O60022 (AL15_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Allergen Asp f 15

Alternative name(s):
Allergen Asp f 13
Allergen=Asp f 15

Gene names

ORF Names:

AFUA_2G12630

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the cerato-platanin family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 152	133	Allergen Asp f 15		PRO_0000004998
Amino acid modifications
	Disulfide bond	53 ↔ 90		By similarity
	Disulfide bond	93 ↔ 148		By similarity
Experimental info
	Sequence conflict	41	1	Y → RD AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O60022 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 5516BEBA23653CB5	FASTA	152	15,944
	10 20 30 40 50 60 MKFTTPISLI SLFVSSALAA PTPENEARDA IPVSVSYDPR YDNAGTSMND VSCSNGVNGL 70 80 90 100 110 120 VTKWPTFGSV PGFARIGGAP TIPGWNSPNC GKCYKLQYEQ NTIYVTAIDA APGGFNIATS 130 140 150 AMDQLTNGMA VELGRVQATY EEADPSHCAS GV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel allergen of Aspergillus fumigatus (rAsp f 13) shares homology with a 19 kD antigen of Coccidioides immitis." Hemmann S., Blaser K., Crameri R. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 42202 / AF-102 / Ag 507.
[2]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.
[3]	Sarma P.U., Gupta T.M., Fairwell T. Submitted (DEC-1999) to UniProtKB Cited for: PROTEIN SEQUENCE OF 29-49. Strain: AF-285 / Indian isolate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ002026 mRNA. Translation: CAA05149.1. AAHF01000001 Genomic DNA. Translation: EAL93557.1.
RefSeq	XP_755595.1. XM_750502.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O60022.
Protein family/group databases
Allergome	3112. Asp f 15.0101. 67. Asp f 15.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFUAT00004138; CADAFUAP00004138; CADAFUAG00004138.
GeneID	3512975.
KEGG	afm:AFUA_2G12630.
Phylogenomic databases
eggNOG	fuNOG12453.
GeneTree	EFGT00050000006250.
HOGENOM	HBG330631.
OrthoDB	EOG4XWK7F.
Family and domain databases
InterPro	IPR009009. Barwin-related_endoglucanase. IPR010829. Cerato-platanin. [Graphical view]
Pfam	PF07249. Cerato-platanin. 1 hit. [Graphical view]
SUPFAM	SSF50685. Barwin_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AL15_ASPFU

Accession

Primary (citable) accession number: O60022
Secondary accession number(s): P82261, Q4X0Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program