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Protein

Peptidyl-prolyl cis-trans isomerase ssp-1

Gene

ssp-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Site-specific PPIase with respect to the amino acid N-terminal to the proline residue. Peptides with glutamate, phosphoserine, or phosphothreonine in the -1 position are the best substrates. It is not only able to isomerize small peptides but is also active in protein folding.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase ssp-1 (EC:5.2.1.8)
Short name:
PPIase ssp-1
Gene namesi
Name:ssp-1
ORF Names:NCU08554
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 3, Linkage Group III

Organism-specific databases

EuPathDBiFungiDB:NCU08554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Peptidyl-prolyl cis-trans isomerase ssp-1PRO_0000193434Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO60045.
SMRiO60045. Positions 5-55, 72-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 4135WWPROSITE-ProRule annotationAdd
BLAST
Domaini71 – 182112PpiCPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 7112Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 PpiC domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000275331.
InParanoidiO60045.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG092C4TRA.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS50198. PPIC_PPIASE_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTIETGLP EDWEVRHSQS KNLPYYFNSA TKTSRWEPPS GTDVDKLKIY
60 70 80 90 100
MAKYHSPTSQ QQQQQQQQQP QGKIRCAHLL VKHNQSRRPS SWRESEITRT
110 120 130 140 150
KQEALTTLQG FEQRIKSGSI SLGELALTES DCSSARKRGD LGYFGRGDMQ
160 170 180
KEFEDAAFAL KPGEISGIVD TASGLHLIER LE
Length:182
Mass (Da):20,615
Last modified:December 4, 2007 - v3
Checksum:i111D0497DFFF733A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671G → D in CAA06818 (PubMed:9822668).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006023 mRNA. Translation: CAA06818.1.
CM002238 Genomic DNA. Translation: EAA33800.2.
RefSeqiXP_963036.2. XM_957943.3.

Genome annotation databases

EnsemblFungiiEFNCRT00000004618; EFNCRP00000004618; EFNCRG00000004612.
GeneIDi3879175.
KEGGincr:NCU08554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006023 mRNA. Translation: CAA06818.1.
CM002238 Genomic DNA. Translation: EAA33800.2.
RefSeqiXP_963036.2. XM_957943.3.

3D structure databases

ProteinModelPortaliO60045.
SMRiO60045. Positions 5-55, 72-182.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000004618; EFNCRP00000004618; EFNCRG00000004612.
GeneIDi3879175.
KEGGincr:NCU08554.

Organism-specific databases

EuPathDBiFungiDB:NCU08554.

Phylogenomic databases

HOGENOMiHOG000275331.
InParanoidiO60045.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG092C4TRA.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS50198. PPIC_PPIASE_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSP1_NEUCR
AccessioniPrimary (citable) accession number: O60045
Secondary accession number(s): Q7RVY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.