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Protein

Transcription initiation factor TFIID subunit 10

Gene

taf10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 10
Alternative name(s):
TBP-associated factor 10
Gene namesi
Name:taf10Imported
ORF Names:SPBC21H7.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC21H7.02.
PomBaseiSPBC21H7.02. taf10.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
  • SAGA complex Source: PomBase
  • transcription factor TFIID complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Transcription initiation factor TFIID subunit 10PRO_0000326090Add
BLAST

Proteomic databases

MaxQBiO60171.

Interactioni

Subunit structurei

Component of the TFIID, SAGA, and SLIK complexes.By similarity

Protein-protein interaction databases

BioGridi277140. 6 interactions.
IntActiO60171. 2 interactions.
MINTiMINT-8210510.

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF10 family.Sequence analysis

Phylogenomic databases

HOGENOMiHOG000175811.
InParanoidiO60171.
KOiK03134.
OrthoDBiEOG092C3BLF.
PhylomeDBiO60171.

Family and domain databases

CDDicd07982. TAF10. 1 hit.
InterProiIPR003923. TFIID_30kDa.
[Graphical view]
PANTHERiPTHR21242. PTHR21242. 1 hit.
PfamiPF03540. TFIID_30kDa. 1 hit.
[Graphical view]
PIRSFiPIRSF017246. TFIID_TAF10. 1 hit.
PRINTSiPR01443. TFIID30KDSUB.

Sequencei

Sequence statusi: Complete.

O60171-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDINNNEPA ENIEQPKQEP EDGNNSMSVD EQPETSSTNL PTGDNLAPMS
60 70 80 90 100
VESPAHLNNE DSPKSDDSRE RHGSNYVIEP HLELRDMAKD KTLENFLAQM
110 120 130 140 150
DDYSPLIPDV LLDYYLSLSG FKCVDPRLKK LLGLTAQKFI SDVAQDAYQY
160 170 180 190 200
SKIRTGSSNA SSTTFGAQNF GAGGASGIGS SGRRGDRGKT VLTVDDLSAA
210
LNEYGINLKR PDFFR
Length:215
Mass (Da):23,526
Last modified:August 1, 1998 - v1
Checksum:iE314301007678DA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18862.1.
PIRiT39928.
RefSeqiNP_595927.1. NM_001021835.2.

Genome annotation databases

EnsemblFungiiSPBC21H7.02.1; SPBC21H7.02.1:pep; SPBC21H7.02.
GeneIDi2540614.
KEGGispo:SPBC21H7.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18862.1.
PIRiT39928.
RefSeqiNP_595927.1. NM_001021835.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277140. 6 interactions.
IntActiO60171. 2 interactions.
MINTiMINT-8210510.

Proteomic databases

MaxQBiO60171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC21H7.02.1; SPBC21H7.02.1:pep; SPBC21H7.02.
GeneIDi2540614.
KEGGispo:SPBC21H7.02.

Organism-specific databases

EuPathDBiFungiDB:SPBC21H7.02.
PomBaseiSPBC21H7.02. taf10.

Phylogenomic databases

HOGENOMiHOG000175811.
InParanoidiO60171.
KOiK03134.
OrthoDBiEOG092C3BLF.
PhylomeDBiO60171.

Enzyme and pathway databases

ReactomeiR-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiO60171.

Family and domain databases

CDDicd07982. TAF10. 1 hit.
InterProiIPR003923. TFIID_30kDa.
[Graphical view]
PANTHERiPTHR21242. PTHR21242. 1 hit.
PfamiPF03540. TFIID_30kDa. 1 hit.
[Graphical view]
PIRSFiPIRSF017246. TFIID_TAF10. 1 hit.
PRINTSiPR01443. TFIID30KDSUB.
ProtoNetiSearch...

Entry informationi

Entry nameiTAF10_SCHPO
AccessioniPrimary (citable) accession number: O60171
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.