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Protein

Putative helicase mug81

Gene

mug81

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in meiosis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi300 – 3078ATPPROSITE-ProRule annotation
Nucleotide bindingi1157 – 11648ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Meiosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative helicase mug81 (EC:3.6.4.-)
Alternative name(s):
Meiotically up-regulated gene 81 protein
Gene namesi
Name:mug81
ORF Names:SPBC13G1.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC13G1.10c.
PomBaseiSPBC13G1.10c. mug81.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19351935Putative helicase mug81PRO_0000102100Add
BLAST

Proteomic databases

MaxQBiO60072.
PRIDEiO60072.

Interactioni

Protein-protein interaction databases

BioGridi276228. 87 interactions.
MINTiMINT-4676948.

Structurei

3D structure databases

ProteinModelPortaliO60072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini287 – 479193Helicase ATP-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini513 – 723211Helicase C-terminal 1PROSITE-ProRule annotationAdd
BLAST
Domaini787 – 1093307SEC63 1Add
BLAST
Domaini1144 – 1319176Helicase ATP-binding 2PROSITE-ProRule annotationAdd
BLAST
Domaini1351 – 1546196Helicase C-terminal 2PROSITE-ProRule annotationAdd
BLAST
Domaini1618 – 1934317SEC63 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi421 – 4244DEVH box
Motifi1261 – 12644DEIH box

Domaini

Composed of two similar domains.

Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.Curated
Contains 2 helicase ATP-binding domains.PROSITE-ProRule annotation
Contains 2 helicase C-terminal domains.PROSITE-ProRule annotation
Contains 2 SEC63 domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000157749.
InParanoidiO60072.
KOiK18664.
OMAiGKIMSYY.
OrthoDBiEOG7XDBQ3.
PhylomeDBiO60072.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
3.40.50.300. 4 hits.
InterProiIPR003593. AAA+_ATPase.
IPR000008. C2_dom.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR027417. P-loop_NTPase.
IPR004179. Sec63-dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 2 hits.
PF00271. Helicase_C. 2 hits.
PF02889. Sec63. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM00487. DEXDc. 2 hits.
SM00490. HELICc. 2 hits.
SM00973. Sec63. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
SSF52540. SSF52540. 5 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 2 hits.
PS51194. HELICASE_CTER. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVELNYVVN HLEKLGPASF CDTPYSFSLS DSNAELGALS LKVDEILKTN
60 70 80 90 100
YNLINPEDVT DSDNNEFALK DLTWLQNCCN EISQSSSTEL DASVLFEAVI
110 120 130 140 150
MSLKATEDQC AIQEDLLNLV GLDHIDLISD IVANSSNLIE EYMNQNDTSI
160 170 180 190 200
AAQLSDGYTS EAGSSATHGQ GLLDSLKSRP RRFSRSRDNR GPLFTGQQVF
210 220 230 240 250
EVEKYPHVYG DKRLGNTISV IGKKFALPAG SEREDYQKYE EIIVPHAQRA
260 270 280 290 300
PQMQGEKLLE ISSMDILCRK TFLSYQTLNR IQSLVYPIAY KTNENMLICA
310 320 330 340 350
PTGAGKTDVA LLAMLQTISN YVESMNLMDE SEPLDVHRDD FKIVYIAPMK
360 370 380 390 400
ALAAEVVEKM GKRLAWLGLK TRELTGDMQL TKTEIAETQI LVTTPEKWDV
410 420 430 440 450
VTRKSVGDTQ LAEKVRLVII DEVHMLHDER GAVIESLVAR TQRLVETSQQ
460 470 480 490 500
MIRIVGLSAT LPNYLDVADF LGVNRYKGLF YFSSAFRPCP IEQHFIGAKG
510 520 530 540 550
SPKIVNSNID EACFDKVLKL IQEGHQVMIF VHSRKETINS AKKLREQFFH
560 570 580 590 600
EGEADLLDNS QHEKYSLAQR DVSKSKNKEL KELFKYSMGI HNAGMLRSDR
610 620 630 640 650
HLTERLFSMG ILKILCCTAT LAWGVNLPAY AVLIKGTQLY DPQKGSFVDL
660 670 680 690 700
GVLDVLQIFG RAGRPQFESS AVAYIITTHD KLSHYISVVT QQSPIESRFT
710 720 730 740 750
DRLVDNLNAE VSLGTVTNID EAVSWLGYTY LYIRMRRNPL VYGIAYDELV
760 770 780 790 800
EDPLLGSKRR ELVSVAAGRL ADNQMIVYNK KNGYLIPKDL GRIASNYYIN
810 820 830 840 850
YQTVSTLNNL LKSKMSEADI IALLSQCSEF SQIKSRENEH RELESLMENS
860 870 880 890 900
SPCQLRDSIS NTSGKVNVIL QSYISRAHVE DFTLTSDTNY VAQNAGRITR
910 920 930 940 950
ALFEIAMSRT WASAFTILSL NKSIDRRQWS FEHPLLQFDL PHDLAVKVEN
960 970 980 990 1000
QCGSLSLEEL SDMSTGELGD LIHNRKMGPT VKKFISKLPL LNINVDLLPL
1010 1020 1030 1040 1050
TKNVLRLVLN ITPNFNWDMR YHGNSQMFWI FVEDSNGLEI LHHEQLLLNK
1060 1070 1080 1090 1100
RNVSTSHLLS FTIPVSNPLP SQLYIIAVSD KWLGAETVTP VSLSNVVFHD
1110 1120 1130 1140 1150
DSNPITELLD LQPLPITALH DPVLEGICAK RFSFFNAVQT QFFHTIYHTD
1160 1170 1180 1190 1200
TNIFVGAPTG SGKTMAAELA TWRALHNYPK SKVVYIAPMK ALVKERVKDW
1210 1220 1230 1240 1250
GHRLVEPMGI SMIELTGDTN PDVKAVTNAN IIITTPEKWD GITRSWKSRK
1260 1270 1280 1290 1300
YVQDVSLIIL DEIHLLGSDR GPVLEMIVSR MNYVASQTNK KVRVLGLSTA
1310 1320 1330 1340 1350
VANANDLANW LNIRDGLFNF RHSVRPVPLE IYIDGFPGRA YCPRMMSMNK
1360 1370 1380 1390 1400
PAFQAIKTHS PTQPVLIFVS SRRQTRLTAK DLIAFCGLED NPRRFLYMDE
1410 1420 1430 1440 1450
EELEMIVSEV EDKSLKLALP FGIALHHAGL TENDRKISEE LFVNNKVQIL
1460 1470 1480 1490 1500
IATSTLAWGV NTPAHLVIVK GTEYYDAKIG GYKDMDLTDV LQMLGRAGRP
1510 1520 1530 1540 1550
QFDNSGVARI FVQDIKKSFY KHFLHSGFPV ESYLHKVLDN HLNAEIATGT
1560 1570 1580 1590 1600
IDCIQGAMDF LTCTYFYRRV HQNPVYYGAD GDDQKSIDTY LSKLVVTAFN
1610 1620 1630 1640 1650
ELEKSACIYR VNEETYAPTT LGRIVSYYYL FHTTIRNFVQ KITENAEFDL
1660 1670 1680 1690 1700
ALQLLAEASE FDDLAIRHNE DLINIEINKS LKYSAACLNL PMVDAHVKAF
1710 1720 1730 1740 1750
ILTQAHMARL KLPVDDYVTD TSTVLDQVIR IIQSYIDVSA ELGYSHVCLQ
1760 1770 1780 1790 1800
YISLMQCLKQ ACYPSEIYRA SLPGLNASSE KEARDYLNKF AGNKTDELYQ
1810 1820 1830 1840 1850
MLCNDPNVFD IESLVNSLIS YPKMNIEVSQ SSSDKLLLYL RRLNQPLNPD
1860 1870 1880 1890 1900
FYIFAPLFPK PQSEGFFVLI IDSETQELFA IRRASFAGRR NDDSIRLSLR
1910 1920 1930
ISMDIPPTCR NRNVKVMVVC DGYPLIYEHK IVLMI
Length:1,935
Mass (Da):218,565
Last modified:August 1, 1998 - v1
Checksum:i0D2C5981BAC5D1CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18663.1.
PIRiT39411.
RefSeqiNP_596560.1. NM_001022481.2.

