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O60224

- SSX4_HUMAN

UniProt

O60224 - SSX4_HUMAN

Protein

Protein SSX4

Gene

SSX4

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Could act as a modulator of transcription.

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SSX4
    Alternative name(s):
    Cancer/testis antigen 5.4
    Short name:
    CT5.4
    Gene namesi
    Name:SSX4
    Synonyms:SSX4A
    AND
    Name:SSX4B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:11338. SSX4.
    HGNC:16880. SSX4B.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36162.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Protein SSX4PRO_0000181831Add
    BLAST

    Proteomic databases

    PaxDbiO60224.
    PRIDEiO60224.

    PTM databases

    PhosphoSiteiO60224.

    Expressioni

    Gene expression databases

    BgeeiO60224.
    CleanExiHS_SSX4.
    HS_SSX4B.
    GenevestigatoriO60224.

    Organism-specific databases

    HPAiHPA045683.

    Interactioni

    Protein-protein interaction databases

    BioGridi112637. 4 interactions.
    IntActiO60224. 1 interaction.
    MINTiMINT-1474715.
    STRINGi9606.ENSP00000366081.

    Structurei

    3D structure databases

    ProteinModelPortaliO60224.
    SMRiO60224. Positions 19-70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 8364KRAB-relatedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SSX family.Curated
    Contains 1 KRAB-related domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG290722.
    HOGENOMiHOG000231461.
    HOVERGENiHBG002056.
    InParanoidiO60224.
    OMAiKLNYEVM.
    OrthoDBiEOG7DNNX1.
    PhylomeDBiO60224.
    TreeFamiTF338517.

    Family and domain databases

    InterProiIPR001909. Krueppel-associated_box.
    IPR003655. Krueppel-associated_box-rel.
    IPR028804. SSX.
    IPR019041. SSXRD_motif.
    [Graphical view]
    PANTHERiPTHR14112. PTHR14112. 1 hit.
    PfamiPF09514. SSXRD. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50806. KRAB_RELATED. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60224-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNGDDAFARR PRDDAQISEK LRKAFDDIAK YFSKKEWEKM KSSEKIVYVY    50
    MKLNYEVMTK LGFKVTLPPF MRSKRAADFH GNDFGNDRNH RNQVERPQMT 100
    FGSLQRIFPK IMPKKPAEEE NGLKEVPEAS GPQNDGKQLC PPGNPSTLEK 150
    INKTSGPKRG KHAWTHRLRE RKQLVVYEEI SDPEEDDE 188
    Length:188
    Mass (Da):21,858
    Last modified:August 1, 1998 - v1
    Checksum:i4ACA2A8737507AE5
    GO
    Isoform 2 (identifier: O60224-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         111-153: IMPKKPAEEE...NPSTLEKINK → DPKGGNMPGP...NSPRGYDTCP
         154-188: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:153
    Mass (Da):17,918
    Checksum:i803D9A3205389854
    GO

    Sequence cautioni

    The sequence AAI03865.1 differs from that shown. Reason: Several sequencing errors.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei111 – 15343IMPKK…EKINK → DPKGGNMPGPTDCVRESSWW FMKRSATLRKMTSNSPRGYD TCP in isoform 2. 1 PublicationVSP_054114Add
    BLAST
    Alternative sequencei154 – 18835Missing in isoform 2. 1 PublicationVSP_054115Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90841 mRNA. Translation: AAC05820.1.
    AL606490, AF196972 Genomic DNA. Translation: CAI40260.1.
    AL606490 Genomic DNA. Translation: CAI40273.1.
    BC005325 mRNA. Translation: AAH05325.1.
    BC103864 mRNA. Translation: AAI03865.1. Sequence problems.
    BC137394 mRNA. Translation: AAI37395.1.
    BC137395 mRNA. Translation: AAI37396.1.
    CCDSiCCDS35240.1. [O60224-1]
    CCDS35241.1. [O60224-1]
    CCDS43934.1. [O60224-2]
    CCDS43935.1. [O60224-2]
    RefSeqiNP_001030004.1. NM_001034832.3. [O60224-1]
    NP_001035702.1. NM_001040612.2. [O60224-2]
    NP_005627.1. NM_005636.3. [O60224-1]
    NP_783856.1. NM_175729.1. [O60224-2]
    UniGeneiHs.558402.
    Hs.648298.

