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Protein

Putative proline--tRNA ligase C19C7.06

Gene

prs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative proline--tRNA ligase C19C7.06 (EC:6.1.1.15)
Alternative name(s):
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Name:prs1
ORF Names:SPBC19C7.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19C7.06.
PomBaseiSPBC19C7.06. prs1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Putative proline--tRNA ligase C19C7.06PRO_0000317133Add
BLAST

Proteomic databases

MaxQBiO60155.

Interactioni

Protein-protein interaction databases

BioGridi276959. 1 interaction.
MINTiMINT-4677639.

Structurei

3D structure databases

ProteinModelPortaliO60155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000167538.
InParanoidiO60155.
KOiK01881.
OMAiWCEDIAT.
OrthoDBiEOG7MWH5Z.
PhylomeDBiO60155.

Family and domain databases

Gene3Di3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
3.90.960.10. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
IPR007214. YbaK/aa-tRNA-synth-assoc-dom.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF04073. tRNA_edit. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SMARTiSM00946. ProRS-C_1. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55826. SSF55826. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDSLVSCL EQLITDDLKL VEHQEVSNGA TWASALQSTK DVPSHALTKT
60 70 80 90 100
IVLKPKTAKS QTVVPIILAA LETTSTPSGI AAKAVGSKEA RMAAADLVEE
110 120 130 140 150
VFGIPPTDVG IFSVNKENAS KVHVVLDAAL IQHNGLLAFH PSSSAKTVFV
160 170 180 190 200
SPAAVQTYLK SVGVNPIIVD FSAPGSATAP SKPAAQKKKA EPSKNDAAIE
210 220 230 240 250
NAALIGITVR KDADFPNWYQ QVLTKSDMIE YYDISGCYIL KPWSYSIWEA
260 270 280 290 300
IQGWFDKEIK KLGVRNGYFP LFVSSKVLEK EKDHVEGFAP EVAWVTRAGT
310 320 330 340 350
SELDEPIAIR PTSETVMYPY YAKWIRSHRD LPLKLNQWNS VVRWEFKNPQ
360 370 380 390 400
PFLRTREFLW QEGHTAHMTL EGATEEVHQI LDLYARIYTD LLAVPVIKGV
410 420 430 440 450
KSENEKFAGG MFTTTVEGYI PTTGRGIQGA TSHCLGQNFS KMFNIVVEDP
460 470 480 490 500
NAEIGPTGER PKLFVWQNSW GLSTRTIGVA VMVHGDDKGL KLPPAIALVQ
510 520 530 540 550
SVVVPCGITN KTTDQERNEI EGFCSKLADR LNAADIRTEA DLRAYTPGYK
560 570 580 590 600
FSHWEMKGVP LRLEYGPNDA KKNQVTAVRR DTFEKIPVPL NNLEKGVSDL
610 620 630 640 650
LAKIQTNMYE TAKAERDAHV VKVKEWADFV PALNKKNIVM IPWCNTTECE
660 670 680 690 700
KEIKKNSARQ VNGDEPEDEK APSMGAKSLC IPLEQPSGED AIIEGTTKCA
710
GCGNLAKVWG LFGRSY
Length:716
Mass (Da):78,875
Last modified:August 1, 1998 - v1
Checksum:i8C7BDEA8FFE782A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19574.1.
PIRiT39812.
RefSeqiNP_596162.1. NM_001022082.2.

Genome annotation databases

EnsemblFungiiSPBC19C7.06.1; SPBC19C7.06.1:pep; SPBC19C7.06.
GeneIDi2540431.
KEGGispo:SPBC19C7.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19574.1.
PIRiT39812.
RefSeqiNP_596162.1. NM_001022082.2.

3D structure databases

ProteinModelPortaliO60155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276959. 1 interaction.
MINTiMINT-4677639.

Proteomic databases

MaxQBiO60155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC19C7.06.1; SPBC19C7.06.1:pep; SPBC19C7.06.
GeneIDi2540431.
KEGGispo:SPBC19C7.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC19C7.06.
PomBaseiSPBC19C7.06. prs1.

Phylogenomic databases

HOGENOMiHOG000167538.
InParanoidiO60155.
KOiK01881.
OMAiWCEDIAT.
OrthoDBiEOG7MWH5Z.
PhylomeDBiO60155.

Miscellaneous databases

PROiO60155.

Family and domain databases

Gene3Di3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
3.90.960.10. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
IPR007214. YbaK/aa-tRNA-synth-assoc-dom.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF04073. tRNA_edit. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SMARTiSM00946. ProRS-C_1. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55826. SSF55826. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPRS1_SCHPO
AccessioniPrimary (citable) accession number: O60155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.