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O59921

- TPS1_EMENI

UniProt

O59921 - TPS1_EMENI

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

tpsA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: ASPGD
    2. trehalose-phosphatase activity Source: ASPGD

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: ASPGD
    2. cellular response to heat Source: ASPGD
    3. cellular response to hydrogen peroxide Source: ASPGD
    4. dephosphorylation Source: GOC
    5. fungal-type cell wall organization Source: ASPGD
    6. trehalose biosynthetic process Source: ASPGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT20. Glycosyltransferase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
    Alternative name(s):
    Trehalose-6-phosphate synthase
    UDP-glucose-glucosephosphate glucosyltransferase
    Gene namesi
    Name:tpsA
    ORF Names:AN5523
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome V

    Subcellular locationi

    GO - Cellular componenti

    1. alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) Source: ASPGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000122497Add
    BLAST

    Proteomic databases

    PRIDEiO59921.

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00003562.

    Structurei

    3D structure databases

    ProteinModelPortaliO59921.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 20 family.Curated

    Phylogenomic databases

    eggNOGiCOG0380.
    HOGENOMiHOG000191477.
    KOiK00697.
    OMAiWLAYREA.
    OrthoDBiEOG76QFS6.

    Family and domain databases

    InterProiIPR001830. Glyco_trans_20.
    IPR012766. Trehalose_OtsA.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O59921-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGVEKSSQN ESRLLLVSNR LPITIKRSED GKYDFSMSSG GLVSGLSGLS    50
    KTTTFQWYGW PGLEVPEEEI PTLKNRLKEE YNAIPVFIDD ELADRHYNGF 100
    SNSILWPLFH YHPGEITFDE SAWEAYKEAN RLFAQAVASQ VQDGDLIWVH 150
    DYHLMLLPEM LREEIGNTKK NIKIGFFLHT PFPSSEIYRI LPVRNELLLG 200
    LLHCDLIGFH TYDYTRHFLS ACSRLLGLPT TPNGIEFQGK IIACGAFPIG 250
    IDPEKFKEGL KKEKVQKRIA TLEQKFQGVK LMVGVDRLDY IKGVPQKLHA 300
    LEVFLSDHPE WVGKVVLVQV AVPSRQDVEE YQNLRAVVNE LVGRINGKFG 350
    TVEFMPIHFL HKSVNFDELI ALYAVSDACV VSSTRDGMNL VSYEYIATQE 400
    KRHGSLVLSE FAGAAQSLNG SIIVNPWNTE ELAAAYHEAV TMSDEQRALN 450
    FSKLDKYVNK YTSAFWGQSF VTELTRISEQ AAGKLPTKET PVNGETSKLE 500
    TSSQ 504
    Length:504
    Mass (Da):56,801
    Last modified:August 1, 1998 - v1
    Checksum:i2CC239AF768BCA94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043230 Genomic DNA. Translation: AAC18060.1.
    AACD01000094 Genomic DNA. Translation: EAA62683.1.
    BN001305 Genomic DNA. Translation: CBF81745.1.
    RefSeqiXP_663127.1. XM_658035.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00003562; CADANIAP00003562; CADANIAG00003562.
    GeneIDi2871815.
    KEGGiani:AN5523.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043230 Genomic DNA. Translation: AAC18060.1 .
    AACD01000094 Genomic DNA. Translation: EAA62683.1 .
    BN001305 Genomic DNA. Translation: CBF81745.1 .
    RefSeqi XP_663127.1. XM_658035.1.

    3D structure databases

    ProteinModelPortali O59921.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00003562.

    Protein family/group databases

    CAZyi GT20. Glycosyltransferase Family 20.

    Proteomic databases

    PRIDEi O59921.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00003562 ; CADANIAP00003562 ; CADANIAG00003562 .
    GeneIDi 2871815.
    KEGGi ani:AN5523.2.

    Phylogenomic databases

    eggNOGi COG0380.
    HOGENOMi HOG000191477.
    KOi K00697.
    OMAi WLAYREA.
    OrthoDBi EOG76QFS6.

    Family and domain databases

    InterProi IPR001830. Glyco_trans_20.
    IPR012766. Trehalose_OtsA.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the Aspergillus nidulans tpsA gene encoding trehalose-6-phosphate synthase."
      d'Enfert C., Wolschek M., Kubicek C.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiTPS1_EMENI
    AccessioniPrimary (citable) accession number: O59921
    Secondary accession number(s): C8VG92, Q5B1Q7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3