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O60132

- TEA4_SCHPO

UniProt

O60132 - TEA4_SCHPO

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Protein
Tip elongation aberrant protein Tea4
Gene
tea4, wsh3, SPBC1706.01
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for the establishment of cell polarity and localized actin assembly at new cell ends.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. protein binding, bridging Source: PomBase
Complete GO annotation...

GO - Biological processi

  1. activation of bipolar cell growth Source: PomBase
  2. cellular protein localization Source: PomBase
  3. establishment or maintenance of actin cytoskeleton polarity Source: PomBase
  4. establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  5. microtubule-based process Source: PomBase
  6. regulation of filamentous growth Source: PomBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tip elongation aberrant protein Tea4
Alternative name(s):
Cell polarity protein tea4
Win1-interacting SH3 domain protein
Gene namesi
Name:tea4
Synonyms:wsh3
ORF Names:SPBC1706.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC1706.01.

Subcellular locationi

Cytoplasmcytoskeleton
Note: Through it's binding with tea1, is transported by the cytoplasmic microtubule system and is localized at cell tips, microtubule plus ends and cytoplasmic dots.2 Publications

GO - Cellular componenti

  1. Tea1 cell-end complex Source: PomBase
  2. cell cortex of cell tip Source: PomBase
  3. cell tip Source: PomBase
  4. cytosol Source: PomBase
  5. microtubule cytoskeleton Source: PomBase
  6. non-growing cell tip Source: PomBase
  7. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Tip elongation aberrant protein Tea4
PRO_0000259412Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351Phosphotyrosine1 Publication
Modified residuei36 – 361Phosphoserine1 Publication
Modified residuei40 – 401Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60132.

Interactioni

Subunit structurei

An essential component of the tea1 cell-end complex. Interacts with win1, tea1 and for3. Interacts with tip1 in the presence of tea1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
dis2P136812EBI-1099982,EBI-4320127
for3O945325EBI-1099982,EBI-1102572
pom1Q096905EBI-1099982,EBI-4319163
tea1P870619EBI-1099982,EBI-875376
win1O743042EBI-1099982,EBI-1099995

Protein-protein interaction databases

BioGridi276197. 35 interactions.
IntActiO60132. 7 interactions.
MINTiMINT-4677492.
STRINGi4896.SPBC1706.01-1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 19162SH3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni527 – 821295Interaction with tea1
Add
BLAST
Regioni599 – 821223Interaction with win1
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi108 – 1114Poly-Glu
Compositional biasi272 – 704433Ser-rich
Add
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG291368.
OrthoDBiEOG7MSMZD.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60132-1 [UniParc]FASTAAdd to Basket

« Hide

MLHMNSASSA DSMEIMESHF DPTQQNDSTI IESRYSPEEY LEQSFEIQRI    50
ISGENSEPQT VASQEISDSQ EEDTTLTSSQ FEDCGTEYNE VVEDDEFRSE 100
DEDDFMDEEE EYALYEAELS SSPSIHEEVI DCNFVHAIRG FEATVEGQVD 150
ATKGDMMILL DDSNSYWWLV KMCKNLAIGY LPAEYIETPS ERLARLNKYK 200
NSETSNSQQS VTLPPLDIVE KTLEAPSPNF RIKRVTFTCS SNSSDDEMDS 250
ENDYEAMVNR TVAENGLEIE FSDSSDSSLS AEYRSESEDH VTDSPAYVDL 300
TELEGGFNQF NSTSFQSTSP LGLEIVETEI NGSSTTADSK NSHSPYSKFS 350
SAYPDAENSN ISKINISIAG NKELYGNATQ SDPSLYSTWI ANKHKTASSA 400
TVDSPLRRSL SVDAMQSNAS FSSYSSTSNT DKSLRPSSYS AVSESSNFTH 450
DVSRDNKEIS LNAPKSIIVS QSDSFDTSNV TQDAPNDVEK EPISGQMPNN 500
LSVQSLKQLE VYPIRHSVSI EMPSEKLLSP RLYSSSTPSS PTKGFQKDDE 550
EDSENRKQAD KVELSPSSLL RQMSLPVDSS SQSDAQCTTS SVYITAERKA 600
FSQSSIDLST LSNHHVNNEI NRRSFAGGFT SLADELSEMR ELLHESPAPL 650
ECNEEMVIPT PELDASSAIP SSSISHDEDL LPRKNTEEST SSSSFSSLIT 700
SPASLQYDEN PFKQSVVAEL NNNSSSVPFV DSAHASDIHA YDNDHVSTKN 750
KEFNRRLREF ILDPDSLSGL YWSVKSAGVR ASRRVSRNIE GESVSSDLDD 800
IFANVLKGLS DEMASLLNTN R 821
Length:821
Mass (Da):90,794
Last modified:October 3, 2012 - v2
Checksum:iB1DC53794E56D73E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA19002.2.
PIRiT39626.
RefSeqiNP_595240.2. NM_001021146.2.

Genome annotation databases

EnsemblFungiiSPBC1706.01.1; SPBC1706.01.1:pep; SPBC1706.01.
GeneIDi2539642.
KEGGispo:SPBC1706.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA19002.2 .
PIRi T39626.
RefSeqi NP_595240.2. NM_001021146.2.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

BioGridi 276197. 35 interactions.
IntActi O60132. 7 interactions.
MINTi MINT-4677492.
STRINGi 4896.SPBC1706.01-1.

Proteomic databases

MaxQBi O60132.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC1706.01.1 ; SPBC1706.01.1:pep ; SPBC1706.01 .
GeneIDi 2539642.
KEGGi spo:SPBC1706.01.

Organism-specific databases

PomBasei SPBC1706.01.

Phylogenomic databases

eggNOGi NOG291368.
OrthoDBi EOG7MSMZD.

Miscellaneous databases

NextBioi 20800796.

Family and domain databases

InterProi IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe."
    Tatebe H., Shimada K., Uzawa S., Morigasaki S., Shiozaki K.
    Curr. Biol. 15:1006-1015(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TEA1 AND WIN1.
  4. "Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity."
    Martin S.G., McDonald W.H., Yates J.R. III, Chang F.
    Dev. Cell 8:479-491(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FOR3; TEA1 AND TIP1, SUBCELLULAR LOCATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-35; SER-36 AND TYR-40, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiTEA4_SCHPO
AccessioniPrimary (citable) accession number: O60132
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 3, 2012
Last modified: June 11, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi