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Protein

Fork head protein homolog 2

Gene

fkh2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for promoter sequence element PCB-driven, M-phase-specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Binds, cooperatively with mcm1, the CLB cluster regulatory elements throughout the cell cycle. Regulates the periodic transcription of cdc15 and spo12. Required for the correct timing, positioning and contraction of the division septum.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi223 – 318Fork-headPROSITE-ProRule annotationAdd BLAST96

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • cell differentiation Source: GO_Central
  • chromatin remodeling Source: PomBase
  • division septum assembly Source: UniProtKB-KW
  • positive regulation of induction of conjugation with cellular fusion Source: PomBase
  • positive regulation of transcription by RNA polymerase II Source: PomBase
  • regulation of meiotic cell cycle Source: PomBase
  • regulation of transcription by RNA polymerase II Source: PomBase

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCell cycle, Cell division, Mitosis, Septation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Fork head protein homolog 2
Gene namesi
Name:fkh2
ORF Names:SPBC16G5.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16G5.15c
PomBaseiSPBC16G5.15c fkh2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000919051 – 642Fork head protein homolog 2Add BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319Phosphoserine1 Publication1
Modified residuei321Phosphoserine1 Publication1
Modified residuei322Phosphoserine1 Publication1
Modified residuei334Phosphoserine1 Publication1
Modified residuei336Phosphoserine1 Publication1
Modified residuei375Phosphoserine1 Publication1
Modified residuei535Phosphoserine1 Publication1
Modified residuei626Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated. Occurs periodically during mitosis.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60129
PaxDbiO60129
PRIDEiO60129

PTM databases

iPTMnetiO60129

Interactioni

Protein-protein interaction databases

BioGridi276256, 15 interactors
STRINGi4896.SPBC16G5.15c.1

Structurei

3D structure databases

ProteinModelPortaliO60129
SMRiO60129
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 160FHAPROSITE-ProRule annotationAdd BLAST65

Phylogenomic databases

InParanoidiO60129
OrthoDBiEOG092C0D3W
PhylomeDBiO60129

Family and domain databases

CDDicd00059 FH, 1 hit
cd00060 FHA, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR001766 Fork_head_dom
IPR008984 SMAD_FHA_dom_sf
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

O60129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRRLESKS EHISDDEERK EQLDYKKQMD VDTDRNIVLN GRLESQIAKL
60 70 80 90 100
SVPPHEMRVV DDYSNSKNAE RHSGEIQAYA KFAGSTWTYY VKKIRIILGR
110 120 130 140 150
EPANPSPKGK NEDLEVIDMN FGPSKVVSRK HAVVEYDLDD QTWNCSVYGR
160 170 180 190 200
NGIKVDGKLF KNGETVKLTS GSILEVAGLQ MMFVLPNAAE QKQTDESTIK
210 220 230 240 250
EDAIKSEISA AVNDAAEYGD NKKPPYSYSV MIAQAILSSS ECMMTLSNIY
260 270 280 290 300
SWISTHYPYY RTTKSGWQNS IRHNLSLNKA FRKVPRKSGE QGKGMKWSIV
310 320 330 340 350
PEFREEFIAK TRKTPRKRSP SSPVPLLAKK REGSPSLPIP ILPKMKDTSI
360 370 380 390 400
PAAEPASSTT SARDQTPSTP KDVGSPSTAE TSAEEKQMET YKTPTHAALS
410 420 430 440 450
DIISTHDYAL DANSASQTKK AAFGSPIGSS TYPTSSPAPF WKYVAVPNPH
460 470 480 490 500
DWPQVGSYDT ISPYRNPVNS HLIYSQIQQS SPKKIDEQLH DLQGVDLVNG
510 520 530 540 550
FEGISSWRES MVNKLRSSVS DSPTMNLANS NSKSSPVAVQ RVSTLPQASA
560 570 580 590 600
NKQAKEMESK MSNSPTQKSK TEENNQAVRA ILDASATMEK QYDLHRLPTP
610 620 630 640
TSQTESASVP QIANPPNSQN LVKEKSPQQY IQVPQSNVKS SA
Length:642
Mass (Da):71,174
Last modified:August 1, 1998 - v1
Checksum:iDBEC705EF3C595B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA19034.1
PIRiT39607
RefSeqiNP_596764.1, NM_001023784.2

Genome annotation databases

EnsemblFungiiSPBC16G5.15c.1; SPBC16G5.15c.1:pep; SPBC16G5.15c
GeneIDi2539703
KEGGispo:SPBC16G5.15c

Similar proteinsi

Entry informationi

Entry nameiFKH2_SCHPO
AccessioniPrimary (citable) accession number: O60129
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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