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O60132

- TEA4_SCHPO

UniProt

O60132 - TEA4_SCHPO

Protein

Tip elongation aberrant protein Tea4

Gene

tea4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for the establishment of cell polarity and localized actin assembly at new cell ends.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein binding, bridging Source: PomBase

    GO - Biological processi

    1. activation of bipolar cell growth Source: PomBase
    2. cellular protein localization Source: PomBase
    3. establishment or maintenance of actin cytoskeleton polarity Source: PomBase
    4. establishment or maintenance of cell polarity regulating cell shape Source: PomBase
    5. microtubule-based process Source: PomBase
    6. regulation of filamentous growth Source: PomBase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tip elongation aberrant protein Tea4
    Alternative name(s):
    Cell polarity protein tea4
    Win1-interacting SH3 domain protein
    Gene namesi
    Name:tea4Imported
    Synonyms:wsh31 Publication
    ORF Names:SPBC1706.01
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1706.01.

    Subcellular locationi

    Cytoplasmcytoskeleton 2 Publications
    Note: Through it's binding with tea1, is transported by the cytoplasmic microtubule system and is localized at cell tips, microtubule plus ends and cytoplasmic dots.

    GO - Cellular componenti

    1. cell cortex of cell tip Source: PomBase
    2. cell tip Source: PomBase
    3. cytosol Source: PomBase
    4. microtubule cytoskeleton Source: PomBase
    5. non-growing cell tip Source: PomBase
    6. nucleus Source: PomBase
    7. Tea1 cell-end complex Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 821821Tip elongation aberrant protein Tea4PRO_0000259412Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351Phosphotyrosine1 Publication
    Modified residuei36 – 361Phosphoserine1 Publication
    Modified residuei40 – 401Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO60132.

    Interactioni

    Subunit structurei

    An essential component of the tea1 cell-end complex. Interacts with win1, tea1 and for3. Interacts with tip1 in the presence of tea1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    dis2P136812EBI-1099982,EBI-4320127
    for3O945325EBI-1099982,EBI-1102572
    pom1Q096905EBI-1099982,EBI-4319163
    tea1P870619EBI-1099982,EBI-875376
    win1O743042EBI-1099982,EBI-1099995

    Protein-protein interaction databases

    BioGridi276197. 35 interactions.
    IntActiO60132. 7 interactions.
    MINTiMINT-4677492.
    STRINGi4896.SPBC1706.01-1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini130 – 19162SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni527 – 821295Interaction with tea1Add
    BLAST
    Regioni599 – 821223Interaction with win1Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi108 – 1114Poly-Glu
    Compositional biasi272 – 704433Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG291368.
    OrthoDBiEOG7MSMZD.

    Family and domain databases

    InterProiIPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60132-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHMNSASSA DSMEIMESHF DPTQQNDSTI IESRYSPEEY LEQSFEIQRI    50
    ISGENSEPQT VASQEISDSQ EEDTTLTSSQ FEDCGTEYNE VVEDDEFRSE 100
    DEDDFMDEEE EYALYEAELS SSPSIHEEVI DCNFVHAIRG FEATVEGQVD 150
    ATKGDMMILL DDSNSYWWLV KMCKNLAIGY LPAEYIETPS ERLARLNKYK 200
    NSETSNSQQS VTLPPLDIVE KTLEAPSPNF RIKRVTFTCS SNSSDDEMDS 250
    ENDYEAMVNR TVAENGLEIE FSDSSDSSLS AEYRSESEDH VTDSPAYVDL 300
    TELEGGFNQF NSTSFQSTSP LGLEIVETEI NGSSTTADSK NSHSPYSKFS 350
    SAYPDAENSN ISKINISIAG NKELYGNATQ SDPSLYSTWI ANKHKTASSA 400
    TVDSPLRRSL SVDAMQSNAS FSSYSSTSNT DKSLRPSSYS AVSESSNFTH 450
    DVSRDNKEIS LNAPKSIIVS QSDSFDTSNV TQDAPNDVEK EPISGQMPNN 500
    LSVQSLKQLE VYPIRHSVSI EMPSEKLLSP RLYSSSTPSS PTKGFQKDDE 550
    EDSENRKQAD KVELSPSSLL RQMSLPVDSS SQSDAQCTTS SVYITAERKA 600
    FSQSSIDLST LSNHHVNNEI NRRSFAGGFT SLADELSEMR ELLHESPAPL 650
    ECNEEMVIPT PELDASSAIP SSSISHDEDL LPRKNTEEST SSSSFSSLIT 700
    SPASLQYDEN PFKQSVVAEL NNNSSSVPFV DSAHASDIHA YDNDHVSTKN 750
    KEFNRRLREF ILDPDSLSGL YWSVKSAGVR ASRRVSRNIE GESVSSDLDD 800
    IFANVLKGLS DEMASLLNTN R 821
    Length:821
    Mass (Da):90,794
    Last modified:October 3, 2012 - v2
    Checksum:iB1DC53794E56D73E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA19002.2.
    PIRiT39626.
    RefSeqiNP_595240.2. NM_001021146.2.

    Genome annotation databases

    EnsemblFungiiSPBC1706.01.1; SPBC1706.01.1:pep; SPBC1706.01.
    GeneIDi2539642.
    KEGGispo:SPBC1706.01.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA19002.2 .
    PIRi T39626.
    RefSeqi NP_595240.2. NM_001021146.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276197. 35 interactions.
    IntActi O60132. 7 interactions.
    MINTi MINT-4677492.
    STRINGi 4896.SPBC1706.01-1.

    Proteomic databases

    MaxQBi O60132.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1706.01.1 ; SPBC1706.01.1:pep ; SPBC1706.01 .
    GeneIDi 2539642.
    KEGGi spo:SPBC1706.01.

    Organism-specific databases

    PomBasei SPBC1706.01.

    Phylogenomic databases

    eggNOGi NOG291368.
    OrthoDBi EOG7MSMZD.

    Miscellaneous databases

    NextBioi 20800796.

    Family and domain databases

    InterProi IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Comparative functional genomics of the fission yeasts."
      Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
      , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
      Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL.
    3. "Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe."
      Tatebe H., Shimada K., Uzawa S., Morigasaki S., Shiozaki K.
      Curr. Biol. 15:1006-1015(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TEA1 AND WIN1.
    4. "Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity."
      Martin S.G., McDonald W.H., Yates J.R. III, Chang F.
      Dev. Cell 8:479-491(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FOR3; TEA1 AND TIP1, SUBCELLULAR LOCATION.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-35; SER-36 AND TYR-40, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiTEA4_SCHPO
    AccessioniPrimary (citable) accession number: O60132
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3