Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock protein 60, mitochondrial

Gene

HSP60

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 60, mitochondrial
Alternative name(s):
60 kDa chaperonin
Protein Cpn60
Gene namesi
Name:HSP60
ORF Names:PAAG_08059
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisParacoccidioides
Proteomesi
  • UP000002059 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 592Heat shock protein 60, mitochondrialPRO_0000005042
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiO60008.

Interactioni

Protein-protein interaction databases

STRINGi502779.XP_002789992.1.

Structurei

3D structure databases

ProteinModelPortaliO60008.
SMRiO60008. Positions 39-567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
KOiK04077.
OrthoDBiEOG092C1JWK.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAFTSSRA SVLSSASSTR APLSRFRSAG VGLQQQRFAH KELKFGVEAR
60 70 80 90 100
ASLLKGIDTL AKAVTTTLGP KGRNVLIESP YGSPKITKDG VTVAKAVTLQ
110 120 130 140 150
DKFENLGARL LQDVASKTNE VAGDGTTTAT VLARAIFSET VKNVAAGCNP
160 170 180 190 200
MDLRRGIQSA VEAVVEYLQT NKRDITTTEE IAQVATISAN GDTHVGKLIS
210 220 230 240 250
NAMEKVGKEG VITVKDGKTI DDELEVTEGM RFDRGYVSPY FITDTKAQKV
260 270 280 290 300
EFEKPLILLS EKKISAVQDI IPALEASTSL RRPLVIIAED IEGEALAVCI
310 320 330 340 350
LNKLRGQLQV AAVKAPGFGD NRKSILGDIG ILTNATVFTD ELDLKLEKAT
360 370 380 390 400
PDMLGSTGSI TITKEDTIIL NGEGSKDAIA QRCEQIRSVI SDPATSDYEK
410 420 430 440 450
EKLQERLAKL SGGVAVIKVG GASEIEVGEK KDRVVDALNA TRAAVEEGIL
460 470 480 490 500
PGGGTALLKA AANGLTSLNP TNFDQKLGIS IIKNAITRPA RTIVENSGLE
510 520 530 540 550
GSVIVGKLTD DFAGDFNRGF DSARGEYVDM IGAGIVDPLK VVRTALVDAS
560 570 580 590
GVASLLGTTE VAIVEAPEEK VPAGSGAGGM GGGMGGMGGG MF
Length:592
Mass (Da):62,133
Last modified:August 1, 1998 - v1
Checksum:iA90CCC826B5138ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059523 Genomic DNA. Translation: AAC14712.1.
KN294020 Genomic DNA. Translation: EEH37641.1.
RefSeqiXP_002789992.1. XM_002789946.2.

Genome annotation databases

EnsemblFungiiEEH37641; EEH37641; PAAG_08059.
GeneIDi9093251.
KEGGipbl:PAAG_08059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059523 Genomic DNA. Translation: AAC14712.1.
KN294020 Genomic DNA. Translation: EEH37641.1.
RefSeqiXP_002789992.1. XM_002789946.2.

3D structure databases

ProteinModelPortaliO60008.
SMRiO60008. Positions 39-567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi502779.XP_002789992.1.

Proteomic databases

PRIDEiO60008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEH37641; EEH37641; PAAG_08059.
GeneIDi9093251.
KEGGipbl:PAAG_08059.

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
KOiK04077.
OrthoDBiEOG092C1JWK.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP60_PARBA
AccessioniPrimary (citable) accession number: O60008
Secondary accession number(s): C1HBB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.