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O60037

- 6PGD_CUNEL

UniProt

O60037 - 6PGD_CUNEL

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

6-PGD

Organism
Cunninghamella elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei105 – 1051NADPBy similarity
    Binding sitei105 – 1051SubstrateBy similarity
    Active sitei186 – 1861Proton acceptorBy similarity
    Active sitei193 – 1931Proton donorBy similarity
    Binding sitei194 – 1941SubstrateBy similarity
    Binding sitei263 – 2631Substrate; via amide nitrogenBy similarity
    Binding sitei290 – 2901SubstrateBy similarity
    Binding sitei449 – 4491Substrate; shared with dimeric partnerBy similarity
    Binding sitei455 – 4551Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176NADPBy similarity
    Nucleotide bindingi35 – 373NADPBy similarity
    Nucleotide bindingi77 – 793NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:6-PGD
    OrganismiCunninghamella elegans
    Taxonomic identifieri4853 [NCBI]
    Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesCunninghamellaceaeCunninghamella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4854856-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090073Add
    BLAST

    Proteomic databases

    PRIDEiO60037.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO60037.
    SMRiO60037. Positions 4-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni131 – 1333Substrate bindingBy similarity
    Regioni189 – 1902Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60037-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEAVADIGL IGLAVMGQNL ILNMNDHGFV VCAYNRTTSK VDDFLANEAK    50
    GTNVVGAHSV EELCAKLKRP RKVMLLVKAG SAVDAFIDQL LPHLEEGDII 100
    IDGGNSHFPD SIRRTKELEA KGILFVGSGV SGGEEGARYG PSLMPGGNSK 150
    AWEHIQPIFQ AIAAKAPDGA SCCEWVGETG AGHYVKMVHN GIEYGDMQLI 200
    TEVYQILHEG LGLSHDEMAD IFEEWNKGDL DSFLIEITRD ILRFKDTDGQ 250
    PLVTKIRDTA GQKGTGKWTA IDSLDRGIPV TLIGEAVYSR CLSSLKDERV 300
    RASKILQGPS SSKFTGDKKT FIAQLGQALY AAKIVSYAQG YMLMRQAAKD 350
    YEWKLNNAGI ALMWRGGCII RSVFLGKIRD AYTKNPELEN LLFDDFFKDA 400
    TAKAQDAWRN VTAQAVLMGI PTPALSTALN FYDGLRHEIL PANLLQAQRD 450
    YFGAHTYELL HTPGKWVHTN WTGRGGNVSA STYDA 485
    Length:485
    Mass (Da):53,102
    Last modified:August 1, 1998 - v1
    Checksum:iF7E6DDFF3D21EFB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17297 mRNA. Translation: CAA76734.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17297 mRNA. Translation: CAA76734.1 .

    3D structure databases

    ProteinModelPortali O60037.
    SMRi O60037. Positions 4-476.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O60037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and sequencing of a cDNA encoding 6-phosphogluconate dehydrogenase from a fungus, Cunninghamella elegans and expression of the gene in Escherichia coli."
      Wang R.F., Khan A.A., Cao W.W., Cerniglia C.E.
      FEMS Microbiol. Lett. 169:397-402(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ATCC 36112 / DSM 8217.

    Entry informationi

    Entry namei6PGD_CUNEL
    AccessioniPrimary (citable) accession number: O60037
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3