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Protein

Heat shock protein 60, mitochondrial

Gene

HSP60

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 60, mitochondrial
Alternative name(s):
60 kDa chaperonin
Protein Cpn60
Gene namesi
Name:HSP60
ORF Names:PAAG_08059
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisParacoccidioides
Proteomesi
  • UP000002059 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PAAG_08059

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000005042? – 592Heat shock protein 60, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiO60008

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi502779.XP_002789992.1

Structurei

3D structure databases

ProteinModelPortaliO60008
SMRiO60008
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356 Eukaryota
COG0459 LUCA
KOiK04077
OrthoDBiEOG092C1JWK

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAFTSSRA SVLSSASSTR APLSRFRSAG VGLQQQRFAH KELKFGVEAR
60 70 80 90 100
ASLLKGIDTL AKAVTTTLGP KGRNVLIESP YGSPKITKDG VTVAKAVTLQ
110 120 130 140 150
DKFENLGARL LQDVASKTNE VAGDGTTTAT VLARAIFSET VKNVAAGCNP
160 170 180 190 200
MDLRRGIQSA VEAVVEYLQT NKRDITTTEE IAQVATISAN GDTHVGKLIS
210 220 230 240 250
NAMEKVGKEG VITVKDGKTI DDELEVTEGM RFDRGYVSPY FITDTKAQKV
260 270 280 290 300
EFEKPLILLS EKKISAVQDI IPALEASTSL RRPLVIIAED IEGEALAVCI
310 320 330 340 350
LNKLRGQLQV AAVKAPGFGD NRKSILGDIG ILTNATVFTD ELDLKLEKAT
360 370 380 390 400
PDMLGSTGSI TITKEDTIIL NGEGSKDAIA QRCEQIRSVI SDPATSDYEK
410 420 430 440 450
EKLQERLAKL SGGVAVIKVG GASEIEVGEK KDRVVDALNA TRAAVEEGIL
460 470 480 490 500
PGGGTALLKA AANGLTSLNP TNFDQKLGIS IIKNAITRPA RTIVENSGLE
510 520 530 540 550
GSVIVGKLTD DFAGDFNRGF DSARGEYVDM IGAGIVDPLK VVRTALVDAS
560 570 580 590
GVASLLGTTE VAIVEAPEEK VPAGSGAGGM GGGMGGMGGG MF
Length:592
Mass (Da):62,133
Last modified:August 1, 1998 - v1
Checksum:iA90CCC826B5138ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059523 Genomic DNA Translation: AAC14712.1
KN294020 Genomic DNA Translation: EEH37641.1
RefSeqiXP_002789992.1, XM_002789946.2

Genome annotation databases

EnsemblFungiiEEH37641; EEH37641; PAAG_08059
GeneIDi9093251
KEGGipbl:PAAG_08059

Similar proteinsi

Entry informationi

Entry nameiHSP60_PARBA
AccessioniPrimary (citable) accession number: O60008
Secondary accession number(s): C1HBB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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