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O60052 (FNTA_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
EC=2.5.1.58
EC=2.5.1.59
Alternative name(s):
CAAX farnesyltransferase subunit alpha
FTase-alpha
Ras proteins prenyltransferase subunit alpha
Type I protein geranyl-geranyltransferase subunit alpha
Short name=GGTase-I-alpha
Gene names
Name:cwp1
ORF Names:SPAPB1A10.04c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Ref.1

Catalytic activity

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Subunit structure

Heterodimer of an alpha and a beta subunit. Ref.1

Sequence similarities

Belongs to the protein prenyltransferase subunit alpha family.

Contains 5 PFTA repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
PRO_0000119753

Regions

Repeat57 – 9135PFTA 1
Repeat92 – 12534PFTA 2
Repeat126 – 16035PFTA 3
Repeat161 – 19434PFTA 4
Repeat199 – 23335PFTA 5

Sequences

Sequence LengthMass (Da)Tools
O60052 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 840889770F11451E

FASTA29434,876
        10         20         30         40         50         60 
MDPIDPELNE ILDFTEYGPL TPIPQDDGEN PLAKICYTTG YEQGMAYFRA IMAKKEYSLR 

        70         80         90        100        110        120 
ALNLTGFLIM NNPAHYTVWA YRFQILNHTP SYIDNELEWL DEIAEDFQKN YQVWHHRQKI 

       130        140        150        160        170        180 
LSLTKNYERE LEFTKKMFEI DSKNYHVWSY RVWILQNFND YSQELKLTNE LLEKDIYNNS 

       190        200        210        220        230        240 
AWNHRFYVLF ETSKVVSWSL EEELNYLKDK ILFAPDNQSA WNYLCGVLDK SGPSKLDNLI 

       250        260        270        280        290 
ANLRKNLPAL HKPLLEFLAM YEPSSSEEIY QKLANEVDVP HAALWTWMSQ RSNP

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe."
Arellano M., Coll P.M., Yang W., Duran A., Tamanoi F., Perez P.
Mol. Microbiol. 29:1357-1367(1998) [PubMed: 9781874] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT.
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ223304 Genomic DNA. Translation: CAA11246.1.
CU329670 Genomic DNA. Translation: CAC21477.1.
RefSeqNP_593518.1. NM_001018952.1.

3D structure databases

ProteinModelPortalO60052.
ModBaseSearch...

Protein-protein interaction databases

STRINGO60052.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAPB1A10.04c.1; SPAPB1A10.04c.1:pep; SPAPB1A10.04c.
GeneID2543143.
GenomeReviewsGene locus cwp1 in contig CU329670_GR.
KEGGspo:SPAPB1A10.04c.
NMPDRfig|4896.1.peg.3488.

Organism-specific databases

GeneDB_SpombeSPAPB1A10.04c.

Phylogenomic databases

eggNOGfuNOG08714.
GeneTreeEFGT00050000004025.
OMAFNNSAWN.
OrthoDBEOG43NBNJ.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-001199-MONOMER.

Gene expression databases

ArrayExpressO60052.

Family and domain databases

InterProIPR002088. Prenyl_trans_a.
IPR008940. Prenyltransferase.
[Graphical view]
Gene3DG3DSA:1.25.40.120. Prenyl_trans. 1 hit.
KOK05955.
PfamPF01239. PPTA. 5 hits.
[Graphical view]
PROSITEPS51147. PFTA. 5 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFNTA_SCHPO
AccessionPrimary (citable) accession number: O60052
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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