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Protein

U3 small nucleolar RNA-associated protein 4

Gene

utp4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Transcription

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 4
Short name:
U3 snoRNA-associated protein 4
Alternative name(s):
U3 protein 4 required for transcription
Gene namesi
Name:utp4
ORF Names:SPBC19F5.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19F5.02c.
PomBaseiSPBC19F5.02c. utp4.

Subcellular locationi

GO - Cellular componenti

  • mitotic spindle Source: PomBase
  • nucleus Source: PomBase
  • small-subunit processome Source: PomBase
  • t-UTP complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079211 – 710U3 small nucleolar RNA-associated protein 4Add BLAST710

Proteomic databases

MaxQBiO60161.
PRIDEiO60161.

Interactioni

Subunit structurei

Component of the ribosomal small subunit (SSU) processome.By similarity

Protein-protein interaction databases

BioGridi277042. 13 interactors.
MINTiMINT-4677680.

Structurei

3D structure databases

ProteinModelPortaliO60161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 59WD 1Sequence analysisAdd BLAST49
Repeati64 – 105WD 2Sequence analysisAdd BLAST42
Repeati108 – 147WD 3Sequence analysisAdd BLAST40
Repeati154 – 192WD 4Sequence analysisAdd BLAST39
Repeati199 – 241WD 5Sequence analysisAdd BLAST43
Repeati290 – 327WD 6Sequence analysisAdd BLAST38
Repeati328 – 365WD 7Sequence analysisAdd BLAST38
Repeati488 – 527WD 8Sequence analysisAdd BLAST40
Repeati529 – 569WD 9Sequence analysisAdd BLAST41

Sequence similaritiesi

Contains 9 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000246731.
InParanoidiO60161.
KOiK14548.
OMAiREFTQFA.
OrthoDBiEOG092C0VWT.
PhylomeDBiO60161.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR011044. Quino_amine_DH_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIHRCRFID YTPSAITAMA FSHKSGQNDS MPNNLLLAVG RASGNIEIWN
60 70 80 90 100
PRNDWCLKTV LYGGVDRSIE GIVWSTGEEE LRLFSIGFST TITEWNLHTG
110 120 130 140 150
KPLVNQDSNA GAIWSIAICD ETKTLAVGCD DGSCVLFDIS GGPGVIEFKR
160 170 180 190 200
VLMRQTSRIL SLDFQTKDHL VGGCADGVIK VWDLSTPNSA IISRMQVDRA
210 220 230 240 250
RKGEAALIWA VKSLRDGTIV SADSSGAVKF WNGKFFTLSQ SFKLHLADAL
260 270 280 290 300
CLGVSANGDM VFSSGIDRKT IQYSREGGKR EWVSNSFRRF HSHDVRCMAV
310 320 330 340 350
FECKSLDVLI SGGMDMMLAV IPVRQFNRKN HRMISAVPQR PRMAVAPKAR
360 370 380 390 400
LFMLWNDHEV LLWRIGSPGY RFLLKIVLAD EENISHAAIS PDGELIAISS
410 420 430 440 450
VLRTKLYQLQ YSDENVKVET VEDSFLSNIG ASLLSFTVDK NKLILVSNDS
460 470 480 490 500
EIFLIELSRL DSRQLEVFEL SQPTSKKIAP RQRSNVSSMC DGICSIAVSS
510 520 530 540 550
DGDYFAVADT VGNIFCYSLS NLTYSELPRV NTYVRAMAFR PDVRGRLAVA
560 570 580 590 600
TAGNQVYEFD VQSRKLSEWS KNNSTNMPKE FSQLLDKAFG AFFDSKHPSR
610 620 630 640 650
FWIWSANWVS FFDLNLQLPA PRAAGKRKIE MNATVDGNLN DKKLANANSN
660 670 680 690 700
GISNYGTGDS RCFWITHKYR PMLLVGSVGN SELLVVERPI ADMLMSKSMP
710
ASFYEHKFGS
Length:710
Mass (Da):79,121
Last modified:August 1, 1998 - v1
Checksum:iF7E06170AF75C075
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18650.1.
PIRiT39820.
RefSeqiNP_596540.1. NM_001022461.2.

Genome annotation databases

EnsemblFungiiSPBC19F5.02c.1; SPBC19F5.02c.1:pep; SPBC19F5.02c.
GeneIDi2540514.
KEGGispo:SPBC19F5.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18650.1.
PIRiT39820.
RefSeqiNP_596540.1. NM_001022461.2.

3D structure databases

ProteinModelPortaliO60161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277042. 13 interactors.
MINTiMINT-4677680.

Proteomic databases

MaxQBiO60161.
PRIDEiO60161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC19F5.02c.1; SPBC19F5.02c.1:pep; SPBC19F5.02c.
GeneIDi2540514.
KEGGispo:SPBC19F5.02c.

Organism-specific databases

EuPathDBiFungiDB:SPBC19F5.02c.
PomBaseiSPBC19F5.02c. utp4.

Phylogenomic databases

HOGENOMiHOG000246731.
InParanoidiO60161.
KOiK14548.
OMAiREFTQFA.
OrthoDBiEOG092C0VWT.
PhylomeDBiO60161.

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiO60161.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR011044. Quino_amine_DH_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUTP4_SCHPO
AccessioniPrimary (citable) accession number: O60161
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.