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Protein

ATP-dependent RNA helicase dbp7

Gene

dbp7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi185 – 1928ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase dbp7 (EC:3.6.4.13)
Gene namesi
Name:dbp7
ORF Names:SPBC21H7.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC21H7.04.
PomBaseiSPBC21H7.04. dbp7.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 709709ATP-dependent RNA helicase dbp7PRO_0000232259Add
BLAST

Proteomic databases

MaxQBiO60173.

Interactioni

Protein-protein interaction databases

MINTiMINT-4677786.

Structurei

3D structure databases

ProteinModelPortaliO60173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 366195Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini404 – 580177Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi138 – 16730Q motifAdd
BLAST
Motifi301 – 3044DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000268799.
InParanoidiO60173.
KOiK14806.
OMAiADHIENT.
OrthoDBiEOG7FNCGZ.
PhylomeDBiO60173.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEPLLLNF VVDNAQSRKP EALKSSRRWT DRARDRKRQK RNSNESSKST
60 70 80 90 100
VKRNSGTNGA STDYKNSQKE KVINPVFDPR KPAHELKGNK RDNTFVTSLF
110 120 130 140 150
TGDDSEHFSQ DVGQNLEDNQ ISNIGTTKEA SNAPIKTTNF AGVQLDTQLA
160 170 180 190 200
DHLNNKMNIS APTAIQSCCL PALLNTDDKD AFIEAQTGSG KTLAYLLPIV
210 220 230 240 250
QRLIRLPKNL HTRTSGIYAV IMAPTRELCQ QIYNVANKLN NNPLSHWIVS
260 270 280 290 300
CNVIGGEKKK SEKARIRKGV NILIGTPGRL ADHLENTEAL DVSQVRWVVL
310 320 330 340 350
DEGDRLMDMG FEETLTKILS YLESQSSIIK KDLSIPSRKV TMLCSATMKD
360 370 380 390 400
TVKRLSDSAL KDALYLKSSI VEETNDGYSQ APEQLLQRYV VVPPKLRLVS
410 420 430 440 450
LVALLRSHVR SYKKIIIFLS CSDSVDFHFE AFRCAINADE MEEAVKEKPD
460 470 480 490 500
SEGDIISNAP ALRIDGKSNV YRLHGSLSQQ IRTSTLNLFS SSEDSGSHIL
510 520 530 540 550
LCTDVAARGL DLPNVDLVVQ YDAPFSTDDY LHRIGRTARA GHNGAAIMFL
560 570 580 590 600
LPKESEYINL LKSSVSANIL EQPNGPSGLL SAGFSQGKTN TNDWQDRATE
610 620 630 640 650
WQLELERFIL ENEPMRNIAK RAFTSYVRAY ATHLSSERSI FNMRDLHLGH
660 670 680 690 700
IAKSFALREA PGKISGANSS KPRKQGGSVD KGKSKSSKDI AALMHRKAME

HYSTEHNIG
Length:709
Mass (Da):78,831
Last modified:August 1, 1998 - v1
Checksum:iE9E91C1DF92F51AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18864.1.
PIRiT39930.
RefSeqiNP_595929.1. NM_001021837.2.

Genome annotation databases

EnsemblFungiiSPBC21H7.04.1; SPBC21H7.04.1:pep; SPBC21H7.04.
GeneIDi2540518.
KEGGispo:SPBC21H7.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18864.1.
PIRiT39930.
RefSeqiNP_595929.1. NM_001021837.2.

3D structure databases

ProteinModelPortaliO60173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4677786.

Proteomic databases

MaxQBiO60173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC21H7.04.1; SPBC21H7.04.1:pep; SPBC21H7.04.
GeneIDi2540518.
KEGGispo:SPBC21H7.04.

Organism-specific databases

EuPathDBiFungiDB:SPBC21H7.04.
PomBaseiSPBC21H7.04. dbp7.

Phylogenomic databases

HOGENOMiHOG000268799.
InParanoidiO60173.
KOiK14806.
OMAiADHIENT.
OrthoDBiEOG7FNCGZ.
PhylomeDBiO60173.

Miscellaneous databases

PROiO60173.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiDBP7_SCHPO
AccessioniPrimary (citable) accession number: O60173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1460 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.