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Protein

FK506-binding protein 2

Gene

fkr-5

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 2 (EC:5.2.1.8)
Short name:
FKBP2
Alternative name(s):
FK506-resistance protein 5
NcFKBP22
Peptidyl-prolyl cis-trans isomerase fkr-5
Short name:
PPIase fkr-5
Gene namesi
Name:fkr-5
ORF Names:NCU02455
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 7, Linkage Group VII

Organism-specific databases

EuPathDBiFungiDB:NCU02455.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000002551121 – 217FK506-binding protein 2Add BLAST197

Interactioni

Protein-protein interaction databases

IntActiO60046. 5 interactors.
MINTiMINT-4653629.

Structurei

3D structure databases

ProteinModelPortaliO60046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 129PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi214 – 217Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiO60046.
OrthoDBiEOG092C52SD.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSIFLSLSL LASATVGVLA AEELGIDVTV PVECDRKTRK GDKINVHYRG
60 70 80 90 100
TLQSNGQQFD ASYDRGTPFS FKLGGGQVIK GWDEGLVDMC IGEKRTLTVP
110 120 130 140 150
PSYGYGQRSI GPIPAGSTLI FETELIGIDG VPKPESIVYK QAAEKAEEAA
160 170 180 190 200
SAVEEKVAEA TDKAGGKIAD ATKKVEEKAE EASANVVEKV ASVVSGAAEA
210
VKTVVADTDD VQEHNEL
Length:217
Mass (Da):22,915
Last modified:August 1, 1998 - v1
Checksum:i72313067521BCDAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006297 mRNA. Translation: CAA06962.1.
CM002242 Genomic DNA. Translation: EAA30274.3.
RefSeqiXP_959510.3. XM_954417.3.

Genome annotation databases

EnsemblFungiiEAA30274; EAA30274; NCU02455.
GeneIDi3875657.
KEGGincr:NCU02455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006297 mRNA. Translation: CAA06962.1.
CM002242 Genomic DNA. Translation: EAA30274.3.
RefSeqiXP_959510.3. XM_954417.3.

3D structure databases

ProteinModelPortaliO60046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO60046. 5 interactors.
MINTiMINT-4653629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA30274; EAA30274; NCU02455.
GeneIDi3875657.
KEGGincr:NCU02455.

Organism-specific databases

EuPathDBiFungiDB:NCU02455.

Phylogenomic databases

InParanoidiO60046.
OrthoDBiEOG092C52SD.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP2_NEUCR
AccessioniPrimary (citable) accession number: O60046
Secondary accession number(s): Q7S451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.