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Protein

Fork head protein homolog 2

Gene

fkh2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for promoter sequence element PCB-driven, M-phase-specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Binds, cooperatively with mcm1, the CLB cluster regulatory elements throughout the cell cycle. Regulates the periodic transcription of cdc15 and spo12. Required for the correct timing, positioning and contraction of the division septum.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi223 – 31896Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • barrier septum assembly Source: UniProtKB-KW
  • mitotic nuclear division Source: UniProtKB-KW
  • positive regulation of induction of conjugation with cellular fusion Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  • regulation of transcription, DNA-templated Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Septation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fork head protein homolog 2
Gene namesi
Name:fkh2
ORF Names:SPBC16G5.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16G5.15c.
PomBaseiSPBC16G5.15c. fkh2.

Subcellular locationi

GO - Cellular componenti

  • M/G1 phase-specific MADS box-forkhead transcription factor complex Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Fork head protein homolog 2PRO_0000091905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191Phosphoserine1 Publication
Modified residuei321 – 3211Phosphoserine1 Publication
Modified residuei322 – 3221Phosphoserine1 Publication
Modified residuei334 – 3341Phosphoserine1 Publication
Modified residuei336 – 3361Phosphoserine1 Publication
Modified residuei375 – 3751Phosphoserine1 Publication
Modified residuei535 – 5351Phosphoserine1 Publication
Modified residuei626 – 6261Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated. Occurs periodically during mitosis.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60129.

PTM databases

iPTMnetiO60129.

Interactioni

Protein-protein interaction databases

BioGridi276256. 15 interactions.
MINTiMINT-4677459.

Structurei

3D structure databases

ProteinModelPortaliO60129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 16065FHAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation
Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO60129.
OrthoDBiEOG092C0D3W.
PhylomeDBiO60129.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR001766. Fork_head_dom.
IPR008984. SMAD_FHA_domain.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRRLESKS EHISDDEERK EQLDYKKQMD VDTDRNIVLN GRLESQIAKL
60 70 80 90 100
SVPPHEMRVV DDYSNSKNAE RHSGEIQAYA KFAGSTWTYY VKKIRIILGR
110 120 130 140 150
EPANPSPKGK NEDLEVIDMN FGPSKVVSRK HAVVEYDLDD QTWNCSVYGR
160 170 180 190 200
NGIKVDGKLF KNGETVKLTS GSILEVAGLQ MMFVLPNAAE QKQTDESTIK
210 220 230 240 250
EDAIKSEISA AVNDAAEYGD NKKPPYSYSV MIAQAILSSS ECMMTLSNIY
260 270 280 290 300
SWISTHYPYY RTTKSGWQNS IRHNLSLNKA FRKVPRKSGE QGKGMKWSIV
310 320 330 340 350
PEFREEFIAK TRKTPRKRSP SSPVPLLAKK REGSPSLPIP ILPKMKDTSI
360 370 380 390 400
PAAEPASSTT SARDQTPSTP KDVGSPSTAE TSAEEKQMET YKTPTHAALS
410 420 430 440 450
DIISTHDYAL DANSASQTKK AAFGSPIGSS TYPTSSPAPF WKYVAVPNPH
460 470 480 490 500
DWPQVGSYDT ISPYRNPVNS HLIYSQIQQS SPKKIDEQLH DLQGVDLVNG
510 520 530 540 550
FEGISSWRES MVNKLRSSVS DSPTMNLANS NSKSSPVAVQ RVSTLPQASA
560 570 580 590 600
NKQAKEMESK MSNSPTQKSK TEENNQAVRA ILDASATMEK QYDLHRLPTP
610 620 630 640
TSQTESASVP QIANPPNSQN LVKEKSPQQY IQVPQSNVKS SA
Length:642
Mass (Da):71,174
Last modified:August 1, 1998 - v1
Checksum:iDBEC705EF3C595B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19034.1.
PIRiT39607.
RefSeqiNP_596764.1. NM_001023784.2.

Genome annotation databases

EnsemblFungiiSPBC16G5.15c.1; SPBC16G5.15c.1:pep; SPBC16G5.15c.
GeneIDi2539703.
KEGGispo:SPBC16G5.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19034.1.
PIRiT39607.
RefSeqiNP_596764.1. NM_001023784.2.

3D structure databases

ProteinModelPortaliO60129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276256. 15 interactions.
MINTiMINT-4677459.

PTM databases

iPTMnetiO60129.

Proteomic databases

MaxQBiO60129.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC16G5.15c.1; SPBC16G5.15c.1:pep; SPBC16G5.15c.
GeneIDi2539703.
KEGGispo:SPBC16G5.15c.

Organism-specific databases

EuPathDBiFungiDB:SPBC16G5.15c.
PomBaseiSPBC16G5.15c. fkh2.

Phylogenomic databases

InParanoidiO60129.
OrthoDBiEOG092C0D3W.
PhylomeDBiO60129.

Miscellaneous databases

PROiO60129.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR001766. Fork_head_dom.
IPR008984. SMAD_FHA_domain.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKH2_SCHPO
AccessioniPrimary (citable) accession number: O60129
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.