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O60101

- PGK_SCHPO

UniProt

O60101 - PGK_SCHPO

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Protein
Phosphoglycerate kinase
Gene
pgk1, SPBC14F5.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei217 – 2171ATP By similarity
Binding sitei310 – 3101ATP; via carbonyl oxygen By similarity
Binding sitei341 – 3411ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi370 – 3734ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: PomBase

GO - Biological processi

  1. gluconeogenesis Source: PomBase
  2. glycolytic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk1
ORF Names:SPBC14F5.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC14F5.04c.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Phosphoglycerate kinaseUniRule annotation
PRO_0000145889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751Phosphotyrosine1 Publication
Modified residuei76 – 761Phosphoserine1 Publication
Modified residuei143 – 1431Phosphoserine1 Publication
Modified residuei172 – 1721Phosphoserine1 Publication
Modified residuei173 – 1731Phosphoserine1 Publication
Modified residuei183 – 1831Phosphoserine1 Publication
Modified residuei253 – 2531Phosphoserine1 Publication
Modified residuei260 – 2601Phosphoserine1 Publication
Modified residuei299 – 2991Phosphothreonine1 Publication
Modified residuei328 – 3281Phosphoserine1 Publication
Modified residuei351 – 3511Phosphoserine1 Publication
Modified residuei373 – 3731Phosphothreonine1 Publication
Modified residuei387 – 3871Phosphoserine1 Publication
Modified residuei390 – 3901Phosphoserine1 Publication
Modified residuei412 – 4121Phosphoserine1 Publication
Modified residuei413 – 4131Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60101.
PaxDbiO60101.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

BioGridi276315. 10 interactions.
IntActiO60101. 2 interactions.
MINTiMINT-4677183.
STRINGi4896.SPBC14F5.04c-1.

Structurei

3D structure databases

ProteinModelPortaliO60101.
SMRiO60101. Positions 2-414.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate binding By similarity
Regioni63 – 664Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiFNVPLRE.
OrthoDBiEOG71K6D7.
PhylomeDBiO60101.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60101-1 [UniParc]FASTAAdd to Basket

« Hide

MSLSTKLAIT DVDLKGKNVL IRVDFNVPLD GDRITNNARI VGALPTIKYA    50
LEQQPKAVIL MSHLGRPNGA RVAKYSLKPV AAELSKLLGK PVKFLDDCVG 100
PEVEKACKEA KGGEVILLEN LRFHIEEEGS AKVDGKKVKA DASAVEAFRK 150
SLTSLGDIFV NDAFGTAHRA HSSMVGVDLP RVSGFLMKKE LDYFSKALEN 200
PARPFLAILG GAKVADKIQL IDNLLDKVNR LIICGGMAFT FLKVLNGMKI 250
GDSLFDEAGS KNVESMMAKA KKNNVEVFLP VDFVTADKFD KDAKVGSATA 300
EEGIPDGWMG LDCGPKSSAK FAEVITTSKT IVWNGPAGVF EFDNFAKGTK 350
SMLDACVKTC EAGNVVIVGG GDTATVAKKY GKEDALSHVS TGGGASLELL 400
EGKALPGVVA LSSK 414
Length:414
Mass (Da):43,964
Last modified:August 1, 1998 - v1
Checksum:iF40D706D5487EB4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA19322.1.
PIRiT39450.
RefSeqiNP_596730.1. NM_001022656.2.

Genome annotation databases

EnsemblFungiiSPBC14F5.04c.1; SPBC14F5.04c.1:pep; SPBC14F5.04c.
GeneIDi2539764.
KEGGispo:SPBC14F5.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA19322.1 .
PIRi T39450.
RefSeqi NP_596730.1. NM_001022656.2.

3D structure databases

ProteinModelPortali O60101.
SMRi O60101. Positions 2-414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276315. 10 interactions.
IntActi O60101. 2 interactions.
MINTi MINT-4677183.
STRINGi 4896.SPBC14F5.04c-1.

Proteomic databases

MaxQBi O60101.
PaxDbi O60101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC14F5.04c.1 ; SPBC14F5.04c.1:pep ; SPBC14F5.04c .
GeneIDi 2539764.
KEGGi spo:SPBC14F5.04c.

Organism-specific databases

PomBasei SPBC14F5.04c.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227107.
KOi K00927.
OMAi FNVPLRE.
OrthoDBi EOG71K6D7.
PhylomeDBi O60101.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Miscellaneous databases

NextBioi 20800914.
PROi O60101.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-75; SER-76; SER-143; SER-172; SER-173; SER-183; SER-253; SER-260; THR-299; SER-328; SER-351; THR-373; SER-387; SER-390; SER-412 AND SER-413, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPGK_SCHPO
AccessioniPrimary (citable) accession number: O60101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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