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O60079

- UBP12_SCHPO

UniProt

O60079 - UBP12_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 12

Gene

ubp12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei320 – 3201NucleophilePROSITE-ProRule annotation
    Active sitei935 – 9351Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: PomBase
    2. ubiquitin thiolesterase activity Source: PomBase

    GO - Biological processi

    1. protein deubiquitination Source: PomBase
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A64.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 12 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 12
    Ubiquitin thioesterase 12
    Ubiquitin-specific-processing protease 12
    Gene namesi
    Name:ubp12
    ORF Names:SPCC1494.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC1494.05c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 979979Probable ubiquitin carboxyl-terminal hydrolase 12PRO_0000080612Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Phosphoserine1 Publication
    Modified residuei37 – 371Phosphoserine1 Publication
    Modified residuei39 – 391Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO60079.

    Interactioni

    Protein-protein interaction databases

    BioGridi275564. 5 interactions.
    MINTiMINT-4677005.
    STRINGi4896.SPCC1494.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO60079.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 152102DUSPPROSITE-ProRule annotationAdd
    BLAST
    Domaini311 – 977667USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 DUSP domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    KOiK11835.
    OMAiDANESHK.
    OrthoDBiEOG7R2BSX.
    PhylomeDBiO60079.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 1 hit.
    PROSITEiPS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60079-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSLSESSTS SYHGKRPRSL SEESQSSSNM DDISQKSISL GDASEISKNL    50
    PSIAEQKQLI GELVNNQPEL ELGQVDNYIL SYSWYERLCS YLAEDGPFPG 100
    PVDQEDIADL ETGTLKPDLQ EEIDFTIISR DVWDLLVRWY GLKGPEFPRE 150
    TVNLGSESHP HLVVEVYPPI FSLTLLSTNA VDANESHKPK KISLSSKSTL 200
    EDLLEGVKYT LSLPSDQFRL WRVDTDQPLH RTIDPSSFIK INSKEIIDFL 250
    EKSKTLVELG MDSSCSLVAE CMINETWPVD RALRLQFLIQ QRNNQSSNEE 300
    QKQEKRVPGT CGLSNLGNTC YMNSALQCLT HTRELRDFFT SDEWKNQVNE 350
    SNPLGMGGQV ASIFASLIKS LYSPEHSSFA PRQFKATIGK FNHSFLGYGQ 400
    QDSQEFLAFL LDGLHEDLNR IYQKPYTSKP DLYEVDEEKI KNTAEECWRL 450
    HKLRNDSLIV DLFQGMYRST LVCPVCNTVS ITFDPFMDLT LPLPVKQVWS 500
    HTVTFIPADT NLTPLAIEVV LESKAATIED LVKYVAEKSG CSDYRKILVT 550
    ETYKGRFYRF LTQLSKSLLM EISEEDEIYL YELERPYEDG SDDILVPVYH 600
    ISDDSTNSAN SYMSSRDFGH PFVLQLSDNE VTDASFISEK LKLKYQQFTT 650
    LKNLKNIDSL ESLELGHEDE QVQKGPLDVD MDHSQTPLFE MRVFHDRFEK 700
    IPTGWNMSVS NLPLLTERDK KDLESTVDPL DAHSIEEEDD SEFKDVAPGS 750
    YPEPSKSNEN TKLTAKENDR LLIQGDLLVC EWPEKSYQFV FSVAPSSPQM 800
    GRSLWLESKT ILSDKKDDSE DSRTITLNDC LDEFEKTEQL GEEDPWYCPT 850
    CKEFRQASKQ MEIWRCPEIL IFHLKRFSSE RRFRDKIDDL VEFPIDNLDM 900
    SMRTGSYKLS EKENPKLIYE LYAVDNHYGG LGGGHYTAFA KNPDNGQFYC 950
    FDDSRVTPVC PEETVTSAAY LLFYRRKTS 979
    Length:979
    Mass (Da):111,967
    Last modified:August 1, 1998 - v1
    Checksum:iA705444BCDB437D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA19303.1.
    PIRiT41006.
    RefSeqiNP_588530.1. NM_001023518.2.

    Genome annotation databases

    EnsemblFungiiSPCC1494.05c.1; SPCC1494.05c.1:pep; SPCC1494.05c.
    GeneIDi2538990.
    KEGGispo:SPCC1494.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA19303.1 .
    PIRi T41006.
    RefSeqi NP_588530.1. NM_001023518.2.

    3D structure databases

    ProteinModelPortali O60079.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275564. 5 interactions.
    MINTi MINT-4677005.
    STRINGi 4896.SPCC1494.05c-1.

    Protein family/group databases

    MEROPSi C19.A64.

    Proteomic databases

    MaxQBi O60079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC1494.05c.1 ; SPCC1494.05c.1:pep ; SPCC1494.05c .
    GeneIDi 2538990.
    KEGGi spo:SPCC1494.05c.

    Organism-specific databases

    PomBasei SPCC1494.05c.

    Phylogenomic databases

    eggNOGi COG5560.
    KOi K11835.
    OMAi DANESHK.
    OrthoDBi EOG7R2BSX.
    PhylomeDBi O60079.

    Miscellaneous databases

    NextBioi 20800165.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 1 hit.
    PROSITEi PS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-37 AND SER-39, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiUBP12_SCHPO
    AccessioniPrimary (citable) accession number: O60079
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3