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Protein

Homoserine O-acetyltransferase

Gene

met6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (met6)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei163NucleophileBy similarity1
Active sitei403By similarity1
Active sitei432By similarity1

GO - Molecular functioni

GO - Biological processi

  • homoserine metabolic process Source: PomBase
  • methionine biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.

Protein family/group databases

ESTHERischpo-met2. AlphaBeta_hydrolase.
MEROPSiS33.A41.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferase (EC:2.3.1.31)
Alternative name(s):
Homoserine O-trans-acetylase
Gene namesi
Name:met6
ORF Names:SPBC56F2.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

PomBaseiSPBC56F2.11. met6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001557561 – 489Homoserine O-acetyltransferaseAdd BLAST489

Proteomic databases

MaxQBiO60062.
PRIDEiO60062.

Interactioni

Protein-protein interaction databases

MINTiMINT-4676856.

Structurei

3D structure databases

ProteinModelPortaliO60062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 438AB hydrolase-1Sequence analysisAdd BLAST370

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. HTA family.Curated

Phylogenomic databases

HOGENOMiHOG000246301.
InParanoidiO60062.
OrthoDBiEOG092C22L6.
PhylomeDBiO60062.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

O60062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQSPIESI VFTDSCHPSQ QENKFVQLIS DQKIAIVPKF TLECGDILYD
60 70 80 90 100
VPVAFKTWGT LNKEGNNCLL LCHALSGSAD AGDWWGPLLG PGRAFDPSHF
110 120 130 140 150
FIVCLNSLGS PYGSASPVTW NAETHSVYGP EFPLATIRDD VNIHKLILQR
160 170 180 190 200
LGVKQIAMAV GGSMGGMLVL EWAFDKEFVR SIVPISTSLR HSAWCISWSE
210 220 230 240 250
AQRQSIYSDP KFNDGYYGID DQPVSGLGAA RMSALLTYRS KCSFERRFAR
260 270 280 290 300
TVPDASRHPY PDRLPTPLTP SNAHWVVHNE GNRNRRERPC RSNGSSPTSE
310 320 330 340 350
SALNSPASSV SSLPSLGASQ TTDSSSLNQS SLLRRPANTY FSAQSYLRYQ
360 370 380 390 400
AKKFVSRFDA NCYISITKKL DTHDITRGRG SDSPKEVMKD LSLPVLVLGI
410 420 430 440 450
ESDGLFTFDE QVEIAKSFPN ATLEKIISAE GHDGFLLEFT QVNSHIQKFQ
460 470 480
KEHLIDIMSQ TNSFERLDSQ VNDTNRESVF GEMEDITSW
Length:489
Mass (Da):54,311
Last modified:August 1, 1998 - v1
Checksum:i46B95C30A099041E
GO

Sequence cautioni

The sequence CAA18890 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223985 Genomic DNA. Translation: CAA11759.1.
CU329671 Genomic DNA. Translation: CAA18890.2. Sequence problems.
PIRiT43422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223985 Genomic DNA. Translation: CAA11759.1.
CU329671 Genomic DNA. Translation: CAA18890.2. Sequence problems.
PIRiT43422.

3D structure databases

ProteinModelPortaliO60062.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4676856.

Protein family/group databases

ESTHERischpo-met2. AlphaBeta_hydrolase.
MEROPSiS33.A41.

Proteomic databases

MaxQBiO60062.
PRIDEiO60062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

PomBaseiSPBC56F2.11. met6.

Phylogenomic databases

HOGENOMiHOG000246301.
InParanoidiO60062.
OrthoDBiEOG092C22L6.
PhylomeDBiO60062.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.

Miscellaneous databases

PROiO60062.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMET2_SCHPO
AccessioniPrimary (citable) accession number: O60062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.