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O60123

- KEX1_SCHPO

UniProt

O60123 - KEX1_SCHPO

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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei175 – 1751By similarity
Active sitei367 – 3671By similarity
Active sitei427 – 4271By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: PomBase

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cellular protein catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:SPBC16G5.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC16G5.09.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane By similarity; Single-pass type I membrane protein By similarity. Vacuole membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 468447LumenalSequence AnalysisAdd
BLAST
Transmembranei469 – 48921HelicalSequence AnalysisAdd
BLAST
Topological domaini490 – 51021CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. fungal-type vacuole Source: PomBase
  2. integral component of membrane Source: UniProtKB-KW
  3. trans-Golgi network Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 510489Pheromone-processing carboxypeptidase kex1PRO_0000314765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60123.

Interactioni

Protein-protein interaction databases

BioGridi276735. 6 interactions.
MINTiMINT-4677383.
STRINGi4896.SPBC16G5.09-1.

Structurei

3D structure databases

ProteinModelPortaliO60123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiO60123.
KOiK01288.
OMAiERANDEW.
OrthoDBiEOG7TJ3SJ.
PhylomeDBiO60123.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60123-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISKLLKIVL LTAGVIGNTL ADSRIHEQYL VKAFPNEPVD YEGRMHAGHL
60 70 80 90 100
NQTDQLDGDL FFWMFESVKP EYEHRSILWL NGGPGCSSED GSLMEVGPFR
110 120 130 140 150
LDDNNTFQLN PGRWDELGNL LFVDQPLGTG YSYSLAKDFQ SNNEKMANDF
160 170 180 190 200
SIFFEKFLEE FPERANDEWF IAGESFAGQY IPHIAAKLKE KNLVNLGGLA
210 220 230 240 250
IGNGWINPLS HYETYLNYLV EKGMVDFESE LGQYLHHSWA ECLLAFDKIG
260 270 280 290 300
SGSGDLSKCE SFLGDILYMV SKEPGKACMN MYDISLESTY PTCGMDWPYD
310 320 330 340 350
LSYLTEFLST REAMTSLNVN LEKVHDWEEC NDDVALQYAR EGIESSSKLI
360 370 380 390 400
QDLVSTVPIL LFYGENDFLC NYLSGEKLTR SLEWNGAVGF QNQSAQPFYL
410 420 430 440 450
PGYSDQPSGS YVSSRNLTFA RIVEASHMVP YDHPNEMKTL ITAFFNNDFA
460 470 480 490 500
SLPSVPKPSP DLGNGNYKWL YLGLIPVALT IIILFSIYLC RRFGLFGLSK
510
QRYQPISPTP
Length:510
Mass (Da):57,644
Last modified:August 1, 1998 - v1
Checksum:i9D0D6B82FD1BC9E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19029.1.
PIRiT39601.
RefSeqiNP_596758.1. NM_001023778.2.

Genome annotation databases

EnsemblFungiiSPBC16G5.09.1; SPBC16G5.09.1:pep; SPBC16G5.09.
GeneIDi2540202.
KEGGispo:SPBC16G5.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19029.1 .
PIRi T39601.
RefSeqi NP_596758.1. NM_001023778.2.

3D structure databases

ProteinModelPortali O60123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276735. 6 interactions.
MINTi MINT-4677383.
STRINGi 4896.SPBC16G5.09-1.

Protein family/group databases

MEROPSi S10.A67.

Proteomic databases

MaxQBi O60123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC16G5.09.1 ; SPBC16G5.09.1:pep ; SPBC16G5.09 .
GeneIDi 2540202.
KEGGi spo:SPBC16G5.09.

Organism-specific databases

PomBasei SPBC16G5.09.

Phylogenomic databases

eggNOGi COG2939.
InParanoidi O60123.
KOi K01288.
OMAi ERANDEW.
OrthoDBi EOG7TJ3SJ.
PhylomeDBi O60123.

Miscellaneous databases

NextBioi 20801334.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKEX1_SCHPO
AccessioniPrimary (citable) accession number: O60123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3