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O60216

- RAD21_HUMAN

UniProt

O60216 - RAD21_HUMAN

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Protein

Double-strand-break repair protein rad21 homolog

Gene

RAD21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei172 – 1732Cleavage; by ESPL1
Sitei279 – 2802Cleavage; by caspase-3 or caspase-7
Sitei450 – 4512Cleavage; by ESPL1

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. chromosome segregation Source: UniProtKB-KW
  3. DNA recombination Source: ProtInc
  4. double-strand break repair Source: ProtInc
  5. mitotic cell cycle Source: Reactome
  6. mitotic nuclear division Source: UniProtKB-KW
  7. protein localization to chromatin Source: UniProtKB
  8. reciprocal meiotic recombination Source: ProtInc
  9. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Chromosome partition, DNA damage, DNA repair, Mitosis

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000164754-MONOMER.
ReactomeiREACT_150266. Establishment of Sister Chromatid Cohesion.
REACT_150421. Cohesin Loading onto Chromatin.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_75792. Meiotic synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Double-strand-break repair protein rad21 homolog
Short name:
hHR21
Alternative name(s):
Nuclear matrix protein 1
Short name:
NXP-1
SCC1 homolog
Gene namesi
Name:RAD21
Synonyms:HR21, KIAA0078, NXP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:9811. RAD21.

Subcellular locationi

Nucleus. Chromosome. Chromosomecentromere
Note: Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis.

GO - Cellular componenti

  1. chromosome Source: Reactome
  2. chromosome, centromeric region Source: Reactome
  3. cohesin complex Source: BHF-UCL
  4. cytosol Source: Reactome
  5. membrane Source: UniProtKB
  6. nuclear meiotic cohesin complex Source: Ensembl
  7. nucleoplasm Source: Reactome
  8. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Cornelia de Lange syndrome 4 (CDLS4) [MIM:614701]: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. It is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti376 – 3761P → R in CDLS4. 1 Publication
VAR_068691
Natural varianti585 – 5851C → R in CDLS4. 1 Publication
VAR_068692

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi172 – 1721R → A: Abolishes first cleavage by ESPL1. 1 Publication
Mutagenesisi279 – 2791D → A: Abolishes cleavage by caspase-3. 2 Publications
Mutagenesisi450 – 4501R → A: Abolishes second cleavage by ESPL1. 1 Publication

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi614701. phenotype.
Orphaneti199. Cornelia de Lange syndrome.
PharmGKBiPA34170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Double-strand-break repair protein rad21 homologPRO_0000097872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461Phosphoserine2 Publications
Modified residuei153 – 1531Phosphoserine2 Publications
Modified residuei175 – 1751Phosphoserine2 Publications

Post-translational modificationi

Cleaved by separase/ESPL1 at the onset of anaphase. Cleaved by caspase-3 and caspase-7 at the beginning of apoptosis. The cleavage by ESPL1 and caspase-3 take place at different sites.3 Publications
Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to its phosphorylation by PLK.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60216.
PaxDbiO60216.
PeptideAtlasiO60216.
PRIDEiO60216.

PTM databases

PhosphoSiteiO60216.

Miscellaneous databases

PMAP-CutDBO60216.

Expressioni

Gene expression databases

BgeeiO60216.
CleanExiHS_RAD21.
ExpressionAtlasiO60216. baseline and differential.
GenevestigatoriO60216.

Organism-specific databases

HPAiCAB022065.
HPA020044.

Interactioni

Subunit structurei

Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Found in a complex with SMC1A, SMC3, CDCA5, PDS5A/APRIN and PDS5B/SCC-112. Interacts with PDS5B and WAPAL; the interaction is direct.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PDS5AQ29RF73EBI-80739,EBI-1175454
PDS5BQ9NTI54EBI-80739,EBI-1175604
SMC3Q9UQE710EBI-80739,EBI-80718
SSU72Q9NP779EBI-80739,EBI-2515416
WAPALQ7Z5K211EBI-80739,EBI-1022242

Protein-protein interaction databases

BioGridi111822. 245 interactions.
DIPiDIP-29201N.
IntActiO60216. 24 interactions.
MINTiMINT-2999858.
STRINGi9606.ENSP00000297338.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4PJUX-ray3.05B281-420[»]
4PJWX-ray2.85B281-420[»]
4PK7X-ray2.95B281-420[»]
ProteinModelPortaliO60216.
SMRiO60216. Positions 557-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni287 – 403117Interaction with WAPAL and PDS5BAdd
BLAST
Regioni362 – 40342Interaction with STAG1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi469 – 51042Pro-richAdd
BLAST

Domaini

The C-terminal part associates with the head of SMC1A, while the N-terminal part binds to the head of SMC3.By similarity

Sequence similaritiesi

Belongs to the rad21 family.Curated

Phylogenomic databases

eggNOGiNOG249424.
GeneTreeiENSGT00390000011606.
HOGENOMiHOG000233800.
HOVERGENiHBG059956.
InParanoidiO60216.
KOiK06670.
OMAiVPREEQQ.
OrthoDBiEOG7B31N3.
PhylomeDBiO60216.
TreeFamiTF101215.

