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Protein

Pescadillo homolog

Gene

ppp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Pescadillo homologUniRule annotation
Alternative name(s):
Nucleolar protein 7 homologUniRule annotation
Gene namesi
Name:ppp1
Synonyms:nop7
ORF Names:SPBC19F5.05c, SPBC25D12.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19F5.05c.
PomBaseiSPBC19F5.05c. ppp1.

Subcellular locationi

  • Nucleusnucleoplasm UniRule annotation
  • Nucleusnucleolus UniRule annotation1 Publication

GO - Cellular componenti

  • nucleolus Source: PomBase
  • nucleoplasm Source: UniProtKB-SubCell
  • nucleus Source: PomBase
  • PeBoW complex Source: PomBase
  • preribosome, large subunit precursor Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Pescadillo homologPRO_0000186191Add
BLAST

Proteomic databases

MaxQBiO60164.

PTM databases

SwissPalmiO60164.

Interactioni

Subunit structurei

Component of the NOP7 complex, composed of erb1/SPBC4F6.13c, ppp1/SPBC19F5.05c and ytm1/SPAC890.04c. Within the NOP7 complex erb1/SPBC4F6.13c appears to interact directly with ppp1/SPBC19F5.05c and ytm1/SPAC890.04c. The NOP7 complex also associates with the 66S pre-ribosome.UniRule annotation

Protein-protein interaction databases

BioGridi277184. 2 interactions.
MINTiMINT-4677707.

Structurei

3D structure databases

ProteinModelPortaliO60164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini348 – 44194BRCTUniRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili497 – 604108UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pescadillo family.UniRule annotation
Contains 1 BRCT domain.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000006022.
InParanoidiO60164.
KOiK14843.
OMAiMQISNDR.
OrthoDBiEOG7HHX2C.
PhylomeDBiO60164.

Family and domain databases

Gene3Di3.40.50.10190. 1 hit.
HAMAPiMF_03028. Pescadillo.
InterProiIPR001357. BRCT_dom.
IPR010613. PES.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF06732. Pescadillo_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVKQKGKA GAARIYITRN QALKKLQLTL ADFRRICILK GVYPREPKNK
60 70 80 90 100
KKANKGSTAP VTFYYTKDIQ YLLHEPIVQK FREYKVFARK LSKALGKGEL
110 120 130 140 150
ETAKRLEARK PTYSLDHIIK ERYPTFHDAL KDIDDALSML FLFSTMPVTD
160 170 180 190 200
KIGAATVANC ERLCAEFQHY VIRSNSLRKA FLSIKGIYYQ AEIFGEQITW
210 220 230 240 250
IVPYKFAQSV PTDVDFRIMH TFLEFYQALM GFVNFKLYNT LGLRYPPKID
260 270 280 290 300
VAKSESAAGL AAYELEESSS LPAIVHGNNK NARKNIATLK SKIRDIVNSD
310 320 330 340 350
ANVVEQSEKT TEDADEEPET EENLDEFKPA DGADNEDSKS LVSHISSSNT
360 370 380 390 400
SLFSNFTFFL SREVPRFSLE FVIRAFGGKV GWDPILGSGS PFSESDPVIT
410 420 430 440 450
HHICDRPHIS QKYEGRIYIQ PQWVYDSINK GILERTDLYA CGATLPPHLS
460 470 480 490 500
PFVKVGENDY DPEAELSAEE NDDVSEALDD NISGEAVPIS KKNDEPENVE
510 520 530 540 550
QIDDAEEEDL EHQRELEAEA GGVAYSEYVK QNSKSAKKTK KRQRDTLTAE
560 570 580 590 600
EKEEKEAKEL SKMMMSNKQR KLYSKLKNEN SKNENYNNAL RNRKRDIEKR

KKLKVEN
Length:607
Mass (Da):69,189
Last modified:August 1, 1998 - v1
Checksum:i3222C4E7903A7351
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18653.1.
AB027979 Genomic DNA. Translation: BAA87283.1.
PIRiT39823.
RefSeqiNP_596543.1. NM_001022464.2.

Genome annotation databases

EnsemblFungiiSPBC19F5.05c.1; SPBC19F5.05c.1:pep; SPBC19F5.05c.
GeneIDi2540659.
KEGGispo:SPBC19F5.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18653.1.
AB027979 Genomic DNA. Translation: BAA87283.1.
PIRiT39823.
RefSeqiNP_596543.1. NM_001022464.2.

3D structure databases

ProteinModelPortaliO60164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277184. 2 interactions.
MINTiMINT-4677707.

PTM databases

SwissPalmiO60164.

Proteomic databases

MaxQBiO60164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC19F5.05c.1; SPBC19F5.05c.1:pep; SPBC19F5.05c.
GeneIDi2540659.
KEGGispo:SPBC19F5.05c.

Organism-specific databases

EuPathDBiFungiDB:SPBC19F5.05c.
PomBaseiSPBC19F5.05c. ppp1.

Phylogenomic databases

HOGENOMiHOG000006022.
InParanoidiO60164.
KOiK14843.
OMAiMQISNDR.
OrthoDBiEOG7HHX2C.
PhylomeDBiO60164.

Miscellaneous databases

PROiO60164.

Family and domain databases

Gene3Di3.40.50.10190. 1 hit.
HAMAPiMF_03028. Pescadillo.
InterProiIPR001357. BRCT_dom.
IPR010613. PES.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF06732. Pescadillo_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 65-116, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.

Entry informationi

Entry nameiPESC_SCHPO
AccessioniPrimary (citable) accession number: O60164
Secondary accession number(s): Q9US84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.