Tip elongation aberrant protein Tea4 - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

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O60132 (TEA4_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 69. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tip elongation aberrant protein Tea4

Alternative name(s):
Cell polarity protein tea4
Win1-interacting SH3 domain protein

Gene names

Name:	tea4
Synonyms:	wsh3
ORF Names:	SPBC1706.01

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	809 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for the establishment of cell polarity and localized actin assembly at new cell ends. Ref.2 Ref.3
Subunit structure	An essential component of the tea1 cell-end complex. Interacts with win1, tea1 and for3. Interacts with tip1 in the presence of tea1. Ref.2 Ref.3
Subcellular location	Cytoplasm › cytoskeleton. Note: Through it's binding with tea1, is transported by the cytoplasmic microtubule system and is localized at cell tips, microtubule plus ends and cytoplasmic dots. Ref.2 Ref.3
Sequence similarities	Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Domain	SH3 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of bipolar cell growth Inferred from mutant phenotype. Source: GeneDB_Spombe cellular protein localization Inferred from genetic interaction. Source: GeneDB_Spombe establishment or maintenance of actin cytoskeleton polarity Inferred from mutant phenotype. Source: GeneDB_Spombe microtubule-based process Inferred by curator. Source: GeneDB_Spombe regulation of filamentous growth Inferred from mutant phenotype. Source: GeneDB_Spombe
Cellular component	Tea1 cell-end complex Inferred from direct assay. Source: GeneDB_Spombe cell cortex of cell tip Inferred from direct assay. Source: GeneDB_Spombe cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	protein binding Inferred from physical interaction Ref.3 Ref.2. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
dis2	P13681	2	EBI-1099982,EBI-4320127
for3	O94532	5	EBI-1099982,EBI-1102572
pom1	Q09690	5	EBI-1099982,EBI-4319163
tea1	P87061	9	EBI-1099982,EBI-875376
win1	O74304	2	EBI-1099982,EBI-1099995

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 809

809

Tip elongation aberrant protein Tea4

PRO_0000259412

Regions

Domain

118 – 179

SH3

Region

515 – 809

295

Interaction with tea1 Ref.3

Region

587 – 809

223

Interaction with win1 Ref.2

Compositional bias

96 – 99

Poly-Glu

Compositional bias

260 – 692

433

Ser-rich

Amino acid modifications

Modified residue

Phosphotyrosine Ref.4

Modified residue

Phosphoserine Ref.4

Modified residue

Phosphotyrosine Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

O60132 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 2D1386C6BE0A046B
Show »

FASTA

809

89,562

        10         20         30         40         50         60 
MEIMESHFDP TQQNDSTIIE SRYSPEEYLE QSFEIQRIIS GENSEPQTVA SQEISDSQEE 

        70         80         90        100        110        120 
DTTLTSSQFE DCGTEYNEVV EDDEFRSEDE DDFMDEEEEY ALYEAELSSS PSIHEEVIDC 

       130        140        150        160        170        180 
NFVHAIRGFE ATVEGQVDAT KGDMMILLDD SNSYWWLVKM CKNLAIGYLP AEYIETPSER 

       190        200        210        220        230        240 
LARLNKYKNS ETSNSQQSVT LPPLDIVEKT LEAPSPNFRI KRVTFTCSSN SSDDEMDSEN 

       250        260        270        280        290        300 
DYEAMVNRTV AENGLEIEFS DSSDSSLSAE YRSESEDHVT DSPAYVDLTE LEGGFNQFNS 

       310        320        330        340        350        360 
TSFQSTSPLG LEIVETEING SSTTADSKNS HSPYSKFSSA YPDAENSNIS KINISIAGNK 

       370        380        390        400        410        420 
ELYGNATQSD PSLYSTWIAN KHKTASSATV DSPLRRSLSV DAMQSNASFS SYSSTSNTDK 

       430        440        450        460        470        480 
SLRPSSYSAV SESSNFTHDV SRDNKEISLN APKSIIVSQS DSFDTSNVTQ DAPNDVEKEP 

       490        500        510        520        530        540 
ISGQMPNNLS VQSLKQLEVY PIRHSVSIEM PSEKLLSPRL YSSSTPSSPT KGFQKDDEED 

       550        560        570        580        590        600 
SENRKQADKV ELSPSSLLRQ MSLPVDSSSQ SDAQCTTSSV YITAERKAFS QSSIDLSTLS 

       610        620        630        640        650        660 
NHHVNNEINR RSFAGGFTSL ADELSEMREL LHESPAPLEC NEEMVIPTPE LDASSAIPSS 

       670        680        690        700        710        720 
SISHDEDLLP RKNTEESTSS SSFSSLITSP ASLQYDENPF KQSVVAELNN NSSSVPFVDS 

       730        740        750        760        770        780 
AHASDIHAYD NDHVSTKNKE FNRRLREFIL DPDSLSGLYW SVKSAGVRAS RRVSRNIEGE 

       790        800 
SVSSDLDDIF ANVLKGLSDE MASLLNTNR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe." Tatebe H., Shimada K., Uzawa S., Morigasaki S., Shiozaki K. Curr. Biol. 15:1006-1015(2005) [PubMed: 15936270] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TEA1 AND WIN1.
[3]	"Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity." Martin S.G., McDonald W.H., Yates J.R. III, Chang F. Dev. Cell 8:479-491(2005) [PubMed: 15809031] [Abstract] Cited for: FUNCTION, INTERACTION WITH FOR3; TEA1 AND TIP1, SUBCELLULAR LOCATION.
[4]	"Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-23; SER-24 AND TYR-28, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAA19002.1.
PIR	T39626.
RefSeq	NP_595240.1. NM_001021146.1.
3D structure databases
HSSP	HSSP built from PDB template 1N5Z based on UniProtKB P80667.
ProteinModelPortal	O60132.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60132. 7 interactions.
STRING	O60132.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2539642.
GenomeReviews	Gene locus tea4 in contig CU329671_GR.
KEGG	spo:SPBC1706.01.
NMPDR	fig\|4896.1.peg.1106.
Organism-specific databases
GeneDB_Spombe	SPBC1706.01.
Phylogenomic databases
eggNOG	fuNOG06503.
GeneTree	EFGT00050000002830.
OrthoDB	EOG4Q885P.
Gene expression databases
ArrayExpress	O60132.
Family and domain databases
InterPro	IPR001452. SH3_domain. [Graphical view]
Pfam	PF00018. SH3_1. 1 hit. [Graphical view]
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TEA4_SCHPO

Accession

Primary (citable) accession number: O60132

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	August 1, 1998
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents