ID   TYR1_SCHPO              Reviewed;         431 AA.
AC   O60078; P78863;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=Probable prephenate dehydrogenase [NADP+];
DE            Short=PRDH;
DE            EC=1.3.1.13;
GN   ORFNames=SPCC1494.04c;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-431.
RC   STRAIN=PR745;
RX   MEDLINE=98162722; PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA   Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT   "Identification of open reading frames in Schizosaccharomyces pombe
RT   cDNAs.";
RL   DNA Res. 4:363-369(1997).
CC   -!- CATALYTIC ACTIVITY: Prephenate + NADP(+) = 4-hydroxyphenylpyruvate
CC       + CO(2) + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; L-
CC       tyrosine from prephenate: step 1/2.
CC   -!- SIMILARITY: Contains 1 prephenate/arogenate dehydrogenase domain.
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DR   EMBL; CU329672; CAA19302.1; -; Genomic_DNA.
DR   EMBL; D89213; BAA13874.1; -; mRNA.
DR   PIR; T41005; T41005.
DR   PIR; T43017; T43017.
DR   RefSeq; NP_588529.1; -.
DR   GeneID; 2539274; -.
DR   KEGG; spo:SPCC1494.04c; -.
DR   NMPDR; fig|4896.1.peg.867; -.
DR   GeneDB_Spombe; SPCC1494.04c; -.
DR   OMA; O60078; HVYAGLA.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-000428-MON; -.
DR   BRENDA; 1.3.1.13; 653.
DR   ArrayExpress; O60078; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IMP:GeneDB_SPombe.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IMP:GeneDB_SPombe.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR003099; Prephen_DH.
DR   InterPro; IPR012385; Prephenate_DH_fun.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF02153; PDH; 1.
DR   PIRSF; PIRSF036510; PDH_fung; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase; Tyrosine biosynthesis.
FT   CHAIN         1    431       Probable prephenate dehydrogenase
FT                                [NADP+].
FT                                /FTId=PRO_0000119207.
FT   DOMAIN        5    285       Prephenate/arogenate dehydrogenase.
FT   NP_BIND       5     34       NADP (Potential).
FT   CONFLICT    429    431       QKM -> KKCDFLIAAFCVYNS (in Ref. 2;
FT                                BAA13874).
SQ   SEQUENCE   431 AA;  48906 MW;  C598458426E620D7 CRC64;
     MKETFQVGII GFGDMGRLYA EYISKAGWRV NVCDRPENYE SIQATYGNGG YTVLKDGFQV
     SRTSDYILYS VEAEHIDKVV ALYGPATKVG AIVGGQTSCK APEMNAFEKY LPEDVDIISC
     HSMHGPKVNP KSQPLVIIRH RASDEHFEIV NEILSCFKSS VVYLSAKEHD RITADTQAVT
     HAAFLTMGLA WHANNQYPWE INRWCGGIEN IKMNLSMRIY SSKWHVYAGL AILNPEAQRQ
     IQQYASSVTE LFKLAISGKA KEYEDRIRNA GKFVFGENMD RNSSGLLLSD ELLDQYSISN
     IPKDESKRNS HLSILAIVDS WSKLGIHPQN HMICSTPLFR LWVGVSEYVF RHPGLLDSCI
     YTATKHNDFS PDDLEFVVAV RSWSECVAAK DFTTYKKRFL ETQEYFRPRF EEATRVGNAM
     ISKLLENLQK M
//