O60058 (AFG2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATPase family gene 2 protein

Gene names

Name:	afg2
ORF Names:	SPBC56F2.07c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	809 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm Ref.2.
Sequence similarities	Belongs to the AAA ATPase family. AFG2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ribosomal large subunit biogenesis Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 809	809	ATPase family gene 2 protein		PRO_0000310282
Regions
	Nucleotide binding	320 – 327	8	ATP 1 Potential
	Nucleotide binding	589 – 596	8	ATP 2 Potential

Sequences

	Sequence		Length	Mass (Da)
	O60058 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: C32BED83A7F876B8	FASTA	809	88,472
	10 20 30 40 50 60 MSVAIKFTVK INDGSLRRQQ TRHVFLSPAA LNRLKLSPSQ VIYLKHKGGE AVGITQSVKG 70 80 90 100 110 120 NGIGPFEILI SPLLAKWANL KAFQRVNISQ YVHPLKEAEG IKIVASLSSN NEPIPESLIR 130 140 150 160 170 180 KELLEIRYLH PGMIVMGESP MNMAKSGSKN LSSENMATEI FEINSGLSAQ SGTEVGSSQS 190 200 210 220 230 240 SPSVNESEPK ATEDLDELSP GSYKVKEIHI RSPSNLIEAI SDMSLDEPRI YKFTAASSME 250 260 270 280 290 300 IETPDLLKLP HEDRTQSAYN QGSEETQNFD GPPSAVTFSS IGGLQAQIAQ IRDIVELPFQ 310 320 330 340 350 360 NPELFKFFNI MPPRGVLLYG PPGTGKTMVM RAVAAEANAQ VFTIDGPSVV GKYLGETESR 370 380 390 400 410 420 LRKIFEDARA HQPSIIFIDE IDALAPKRTE DVSEAESRAV ATLLTLLDGM ANAGKVVVIA 430 440 450 460 470 480 ATNRPNSIDE ALRRPGRLEK EIEIGIPDKS ARLDIIKLLL SGVPNEINDA QLEDLASRTH 490 500 510 520 530 540 AYVGADLAAV VREAALRAIK RTISLQKDTS GLDIFGAVQM DDLEFALSSV RQSAMREFMM 550 560 570 580 590 600 ESPNVHWSDI GGQEEVKQKL KESVEWPLTH GETFSRLGVR PPKGVLLYGP PGCSKTITAK 610 620 630 640 650 660 AIATETGLNF IAVKGPELFD KFVGESERAV RQVFQKARQA SPSVIFFDEI DALTANRGED 670 680 690 700 710 720 NSSDRVVAAL LNELDGIEAL RNVLVLAATN RPDMIDPALM RPGRLDRLLY VGPPNFEARK 730 740 750 760 770 780 QIVKIQAEKM KFAEDVDLDL IAEKTEGCSG AEVVALCQEA GLIAMHEDLE AKEICQAHFK 790 800 TALLALRKAI TRDMLEYYAS FSESVTSIS

References

[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAA18886.1.
PIR	T40537.
RefSeq	NP_596710.1. NM_001022635.1.
3D structure databases
HSSP	HSSP built from PDB template 1YPW based on UniProtKB Q01853.
ProteinModelPortal	O60058.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPBC56F2.07c.1; SPBC56F2.07c.1:pep; SPBC56F2.07c.
GeneID	2540537.
GenomeReviews	Gene locus afg2 in contig CU329671_GR.
KEGG	spo:SPBC56F2.07c.
NMPDR	fig|4896.1.peg.2576.
Organism-specific databases
GeneDB_Spombe	SPBC56F2.07c.
Phylogenomic databases
eggNOG	fuNOG07751.
GeneTree	EFGT00050000000010.
HOGENOM	HBG597299.
OMA	CVANEND.
OrthoDB	EOG49CTH0.
Gene expression databases
ArrayExpress	O60058.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. [Graphical view]
KO	K14575.
Pfam	PF00004. AAA. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00674. AAA. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AFG2_SCHPO

Accession

Primary (citable) accession number: O60058

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program