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Protein

Transcription factor spt8

Gene

spt8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor spt8
Gene namesi
Name:spt8
Synonyms:sep9
ORF Names:SPBC14C8.17c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC14C8.17c.
PomBaseiSPBC14C8.17c. spt8.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
  • SAGA complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Transcription factor spt8PRO_0000358862Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60097.

PTM databases

SwissPalmiO60097.

Interactioni

Subunit structurei

Component of the SAGA complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276326. 9 interactions.
IntActiO60097. 2 interactions.
MINTiMINT-8210498.

Structurei

3D structure databases

ProteinModelPortaliO60097.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati116 – 15540WD 1Add
BLAST
Repeati186 – 22540WD 2Add
BLAST
Repeati230 – 27142WD 3Add
BLAST
Repeati348 – 38942WD 4Add
BLAST
Repeati395 – 43440WD 5Add
BLAST
Repeati440 – 47839WD 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 3310Poly-Asp

Sequence similaritiesi

Belongs to the WD repeat SPT8 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000173633.
InParanoidiO60097.
KOiK11360.
OMAiERTPPWC.
OrthoDBiEOG7FJH8N.
PhylomeDBiO60097.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEESESFS YPMLLPSDGL YPEDDDDADM DQDKNPEENV MNEKEDEDVD
60 70 80 90 100
AVDEKSGEED VEMDTMEDEN ENDEDTEQTS EKKETEETPK ENPLEKLKQK
110 120 130 140 150
ASTASFYDVV PTLAIPMATS INAFAFTSDL KWLFTGGEDG YIRKYDFFPS
160 170 180 190 200
INGDLSLTVA QRHPFVDTVT KAGILLNYWE NAYDGNKPSS VYSLAAHSRG
210 220 230 240 250
LWVLSGVNNG DIILYSTRHQ EGYPVTSLKK HTAPVSCLAL HGSEKKVLSG
260 270 280 290 300
SWDKMVYYWD LNTGDAISTY NCESGQISNI VYRPSGAVNP WGSESDDMRS
310 320 330 340 350
LFGTPASSSS YDALFDEEVE KAIEEETKSV QANEENETEK PSQTESTTNN
360 370 380 390 400
DNIKAPSESS SEESNIFLTT SIDGVMNVWD HRMVDSVLKY PVPKGVPPWA
410 420 430 440 450
MSACWSPDGN NIYIGRRNGI VEEYNIHSGK EPVRSLKMPL DSGPVSNVYS
460 470 480 490 500
MPNGRHLVIS SFDNIRLYDL QSKAGIGFLI IPGHHGGLVS SLYVDTSCQF
510 520
MFSASGNRGW QGTTTEVFLG YQIMTS
Length:526
Mass (Da):58,418
Last modified:August 1, 1998 - v1
Checksum:i5F4096B0233B3D5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18434.1.
PIRiT39445.
RefSeqiNP_595920.1. NM_001021828.2.

Genome annotation databases

EnsemblFungiiSPBC14C8.17c.1; SPBC14C8.17c.1:pep; SPBC14C8.17c.
GeneIDi2539775.
KEGGispo:SPBC14C8.17c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18434.1.
PIRiT39445.
RefSeqiNP_595920.1. NM_001021828.2.

3D structure databases

ProteinModelPortaliO60097.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276326. 9 interactions.
IntActiO60097. 2 interactions.
MINTiMINT-8210498.

PTM databases

SwissPalmiO60097.

Proteomic databases

MaxQBiO60097.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC14C8.17c.1; SPBC14C8.17c.1:pep; SPBC14C8.17c.
GeneIDi2539775.
KEGGispo:SPBC14C8.17c.

Organism-specific databases

EuPathDBiFungiDB:SPBC14C8.17c.
PomBaseiSPBC14C8.17c. spt8.

Phylogenomic databases

HOGENOMiHOG000173633.
InParanoidiO60097.
KOiK11360.
OMAiERTPPWC.
OrthoDBiEOG7FJH8N.
PhylomeDBiO60097.

Miscellaneous databases

PROiO60097.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPT8_SCHPO
AccessioniPrimary (citable) accession number: O60097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.