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Protein

Endo-1,4-beta-xylanase

Gene

xlnA

Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has xylanase activity. Seems to be involved in the release of sugars from the hemicellulolytic fraction in the compost.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471Proton donorBy similarity
Active sitei252 – 2521NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. endo-1,4-beta-xylanase activity Source: UniProtKB-EC

GO - Biological processi

  1. xylan catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.
mycoCLAPiXYN10A_AGABI.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase (EC:3.2.1.8)
Short name:
Xylanase
Gene namesi
Name:xlnA
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 333316Endo-1,4-beta-xylanasePRO_0000007962Add
BLAST

Proteomic databases

PRIDEiO60206.

Expressioni

Inductioni

Repressed on glucose.

Structurei

3D structure databases

ProteinModelPortaliO60206.
SMRiO60206. Positions 19-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

OMAiNHVTNLV.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60206-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYLVAFMLLA ILPTGYCQLN TLAVRAGKKY FGTATDNPEL GDAPYVAQLG
60 70 80 90 100
NTADFNQITA GNSMKWDATE PSRGTFTFSN GDTVANMARN RGQLLRGHTC
110 120 130 140 150
VWHSQLPNWV TSGNFDNSTL LSIVQNHCST LVSHYRGQMY SWDVVNEPFN
160 170 180 190 200
EDGSFRQSVF FQKTGTAYIA TALRAARNAD PNTKLYINDF NIEGTGAKST
210 220 230 240 250
GMINLVRSLQ QQNVPIDGIG VQAHLIVGQI PSSIQQNLQN FANLGVEVAI
260 270 280 290 300
TELDIRMTLP VTQQKLEQQQ EDYRTVIRAC KAVSRCVGVT VWDWTDRYSW
310 320 330
VPGVFNGEGA ACPWDENLAK KPAYQGIVDG WSQ
Length:333
Mass (Da):36,847
Last modified:August 1, 1998 - v1
Checksum:iCFAD93D81145E90A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83310 Genomic DNA. Translation: CAB05886.1.
Z83199 mRNA. Translation: CAB05665.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83310 Genomic DNA. Translation: CAB05886.1.
Z83199 mRNA. Translation: CAB05665.1.

3D structure databases

ProteinModelPortaliO60206.
SMRiO60206. Positions 19-331.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.
mycoCLAPiXYN10A_AGABI.

Proteomic databases

PRIDEiO60206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OMAiNHVTNLV.

Enzyme and pathway databases

UniPathwayiUPA00114.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An endo-1,4-beta-xylanase-encoding gene from Agaricus bisporus is regulated by compost-specific factors."
    De Groot P.W.J., Basten D.E.J.W., Sonnenberg A.S.M., van Griensven L.J.L.D., Visser J., Schaap P.J.
    J. Mol. Biol. 277:273-284(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Horst H39 and Horst U1.

Entry informationi

Entry nameiXLNA_AGABI
AccessioniPrimary (citable) accession number: O60206
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.