O60225 (SSX5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SSX5

Gene names

Name:

SSX5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Could act as a modulator of transcription.
Sequence similarities	Belongs to the SSX family. Contains 1 KRAB-related domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60225-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60225-2)

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: K → KHPWRQVCDRGIHLVNLSPFWKVGREPASSIKALLCGRGEAR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Protein SSX5		PRO_0000181832
Regions
	Domain	20 – 83	64	KRAB-related
Natural variations
	Alternative sequence	23	1	K → KHPWRQVCDRGIHLVNLSPF WKVGREPASSIKALLCGRGE AR in isoform 2.		VSP_006274
	Natural variant	19	1	E → Q. Ref.1 Ref.3 Corresponds to variant rs4824675 [ dbSNP | Ensembl ].		VAR_027805
Experimental info
	Sequence conflict	184	1	Q → P in AAC05821. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 3, 2006. Version 3. Checksum: DBFA61D8B1295A27	FASTA	188	21,660
	10 20 30 40 50 60 MNGDDAFVRR PRVGSQIPEK MQKAFDDIAK YFSEKEWEKM KASEKIIYVY MKRKYEAMTK 70 80 90 100 110 120 LGFKATLPPF MRNKRVADFQ GNDFDNDPNR GNQVEHPQMT FGRLQGIFPK ITPEKPAEEG 130 140 150 160 170 180 NDSKGVPEAS GPQNNGKQLR PSGKLNTSEK VNKTSGPKRG KHAWTHRVRE RKQLVIYEEI SDPQEDDE
	Isoform 2 [UniParc]. Checksum: F2EC22A6B5C02F08	FASTA	229	26,284
	10 20 30 40 50 60 MNGDDAFVRR PRVGSQIPEK MQKHPWRQVC DRGIHLVNLS PFWKVGREPA SSIKALLCGR 70 80 90 100 110 120 GEARAFDDIA KYFSEKEWEK MKASEKIIYV YMKRKYEAMT KLGFKATLPP FMRNKRVADF 130 140 150 160 170 180 QGNDFDNDPN RGNQVEHPQM TFGRLQGIFP KITPEKPAEE GNDSKGVPEA SGPQNNGKQL 190 200 210 220 RPSGKLNTSE KVNKTSGPKR GKHAWTHRVR ERKQLVIYEE ISDPQEDDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SSX: a multigene family with several members transcribed in normal testis and human cancer." Gure A.O., Tuereci O., Sahin U., Tsang S., Scanlan M.J., Jager E., Knuth A., Pfreundschuh M., Old L.J., Chen Y.-T. Int. J. Cancer 72:965-971(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-19.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLN-19. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U90842 mRNA. Translation: AAC05821.1. AL683817, AL356464 Genomic DNA. Translation: CAI41133.1. AL683817, AL356464 Genomic DNA. Translation: CAI41134.1. AL356464, AL683817 Genomic DNA. Translation: CAI40523.1. AL356464, AL683817 Genomic DNA. Translation: CAI40524.1. BC016640 mRNA. Translation: AAH16640.1.
IPI	IPI00028378. IPI00220969.
RefSeq	NP_066295.3. NM_021015.3. NP_783729.1. NM_175723.1.
UniGene	Hs.166198.
3D structure databases
ProteinModelPortal	O60225.
SMR	O60225. Positions 19-70.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000312415.
PTM databases
PhosphoSite	O60225.
Proteomic databases
PaxDb	O60225.
PRIDE	O60225.
Protocols and materials databases
DNASU	6758.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311798; ENSP00000312415; ENSG00000165583. ENST00000347757; ENSP00000290558; ENSG00000165583. ENST00000376923; ENSP00000366122; ENSG00000165583. ENST00000594016; ENSP00000469469; ENSG00000268256. ENST00000594778; ENSP00000473180; ENSG00000268256. ENST00000596327; ENSP00000472588; ENSG00000268256.
GeneID	6758.
KEGG	hsa:6758.
UCSC	uc004diz.1. human. uc004dja.1. human.
Organism-specific databases
CTD	6758.
GeneCards	GC0XM048045.
HGNC	HGNC:11339. SSX5.
MIM	300327. gene.
neXtProt	NX_O60225.
PharmGKB	PA36163.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147456.
HOGENOM	HOG000231461.
HOVERGEN	HBG002056.
OMA	EKEWEKM.
Gene expression databases
ArrayExpress	O60225.
Bgee	O60225.
CleanEx	HS_SSX5.
Genevestigator	O60225.
GermOnline	ENSG00000165583. Homo sapiens.
Family and domain databases
InterPro	IPR001909. Krueppel-associated_box. IPR003655. Krueppel-associated_box-rel. IPR019041. SSXRD_motif. [Graphical view]
Pfam	PF09514. SSXRD. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50806. KRAB_RELATED. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6758.
NextBio	26374.
SOURCE	Search...

Entry information

Entry name

SSX5_HUMAN

Accession

Primary (citable) accession number: O60225
Secondary accession number(s): Q5JQ59, Q5JQ60, Q96AW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	October 3, 2006
Last modified:	May 1, 2013
This is version 108 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.