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Protein

Probable glucoamylase

Gene

meu17

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147SubstrateBy similarity1
Active sitei203Proton acceptorBy similarity1
Active sitei206Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Meiosis, Polysaccharide degradation

Protein family/group databases

CAZyiGH15 Glycoside Hydrolase Family 15

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucoamylase (EC:3.2.1.3)
Alternative name(s):
1,4-alpha-D-glucan glucohydrolase
Glucan 1,4-alpha-glucosidase
Meiotic expression up-regulated protein 17
Gene namesi
Name:meu17
ORF Names:SPBC14C8.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC14C8.05c
PomBaseiSPBC14C8.05c meu17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000000147917 – 28By similarityAdd BLAST12
ChainiPRO_000000148029 – 450Probable glucoamylaseAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60087
PRIDEiO60087

Interactioni

Protein-protein interaction databases

BioGridi276237, 1 interactor
STRINGi4896.SPBC14C8.05c.1

Structurei

3D structure databases

ProteinModelPortaliO60087
SMRiO60087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 15 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000182646
InParanoidiO60087
KOiK01178
OMAiEGNPWFI
OrthoDBiEOG092C1YYH
PhylomeDBiO60087

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR000165 Glucoamylase
IPR011613 Glyco_hydro_15/PHK
PfamiView protein in Pfam
PF00723 Glyco_hydro_15, 1 hit
PRINTSiPR00736 GLHYDRLASE15
SUPFAMiSSF48208 SSF48208, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTYWLFLLL GGVVSAESLL SPNKRSKEAS MDEWTDQQKG IAMGHMLNNI
60 70 80 90 100
GDSGMHAKDI NPGCIIASPS TDSPDYYYQW VRDSALTIMT ILDRFFEGDK
110 120 130 140 150
GLEPIIVKYM DEMVRLQKVP NPSGDFYAGG LGEPKFNVDG TSYDGDWGRP
160 170 180 190 200
QNDSPALRAI AFIKYMNYLF ENGKEVHEVT VWIEAVLADL DYTANHWTEA
210 220 230 240 250
SFDLWEEIKD VHYFTLAVQK RAMQDGTAFA KRIGAPDQAA LYQRTIEPID
260 270 280 290 300
LKLGEFWDPG MGVIKGYKGR VDRSGLDCST LLASLYSNEF DMHILPTLLK
310 320 330 340 350
LQETMTRDYP VNQGWKQAMG RYPEDVYDGV SKSIGNPWFI CTSSAAEIIY
360 370 380 390 400
KAIAYYDNKG LPELTEYNIH FFMKFAEFGD PYNWSVIRKN MHTYADNFLK
410 420 430 440 450
AVAEFQHPNG SMSEQFSRDD GHQKGARDLT WSYSSLLNAI YRREAIKGSV
Length:450
Mass (Da):51,164
Last modified:August 1, 1998 - v1
Checksum:i31C5BF2A8E4785FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA18423.1
AB054301 mRNA Translation: BAB60870.1
PIRiT39433
RefSeqiNP_595908.1, NM_001021816.2

Genome annotation databases

EnsemblFungiiSPBC14C8.05c.1; SPBC14C8.05c.1:pep; SPBC14C8.05c
GeneIDi2539682
KEGGispo:SPBC14C8.05c

Similar proteinsi

Entry informationi

Entry nameiAMYG_SCHPO
AccessioniPrimary (citable) accession number: O60087
Secondary accession number(s): Q96WS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health