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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175By similarity1
Active sitei367By similarity1
Active sitei427By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.

Protein family/group databases

ESTHERischpo-KEX1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:SPBC16G5.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16G5.09.
PomBaseiSPBC16G5.09. kex1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 468LumenalSequence analysisAdd BLAST447
Transmembranei469 – 489HelicalSequence analysisAdd BLAST21
Topological domaini490 – 510CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031476522 – 510Pheromone-processing carboxypeptidase kex1Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi392N-linked (GlcNAc...)Sequence analysis1
Glycosylationi416N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60123.
PRIDEiO60123.

Interactioni

Protein-protein interaction databases

BioGridi276735. 6 interactors.
MINTiMINT-4677383.

Structurei

3D structure databases

ProteinModelPortaliO60123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO60123.
KOiK01288.
OrthoDBiEOG092C255X.
PhylomeDBiO60123.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISKLLKIVL LTAGVIGNTL ADSRIHEQYL VKAFPNEPVD YEGRMHAGHL
60 70 80 90 100
NQTDQLDGDL FFWMFESVKP EYEHRSILWL NGGPGCSSED GSLMEVGPFR
110 120 130 140 150
LDDNNTFQLN PGRWDELGNL LFVDQPLGTG YSYSLAKDFQ SNNEKMANDF
160 170 180 190 200
SIFFEKFLEE FPERANDEWF IAGESFAGQY IPHIAAKLKE KNLVNLGGLA
210 220 230 240 250
IGNGWINPLS HYETYLNYLV EKGMVDFESE LGQYLHHSWA ECLLAFDKIG
260 270 280 290 300
SGSGDLSKCE SFLGDILYMV SKEPGKACMN MYDISLESTY PTCGMDWPYD
310 320 330 340 350
LSYLTEFLST REAMTSLNVN LEKVHDWEEC NDDVALQYAR EGIESSSKLI
360 370 380 390 400
QDLVSTVPIL LFYGENDFLC NYLSGEKLTR SLEWNGAVGF QNQSAQPFYL
410 420 430 440 450
PGYSDQPSGS YVSSRNLTFA RIVEASHMVP YDHPNEMKTL ITAFFNNDFA
460 470 480 490 500
SLPSVPKPSP DLGNGNYKWL YLGLIPVALT IIILFSIYLC RRFGLFGLSK
510
QRYQPISPTP
Length:510
Mass (Da):57,644
Last modified:August 1, 1998 - v1
Checksum:i9D0D6B82FD1BC9E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19029.1.
PIRiT39601.
RefSeqiNP_596758.1. NM_001023778.2.

Genome annotation databases

EnsemblFungiiSPBC16G5.09.1; SPBC16G5.09.1:pep; SPBC16G5.09.
GeneIDi2540202.
KEGGispo:SPBC16G5.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19029.1.
PIRiT39601.
RefSeqiNP_596758.1. NM_001023778.2.

3D structure databases

ProteinModelPortaliO60123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276735. 6 interactors.
MINTiMINT-4677383.

Protein family/group databases

ESTHERischpo-KEX1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Proteomic databases

MaxQBiO60123.
PRIDEiO60123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC16G5.09.1; SPBC16G5.09.1:pep; SPBC16G5.09.
GeneIDi2540202.
KEGGispo:SPBC16G5.09.

Organism-specific databases

EuPathDBiFungiDB:SPBC16G5.09.
PomBaseiSPBC16G5.09. kex1.

Phylogenomic databases

InParanoidiO60123.
KOiK01288.
OrthoDBiEOG092C255X.
PhylomeDBiO60123.

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiO60123.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_SCHPO
AccessioniPrimary (citable) accession number: O60123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.