    Genome annotation databases

    EnsembliENST00000595235; ENSP00000469394; ENSG00000269791. [O60224-1]
    ENST00000595689; ENSP00000469011; ENSG00000268009. [O60224-1]
    GeneIDi548313.
    6759.
    KEGGihsa:548313.
    hsa:6759.
    UCSCiuc004djf.2. human. [O60224-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90841 mRNA. Translation: AAC05820.1 .
    AL606490 , AF196972 Genomic DNA. Translation: CAI40260.1 .
    AL606490 Genomic DNA. Translation: CAI40273.1 .
    BC005325 mRNA. Translation: AAH05325.1 .
    BC103864 mRNA. Translation: AAI03865.1 . Sequence problems.
    BC137394 mRNA. Translation: AAI37395.1 .
    BC137395 mRNA. Translation: AAI37396.1 .
    CCDSi CCDS35240.1. [O60224-1 ]
    CCDS35241.1. [O60224-1 ]
    CCDS43934.1. [O60224-2 ]
    CCDS43935.1. [O60224-2 ]
    RefSeqi NP_001030004.1. NM_001034832.3. [O60224-1 ]
    NP_001035702.1. NM_001040612.2. [O60224-2 ]
    NP_005627.1. NM_005636.3. [O60224-1 ]
    NP_783856.1. NM_175729.1. [O60224-2 ]
    UniGenei Hs.558402.
    Hs.648298.

    3D structure databases

    ProteinModelPortali O60224.
    SMRi O60224. Positions 19-70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112637. 4 interactions.
    IntActi O60224. 1 interaction.
    MINTi MINT-1474715.
    STRINGi 9606.ENSP00000366081.

    PTM databases

    PhosphoSitei O60224.

    Proteomic databases

    PaxDbi O60224.
    PRIDEi O60224.

    Protocols and materials databases

    DNASUi 548313.
    6759.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000595235 ; ENSP00000469394 ; ENSG00000269791 . [O60224-1 ]
    ENST00000595689 ; ENSP00000469011 ; ENSG00000268009 . [O60224-1 ]
    GeneIDi 548313.
    6759.
    KEGGi hsa:548313.
    hsa:6759.
    UCSCi uc004djf.2. human. [O60224-1 ]

    Organism-specific databases

    CTDi 548313.
    6759.
    GeneCardsi GC0XM048261.
    GC0XP048242.
    HGNCi HGNC:11338. SSX4.
    HGNC:16880. SSX4B.
    HPAi HPA045683.
    MIMi 300326. gene.
    neXtProti NX_O60224.
    PharmGKBi PA36162.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290722.
    HOGENOMi HOG000231461.
    HOVERGENi HBG002056.
    InParanoidi O60224.
    OMAi KLNYEVM.
    OrthoDBi EOG7DNNX1.
    PhylomeDBi O60224.
    TreeFami TF338517.

    Miscellaneous databases

    ChiTaRSi SSX4B. human.
    GeneWikii SSX4_(gene).
    NextBioi 112252.
    PROi O60224.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60224.
    CleanExi HS_SSX4.
    HS_SSX4B.
    Genevestigatori O60224.

    Family and domain databases

    InterProi IPR001909. Krueppel-associated_box.
    IPR003655. Krueppel-associated_box-rel.
    IPR028804. SSX.
    IPR019041. SSXRD_motif.
    [Graphical view ]
    PANTHERi PTHR14112. PTHR14112. 1 hit.
    Pfami PF09514. SSXRD. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50806. KRAB_RELATED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SSX: a multigene family with several members transcribed in normal testis and human cancer."
      Gure A.O., Tuereci O., Sahin U., Tsang S., Scanlan M.J., Jager E., Knuth A., Pfreundschuh M., Old L.J., Chen Y.-T.
      Int. J. Cancer 72:965-971(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Urinary bladder.

    Entry informationi

    Entry nameiSSX4_HUMAN
    AccessioniPrimary (citable) accession number: O60224
    Secondary accession number(s): A8MYD4
    , B2RPE3, Q3SYD4, Q5JQZ0, Q9UJU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3