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O60172

- PPA3_SCHPO

UniProt

O60172 - PPA3_SCHPO

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Protein

Thiamine-repressible acid phosphatase SPBC21H7.03c

Gene

SPBC21H7.03c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May dephosphorylate thiamine phosphates.By similarity

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691NucleophileBy similarity
Active sitei341 – 3411Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: PomBase

GO - Biological processi

  1. dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine-repressible acid phosphatase SPBC21H7.03c (EC:3.1.3.2)
Gene namesi
ORF Names:SPBC21H7.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC21H7.03c.

Subcellular locationi

Secretedcell wall By similarity

GO - Cellular componenti

  1. cell wall-bounded periplasmic space Source: PomBase
  2. external side of plasma membrane Source: PomBase
  3. extracellular region Source: PomBase
  4. fungal-type cell wall Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 463445Thiamine-repressible acid phosphatase SPBC21H7.03cPRO_0000311718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60172.
PaxDbiO60172.

Expressioni

Inductioni

Repressed by thiamine.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi4896.SPBC21H7.03c-1.

Structurei

3D structure databases

ProteinModelPortaliO60172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Sequence Analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG260296.
HOGENOMiHOG000115655.
InParanoidiO60172.
KOiK01078.
OMAiVESAQWF.
OrthoDBiEOG7B31X6.
PhylomeDBiO60172.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60172-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLCIISLWF LAAFIVNADN VQFEDYESNF FFKEHLGTLS PYHEPYFDGL
60 70 80 90 100
DSAFPETCEI QQVHLLQRHG SRNPTGDVTA TDVYSSQYLN NFQEKLLNGS
110 120 130 140 150
IPVNFSYPEN PLCFIKQWTP VIDAENADQL SSRGRLELFD LGRQLYQRYY
160 170 180 190 200
KLFDSYVYDI NTAEQERVVE SAKWFTYGLF GDKMYEKTNF ILISEGKAAG
210 220 230 240 250
ANSLSMYNAC PVFKDNNFHK NATDAAHAVW RNIFIEPIVN RLAKYFDSSY
260 270 280 290 300
KLTINDVRSL FYICEYEIAI KDHSDFCSIF TPSEFLNFEY DSDLDQAYGG
310 320 330 340 350
GPVSEWASTL GGAYINNLAD SLRNVTNPDF DRKVFLAFTH DSNIIPVEAA
360 370 380 390 400
LGFFPDITPQ NPLPTDKNIY TYSQKTSSFV PFAGNLITEL FFCSDSKYYV
410 420 430 440 450
RHLVNQQVYP LIDCGYGPSG TSDGLCELQA YLNSPIRANS TSNGISIFNT
460
ECQARPTNVT IYF
Length:463
Mass (Da):52,759
Last modified:August 1, 1998 - v1
Checksum:i6C41AF422C6D624A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA18863.1.
PIRiT39929.
RefSeqiNP_595928.1. NM_001021836.2.

Genome annotation databases

EnsemblFungiiSPBC21H7.03c.1; SPBC21H7.03c.1:pep; SPBC21H7.03c.
GeneIDi2540420.
KEGGispo:SPBC21H7.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA18863.1 .
PIRi T39929.
RefSeqi NP_595928.1. NM_001021836.2.

3D structure databases

ProteinModelPortali O60172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4896.SPBC21H7.03c-1.

Proteomic databases

MaxQBi O60172.
PaxDbi O60172.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC21H7.03c.1 ; SPBC21H7.03c.1:pep ; SPBC21H7.03c .
GeneIDi 2540420.
KEGGi spo:SPBC21H7.03c.

Organism-specific databases

PomBasei SPBC21H7.03c.

Phylogenomic databases

eggNOGi NOG260296.
HOGENOMi HOG000115655.
InParanoidi O60172.
KOi K01078.
OMAi VESAQWF.
OrthoDBi EOG7B31X6.
PhylomeDBi O60172.

Miscellaneous databases

NextBioi 20801547.
PROi O60172.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Activation of AP-1-dependent transcription by a truncated translation initiation factor."
    Jenkins C.C.L., Mata J., Crane R.F., Thomas B., Akoulitchev A., Baehler J., Norbury C.J.
    Eukaryot. Cell 4:1840-1850(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiPPA3_SCHPO
AccessioniPrimary (citable) accession number: O60172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3