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Protein

Probable importin subunit beta-4

Gene

kap123

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Required for nuclear protein import, its predominant substrate seems to be ribosomal proteins. Binds to nucleoporins and the GTP-bound form of gsp1 (Ran) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable importin subunit beta-4
Alternative name(s):
Importin-123
Karyopherin subunit beta-4
Karyopherin-123
Gene namesi
Name:kap123
ORF Names:SPBC14F5.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC14F5.03c.
PomBaseiSPBC14F5.03c. kap123.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nuclear envelope Source: PomBase
  • nuclear periphery Source: PomBase
  • nuclear pore Source: PomBase
  • nucleus Source: PomBase
  • protein complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207751 – 1067Probable importin subunit beta-4Add BLAST1067

Proteomic databases

MaxQBiO60100.
PRIDEiO60100.

Interactioni

Protein-protein interaction databases

BioGridi276410. 6 interactors.
DIPiDIP-38714N.
IntActiO60100. 1 interactor.
MINTiMINT-4677168.

Structurei

3D structure databases

ProteinModelPortaliO60100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 94Importin N-terminalPROSITE-ProRule annotationAdd BLAST68
Repeati159 – 196HEAT 1Add BLAST38
Repeati379 – 416HEAT 2Add BLAST38
Repeati420 – 457HEAT 3Add BLAST38
Repeati591 – 633HEAT 4Add BLAST43
Repeati890 – 927HEAT 5Add BLAST38
Repeati1013 – 1050HEAT 6Add BLAST38

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 6 HEAT repeats.PROSITE-ProRule annotation
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000113057.
InParanoidiO60100.
KOiK20221.
OMAiRPAQEYF.
OrthoDBiEOG092C0EXQ.
PhylomeDBiO60100.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS50077. HEAT_REPEAT. 2 hits.
PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAQFTLELT QLLFQSIAPD TTQITEATRA LETKYLKEPG SLLSLFHIMG
60 70 80 90 100
TCENPQVRQL AAIEARKLCH KYWSSVDADV QNQIRSNLLD ITLKEPESIV
110 120 130 140 150
RHAFGRVIAA LAKLDLPEGK WNELSAFLVQ ATMDQNDSIR EMAVYVLYSI
160 170 180 190 200
AETVDLDNKL LLDFVNLFSQ TITDSSRTVR VTSVQGLGAI AEVLESDDKK
210 220 230 240 250
LLHAYRATLP GMLLVLQDVV QVGDVDASKQ VFDVFNTFLI ASGAIISKAL
260 270 280 290 300
GNIIEIITGI ANSKQVDDEI RCMALSFIIS CIRFKSRKLQ ALKLGKPLVL
310 320 330 340 350
TLMEVATEET TDDIDEDCPA RLALRSIDLL STHLSPSQVF YPMFEAACAF
360 370 380 390 400
SQSPQASYRK AALLSIGVAV EGSSESVAGN LPNIFPIIIN GLCDNDMDVR
410 420 430 440 450
QAALLALSQI AVEIPTEVSK HHAQLLPLVF ELMSTQGVKV GKSACNCIDA
460 470 480 490 500
LLEGLDKSEI SGYLPMLMER LVGLLEFSDT PDIKSCVAAA IGSAAFAAQD
510 520 530 540 550
DFIPYFERTM ASLSQCLHTT DDDEGYELRG TVMDTLGAIA NAVGKQAFLP
560 570 580 590 600
YTEQLIQLAY EGIQIDHSRL RECSFCFYAV LARVYKEEFA PFLEHIVPAL
610 620 630 640 650
FKSIDQDESD ILSERIGAPT AEEISQLLDS VETNEEENDE ELEKAMGVNS
660 670 680 690 700
AIAMEKEIAA DALGEICMYV GAPFTPYLEP TVEKLVACTT HFYEGVRKSA
710 720 730 740 750
LSSLWRCATT YYKVCNVPQW QPGLPLKVPV PDTVKNIFEA VRKCTFDTLE
760 770 780 790 800
EEYEKTVATD ILRNFAESIK TCGPVVLGDD YEKLCEVVME VLQKQHIVQA
810 820 830 840 850
GDVFDDDFEE EDIVSNEEVD DTEQDALLID SACDVVIALA VALGGSFADS
860 870 880 890 900
FKVFYPQIVK YYMSKNGNER AMAVACVGEV AGGIESAITP FTRDVFSLFM
910 920 930 940 950
AALEDSEGEV RSNAAYSMGL LCQFSTEDLS SEYLNILQKL QPFFTQEVFR
960 970 980 990 1000
TALDNAIGCI SRLILHNQNA IPVDQVLPIV FSKLPLKEDY LENAPLYHMI
1010 1020 1030 1040 1050
LALYRQQNPC LVQHLGELIP VFASVLTGSP EQLNDELRSE LLSMVKEIAP
1060
QYESVVSNYP QLVALLQ
Length:1,067
Mass (Da):117,834
Last modified:August 1, 1998 - v1
Checksum:i0D90A3CB4DE13BB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19321.1.
AB028002 Genomic DNA. Translation: BAA87306.1.
PIRiT39449.
RefSeqiNP_596729.1. NM_001022655.2.

Genome annotation databases

EnsemblFungiiSPBC14F5.03c.1; SPBC14F5.03c.1:pep; SPBC14F5.03c.
GeneIDi2539863.
KEGGispo:SPBC14F5.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19321.1.
AB028002 Genomic DNA. Translation: BAA87306.1.
PIRiT39449.
RefSeqiNP_596729.1. NM_001022655.2.

3D structure databases

ProteinModelPortaliO60100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276410. 6 interactors.
DIPiDIP-38714N.
IntActiO60100. 1 interactor.
MINTiMINT-4677168.

Proteomic databases

MaxQBiO60100.
PRIDEiO60100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC14F5.03c.1; SPBC14F5.03c.1:pep; SPBC14F5.03c.
GeneIDi2539863.
KEGGispo:SPBC14F5.03c.

Organism-specific databases

EuPathDBiFungiDB:SPBC14F5.03c.
PomBaseiSPBC14F5.03c. kap123.

Phylogenomic databases

HOGENOMiHOG000113057.
InParanoidiO60100.
KOiK20221.
OMAiRPAQEYF.
OrthoDBiEOG092C0EXQ.
PhylomeDBiO60100.

Miscellaneous databases

PROiO60100.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS50077. HEAT_REPEAT. 2 hits.
PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMB4_SCHPO
AccessioniPrimary (citable) accession number: O60100
Secondary accession number(s): Q9US72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.