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Protein

Putative anion/proton exchange transporter C19C7.11

Gene

SPBC19C7.11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Anion/proton exchange transporter involved in iron and copper cation homeostasis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei218Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transportBy similarity1
Sitei275Mediates proton transfer from the protein to the inner aqueous phaseBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Putative anion/proton exchange transporter C19C7.11
Gene namesi
ORF Names:SPBC19C7.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19C7.11.
PomBaseiSPBC19C7.11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicBy similarityAdd BLAST78
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 144LumenalBy similarityAdd BLAST45
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 167CytoplasmicBy similarity2
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 196LumenalBy similarity8
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 252CytoplasmicBy similarityAdd BLAST35
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Topological domaini274 – 284LumenalBy similarityAdd BLAST11
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 322CytoplasmicBy similarityAdd BLAST17
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 362LumenalBy similarityAdd BLAST19
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 418CytoplasmicBy similarityAdd BLAST35
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 442LumenalBy similarity3
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 486CytoplasmicBy similarityAdd BLAST23
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Topological domaini508 – 520LumenalBy similarityAdd BLAST13
Transmembranei521 – 543HelicalSequence analysisAdd BLAST23
Topological domaini544 – 766CytoplasmicBy similarityAdd BLAST223

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003103401 – 766Putative anion/proton exchange transporter C19C7.11Add BLAST766

Proteomic databases

MaxQBiO60159.
PRIDEiO60159.

Interactioni

Subunit structurei

Homodimer.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini580 – 641CBS 1PROSITE-ProRule annotationAdd BLAST62
Domaini676 – 734CBS 2PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000164493.
InParanoidiO60159.
KOiK05012.
OMAiETTATHE.
OrthoDBiEOG092C14Y0.

Family and domain databases

Gene3Di1.10.3080.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
SUPFAMiSSF81340. SSF81340. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQKRADSS SSFDQAERRS LDENERKKKY FFNREGSGID NFETDDRVNE
60 70 80 90 100
IINEQNEENV IDQSRWSKLW RIWNVGYSWF ILSIIGTTVG FAAYMLDIVT
110 120 130 140 150
SWLSDIRRGY CTSHWYYNEK FCCWYSETMG SSCTAWKPWT YKFSLNYLIY
160 170 180 190 200
TAFALLFVLC AAIMVRDVAP LAAGSGISEI KCIISGFLRD SFLSFRVMLV
210 220 230 240 250
KCVGLPLAIA SGLSVGKEGP SVHLATTIGH NISKIFKYAR EGSIRYRDIC
260 270 280 290 300
VASAASGVAV AFGSPIGGVL FGIEEMSGGY DPKMIVYSFF CCLSAVGVLH
310 320 330 340 350
MLNPFRTGQV VLFEVRYSGS WHFFELLFFC FLGIFGGLYG EFVMRLFFLI
360 370 380 390 400
QKLRKKYLSR WGVLDAAFVT VITSLVSFLN PWLRLDMTLG MELLFQECKS
410 420 430 440 450
SSSPELINLC DPSLRTKNTI LLLIATFART IFVTFSYGAK VPAGIFVPSM
460 470 480 490 500
AVGASFGYMI GLIAEMIYQR FPNSVLFLAC HGSESCITPG TYALLGAAAS
510 520 530 540 550
LSGIMHLTVT IVVIMFELTG ALNFILPTVL VVALANSIGN MLGKTGIADR
560 570 580 590 600
SIEINGLPLL EPEKSINSSN TINIPITEVM ASNLITIPSI GFTWRKLLGM
610 620 630 640 650
MEGYDFSGYP VVLDSRSNYL IGYLKKSSLK SSFEAAKLEP SFTFDQQLCF
660 670 680 690 700
GKVDSVGDSK SSKFGESDRI DLSAYMDVNP ISVLHTQSIA NVAVLFEVLS
710 720 730 740 750
PSVIFIEKDG NLVGLISKKD LLLASKYYQE DNDLVNPANR HRAVSTERIN
760
DSYENIELKP LKLNIE
Length:766
Mass (Da):85,162
Last modified:October 3, 2012 - v2
Checksum:i43733DCF104C0AF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19579.2.
PIRiT39817.
RefSeqiNP_596167.2. NM_001022087.2.

Genome annotation databases

EnsemblFungiiSPBC19C7.11.1; SPBC19C7.11.1:pep; SPBC19C7.11.
GeneIDi2540750.
KEGGispo:SPBC19C7.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19579.2.
PIRiT39817.
RefSeqiNP_596167.2. NM_001022087.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiO60159.
PRIDEiO60159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC19C7.11.1; SPBC19C7.11.1:pep; SPBC19C7.11.
GeneIDi2540750.
KEGGispo:SPBC19C7.11.

Organism-specific databases

EuPathDBiFungiDB:SPBC19C7.11.
PomBaseiSPBC19C7.11.

Phylogenomic databases

HOGENOMiHOG000164493.
InParanoidiO60159.
KOiK05012.
OMAiETTATHE.
OrthoDBiEOG092C14Y0.

Miscellaneous databases

PROiO60159.

Family and domain databases

Gene3Di1.10.3080.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
SUPFAMiSSF81340. SSF81340. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYHYB_SCHPO
AccessioniPrimary (citable) accession number: O60159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.