Reviewed,
UniProtKB/Swiss-Prot O60109 (PPB_SCHPO)
Last modified
November 3, 2009.
Version 58.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Alkaline phosphatase EC=3.1.3.1 | ||
| Gene names |
| ||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||
| Taxonomic identifier | 4896 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 532 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | A phosphate monoester + H2O = an alcohol + phosphate. |
| Cofactor | Binds 1 magnesium ion By similarity. Binds 2 zinc ions By similarity. |
| Subcellular location | Membrane; Single-pass type II membrane protein Potential. |
| Sequence similarities | Belongs to the alkaline phosphatase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal-anchor Transmembrane |
| Ligand | Magnesium Metal-binding Zinc |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | fungal-type vacuole Inferred from direct assay. Source: GeneDB_SPombe integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | alkaline phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 532 | 532 | Alkaline phosphatase | PRO_0000186165 | |||||
Regions | |||||||||
| Transmembrane | 27 – 47 | 21 | Signal-anchor for type II membrane protein Potential | ||||||
Sites | |||||||||
| Active site | 115 | 1 | Phosphoserine intermediate By similarity | ||||||
| Metal binding | 68 | 1 | Magnesium By similarity | ||||||
| Metal binding | 68 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 166 | 1 | Magnesium By similarity | ||||||
| Metal binding | 168 | 1 | Magnesium By similarity | ||||||
| Metal binding | 306 | 1 | Magnesium By similarity | ||||||
| Metal binding | 311 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 315 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 352 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 353 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 456 | 1 | Zinc 1 By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 513 – 514 | 2 | PS → HC in AAK07179. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of alkaline phosphatase gene from Schizosaccharomyces pombe." Kang S.-W., Lim C.-J. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.  Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
Cross-references
Sequence databases | |
|---|---|
| AF316541 Genomic DNA. Translation: AAK07179.1. CU329671 Genomic DNA. Translation: CAA19331.1. | |
| PIR | T39459. |
| RefSeq | NP_596739.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AJA based on UniProtKB P00634. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O60109. |
Genome annotation databases | |
| GeneID | 2539926. |
| KEGG | spo:SPBC14F5.13c. |
| NMPDR | fig|4896.1.peg.2605. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC14F5.13c. |
Phylogenomic databases | |
| OMA | SEITHAT. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-004723-MON. |
| BRENDA | 3.1.3.1. 653. |
Gene expression databases | |
| ArrayExpress | O60109. |
Family and domain databases | |
| InterPro | IPR017849. Alkaline_Pase-like_a/b/a. IPR001952. Alkaline_phosphatase. IPR018299. Alkaline_phosphatase_AS. [Graphical view] |
| Gene3D | G3DSA:3.40.720.10. Alk_phosphtse. 1 hit. |
| Pfam | PF00245. Alk_phosphatase. 1 hit. [Graphical view] |
| PRINTS | PR00113. ALKPHPHTASE. |
| SMART | SM00098. alkPPc. 1 hit. [Graphical view] |
| PROSITE | PS00123. ALKALINE_PHOSPHATASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PPB_SCHPO | ||||||||
| Accession | Primary (citable) accession number: O60109 Secondary accession number(s): Q9C427 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |
