Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-binding protein cre-1

Gene

cre-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in carbon catabolite repression. Represses the transcription of a number of genes by binding to a GC-rich region in their promoter (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri78 – 10023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri106 – 13025C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein cre-1
Alternative name(s):
Carbon catabolite repressor
Gene namesi
Name:cre-1
ORF Names:NCU08807
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 4, Linkage Group IV

Organism-specific databases

EuPathDBiFungiDB:NCU08807.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430DNA-binding protein cre-1PRO_0000046877Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO59958.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 4510Poly-Gln
Compositional biasi142 – 1465Poly-Gln

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri78 – 10023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri106 – 13025C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000164217.
InParanoidiO59958.
KOiK09467.
OMAiRIHSNPN.
OrthoDBiEOG7K0ZMS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRVQSAVDF SNLLNPSEST AEKRDHSGSP RQQTAQPQQQ QQQPQPEADM
60 70 80 90 100
ATVGLLRPNG PLPGAQATEP ANELPRPYKC PLCDKAFHRL EHQTRHIRTH
110 120 130 140 150
TGEKPHACQF PGCSKKFSRS DELTRHSRIH SNPNSRRGNK GQQQQQHPLV
160 170 180 190 200
HNHGLQPDMM PPPGPKAIRS APPTAMSSPN VSPPHSYSPY NFAPSGLNPY
210 220 230 240 250
SHSRSSAGSQ SGPDISLLAR AAGQVERDGA AHHHFQPRFQ FYGNTLHAAT
260 270 280 290 300
ASRNQLPGLQ AYHMSRSHSH EDHDDHYGQS YRHAKRSRPN SPNSTAPSSP
310 320 330 340 350
TFSHDSLSPT PDHTPLATPA HSPRLRPHPG LELPPFRNLS LGQQHTTPAL
360 370 380 390 400
APLEPALDGQ FSLPQTPPAA PRSSGMSLTD IISRPDGTQR KLPVPKVAVQ
410 420 430
DLLGPADGFN PSVRNSSSTS LSGAEMMDRL
Length:430
Mass (Da):46,898
Last modified:June 7, 2005 - v2
Checksum:iFDC81F922BDC9195
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti351 – 3511A → T in AAC13555 (PubMed:10361038).Curated
Sequence conflicti369 – 3691A → P in AAC13555 (PubMed:10361038).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055464 mRNA. Translation: AAC13555.1.
CM002239 Genomic DNA. Translation: EAA32758.1.
RefSeqiXP_961994.1. XM_956901.3.

Genome annotation databases

EnsemblFungiiEFNCRT00000008744; EFNCRP00000008726; EFNCRG00000008730.
GeneIDi3878142.
KEGGincr:NCU08807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055464 mRNA. Translation: AAC13555.1.
CM002239 Genomic DNA. Translation: EAA32758.1.
RefSeqiXP_961994.1. XM_956901.3.

3D structure databases

ProteinModelPortaliO59958.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000008744; EFNCRP00000008726; EFNCRG00000008730.
GeneIDi3878142.
KEGGincr:NCU08807.

Organism-specific databases

EuPathDBiFungiDB:NCU08807.

Phylogenomic databases

HOGENOMiHOG000164217.
InParanoidiO59958.
KOiK09467.
OMAiRIHSNPN.
OrthoDBiEOG7K0ZMS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Carbon regulation of ribosomal genes in Neurospora crassa occurs by a mechanism which does not require Cre-1, the homologue of the Aspergillus carbon catabolite repressor, CreA."
    de la Serna I., Ng D., Tyler B.M.
    Fungal Genet. Biol. 26:253-269(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiCRE1_NEUCR
AccessioniPrimary (citable) accession number: O59958
Secondary accession number(s): Q7RVF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 7, 2005
Last modified: November 11, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.