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Protein

Putative proline--tRNA ligase C19C7.06

Gene

prs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative proline--tRNA ligase C19C7.06 (EC:6.1.1.15)
Alternative name(s):
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Name:prs1
ORF Names:SPBC19C7.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19C7.06
PomBaseiSPBC19C7.06 prs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003171331 – 716Putative proline--tRNA ligase C19C7.06Add BLAST716

Proteomic databases

MaxQBiO60155
PaxDbiO60155
PRIDEiO60155

PTM databases

iPTMnetiO60155

Interactioni

Protein-protein interaction databases

BioGridi276959, 1 interactor
STRINGi4896.SPBC19C7.06.1

Structurei

3D structure databases

ProteinModelPortaliO60155
SMRiO60155
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000167538
InParanoidiO60155
KOiK01881
OMAiEVYWVTH
OrthoDBiEOG092C1VT8
PhylomeDBiO60155

Family and domain databases

CDDicd00778 ProRS_core_arch_euk, 1 hit
Gene3Di3.30.110.30, 1 hit
3.40.50.800, 1 hit
3.90.960.10, 1 hit
HAMAPiMF_01571 Pro_tRNA_synth_type3, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004499 Pro-tRNA-ligase_IIa_arc-type
IPR016061 Pro-tRNA_ligase_II_C
IPR017449 Pro-tRNA_synth_II
IPR033721 ProRS_core_arch_euk
IPR036754 YbaK/aa-tRNA-synt-asso_dom_sf
IPR007214 YbaK/aa-tRNA-synth-assoc-dom
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF09180 ProRS-C_1, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PF04073 tRNA_edit, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
SMARTiView protein in SMART
SM00946 ProRS-C_1, 1 hit
SUPFAMiSSF55826 SSF55826, 1 hit
SSF64586 SSF64586, 1 hit
TIGRFAMsiTIGR00408 proS_fam_I, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

O60155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDSLVSCL EQLITDDLKL VEHQEVSNGA TWASALQSTK DVPSHALTKT
60 70 80 90 100
IVLKPKTAKS QTVVPIILAA LETTSTPSGI AAKAVGSKEA RMAAADLVEE
110 120 130 140 150
VFGIPPTDVG IFSVNKENAS KVHVVLDAAL IQHNGLLAFH PSSSAKTVFV
160 170 180 190 200
SPAAVQTYLK SVGVNPIIVD FSAPGSATAP SKPAAQKKKA EPSKNDAAIE
210 220 230 240 250
NAALIGITVR KDADFPNWYQ QVLTKSDMIE YYDISGCYIL KPWSYSIWEA
260 270 280 290 300
IQGWFDKEIK KLGVRNGYFP LFVSSKVLEK EKDHVEGFAP EVAWVTRAGT
310 320 330 340 350
SELDEPIAIR PTSETVMYPY YAKWIRSHRD LPLKLNQWNS VVRWEFKNPQ
360 370 380 390 400
PFLRTREFLW QEGHTAHMTL EGATEEVHQI LDLYARIYTD LLAVPVIKGV
410 420 430 440 450
KSENEKFAGG MFTTTVEGYI PTTGRGIQGA TSHCLGQNFS KMFNIVVEDP
460 470 480 490 500
NAEIGPTGER PKLFVWQNSW GLSTRTIGVA VMVHGDDKGL KLPPAIALVQ
510 520 530 540 550
SVVVPCGITN KTTDQERNEI EGFCSKLADR LNAADIRTEA DLRAYTPGYK
560 570 580 590 600
FSHWEMKGVP LRLEYGPNDA KKNQVTAVRR DTFEKIPVPL NNLEKGVSDL
610 620 630 640 650
LAKIQTNMYE TAKAERDAHV VKVKEWADFV PALNKKNIVM IPWCNTTECE
660 670 680 690 700
KEIKKNSARQ VNGDEPEDEK APSMGAKSLC IPLEQPSGED AIIEGTTKCA
710
GCGNLAKVWG LFGRSY
Length:716
Mass (Da):78,875
Last modified:August 1, 1998 - v1
Checksum:i8C7BDEA8FFE782A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA19574.1
PIRiT39812
RefSeqiNP_596162.1, NM_001022082.2

Genome annotation databases

EnsemblFungiiSPBC19C7.06.1; SPBC19C7.06.1:pep; SPBC19C7.06
GeneIDi2540431
KEGGispo:SPBC19C7.06

Entry informationi

Entry nameiPRS1_SCHPO
AccessioniPrimary (citable) accession number: O60155
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health