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O60011 (ACS1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase 1
EC=6.2.1.1
Alternative name(s):
Acetate--CoA ligase 1
Acyl-activating enzyme 1
Gene names
Name:ACS1
Ordered Locus Names:KLLA0A03333g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be required for assimilation of ethanol and acetate.

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Subcellular location

Microsome Potential. Endoplasmic reticulum Potential.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence caution

The sequence AAC16713.1 differs from that shown. Reason: Frameshift at position 9.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Microsome
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

microsome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 707707Acetyl-coenzyme A synthetase 1
PRO_0000208414

Regions

Motif705 – 7073Microbody targeting signal Potential

Experimental info

Sequence conflict687 – 70721GDVST…DSVKL → ATSPHYPTLVSLST in AAC16713. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O60011 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: 9663996B9AD44C91

FASTA70778,420
        10         20         30         40         50         60 
MSPAVDTAST AKDPISVMKS NASAAAADQI KTHEYEHLTS VPIVQPLPIT DRLSSEAAQK 

        70         80         90        100        110        120 
YKPNLPGGFE EYKSLHKESL ENPAKFYHER AQLLNWFKPY DQVFIPDTEG KPTFENNAWF 

       130        140        150        160        170        180 
TNGQLNACYN LVDRHAFTQP NKVAILYEAD EPGQGYSLTY AELLEQVCKV AQILQYSMNV 

       190        200        210        220        230        240 
KKGDTVAVYM PMIPQALITL LAITRIGAIH SVVFAGFSSN SLRDRINDAY SKTVITTDES 

       250        260        270        280        290        300 
KRGGKTIETK RIVDEALKDT PQVTNVLVFK RTHNENIKYI PGRDLDWDEE VKKYKSYTPC 

       310        320        330        340        350        360 
EPVDSEHPLF LLYTSGSTGA PKGVQHSTAG YLLQALLSMK YTFDIQNDDI FFTAGDIGWI 

       370        380        390        400        410        420 
TGHTYCVYGP LLQGCTTLVF EGTPAYPNFS RYWEIVDKYQ VTQFYVAPTA LRLLKRAGDS 

       430        440        450        460        470        480 
FTEGFSLKSL RSLGSVGEPI AAEVWEWYSE KIGKNELPIV DTYWQTESGS HLVTPLAGGA 

       490        500        510        520        530        540 
TPMKPGAAAF PFFGIDLAVL DPTTGIEQTG EHAEGVLAIK RPWPSFARTI WKNNDRFLDT 

       550        560        570        580        590        600 
YLKPYPGYYF TGDGVARDKD GFFWILGRVD DVVNVSGHRL STAEIEAAII EDDMVAECAV 

       610        620        630        640        650        660 
VGFNDELTGQ AVAAFVVLKN KSSLTAASES ELQDIKKHLI ITVRKDIGPF AAPKLIVLVD 

       670        680        690        700 
DLPKTRSGKI MRRILRKILA GESDQLGDVS TLSNPGIVKH LIDSVKL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF061265 Genomic DNA. Translation: AAC16713.1. Frameshift.
CR382121 Genomic DNA. Translation: CAH02734.1.
RefSeqXP_451146.1. XM_451146.1.

3D structure databases

ProteinModelPortalO60011.
SMRO60011. Positions 70-707.
ModBaseSearch...

Protein-protein interaction databases

STRINGO60011.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896335.
GenomeReviewsGene locus KLLA0A03333g in contig CR382121_GR.
KEGGkla:KLLA0A03333g.

Phylogenomic databases

eggNOGfuNOG05220.
HOGENOMHBG547964.
OMARTHNENI.
OrthoDBEOG4M0J8W.

Family and domain databases

InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACS1_KLULA
AccessionPrimary (citable) accession number: O60011
Secondary accession number(s): Q6CY43
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 27, 2004
Last modified: December 14, 2011
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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