##gff-version 3 O60216 UniProtKB Chain 1 631 . . . ID=PRO_0000097872;Note=Double-strand-break repair protein rad21 homolog O60216 UniProtKB Chain 280 631 . . . ID=PRO_0000446317;Note=64-kDa C-terminal product;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12417729;Dbxref=PMID:12417729 O60216 UniProtKB Region 126 282 . . . Note=Required for interaction with SMARCA5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12198550;Dbxref=PMID:12198550 O60216 UniProtKB Region 154 171 . . . Note=Interaction with NIPBL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32409525;Dbxref=PMID:32409525 O60216 UniProtKB Region 258 285 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60216 UniProtKB Region 287 403 . . . Note=Interaction with WAPL and PDS5B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19696148;Dbxref=PMID:19696148 O60216 UniProtKB Region 362 403 . . . Note=Interaction with STAG1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19696148;Dbxref=PMID:19696148 O60216 UniProtKB Region 423 489 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60216 UniProtKB Region 517 558 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60216 UniProtKB Compositional bias 423 448 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60216 UniProtKB Compositional bias 533 547 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60216 UniProtKB Site 172 173 . . . Note=Cleavage%3B by ESPL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11509732;Dbxref=PMID:11509732 O60216 UniProtKB Site 279 280 . . . Note=Cleavage%3B by caspase-3 or caspase-7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12417729;Dbxref=PMID:12417729 O60216 UniProtKB Site 450 451 . . . Note=Cleavage%3B by ESPL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11509732;Dbxref=PMID:11509732 O60216 UniProtKB Modified residue 46 46 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 O60216 UniProtKB Modified residue 153 153 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:24275569;Dbxref=PMID:19690332,PMID:20068231,PMID:24275569 O60216 UniProtKB Modified residue 175 175 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332 O60216 UniProtKB Modified residue 249 249 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O60216 UniProtKB Modified residue 394 394 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60216 UniProtKB Modified residue 454 454 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60216 UniProtKB Modified residue 545 545 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60216 UniProtKB Modified residue 623 623 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60216 UniProtKB Cross-link 48 48 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 O60216 UniProtKB Cross-link 216 216 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 O60216 UniProtKB Cross-link 418 418 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 O60216 UniProtKB Natural variant 197 631 . . . ID=VAR_083980;Note=In CDLS4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31334757;Dbxref=PMID:31334757 O60216 UniProtKB Natural variant 376 376 . . . ID=VAR_068691;Note=In CDLS4. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22633399;Dbxref=dbSNP:rs387907212,PMID:22633399 O60216 UniProtKB Natural variant 481 481 . . . ID=VAR_014281;Note=Found in a radiation-sensitive cancer patient. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11483345;Dbxref=dbSNP:rs755168088,PMID:11483345 O60216 UniProtKB Natural variant 585 585 . . . ID=VAR_068692;Note=In CDLS4. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22633399;Dbxref=dbSNP:rs387907213,PMID:22633399 O60216 UniProtKB Natural variant 622 622 . . . ID=VAR_081285;Note=In MGS%3B causes delayed food transit along the gut%2C when tested in zebrafish%3B may affect RUNX1 and APOB expression. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25575569;Dbxref=dbSNP:rs775266057,PMID:25575569 O60216 UniProtKB Mutagenesis 1 126 . . . Note=Abolishes interaction with SMC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12198550;Dbxref=PMID:12198550 O60216 UniProtKB Mutagenesis 126 282 . . . Note=Abolishes binding to SMARCA5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12198550;Dbxref=PMID:12198550 O60216 UniProtKB Mutagenesis 172 172 . . . Note=Abolishes first cleavage by ESPL1%2C no effect on nuclear localization. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11509732;Dbxref=PMID:11509732 O60216 UniProtKB Mutagenesis 276 280 . . . Note=Loss of cleavage by caspase-3 or caspase-7. DSPDS->AAPAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12417729;Dbxref=PMID:12417729 O60216 UniProtKB Mutagenesis 279 279 . . . Note=Loss of cleavage by caspase-3 or caspase-7. D->A%2CE;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11875078,ECO:0000269|PubMed:12417729;Dbxref=PMID:11875078,PMID:12417729 O60216 UniProtKB Mutagenesis 282 282 . . . Note=No effect on cleavage by caspase-3 or caspase-7. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11875078;Dbxref=PMID:11875078 O60216 UniProtKB Mutagenesis 450 450 . . . Note=Abolishes second cleavage by ESPL1%2C no effect on nuclear localization. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11509732;Dbxref=PMID:11509732 O60216 UniProtKB Sequence conflict 136 136 . . . Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 O60216 UniProtKB Helix 334 336 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6RRC O60216 UniProtKB Helix 345 347 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4PK7 O60216 UniProtKB Helix 358 365 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QNX O60216 UniProtKB Helix 369 372 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QNX O60216 UniProtKB Helix 383 390 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QNX O60216 UniProtKB Turn 391 393 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4PK7