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O60109

- PPB_SCHPO

UniProt

O60109 - PPB_SCHPO

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Protein
Alkaline phosphatase
Gene
SPBC14F5.13c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 1 magnesium ion By similarity.
Binds 2 zinc ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Magnesium By similarity
Metal bindingi68 – 681Zinc 2 By similarity
Active sitei115 – 1151Phosphoserine intermediate By similarity
Metal bindingi166 – 1661Magnesium By similarity
Metal bindingi168 – 1681Magnesium By similarity
Metal bindingi306 – 3061Magnesium By similarity
Metal bindingi311 – 3111Zinc 1 By similarity
Metal bindingi315 – 3151Zinc 1 By similarity
Metal bindingi352 – 3521Zinc 2 By similarity
Metal bindingi353 – 3531Zinc 2 By similarity
Metal bindingi456 – 4561Zinc 1 By similarity

GO - Molecular functioni

  1. alkaline phosphatase activity Source: PomBase
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. biological regulation Source: PomBase
  2. protein dephosphorylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphatase (EC:3.1.3.1)
Gene namesi
ORF Names:SPBC14F5.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC14F5.13c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. fungal-type vacuole Source: PomBase
  2. fungal-type vacuole membrane Source: PomBase
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Alkaline phosphatase
PRO_0000186165Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60109.

Interactioni

Protein-protein interaction databases

BioGridi276470. 11 interactions.
MINTiMINT-4677261.
STRINGi4896.SPBC14F5.13c-1.

Structurei

3D structure databases

ProteinModelPortaliO60109.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1785.
HOGENOMiHOG000099116.
KOiK01077.
OMAiLKSYNGA.
OrthoDBiEOG71K6C1.
PhylomeDBiO60109.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamiPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00113. ALKPHPHTASE.
SMARTiSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 2 hits.
PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60109-1 [UniParc]FASTAAdd to Basket

« Hide

MASERDPLLP VHGEGPESPS RRNWKTWIKH GILLILVLST VIFFYFFSSH    50
KSKGTNEKPK FVIMMVSDGM GPGSLSMTRS FVETLNDKEG YRLPLDEHLI 100
GSSRTRSSSS LITDSAAGAT AFSCANKTYN GAVGVLDNEK PCGTILEAAK 150
EAGYLTGIVV TSRVTDATPA SFSAHAANRF MQDLIAEYQV GMGPLGRSVD 200
LLFGGGLCSF LPKSTYRSCR SDNLDLLKYA RKKEGFQILL NRTDFDELSN 250
AQLPLLGLFS DYHLSYDIDY QPEVQPKLSE MVETALDVLL NATNEDTSKG 300
FFLLIEGSRI DMASHNNDPI AHVYEVMEYN RAFEIASAFV EKNGGSLIST 350
SDHETGGLTV GRQVSKKYPE YLWKPQVLSL ALHSIEYLAS AIVNHNQNTL 400
LPYIEQFVLP AIGIPDPNPK QIHDIYVARH NIFNLINVLS DIVSVEAQIG 450
WTTHGHTAVD VNVYGVGEVT EHLRGNMENI EIGQFMEIYL NVSLSDVTEK 500
LKDAPIHGAP DRPSLVETSF SDRLVGFGAD LF 532
Length:532
Mass (Da):58,666
Last modified:August 1, 1998 - v1
Checksum:i57A84A66926D545C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti513 – 5142PS → HC in AAK07179. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316541 Genomic DNA. Translation: AAK07179.1.
CU329671 Genomic DNA. Translation: CAA19331.1.
PIRiT39459.
RefSeqiNP_596739.1. NM_001022665.2.

Genome annotation databases

EnsemblFungiiSPBC14F5.13c.1; SPBC14F5.13c.1:pep; SPBC14F5.13c.
GeneIDi2539926.
KEGGispo:SPBC14F5.13c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316541 Genomic DNA. Translation: AAK07179.1 .
CU329671 Genomic DNA. Translation: CAA19331.1 .
PIRi T39459.
RefSeqi NP_596739.1. NM_001022665.2.

3D structure databases

ProteinModelPortali O60109.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276470. 11 interactions.
MINTi MINT-4677261.
STRINGi 4896.SPBC14F5.13c-1.

Proteomic databases

MaxQBi O60109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC14F5.13c.1 ; SPBC14F5.13c.1:pep ; SPBC14F5.13c .
GeneIDi 2539926.
KEGGi spo:SPBC14F5.13c.

Organism-specific databases

PomBasei SPBC14F5.13c.

Phylogenomic databases

eggNOGi COG1785.
HOGENOMi HOG000099116.
KOi K01077.
OMAi LKSYNGA.
OrthoDBi EOG71K6C1.
PhylomeDBi O60109.

Miscellaneous databases

NextBioi 20801069.

Family and domain databases

Gene3Di 3.40.720.10. 1 hit.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view ]
Pfami PF00245. Alk_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00113. ALKPHPHTASE.
SMARTi SM00098. alkPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF53649. SSF53649. 2 hits.
PROSITEi PS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of alkaline phosphatase gene from Schizosaccharomyces pombe."
    Kang S.-W., Lim C.-J.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPPB_SCHPO
AccessioniPrimary (citable) accession number: O60109
Secondary accession number(s): Q9C427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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