O60172 (PPA3_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 73.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Thiamine-repressible acid phosphatase SPBC21H7.03c EC=3.1.3.2 | ||
| Gene names |
| ||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome] | ||
| Taxonomic identifier | 284812 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›  |
Protein attributes
| Sequence length | 463 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | May dephosphorylate thiamine phosphates By similarity. UniProtKB Q01682 |
| Catalytic activity | A phosphate monoester + H2O = an alcohol + phosphate. UniProtKB Q01682 |
| Subcellular location | Secreted › cell wall By similarity UniProtKB Q01682. |
| Induction | Repressed by thiamine. Ref.2 |
| Sequence similarities | Belongs to the histidine acid phosphatase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell wall Secreted |
| Domain | Signal |
| Molecular function | Hydrolase |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular_component | cell wall-bounded periplasmic space Inferred from sequence orthology. Source: PomBase external side of plasma membraneNon-traceable author statement. Source: PomBase extracellular regionInferred from sequence orthology. Source: PomBase fungal-type cell wallInferred from sequence orthology. Source: PomBase |
| Molecular_function | acid phosphatase activity Inferred from sequence orthology. Source: PomBase |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | Potential | ||||||
| Chain | 19 – 463 | 445 | Thiamine-repressible acid phosphatase SPBC21H7.03c | PRO_0000311718 | |||||
Sites | |||||||||
| Active site | 69 | 1 | Nucleophile By similarity UniProtKB P07102 | ||||||
| Active site | 341 | 1 | Proton donor By similarity UniProtKB P15309 | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 98 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 104 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 221 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 324 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 439 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 458 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.  Nurse P.Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [2] | "Activation of AP-1-dependent transcription by a truncated translation initiation factor." Jenkins C.C.L., Mata J., Crane R.F., Thomas B., Akoulitchev A., Baehler J., Norbury C.J. Eukaryot. Cell 4:1840-1850(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329671 Genomic DNA. Translation: CAA18863.1. |
| PIR | T39929. |
| RefSeq | NP_595928.1. NM_001021836.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1QFX based on UniProtKB P34755. |
| ProteinModelPortal | O60172. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 4896.SPBC21H7.03c-1. |
Proteomic databases | |
| PaxDb | O60172. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPBC21H7.03c.1; SPBC21H7.03c.1:pep; SPBC21H7.03c. |
| GeneID | 2540420. |
| KEGG | spo:SPBC21H7.03c. |
Organism-specific databases | |
| PomBase | SPBC21H7.03c. |
Phylogenomic databases | |
| eggNOG | NOG260296. |
| HOGENOM | HOG000115655. |
| KO | K01078. |
| OMA | IRANSTS. |
| OrthoDB | EOG45HW5S. |
Family and domain databases | |
| InterPro | IPR000560. His_Pase_superF_clade-2. IPR016274. Histidine_acid_Pase_euk. [Graphical view] |
| Pfam | PF00328. His_Phos_2. 1 hit. [Graphical view] |
| PIRSF | PIRSF000894. Acid_phosphatase. 1 hit. |
| PROSITE | PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20801547. |
Entry information
| Entry name | PPA3_SCHPO | ||||||||
| Accession | Primary (citable) accession number: O60172 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |