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Protein

cAMP-dependent protein kinase regulatory subunit

Gene

pkaR

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei238 – 2381cAMP 1By similarity
Binding sitei247 – 2471cAMP 1By similarity
Binding sitei359 – 3591cAMP 2By similarity
Binding sitei368 – 3681cAMP 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi160 – 291132cAMP 1Add
BLAST
Nucleotide bindingi292 – 405114cAMP 2Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase regulatory subunit
Short name:
PKA regulatory subunit
Gene namesi
Name:pkaR
ORF Names:AN4987
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome III
  • UP000005890 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AN4987.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412cAMP-dependent protein kinase regulatory subunitPRO_0000205408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO59922.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 159137Dimerization and phosphorylationSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000196669.
InParanoidiO59922.
KOiK04739.
OMAiGDPGHSF.
OrthoDBiEOG092C3TMX.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNYSHSSNN PFLKVSTKED KPSSFHKIAE DEEYEVTSPT DATFRASKNA
60 70 80 90 100
DNSAGGNNPL ESGRAGESGD GIRFGRDPFG NFQGGAEGQD ESSIDPNGFR
110 120 130 140 150
PTGGPDHGFP NNYALGRRTS VSAESLNPTS AGSDSWTPPS HPKSEEQLAR
160 170 180 190 200
LKTAVSNNFL FSHLDDEQSR TVLDALVEKP IPAKDIKVIS QGDAGDYFYI
210 220 230 240 250
VEEGHFDVYI NPSGSVQPGP DGAGTKISTI GPGGSFGELA LMYNAPRAAT
260 270 280 290 300
IVSTEPKSTL WALDRITFRR ILMDSAFQRR RMYEAFLEEV PLLSSLKPYE
310 320 330 340 350
RAKIADALDT IKFPAGEYII KEGDPGDAFY LLESGEAEAF MEGVEEPVKS
360 370 380 390 400
YKRGDYFGEL ALLDDKPRAA SVRAKTEVKV AKLGRDGFKR LLGPVENIMR
410
RTEYSSRPST AT
Length:412
Mass (Da):44,904
Last modified:August 1, 1998 - v1
Checksum:i40F574887A1D5CBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043231 Genomic DNA. Translation: AAC18061.1.
AACD01000084 Genomic DNA. Translation: EAA61065.1.
BN001303 Genomic DNA. Translation: CBF76336.1.
RefSeqiXP_662591.1. XM_657499.1.

Genome annotation databases

EnsemblFungiiCADANIAT00005408; CADANIAP00005408; CADANIAG00005408.
EAA61065; EAA61065; AN4987.2.
GeneIDi2872780.
KEGGiani:AN4987.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043231 Genomic DNA. Translation: AAC18061.1.
AACD01000084 Genomic DNA. Translation: EAA61065.1.
BN001303 Genomic DNA. Translation: CBF76336.1.
RefSeqiXP_662591.1. XM_657499.1.

3D structure databases

ProteinModelPortaliO59922.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00005408; CADANIAP00005408; CADANIAG00005408.
EAA61065; EAA61065; AN4987.2.
GeneIDi2872780.
KEGGiani:AN4987.2.

Organism-specific databases

EuPathDBiFungiDB:AN4987.

Phylogenomic databases

HOGENOMiHOG000196669.
InParanoidiO59922.
KOiK04739.
OMAiGDPGHSF.
OrthoDBiEOG092C3TMX.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKAPR_EMENI
AccessioniPrimary (citable) accession number: O59922
Secondary accession number(s): C8V8P0, Q5B393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.