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Protein

Dolichyl-phosphate beta-glucosyltransferase

Gene

alg5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • dolichyl-phosphate beta-glucosyltransferase activity Source: PomBase
  • transferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-SPO-480985 Synthesis of dolichyl-phosphate-glucose
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-phosphate beta-glucosyltransferase (EC:2.4.1.117)
Short name:
DolP-glucosyltransferase
Alternative name(s):
Asparagine-linked glycosylation protein 5
Gene namesi
Name:alg5
ORF Names:SPBC56F2.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC56F2.10c
PomBaseiSPBC56F2.10c alg5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicBy similarity1
Transmembranei2 – 22Helical; Signal-anchor for type II membrane proteinAdd BLAST21
Topological domaini23 – 322LumenalBy similarityAdd BLAST300

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003117591 – 322Dolichyl-phosphate beta-glucosyltransferaseAdd BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60061
PaxDbiO60061
PRIDEiO60061

Interactioni

Protein-protein interaction databases

BioGridi277568, 52 interactors
STRINGi4896.SPBC56F2.10c.1

Structurei

3D structure databases

ProteinModelPortaliO60061
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000283250
InParanoidiO60061
KOiK00729
OMAiLTPFWSW
OrthoDBiEOG092C4EMU
PhylomeDBiO60061

Family and domain databases

CDDicd04188 DPG_synthase, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR035518 DPG_synthase
IPR001173 Glyco_trans_2-like
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00535 Glycos_transf_2, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

O60061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVYIVLYTC LAGFILLFLV YYYLTHSHCP RKQLEGEETC VFIENGQKKS
60 70 80 90 100
LTLEKWSTSD NIQITVIVPA YNESKRIGNM LQETVDHLEK YYRSSSSAGQ
110 120 130 140 150
RRWEILIVDD ESKDTTVNAV LEFSNKLDLR DHLRVCSLKR NRGKGGAVTW
160 170 180 190 200
GMLYARGQYA IFADADGASQ FSDLELLFKN MPPGPRGGVV VGSRAHMVNT
210 220 230 240 250
AAVVKRSFIR NFLMHCFHKL LQILGIREIG DTQCGFKLFS REAYQSIFPR
260 270 280 290 300
MHVEGWIFDI EVLTLARFFG LPIIEVPITW HEVGGSKMTL LKDSISMAID
310 320
LLVIRLNYTF GIWERPSAKR IT
Length:322
Mass (Da):36,774
Last modified:August 1, 1998 - v1
Checksum:iB97B2EF2C8D872C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA18889.1
PIRiT40534
RefSeqiNP_596707.1, NM_001022632.2

Genome annotation databases

EnsemblFungiiSPBC56F2.10c.1; SPBC56F2.10c.1:pep; SPBC56F2.10c
GeneIDi2541053
KEGGispo:SPBC56F2.10c

Similar proteinsi

Entry informationi

Entry nameiALG5_SCHPO
AccessioniPrimary (citable) accession number: O60061
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health