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Protein

Protein SSX4

Gene

SSX4

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Could act as a modulator of transcription.

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSX4
Alternative name(s):
Cancer/testis antigen 5.4
Short name:
CT5.4
Gene namesi
Name:SSX4
Synonyms:SSX4A
AND
Name:SSX4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11338. SSX4.
HGNC:16880. SSX4B.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Protein SSX4PRO_0000181831Add
BLAST

Proteomic databases

PaxDbiO60224.
PRIDEiO60224.

PTM databases

PhosphoSiteiO60224.

Expressioni

Gene expression databases

BgeeiO60224.
CleanExiHS_SSX4.
HS_SSX4B.
GenevestigatoriO60224.

Organism-specific databases

HPAiHPA045683.

Interactioni

Protein-protein interaction databases

BioGridi112637. 4 interactions.
IntActiO60224. 1 interaction.
MINTiMINT-1474715.
STRINGi9606.ENSP00000366081.

Structurei

3D structure databases

ProteinModelPortaliO60224.
SMRiO60224. Positions 19-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 8364KRAB-relatedPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SSX family.Curated
Contains 1 KRAB-related domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG290722.
GeneTreeiENSGT00390000012484.
HOGENOMiHOG000015389.
HOVERGENiHBG002056.
InParanoidiO60224.
OMAiADFHGND.
OrthoDBiEOG7DNNX1.
PhylomeDBiO60224.
TreeFamiTF338517.

Family and domain databases

InterProiIPR001909. Krueppel-associated_box.
IPR003655. Krueppel-associated_box-rel.
IPR028804. SSX.
IPR019041. SSXRD_motif.
[Graphical view]
PANTHERiPTHR14112. PTHR14112. 1 hit.
PfamiPF09514. SSXRD. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50806. KRAB_RELATED. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60224-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGDDAFARR PRDDAQISEK LRKAFDDIAK YFSKKEWEKM KSSEKIVYVY
60 70 80 90 100
MKLNYEVMTK LGFKVTLPPF MRSKRAADFH GNDFGNDRNH RNQVERPQMT
110 120 130 140 150
FGSLQRIFPK IMPKKPAEEE NGLKEVPEAS GPQNDGKQLC PPGNPSTLEK
160 170 180
INKTSGPKRG KHAWTHRLRE RKQLVVYEEI SDPEEDDE
Length:188
Mass (Da):21,858
Last modified:July 31, 1998 - v1
Checksum:i4ACA2A8737507AE5
GO
Isoform 2 (identifier: O60224-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-153: IMPKKPAEEE...NPSTLEKINK → DPKGGNMPGP...NSPRGYDTCP
     154-188: Missing.

Note: No experimental confirmation available.

Show »
Length:153
Mass (Da):17,918
Checksum:i803D9A3205389854
GO

Sequence cautioni

The sequence AAI03865.1 differs from that shown.Several sequencing errors.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei111 – 15343IMPKK…EKINK → DPKGGNMPGPTDCVRESSWW FMKRSATLRKMTSNSPRGYD TCP in isoform 2. 1 PublicationVSP_054114Add
BLAST
Alternative sequencei154 – 18835Missing in isoform 2. 1 PublicationVSP_054115Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90841 mRNA. Translation: AAC05820.1.
AL606490, AF196972 Genomic DNA. Translation: CAI40260.1.
AL606490 Genomic DNA. Translation: CAI40273.1.
BC005325 mRNA. Translation: AAH05325.1.
BC103864 mRNA. Translation: AAI03865.1. Sequence problems.
BC137394 mRNA. Translation: AAI37395.1.
BC137395 mRNA. Translation: AAI37396.1.
CCDSiCCDS35240.1. [O60224-1]
CCDS35241.1. [O60224-1]
CCDS43934.1. [O60224-2]
CCDS43935.1. [O60224-2]
RefSeqiNP_001030004.1. NM_001034832.3. [O60224-1]
NP_001035702.1. NM_001040612.2. [O60224-2]
NP_005627.1. NM_005636.3. [O60224-1]
NP_783856.1. NM_175729.1. [O60224-2]
UniGeneiHs.558402.
Hs.648298.

