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Protein

Alkaline phosphatase

Gene

SPBC14F5.13c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.PROSITE-ProRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarityNote: Binds 1 Mg2+ ion.By similarity
  • Zn2+By similarityNote: Binds 2 Zn2+ ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68MagnesiumBy similarity1
Metal bindingi68Zinc 2By similarity1
Active sitei115Phosphoserine intermediatePROSITE-ProRule annotation1
Metal bindingi166MagnesiumBy similarity1
Metal bindingi168MagnesiumBy similarity1
Metal bindingi306MagnesiumBy similarity1
Metal bindingi311Zinc 1By similarity1
Metal bindingi315Zinc 1By similarity1
Metal bindingi352Zinc 2By similarity1
Metal bindingi353Zinc 2By similarity1
Metal bindingi456Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-1483166 Synthesis of PA
R-SPO-8935690 Digestion

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphatase (EC:3.1.3.1)
Gene namesi
ORF Names:SPBC14F5.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC14F5.13c
PomBaseiSPBC14F5.13c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861651 – 532Alkaline phosphataseAdd BLAST532

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60109
PaxDbiO60109
PRIDEiO60109

Interactioni

Protein-protein interaction databases

BioGridi276470, 13 interactors
STRINGi4896.SPBC14F5.13c.1

Structurei

3D structure databases

ProteinModelPortaliO60109
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline phosphatase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000099116
InParanoidiO60109
KOiK01077
OMAiFEIDRRN
OrthoDBiEOG092C1UXR
PhylomeDBiO60109

Family and domain databases

CDDicd16012 ALP, 1 hit
Gene3Di3.40.720.10, 2 hits
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR001952 Alkaline_phosphatase
IPR018299 Alkaline_phosphatase_AS
IPR017850 Alkaline_phosphatase_core_sf
PANTHERiPTHR11596 PTHR11596, 1 hit
PfamiView protein in Pfam
PF00245 Alk_phosphatase, 1 hit
PRINTSiPR00113 ALKPHPHTASE
SMARTiView protein in SMART
SM00098 alkPPc, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
PROSITEiView protein in PROSITE
PS00123 ALKALINE_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

O60109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASERDPLLP VHGEGPESPS RRNWKTWIKH GILLILVLST VIFFYFFSSH
60 70 80 90 100
KSKGTNEKPK FVIMMVSDGM GPGSLSMTRS FVETLNDKEG YRLPLDEHLI
110 120 130 140 150
GSSRTRSSSS LITDSAAGAT AFSCANKTYN GAVGVLDNEK PCGTILEAAK
160 170 180 190 200
EAGYLTGIVV TSRVTDATPA SFSAHAANRF MQDLIAEYQV GMGPLGRSVD
210 220 230 240 250
LLFGGGLCSF LPKSTYRSCR SDNLDLLKYA RKKEGFQILL NRTDFDELSN
260 270 280 290 300
AQLPLLGLFS DYHLSYDIDY QPEVQPKLSE MVETALDVLL NATNEDTSKG
310 320 330 340 350
FFLLIEGSRI DMASHNNDPI AHVYEVMEYN RAFEIASAFV EKNGGSLIST
360 370 380 390 400
SDHETGGLTV GRQVSKKYPE YLWKPQVLSL ALHSIEYLAS AIVNHNQNTL
410 420 430 440 450
LPYIEQFVLP AIGIPDPNPK QIHDIYVARH NIFNLINVLS DIVSVEAQIG
460 470 480 490 500
WTTHGHTAVD VNVYGVGEVT EHLRGNMENI EIGQFMEIYL NVSLSDVTEK
510 520 530
LKDAPIHGAP DRPSLVETSF SDRLVGFGAD LF
Length:532
Mass (Da):58,666
Last modified:August 1, 1998 - v1
Checksum:i57A84A66926D545C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti513 – 514PS → HC in AAK07179 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316541 Genomic DNA Translation: AAK07179.1
CU329671 Genomic DNA Translation: CAA19331.1
PIRiT39459
RefSeqiNP_596739.1, NM_001022665.2

Genome annotation databases

EnsemblFungiiSPBC14F5.13c.1; SPBC14F5.13c.1:pep; SPBC14F5.13c
GeneIDi2539926
KEGGispo:SPBC14F5.13c

Similar proteinsi

Entry informationi

Entry nameiPPB_SCHPO
AccessioniPrimary (citable) accession number: O60109
Secondary accession number(s): Q9C427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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