI LGNKVSVKET NSSEESECDD
2460 2470 2480 2490 2500
LDPNTSMEIL NPNFIQEVAP EFLVPLVDVT CLLGDTVILQ CKVCGRPKPT
2510 2520 2530 2540 2550
ITWKGPDQNI LDTDNSSATY TVSSCDSGEI TLKICNLMPQ DSGIYTCIAT
2560 2570 2580 2590 2600
NDHGTTSTSA TVKVQGVPAA PNRPIAQERS CTSVILRWLP PSSTGNCTIS
2610 2620 2630 2640 2650
GYTVEYREEG SQIWQQSVAS TLDTYLVIED LSPGCPYQFR VSASNPWGIS
2660 2670 2680 2690 2700
LPSEPSEFVR LPEYDAAADG ATISWKENFD SAYTELNEIG RGRFSIVKKC
2710 2720 2730 2740 2750
IHKATRKDVA VKFVSKKMKK KEQAAHEAAL LQHLQHPQYI TLHDTYESPT
2760 2770 2780 2790 2800
SYILILELMD DGRLLDYLMN HDELMEEKVA FYIRDIMEAL QYLHNCRVAH
2810 2820 2830 2840 2850
LDIKPENLLI DLRIPVPRVK LIDLEDAVQI SGHFHIHHLL GNPEFAAPEV
2860 2870 2880 2890 2900
IQGIPVSLGT DIWSIGVLTY VMLSGVSPFL DESKEETCIN VCRVDFSFPH
2910 2920 2930 2940 2950
EYFCGVSNAA RDFINVILQE DFRRRPTAAT CLQHPWLQPH NGSYSKIPLD
2960 2970 2980
TSRLACFIER RKHQNDVRPI PNVKSYIVNR VNQGT
Note: Produced by alternative splicing.
Length:2,985
Mass (Da):340,174
Last modified:October 23, 2007 - v2
Checksum:iF4C01D0F2422A92F
GO
Isoform 2 (identifier: O60229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1644-1663: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1664-2985: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.
Show »
Length:1,663
Mass (Da):192,229
Checksum:iFAE683734C83417C
GO
Isoform 3 (identifier: O60229-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-641: Missing.
     709-721: Missing.
     1465-1505: FDENLDVQGE...RHLFLFEISL → SCPPSTGEAS...ARLEERRNDK
     1506-2985: Missing.

Note: Produced by alternative initiation at Met-624 of isoform 1. Inferred by similarity.
Show »
Length:851
Mass (Da):98,659
Checksum:i3F611F4EF00D376C
GO
Isoform 4 (identifier: O60229-4) [UniParc]FASTAAdd to basket
Also known as: DUET, TRAD

The sequence of this isoform differs from the canonical sequence as follows:
     1-1697: Missing.
     1698-1725: EGLVPSSALCISHSRSSVEMDCFFPLVK → MKGGDRAYTRGPSLGWLFAKCCCCFPCR
     1857-1857: S → SS

Note: Produced by alternative splicing.
Show »
Length:1,289
Mass (Da):144,485
Checksum:iC0C2F3DBC8C2B34A
GO
Isoform 5 (identifier: O60229-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1627: Missing.
     1628-1643: ISIASRTSQNTVDSDK → MLKWISWRQSKANKAQ
     1857-1887: Missing.
     2313-2313: Missing.
     2398-2985: Missing.

Note: Produced by alternative splicing.
Show »
Length:738
Mass (Da):82,806
Checksum:i1C9AC959DC07903E
GO
Isoform 6 (identifier: O60229-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1697: Missing.
     1698-1725: EGLVPSSALCISHSRSSVEMDCFFPLVK → MKGGDRAYTRGPSLGWLFAKCCCCFPCR
     1857-1887: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.
Show »
Length:1,257
Mass (Da):141,164
Checksum:iA45112D100678192
GO

Sequence cautioni

The sequence AAH58015 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2458E → G in BAA76314 (PubMed:10023074).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041898196S → L.1 Publication1
Natural variantiVAR_035976213R → W in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0201921326E → D.Corresponds to variant rs2289838dbSNPEnsembl.1
Natural variantiVAR_0356251896S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0571901929R → M.Corresponds to variant rs35298864dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0289031 – 1697Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST1697
Alternative sequenceiVSP_0289041 – 1627Missing in isoform 5. 3 PublicationsAdd BLAST1627
Alternative sequenceiVSP_0289051 – 641Missing in isoform 3. 2 PublicationsAdd BLAST641
Alternative sequenceiVSP_028906709 – 721Missing in isoform 3. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_0289071465 – 1505FDENL…FEISL → SCPPSTGEASSLPRHGGACI MGGKWHEVRQGARLEERRND K in isoform 3. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_0289081506 – 2985Missing in isoform 3. 2 PublicationsAdd BLAST1480
Alternative sequenceiVSP_0289091628 – 1643ISIAS…VDSDK → MLKWISWRQSKANKAQ in isoform 5. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0289101644 – 1663LSGGC…AGHSS → DGNLVPRWHLGPGDPFSTYV in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0289111664 – 2985Missing in isoform 2. 1 PublicationAdd BLAST1322
Alternative sequenceiVSP_0289121698 – 1725EGLVP…FPLVK → MKGGDRAYTRGPSLGWLFAK CCCCFPCR in isoform 4 and isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0289131857 – 1887Missing in isoform 5 and isoform 6. 3 PublicationsAdd BLAST31
Alternative sequenceiVSP_0473531857S → SS in isoform 4. 1 Publication1
Alternative sequenceiVSP_0289142313Missing in isoform 5. 3 Publications1
Alternative sequenceiVSP_0289152398 – 2985Missing in isoform 5. 3 PublicationsAdd BLAST588