Genome annotation databases

EnsembliENST00000595235; ENSP00000469394; ENSG00000269791. [O60224-1]
ENST00000595689; ENSP00000469011; ENSG00000268009. [O60224-1]
ENST00000619890; ENSP00000481765; ENSG00000269791. [O60224-2]
ENST00000620320; ENSP00000483262; ENSG00000268009. [O60224-2]
GeneIDi548313.
6759.
KEGGihsa:548313.
hsa:6759.
UCSCiuc004djf.2. human. [O60224-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90841 mRNA. Translation: AAC05820.1.
AL606490, AF196972 Genomic DNA. Translation: CAI40260.1.
AL606490 Genomic DNA. Translation: CAI40273.1.
BC005325 mRNA. Translation: AAH05325.1.
BC103864 mRNA. Translation: AAI03865.1. Sequence problems.
BC137394 mRNA. Translation: AAI37395.1.
BC137395 mRNA. Translation: AAI37396.1.
CCDSiCCDS35240.1. [O60224-1]
CCDS35241.1. [O60224-1]
CCDS43934.1. [O60224-2]
CCDS43935.1. [O60224-2]
RefSeqiNP_001030004.1. NM_001034832.3. [O60224-1]
NP_001035702.1. NM_001040612.2. [O60224-2]
NP_005627.1. NM_005636.3. [O60224-1]
NP_783856.1. NM_175729.1. [O60224-2]
UniGeneiHs.558402.
Hs.648298.

3D structure databases

ProteinModelPortaliO60224.
SMRiO60224. Positions 19-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112637. 4 interactions.
IntActiO60224. 1 interaction.
MINTiMINT-1474715.
STRINGi9606.ENSP00000366081.

PTM databases

PhosphoSiteiO60224.

Proteomic databases

PaxDbiO60224.
PRIDEiO60224.

Protocols and materials databases

DNASUi548313.
6759.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000595235; ENSP00000469394; ENSG00000269791. [O60224-1]
ENST00000595689; ENSP00000469011; ENSG00000268009. [O60224-1]
ENST00000619890; ENSP00000481765; ENSG00000269791. [O60224-2]
ENST00000620320; ENSP00000483262; ENSG00000268009. [O60224-2]
GeneIDi548313.
6759.
KEGGihsa:548313.
hsa:6759.
UCSCiuc004djf.2. human. [O60224-1]

Organism-specific databases

CTDi548313.
6759.
GeneCardsiGC0XM048261.
GC0XP048242.
HGNCiHGNC:11338. SSX4.
HGNC:16880. SSX4B.
HPAiHPA045683.
MIMi300326. gene.
neXtProtiNX_O60224.
PharmGKBiPA36162.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG290722.
GeneTreeiENSGT00390000012484.
HOGENOMiHOG000015389.
HOVERGENiHBG002056.
InParanoidiO60224.
OMAiADFHGND.
OrthoDBiEOG7DNNX1.
PhylomeDBiO60224.
TreeFamiTF338517.

Miscellaneous databases

ChiTaRSiSSX4B. human.
GeneWikiiSSX4_(gene).
NextBioi112252.
PROiO60224.
SOURCEiSearch...

Gene expression databases

BgeeiO60224.
CleanExiHS_SSX4.
HS_SSX4B.
GenevestigatoriO60224.

Family and domain databases

InterProiIPR001909. Krueppel-associated_box.
IPR003655. Krueppel-associated_box-rel.
IPR028804. SSX.
IPR019041. SSXRD_motif.
[Graphical view]
PANTHERiPTHR14112. PTHR14112. 1 hit.
PfamiPF09514. SSXRD. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50806. KRAB_RELATED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SSX: a multigene family with several members transcribed in normal testis and human cancer."
    Gure A.O., Tuereci O., Sahin U., Tsang S., Scanlan M.J., Jager E., Knuth A., Pfreundschuh M., Old L.J., Chen Y.-T.
    Int. J. Cancer 72:965-971(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Urinary bladder.

Entry informationi

Entry nameiSSX4_HUMAN
AccessioniPrimary (citable) accession number: O60224
Secondary accession number(s): A8MYD4
, B2RPE3, Q3SYD4, Q5JQZ0, Q9UJU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1999
Last sequence update: July 31, 1998
Last modified: March 31, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.