Genome annotation databases

EnsemblFungiiSPBC13G1.10c.1; SPBC13G1.10c.1:pep; SPBC13G1.10c.
GeneIDi2539673.
KEGGispo:SPBC13G1.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18663.1.
PIRiT39411.
RefSeqiNP_596560.1. NM_001022481.2.

3D structure databases

ProteinModelPortaliO60072.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276228. 87 interactions.
MINTiMINT-4676948.

Proteomic databases

MaxQBiO60072.
PRIDEiO60072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC13G1.10c.1; SPBC13G1.10c.1:pep; SPBC13G1.10c.
GeneIDi2539673.
KEGGispo:SPBC13G1.10c.

Organism-specific databases

EuPathDBiFungiDB:SPBC13G1.10c.
PomBaseiSPBC13G1.10c. mug81.

Phylogenomic databases

HOGENOMiHOG000157749.
InParanoidiO60072.
KOiK18664.
OMAiGKIMSYY.
OrthoDBiEOG7XDBQ3.
PhylomeDBiO60072.

Miscellaneous databases

NextBioi20800827.
PROiO60072.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
3.40.50.300. 4 hits.
InterProiIPR003593. AAA+_ATPase.
IPR000008. C2_dom.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR027417. P-loop_NTPase.
IPR004179. Sec63-dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 2 hits.
PF00271. Helicase_C. 2 hits.
PF02889. Sec63. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM00487. DEXDc. 2 hits.
SM00490. HELICc. 2 hits.
SM00973. Sec63. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
SSF52540. SSF52540. 5 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 2 hits.
PS51194. HELICASE_CTER. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events."
    Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L., Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P., Smith G.R., Moreno S.
    Curr. Biol. 15:2056-2062(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MEIOSIS.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMUG81_SCHPO
AccessioniPrimary (citable) accession number: O60072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.