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94190 mRNA. Translation: AAC15791.1.
AB011422 mRNA. Translation: BAA76314.1.
AK125979 mRNA. Translation: BAC86373.1.
AK131379 mRNA. Translation: BAD18530.1.
AC022336 Genomic DNA. No translation available.
AC069233 Genomic DNA. No translation available.
AC080008 Genomic DNA. No translation available.
AC112129 Genomic DNA. No translation available.
AC117401 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79410.1.
BC026865 mRNA. Translation: AAH26865.1.
BC058015 mRNA. Translation: AAH58015.1. Sequence problems.
AL137629 mRNA. Translation: CAB70850.1.
CCDSiCCDS3027.1. [O60229-2]
CCDS3028.1. [O60229-4]
PIRiT46482.
RefSeqiNP_001019831.2. NM_001024660.4.
NP_001309917.1. NM_001322988.1.
NP_001309918.1. NM_001322989.1.
NP_001309923.1. NM_001322994.1.
NP_001309924.1. NM_001322995.1.
NP_001309925.1. NM_001322996.1.
NP_001309926.1. NM_001322997.1.
NP_001309927.1. NM_001322998.1.
NP_001309928.1. NM_001322999.1.
NP_001309929.1. NM_001323000.1.
NP_001309930.1. NM_001323001.1.
NP_003938.1. NM_003947.5. [O60229-2]
NP_008995.2. NM_007064.4. [O60229-4]
UniGeneiHs.13281.
Hs.8004.

Genome annotation databases

EnsembliENST00000240874; ENSP00000240874; ENSG00000160145. [O60229-2]
ENST00000291478; ENSP00000291478; ENSG00000160145. [O60229-4]
GeneIDi8997.
KEGGihsa:8997.
UCSCiuc003ehf.2. human. [O60229-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94190 mRNA. Translation: AAC15791.1.
AB011422 mRNA. Translation: BAA76314.1.
AK125979 mRNA. Translation: BAC86373.1.
AK131379 mRNA. Translation: BAD18530.1.
AC022336 Genomic DNA. No translation available.
AC069233 Genomic DNA. No translation available.
AC080008 Genomic DNA. No translation available.
AC112129 Genomic DNA. No translation available.
AC117401 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79410.1.
BC026865 mRNA. Translation: AAH26865.1.
BC058015 mRNA. Translation: AAH58015.1. Sequence problems.
AL137629 mRNA. Translation: CAB70850.1.
CCDSiCCDS3027.1. [O60229-2]
CCDS3028.1. [O60229-4]
PIRiT46482.
RefSeqiNP_001019831.2. NM_001024660.4.
NP_001309917.1. NM_001322988.1.
NP_001309918.1. NM_001322989.1.
NP_001309923.1. NM_001322994.1.
NP_001309924.1. NM_001322995.1.
NP_001309925.1. NM_001322996.1.
NP_001309926.1. NM_001322997.1.
NP_001309927.1. NM_001322998.1.
NP_001309928.1. NM_001322999.1.
NP_001309929.1. NM_001323000.1.
NP_001309930.1. NM_001323001.1.
NP_003938.1. NM_003947.5. [O60229-2]
NP_008995.2. NM_007064.4. [O60229-4]
UniGeneiHs.13281.
Hs.8004.

3D structure databases

ProteinModelPortaliO60229.
SMRiO60229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114478. 15 interactors.
IntActiO60229. 12 interactors.
MINTiMINT-2865643.

PTM databases

iPTMnetiO60229.
PhosphoSitePlusiO60229.
SwissPalmiO60229.

Polymorphism and mutation databases

BioMutaiKALRN.

Proteomic databases

MaxQBiO60229.
PeptideAtlasiO60229.
PRIDEiO60229.

Protocols and materials databases

DNASUi8997.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240874; ENSP00000240874; ENSG00000160145. [O60229-2]
ENST00000291478; ENSP00000291478; ENSG00000160145. [O60229-4]
GeneIDi8997.
KEGGihsa:8997.
UCSCiuc003ehf.2. human. [O60229-1]

Organism-specific databases

CTDi8997.
DisGeNETi8997.
GeneCardsiKALRN.
HGNCiHGNC:4814. KALRN.
HPAiCAB026456.
HPA011913.
MalaCardsiKALRN.
MIMi604605. gene.
608901. phenotype.
neXtProtiNX_O60229.
OpenTargetsiENSG00000160145.
PharmGKBiPA29189.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119030.
HOGENOMiHOG000294214.
HOVERGENiHBG108598.
InParanoidiO60229.
KOiK15048.
PhylomeDBiO60229.
TreeFamiTF318080.

Enzyme and pathway databases

BioCyciZFISH:HS08448-MONOMER.
ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-5687128. MAPK6/MAPK4 signaling.
SignaLinkiO60229.

Miscellaneous databases

ChiTaRSiKALRN. human.
GeneWikiiKalirin.
GenomeRNAii8997.
PROiO60229.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160145.
CleanExiHS_KALRN.
ExpressionAtlasiO60229. baseline and differential.
GenevisibleiO60229. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 3 hits.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF50729. SSF50729. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKALRN_HUMAN
AccessioniPrimary (citable) accession number: O60229
Secondary accession number(s): A8MSI4
, C9JQ37, Q6ZN45, Q8TBQ5, Q9NSZ4, Q9Y2A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Called DUO because the encoded protein is closely related to but shorter than TRIO.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.