Family and domain databases

Gene3Di1.10.10.580. 1 hit.
InterProiIPR023093. Rad21/Rec8_C.
IPR006909. Rad21/Rec8_C_eu.
IPR006910. Rad21_Rec8_N.
[Graphical view]
PfamiPF04824. Rad21_Rec8. 1 hit.
PF04825. Rad21_Rec8_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60216-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFYAHFVLSK RGPLAKIWLA AHWDKKLTKA HVFECNLESS VESIISPKVK
60 70 80 90 100
MALRTSGHLL LGVVRIYHRK AKYLLADCNE AFIKIKMAFR PGVVDLPEEN
110 120 130 140 150
REAAYNAITL PEEFHDFDQP LPDLDDIDVA QQFSLNQSRV EEITMREEVG
160 170 180 190 200
NISILQENDF GDFGMDDREI MREGSAFEDD DMLVSTTTSN LLLESEQSTS
210 220 230 240 250
NLNEKINHLE YEDQYKDDNF GEGNDGGILD DKLISNNDGG IFDDPPALSE
260 270 280 290 300
AGVMLPEQPA HDDMDEDDNV SMGGPDSPDS VDPVEPMPTM TDQTTLVPNE
310 320 330 340 350
EEAFALEPID ITVKETKAKR KRKLIVDSVK ELDSKTIRAQ LSDYSDIVTT
360 370 380 390 400
LDLAPPTKKL MMWKETGGVE KLFSLPAQPL WNNRLLKLFT RCLTPLVPED
410 420 430 440 450
LRKRRKGGEA DNLDEFLKEF ENPEVPREDQ QQQHQQRDVI DEPIIEEPSR
460 470 480 490 500
LQESVMEASR TNIDESAMPP PPPQGVKRKA GQIDPEPVMP PQQVEQMEIP
510 520 530 540 550
PVELPPEEPP NICQLIPELE LLPEKEKEKE KEKEDDEEEE DEDASGGDQD
560 570 580 590 600
QEERRWNKRT QQMLHGLQRA LAKTGAESIS LLELCRNTNR KQAAAKFYSF
610 620 630
LVLKKQQAIE LTQEEPYSDI IATPGPRFHI I
Length:631
Mass (Da):71,690
Last modified:November 15, 2002 - v2
Checksum:i7D4A6EA6392BE73D
GO

Sequence cautioni

The sequence BAA07554.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361N → I in CAA66940. (PubMed:8812457)Curated

Polymorphismi

Some radiosensitive cancer patients seem to have Arg-481 instead of the conserved Gly-481. It may be that this mutation could contribute to radiosensitivity.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti376 – 3761P → R in CDLS4. 1 Publication
VAR_068691
Natural varianti481 – 4811G → R.1 Publication
VAR_014281
Natural varianti585 – 5851C → R in CDLS4. 1 Publication
VAR_068692

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98294 mRNA. Translation: CAA66940.1.
D38551 mRNA. Translation: BAA07554.2. Different initiation.
AY675320 Genomic DNA. Translation: AAT70725.1.
AK289505 mRNA. Translation: BAF82194.1.
CH471060 Genomic DNA. Translation: EAW91963.1.
BC050381 mRNA. Translation: AAH50381.1.
CCDSiCCDS6321.1.
RefSeqiNP_006256.1. NM_006265.2.
UniGeneiHs.81848.

Genome annotation databases

EnsembliENST00000297338; ENSP00000297338; ENSG00000164754.
GeneIDi5885.
KEGGihsa:5885.
UCSCiuc003yod.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98294 mRNA. Translation: CAA66940.1 .
D38551 mRNA. Translation: BAA07554.2 . Different initiation.
AY675320 Genomic DNA. Translation: AAT70725.1 .
AK289505 mRNA. Translation: BAF82194.1 .
CH471060 Genomic DNA. Translation: EAW91963.1 .
BC050381 mRNA. Translation: AAH50381.1 .
CCDSi CCDS6321.1.
RefSeqi NP_006256.1. NM_006265.2.
UniGenei Hs.81848.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4PJU X-ray 3.05 B 281-420 [» ]
4PJW X-ray 2.85 B 281-420 [» ]
4PK7 X-ray 2.95 B 281-420 [» ]
ProteinModelPortali O60216.
SMRi O60216. Positions 557-624.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111822. 245 interactions.
DIPi DIP-29201N.
IntActi O60216. 24 interactions.
MINTi MINT-2999858.
STRINGi 9606.ENSP00000297338.

PTM databases

PhosphoSitei O60216.

Proteomic databases

MaxQBi O60216.
PaxDbi O60216.
PeptideAtlasi O60216.
PRIDEi O60216.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297338 ; ENSP00000297338 ; ENSG00000164754 .
GeneIDi 5885.
KEGGi hsa:5885.
UCSCi uc003yod.3. human.

