Reviewed, UniProtKB/Swiss-Prot O60064 (YBB2_SCHPO)

Names and origin

Protein names

Recommended name:
    Probable mannose-1-phosphate guanyltransferase
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase
    GDP-mannose pyrophosphorylase

Gene names

ORF Names:

SPBC13G1.02

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in cell wall synthesis where it is required for glycosylation By similarity.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Subcellular location	Cytoplasm. Nucleus Ref.2.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	GDP-mannose biosynthetic process Inferred by curator. Source: GeneDB_SPombe
Cellular component	cytosol Ref.2 Inferred from direct assay. Source: GeneDB_SPombe nucleus Ref.2 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Probable mannose-1-phosphate guanyltransferase		PRO_0000311772

Sequences

	Sequence		Length	Mass (Da)
	O60064-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: D0182B33936935A2	FASTA	414	46,096
	10 20 30 40 50 60 MISSAVILVG GPSRGTRFRP LSFDVPKPLF KIGGREMIYH HLAALSKIES VKDVFLVGFY 70 80 90 100 110 120 DESVFKDFIN EVASHFPSFN RIKYLREYNC LGTGGGLYHF RDQILKGHTS NVFVMHADVC 130 140 150 160 170 180 CSFPLQELLN VHHEKKALVT LMATKVSKED ASNFGCLVEE PSTGRVLHYV DKPSSYLSNI 190 200 210 220 230 240 ISCGIYIFDA SIFDEIKKAY ERRLEEVEKQ LRSLDEGMED YLSLETDVLA PLCSDSSKAI 250 260 270 280 290 300 YAYNTPEFWR QIKTAGSAVP ANSLYLQKAY HDGTLPKPDT EAEIIQPVFI HPNAIVSKGA 310 320 330 340 350 360 KIGPNVSIGA RVRIEDGARI RNSIIQEDCE ISANAVVLHS ILSRHCKIGK WSRVEGSPTL 370 380 390 400 410 PSQHSTTIMR NSVKVQAITV MGADCIVHDE VRVQNCLVLP HKEIKVGLVG EIVM

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAA18655.1.
PIR	T39403.
RefSeq	NP_596551.1.
3D structure databases
HSSP	HSSP built from PDB template 1LXA based on UniProtKB P0A722.
ModBase	Search...
Protein-protein interaction databases
STRING	O60064.
Genome annotation databases
GeneID	2539751.
KEGG	spo:SPBC13G1.02.
NMPDR	fig|4896.1.peg.2417.
Organism-specific databases
GeneDB_Spombe	SPBC13G1.02.
Phylogenomic databases
eggNOG	fuNOG07724.
HOGENOM	HBG688195.
OMA	SALHANR.
OrthoDB	EOG9V70ZQ.
PhylomeDB	O60064.
Enzyme and pathway databases
BRENDA	2.7.7.13. 653.
Gene expression databases
ArrayExpress	O60064.
Family and domain databases
InterPro	IPR005835. NTP_transferase. IPR011004. Trimer_LpxA-like. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YBB2_SCHPO

Accession

Primary (citable) accession number: O60064

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	August 1, 1998
Last modified:	January 19, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)