Reviewed,
UniProtKB/Swiss-Prot O60037 (6PGD_CUNEL)
Last modified
June 16, 2009.
Version 50.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: 6-phosphogluconate dehydrogenase, decarboxylating EC=1.1.1.44 | ||
| Gene names |
| ||
| Organism | Cunninghamella elegans | ||
| Taxonomic identifier | 4853 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Cunninghamellaceae › Cunninghamella |
Protein attributes
| Sequence length | 485 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. |
| Pathway | |
| Sequence similarities | Belongs to the 6-phosphogluconate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pentose shunt |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shuntInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 485 | 485 | 6-phosphogluconate dehydrogenase, decarboxylating | PRO_0000090073 | |||
Sequences
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References
| [1] | "Identification and sequencing of a cDNA encoding 6-phosphogluconate dehydrogenase from a fungus, Cunninghamella elegans and expression of the gene in Escherichia coli." Wang R.F., Khan A.A., Cao W.W., Cerniglia C.E. FEMS Microbiol. Lett. 169:397-402(1998) [PubMed: 9868787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 36112 / DSM 8217. |
Cross-references
Sequence databases | |
|---|---|
| Y17297 mRNA. Translation: CAA76734.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 2PGD based on UniProtKB P00349. |
| SMR | O60037. Positions 4-476. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.44. 2421. |
Family and domain databases | |
| InterPro | IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view] |
| PRINTS | PR00076. 6PGDHDRGNASE. |
| TIGRFAMs | TIGR00873. gnd. 1 hit. |
| PROSITE | PS00461. 6PGD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | 6PGD_CUNEL | ||||||||
| Accession | Primary (citable) accession number: O60037 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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