Organism-specific databases

CTDi 5885.
GeneCardsi GC08M117858.
GeneReviewsi RAD21.
HGNCi HGNC:9811. RAD21.
HPAi CAB022065.
HPA020044.
MIMi 606462. gene.
614701. phenotype.
neXtProti NX_O60216.
Orphaneti 199. Cornelia de Lange syndrome.
PharmGKBi PA34170.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249424.
GeneTreei ENSGT00390000011606.
HOGENOMi HOG000233800.
HOVERGENi HBG059956.
InParanoidi O60216.
KOi K06670.
OMAi VPREEQQ.
OrthoDBi EOG7B31N3.
PhylomeDBi O60216.
TreeFami TF101215.

Enzyme and pathway databases

BioCyci MetaCyc:ENSG00000164754-MONOMER.
Reactomei REACT_150266. Establishment of Sister Chromatid Cohesion.
REACT_150421. Cohesin Loading onto Chromatin.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_75792. Meiotic synapsis.

Miscellaneous databases

ChiTaRSi RAD21. human.
GeneWikii RAD21.
GenomeRNAii 5885.
NextBioi 22884.
PMAP-CutDB O60216.
PROi O60216.
SOURCEi Search...

Gene expression databases

Bgeei O60216.
CleanExi HS_RAD21.
ExpressionAtlasi O60216. baseline and differential.
Genevestigatori O60216.

Family and domain databases

Gene3Di 1.10.10.580. 1 hit.
InterProi IPR023093. Rad21/Rec8_C.
IPR006909. Rad21/Rec8_C_eu.
IPR006910. Rad21_Rec8_N.
[Graphical view ]
Pfami PF04824. Rad21_Rec8. 1 hit.
PF04825. Rad21_Rec8_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse."
    McKay M.J., Troelstra C., van der Spek P., Kanaar R., Smit B., Hagemeijer A., Bootsma D., Hoeijmakers J.H.J.
    Genomics 36:305-315(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "NXP-1, a human protein related to Rad21/Scc1/Mcd1, is a component of the nuclear matrix."
    Sadano H., Sugimoto H., Sakai F., Nomura N., Osumi T.
    Biochem. Biophys. Res. Commun. 267:418-422(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  3. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
    Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
    DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  4. NIEHS SNPs program
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  8. "A potential role for human cohesin in mitotic spindle aster assembly."
    Gregson H.C., Schmiesing J.A., Kim J.-S., Kobayashi T., Zhou S., Yokomori K.
    J. Biol. Chem. 276:47575-47582(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 406-418, IDENTIFICATION IN A COHESIN COMPLEX WITH SMC1A; SMC3; STAG1 OR STAG2.
  9. "Linking sister chromatid cohesion and apoptosis: role of rad21."
    Pati D., Zhang N., Plon S.E.
    Mol. Cell. Biol. 22:8267-8277(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 275-279 (60 KDA PRODUCT), PROTEIN SEQUENCE OF 280-286 (64 KDA C-TERMINAL PRODUCT), CLEAVAGE BY CASPASE-3, FUNCTION, MUTAGENESIS OF ASP-279.
  10. "Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres."
    Hoque M.T., Ishikawa F.
    J. Biol. Chem. 276:5059-5067(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, PHOSPHORYLATION.
  11. "Cohesin cleavage by separase required for anaphase and cytokinesis in human cells."
    Hauf S., Waizenegger I.C., Peters J.-M.
    Science 293:1320-1323(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY ESPL1, MUTAGENESIS OF ARG-172 AND ARG-450.
  12. "Caspase proteolysis of the cohesin component RAD21 promotes apoptosis."
    Chen F., Kamradt M., Mulcahy M., Byun Y., Xu H., McKay M.J., Cryns V.L.
    J. Biol. Chem. 277:16775-16781(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CLEAVAGE BY CASPASE-3, MUTAGENESIS OF ASP-279.
  13. "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates."
    Rankin S., Ayad N.G., Kirschner M.W.
    Mol. Cell 18:185-200(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH SMC1A; SMC3; CDCA5; PDS5A AND PDS5B.
  14. Erratum
    Rankin S., Ayad N.G., Kirschner M.W.
    Mol. Cell 18:609-609(2005)
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-175, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1."
    Shintomi K., Hirano T.
    Genes Dev. 23:2224-2236(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDS5B; STAG1 AND WAPAL.
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153 AND SER-175, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients."
    Severin D.M., Leong T., Cassidy B., Elsaleh H., Peters L., Venter D., Southey M., McKay M.
    Int. J. Radiat. Oncol. Biol. Phys. 50:1323-1331(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARG-481.
  21. Cited for: VARIANTS CDLS4 ARG-376 AND ARG-585.

Entry informationi

Entry nameiRAD21_HUMAN
AccessioniPrimary (citable) accession number: O60216
Secondary accession number(s): A8K0E0, Q15001, Q99568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: October 29, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

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    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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