Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-dependent RNA helicase dbp9

Gene

dbp9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi58 – 658ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase dbp9 (EC:3.6.4.13)
Gene namesi
Name:dbp9
ORF Names:SPCC1494.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1494.06c.
PomBaseiSPCC1494.06c. dbp9.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleolus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595ATP-dependent RNA helicase dbp9PRO_0000232345Add
BLAST

Proteomic databases

MaxQBiO60080.

PTM databases

SwissPalmiO60080.

Interactioni

Protein-protein interaction databases

BioGridi275358. 1 interaction.
MINTiMINT-4677017.

Structurei

3D structure databases

ProteinModelPortaliO60080.
SMRiO60080. Positions 387-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 223179Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini233 – 485253Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi14 – 4229Q motifAdd
BLAST
Motifi171 – 1744DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000253015.
InParanoidiO60080.
KOiK14810.
OMAiVQVNASM.
OrthoDBiEOG092C1XGC.
PhylomeDBiO60080.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSGGIREE SSEKTFSDFN LDPRLQRAIH KCEFEKPTSV QSETIPLALE
60 70 80 90 100
GKDLVAQART GSGKTAAYLI PILELLLKQK QIDENQRGIF ALLLVPTREL
110 120 130 140 150
AQQVYNVLEK LTAFCSKHIR FINVATNSSD TVQRPLLLDL PDIVIATPSR
160 170 180 190 200
CVVHVASGVL PLDKLKFLVI DEADLMLSFG YNEDMKTLSR SLPRGTQSFL
210 220 230 240 250
MSATLSKNIA SLQKLVCRNP FILAVKDKEA SGKLTQYVVK CSEQDKFLLA
260 270 280 290 300
YILLKLRLIK GKILIFVNEI NRCYRLKLFL EQFGLKSLVL NSELPVNSRL
310 320 330 340 350
HILEQYNKGL YQIIIATDES GMMGEIEELE NNVDFVEEEV ISTDQPTLDK
360 370 380 390 400
MKDQENADVN DESILAAAKD KSKKKKRVKQ DKEYGVARGL DFENVACVLN
410 420 430 440 450
FDMPSNTKSY IHRIGRTARA GKPGTAMSFV VPKSEVGKHK PTSLESCKKD
460 470 480 490 500
ESVLRRLEKK QISLQPYSFD KNQIDAFRYR MEDALRAVTT VAVSAARAAE
510 520 530 540 550
LKQELLISEK LKSYFAENPD ELLSLTHDTV SSVRLGHTQR HLRHVPEYLL
560 570 580 590
PKGMQAVNKD IGFVPFKKNN RRKVFKSRKN PKHRHDPLRS MKRKS
Length:595
Mass (Da):67,451
Last modified:August 1, 1998 - v1
Checksum:i98FB3F42AD5C1F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19304.1.
PIRiT41007.
RefSeqiNP_588531.1. NM_001023519.2.

Genome annotation databases

EnsemblFungiiSPCC1494.06c.1; SPCC1494.06c.1:pep; SPCC1494.06c.
GeneIDi2538776.
KEGGispo:SPCC1494.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19304.1.
PIRiT41007.
RefSeqiNP_588531.1. NM_001023519.2.

3D structure databases

ProteinModelPortaliO60080.
SMRiO60080. Positions 387-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275358. 1 interaction.
MINTiMINT-4677017.

PTM databases

SwissPalmiO60080.

Proteomic databases

MaxQBiO60080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1494.06c.1; SPCC1494.06c.1:pep; SPCC1494.06c.
GeneIDi2538776.
KEGGispo:SPCC1494.06c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1494.06c.
PomBaseiSPCC1494.06c. dbp9.

Phylogenomic databases

HOGENOMiHOG000253015.
InParanoidiO60080.
KOiK14810.
OMAiVQVNASM.
OrthoDBiEOG092C1XGC.
PhylomeDBiO60080.

Miscellaneous databases

PROiO60080.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBP9_SCHPO
AccessioniPrimary (citable) accession number: O60080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.