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O60224 (SSX4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SSX4
Alternative name(s):
Cancer/testis antigen 5.4
Short name=CT5.4
Gene names
Name:SSX4
Synonyms:SSX4A
AND
Name:SSX4B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could act as a modulator of transcription.

Sequence similarities

Belongs to the SSX family.

Contains 1 KRAB-related domain.

Sequence caution

The sequence AAI03865.1 differs from that shown. Reason: Several sequencing errors.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: InterPro

   Molecular_functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60224-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60224-2)

The sequence of this isoform differs from the canonical sequence as follows:
     111-153: IMPKKPAEEE...NPSTLEKINK → DPKGGNMPGP...NSPRGYDTCP
     154-188: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Protein SSX4
PRO_0000181831

Regions

Domain20 – 8364KRAB-related

Natural variations

Alternative sequence111 – 15343IMPKK…EKINK → DPKGGNMPGPTDCVRESSWW FMKRSATLRKMTSNSPRGYD TCP in isoform 2.
VSP_054114
Alternative sequence154 – 18835Missing in isoform 2.
VSP_054115

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 4ACA2A8737507AE5

FASTA18821,858
        10         20         30         40         50         60 
MNGDDAFARR PRDDAQISEK LRKAFDDIAK YFSKKEWEKM KSSEKIVYVY MKLNYEVMTK 

        70         80         90        100        110        120 
LGFKVTLPPF MRSKRAADFH GNDFGNDRNH RNQVERPQMT FGSLQRIFPK IMPKKPAEEE 

       130        140        150        160        170        180 
NGLKEVPEAS GPQNDGKQLC PPGNPSTLEK INKTSGPKRG KHAWTHRLRE RKQLVVYEEI 


SDPEEDDE 

« Hide

Isoform 2 [UniParc].

Checksum: 803D9A3205389854
Show »

FASTA15317,918

References

« Hide 'large scale' references
[1]"SSX: a multigene family with several members transcribed in normal testis and human cancer."
Gure A.O., Tuereci O., Sahin U., Tsang S., Scanlan M.J., Jager E., Knuth A., Pfreundschuh M., Old L.J., Chen Y.-T.
Int. J. Cancer 72:965-971(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Urinary bladder.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U90841 mRNA. Translation: AAC05820.1.
AL606490, AF196972 Genomic DNA. Translation: CAI40260.1.
AL606490 Genomic DNA. Translation: CAI40273.1.
BC005325 mRNA. Translation: AAH05325.1.
BC103864 mRNA. Translation: AAI03865.1. Sequence problems.
BC137394 mRNA. Translation: AAI37395.1.
BC137395 mRNA. Translation: AAI37396.1.
CCDSCCDS35240.1.
CCDS35241.1.
RefSeqNP_001030004.1. NM_001034832.3. [O60224-1]
NP_001035702.1. NM_001040612.2. [O60224-2]
NP_005627.1. NM_005636.3. [O60224-1]
NP_783856.1. NM_175729.1. [O60224-2]
UniGeneHs.558402.
Hs.648298.

3D structure databases

ProteinModelPortalO60224.
SMRO60224. Positions 19-70.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112637. 4 interactions.
IntActO60224. 1 interaction.
MINTMINT-1474715.
STRING9606.ENSP00000366081.

PTM databases

PhosphoSiteO60224.

Proteomic databases

PaxDbO60224.
PRIDEO60224.

Protocols and materials databases

DNASU548313.
6759.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375517; ENSP00000364667; ENSG00000204645.
ENST00000376884; ENSP00000366081; ENSG00000198946.
ENST00000376886; ENSP00000366083; ENSG00000204645.
ENST00000396928; ENSP00000380134; ENSG00000198946.
GeneID548313.
6759.
KEGGhsa:548313.
hsa:6759.
UCSCuc004djf.2. human. [O60224-1]

Organism-specific databases

CTD548313.
6759.
GeneCardsGC0XM048261.
GC0XP048242.
HGNCHGNC:11338. SSX4.
HGNC:16880. SSX4B.
HPAHPA045683.
MIM300326. gene.
neXtProtNX_O60224.
PharmGKBPA36162.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG290722.
HOGENOMHOG000231461.
HOVERGENHBG002056.
InParanoidO60224.
OMAKLNYEVM.
OrthoDBEOG7DNNX1.
PhylomeDBO60224.
TreeFamTF338517.

Gene expression databases

BgeeO60224.
CleanExHS_SSX4.
HS_SSX4B.
GenevestigatorO60224.

Family and domain databases

InterProIPR001909. Krueppel-associated_box.
IPR003655. Krueppel-associated_box-rel.
IPR028804. SSX.
IPR019041. SSXRD_motif.
[Graphical view]
PANTHERPTHR14112. PTHR14112. 1 hit.
PfamPF09514. SSXRD. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50806. KRAB_RELATED. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSSX4B. human.
GeneWikiSSX4_(gene).
NextBio112252.
PROO60224.
SOURCESearch...

Entry information

Entry nameSSX4_HUMAN
AccessionPrimary (citable) accession number: O60224
Secondary accession number(s): A8MYD4 expand/collapse secondary AC list , B2RPE3, Q3SYD4, Q5JQZ0, Q9UJU9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM