O59924 (SODC_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn]
EC=1.15.1.1

Gene names

Name:

SOD1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cellular response to oxidative stress Inferred from mutant phenotype. Source: CGD hyphal growth Inferred from mutant phenotype. Source: CGD pathogenesis Inferred from mutant phenotype. Source: CGD superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Non-traceable author statement. Source: UniProtKB
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from direct assay Ref.1. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 154	153	Superoxide dismutase [Cu-Zn]		PRO_0000164112
Sites
	Metal binding	47	1	Copper By similarity
	Metal binding	49	1	Copper By similarity
	Metal binding	64	1	Copper By similarity
	Metal binding	64	1	Zinc By similarity
	Metal binding	72	1	Zinc By similarity
	Metal binding	81	1	Zinc By similarity
	Metal binding	84	1	Zinc By similarity
	Metal binding	121	1	Copper By similarity
Amino acid modifications
	Disulfide bond	58 ↔ 147		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O59924 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 22EEC7F03341BE46	FASTA	154	16,146
	10 20 30 40 50 60 MVKAVAVVRG DSKVQGTVHF EQESESAPTT ISWEIEGNDP NALRGFHIHQ FGDNTNGCTS 70 80 90 100 110 120 AGPHFNPFGK QHGAPEDDER HVGDLGNIST DGNGVAKGTK QDLLIKLIGK DSILGRTIVV 130 140 150 HAGTDDYGKG GFEDSKTTGH AGARPACGVI GLTQ

References

[1]	"Copper- and zinc-containing superoxide dismutase and its gene from Candida albicans." Hwang C.S., Rhie G., Kim S.T., Kim Y.R., Huh W.K., Baek Y.U., Kang S.O. Biochim. Biophys. Acta 1427:245-255(1999) [PubMed: 10216241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF046872 Genomic DNA. Translation: AAC12872.1.
3D structure databases
ProteinModelPortal	O59924.
SMR	O59924. Positions 2-153.
ModBase	Search...
Protein-protein interaction databases
STRING	O59924.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
CGD	CAL0006717. SOD1.
Phylogenomic databases
OMA	EEERHAG.
PhylomeDB	O59924.
Family and domain databases
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_CANAX

Accession

Primary (citable) accession number: O59924

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 23, 2007
Last modified:	October 19, 2011
This is version 66 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program