Reviewed, UniProtKB/Swiss-Prot O60024 (ALL4_ASPFU)

Names and origin

Protein names

Recommended name:
    Allergen Asp f 4
Alternative name(s):
    Allergen=Asp f 4

Gene names

ORF Names:

AFUA_2G03830

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted Probable.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 322	302	Allergen Asp f 4		PRO_0000043341
Experimental info
	Sequence conflict	37	1	R → G in CAA04959. Ref.2
	Sequence conflict	247	1	Q → H in CAA04959. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O60024-1 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 7EE283EB0E444EF0	FASTA	322	34,085
	10 20 30 40 50 60 MQLKNSMLLL TALAAGSSVA RLHGHERRHL HHAGEKREVG DTVYATINGV LVSWINEWSG 70 80 90 100 110 120 EAKTSDAPVS QATPVSNAVA AAAAASTPEP SSSHSDSSSS SGVSADWTNT PAEGEYCTDG 130 140 150 160 170 180 FGGRTEPSGS GIFYKGNVGK PWGSNIIEVS PENAKKYKHV AQFVGSDTDP WTVVFWNKIG 190 200 210 220 230 240 PDGGLTGWYG NSALTLHLEA GETKYVAFDE NSQGAWGAAK GDELPKDQFG GYSCTWGEFD 250 260 270 280 290 300 FDSKINQGWS GWDVSAIQAE NAHHEVQGMK ICNHAGELCS IISHGLSKVI DAYTADLAGV 310 320 DGIGGKVVPG PTRLVVNLDY KE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.
[2]	"Diagnosis of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis by IgE-specific serology with recombinant Aspergillus fumigatus allergens." Hemmann S., Nikolaizik W.H., Schoeni M.H., Blaser K., Crameri R. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-322. Strain: ATCC 42202 / AF-102 / Ag 507.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAHF01000008 Genomic DNA. Translation: EAL87477.1. AJ001732 mRNA. Translation: CAA04959.1.
RefSeq	XP_749515.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3506748.
KEGG	afm:AFUA_2G03830.
Phylogenomic databases
OMA	TVANIAY
OrthoDB	EOG9SFBP2
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ALL4_ASPFU

Accession

Primary (citable) accession number: O60024
Secondary accession number(s): Q4WHX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	December 6, 2005
Last modified:	November 24, 2009
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)