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Protein

Allergen Asp f 15

Gene

AFUA_2G12630

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Allergen Asp f 15
Alternative name(s):
Allergen Asp f 13
Allergen: Asp f 15
Gene namesi
ORF Names:AFUA_2G12630
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiFungiDB:Afu2g12630.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3112. Asp f 15.0101.
67. Asp f 15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 152133Allergen Asp f 15PRO_0000004998Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 90By similarity
Disulfide bondi93 ↔ 148By similarity

Keywords - PTMi

Disulfide bond

Family & Domainsi

Sequence similaritiesi

Belongs to the cerato-platanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000164856.
InParanoidiO60022.
OMAiKFPYIGG.
OrthoDBiEOG72RN9Q.

Family and domain databases

InterProiIPR010829. Cerato-platanin.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF07249. Cerato-platanin. 1 hit.
[Graphical view]
SUPFAMiSSF50685. SSF50685. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTTPISLI SLFVSSALAA PTPENEARDA IPVSVSYDPR YDNAGTSMND
60 70 80 90 100
VSCSNGVNGL VTKWPTFGSV PGFARIGGAP TIPGWNSPNC GKCYKLQYEQ
110 120 130 140 150
NTIYVTAIDA APGGFNIATS AMDQLTNGMA VELGRVQATY EEADPSHCAS

GV
Length:152
Mass (Da):15,944
Last modified:August 1, 1998 - v1
Checksum:i5516BEBA23653CB5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411Y → RD AA sequence (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002026 mRNA. Translation: CAA05149.1.
AAHF01000001 Genomic DNA. Translation: EAL93557.1.
RefSeqiXP_755595.1. XM_750502.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00004138; CADAFUAP00004138; CADAFUAG00004138.
GeneIDi3512975.
KEGGiafm:AFUA_2G12630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002026 mRNA. Translation: CAA05149.1.
AAHF01000001 Genomic DNA. Translation: EAL93557.1.
RefSeqiXP_755595.1. XM_750502.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3112. Asp f 15.0101.
67. Asp f 15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00004138; CADAFUAP00004138; CADAFUAG00004138.
GeneIDi3512975.
KEGGiafm:AFUA_2G12630.

Organism-specific databases

EuPathDBiFungiDB:Afu2g12630.

Phylogenomic databases

HOGENOMiHOG000164856.
InParanoidiO60022.
OMAiKFPYIGG.
OrthoDBiEOG72RN9Q.

Family and domain databases

InterProiIPR010829. Cerato-platanin.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF07249. Cerato-platanin. 1 hit.
[Graphical view]
SUPFAMiSSF50685. SSF50685. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel allergen of Aspergillus fumigatus (rAsp f 13) shares homology with a 19 kD antigen of Coccidioides immitis."
    Hemmann S., Blaser K., Crameri R.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 42202 / AF-102 / Ag 507.
  2. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.
  3. Sarma P.U., Gupta T.M., Fairwell T.
    Submitted (DEC-1999) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 29-49.
    Strain: AF-285 / Indian isolate.

Entry informationi

Entry nameiAL15_ASPFU
AccessioniPrimary (citable) accession number: O60022
Secondary accession number(s): P82261, Q4X0Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.