Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O60109 (PPB_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor

Binds 1 magnesium ion By similarity.

Binds 2 zinc ions By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the alkaline phosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Alkaline phosphatase
PRO_0000186165

Regions

Transmembrane27 – 4721Helical; Signal-anchor for type II membrane protein; Potential

Sites

Active site1151Phosphoserine intermediate By similarity
Metal binding681Magnesium By similarity
Metal binding681Zinc 2 By similarity
Metal binding1661Magnesium By similarity
Metal binding1681Magnesium By similarity
Metal binding3061Magnesium By similarity
Metal binding3111Zinc 1 By similarity
Metal binding3151Zinc 1 By similarity
Metal binding3521Zinc 2 By similarity
Metal binding3531Zinc 2 By similarity
Metal binding4561Zinc 1 By similarity

Experimental info

Sequence conflict513 – 5142PS → HC in AAK07179. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O60109 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 57A84A66926D545C

FASTA53258,666
        10         20         30         40         50         60 
MASERDPLLP VHGEGPESPS RRNWKTWIKH GILLILVLST VIFFYFFSSH KSKGTNEKPK 

        70         80         90        100        110        120 
FVIMMVSDGM GPGSLSMTRS FVETLNDKEG YRLPLDEHLI GSSRTRSSSS LITDSAAGAT 

       130        140        150        160        170        180 
AFSCANKTYN GAVGVLDNEK PCGTILEAAK EAGYLTGIVV TSRVTDATPA SFSAHAANRF 

       190        200        210        220        230        240 
MQDLIAEYQV GMGPLGRSVD LLFGGGLCSF LPKSTYRSCR SDNLDLLKYA RKKEGFQILL 

       250        260        270        280        290        300 
NRTDFDELSN AQLPLLGLFS DYHLSYDIDY QPEVQPKLSE MVETALDVLL NATNEDTSKG 

       310        320        330        340        350        360 
FFLLIEGSRI DMASHNNDPI AHVYEVMEYN RAFEIASAFV EKNGGSLIST SDHETGGLTV 

       370        380        390        400        410        420 
GRQVSKKYPE YLWKPQVLSL ALHSIEYLAS AIVNHNQNTL LPYIEQFVLP AIGIPDPNPK 

       430        440        450        460        470        480 
QIHDIYVARH NIFNLINVLS DIVSVEAQIG WTTHGHTAVD VNVYGVGEVT EHLRGNMENI 

       490        500        510        520        530 
EIGQFMEIYL NVSLSDVTEK LKDAPIHGAP DRPSLVETSF SDRLVGFGAD LF 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of alkaline phosphatase gene from Schizosaccharomyces pombe."
Kang S.-W., Lim C.-J.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF316541 Genomic DNA. Translation: AAK07179.1.
CU329671 Genomic DNA. Translation: CAA19331.1.
PIRT39459.
RefSeqNP_596739.1. NM_001022665.2.

3D structure databases

ProteinModelPortalO60109.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276470. 11 interactions.
MINTMINT-4677261.
STRING4896.SPBC14F5.13c-1.

Proteomic databases

MaxQBO60109.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC14F5.13c.1; SPBC14F5.13c.1:pep; SPBC14F5.13c.
GeneID2539926.
KEGGspo:SPBC14F5.13c.

Organism-specific databases

PomBaseSPBC14F5.13c.

Phylogenomic databases

eggNOGCOG1785.
HOGENOMHOG000099116.
KOK01077.
OMALKSYNGA.
OrthoDBEOG71K6C1.
PhylomeDBO60109.

Family and domain databases

Gene3D3.40.720.10. 1 hit.
InterProIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00113. ALKPHPHTASE.
SMARTSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMSSF53649. SSF53649. 2 hits.
PROSITEPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801069.

Entry information

Entry namePPB_SCHPO
AccessionPrimary (citable) accession number: O60109
Secondary accession number(s): Q9C427
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names