O60064 (YBB2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable mannose-1-phosphate guanyltransferase
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase
GTP-mannose-1-phosphate guanylyltransferase

Gene names

ORF Names:

SPBC13G1.02

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in cell wall synthesis where it is required for glycosylation By similarity.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Subcellular location	Cytoplasm. Nucleus Ref.2.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	GDP-mannose biosynthetic process Inferred by curator. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Probable mannose-1-phosphate guanyltransferase		PRO_0000311772

Sequences

	Sequence		Length	Mass (Da)
	O60064 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: D0182B33936935A2	FASTA	414	46,096
	10 20 30 40 50 60 MISSAVILVG GPSRGTRFRP LSFDVPKPLF KIGGREMIYH HLAALSKIES VKDVFLVGFY 70 80 90 100 110 120 DESVFKDFIN EVASHFPSFN RIKYLREYNC LGTGGGLYHF RDQILKGHTS NVFVMHADVC 130 140 150 160 170 180 CSFPLQELLN VHHEKKALVT LMATKVSKED ASNFGCLVEE PSTGRVLHYV DKPSSYLSNI 190 200 210 220 230 240 ISCGIYIFDA SIFDEIKKAY ERRLEEVEKQ LRSLDEGMED YLSLETDVLA PLCSDSSKAI 250 260 270 280 290 300 YAYNTPEFWR QIKTAGSAVP ANSLYLQKAY HDGTLPKPDT EAEIIQPVFI HPNAIVSKGA 310 320 330 340 350 360 KIGPNVSIGA RVRIEDGARI RNSIIQEDCE ISANAVVLHS ILSRHCKIGK WSRVEGSPTL 370 380 390 400 410 PSQHSTTIMR NSVKVQAITV MGADCIVHDE VRVQNCLVLP HKEIKVGLVG EIVM

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAA18655.1.
PIR	T39403.
RefSeq	NP_596551.1. NM_001022472.1.
3D structure databases
HSSP	HSSP built from PDB template 1LXA based on UniProtKB P0A722.
ProteinModelPortal	O60064.
ModBase	Search...
Protein-protein interaction databases
STRING	O60064.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPBC13G1.02.1; SPBC13G1.02.1:pep; SPBC13G1.02.
GeneID	2539751.
KEGG	spo:SPBC13G1.02.
NMPDR	fig|4896.1.peg.2417.
Organism-specific databases
GeneDB_Spombe	SPBC13G1.02.
Phylogenomic databases
eggNOG	fuNOG07724.
GeneTree	EFGT00050000003561.
HOGENOM	HBG688195.
OMA	GFVGDMQ.
OrthoDB	EOG4FN7S3.
Gene expression databases
ArrayExpress	O60064.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR005835. NTP_transferase. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YBB2_SCHPO

Accession

Primary (citable) accession number: O60064

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program