O59921 (TPS1_EMENI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
EC=2.4.1.15

Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase

Gene names

Name:	tpsA
ORF Names:	AN5523

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]

Taxonomic identifier

227321 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella › Emericella nidulans › mitosporic Emericella nidulans

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.
Sequence similarities	Belongs to the glycosyltransferase 20 family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Alpha,alpha-trehalose-phosphate synthase [UDP-forming]		PRO_0000122497

Sequences

	Sequence		Length	Mass (Da)
	O59921 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 2CC239AF768BCA94	FASTA	504	56,801
	10 20 30 40 50 60 MPGVEKSSQN ESRLLLVSNR LPITIKRSED GKYDFSMSSG GLVSGLSGLS KTTTFQWYGW 70 80 90 100 110 120 PGLEVPEEEI PTLKNRLKEE YNAIPVFIDD ELADRHYNGF SNSILWPLFH YHPGEITFDE 130 140 150 160 170 180 SAWEAYKEAN RLFAQAVASQ VQDGDLIWVH DYHLMLLPEM LREEIGNTKK NIKIGFFLHT 190 200 210 220 230 240 PFPSSEIYRI LPVRNELLLG LLHCDLIGFH TYDYTRHFLS ACSRLLGLPT TPNGIEFQGK 250 260 270 280 290 300 IIACGAFPIG IDPEKFKEGL KKEKVQKRIA TLEQKFQGVK LMVGVDRLDY IKGVPQKLHA 310 320 330 340 350 360 LEVFLSDHPE WVGKVVLVQV AVPSRQDVEE YQNLRAVVNE LVGRINGKFG TVEFMPIHFL 370 380 390 400 410 420 HKSVNFDELI ALYAVSDACV VSSTRDGMNL VSYEYIATQE KRHGSLVLSE FAGAAQSLNG 430 440 450 460 470 480 SIIVNPWNTE ELAAAYHEAV TMSDEQRALN FSKLDKYVNK YTSAFWGQSF VTELTRISEQ 490 500 AAGKLPTKET PVNGETSKLE TSSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the Aspergillus nidulans tpsA gene encoding trehalose-6-phosphate synthase." d'Enfert C., Wolschek M., Kubicek C. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]	"The 2008 update of the Aspergillus nidulans genome annotation: a community effort." Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G. Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF043230 Genomic DNA. Translation: AAC18060.1. AACD01000094 Genomic DNA. Translation: EAA62683.1. BN001305 Genomic DNA. Translation: CBF81745.1.
RefSeq	XP_663127.1. XM_658035.1.
3D structure databases
ProteinModelPortal	O59921.
ModBase	Search...
Protein-protein interaction databases
STRING	162425.CADANIAP00003562.
Protein family/group databases
CAZy	GT20. Glycosyltransferase Family 20.
Proteomic databases
PRIDE	O59921.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANIAT00003562; CADANIAP00003562; CADANIAG00003562.
GeneID	2871815.
KEGG	ani:AN5523.2.
Phylogenomic databases
eggNOG	COG0380.
HOGENOM	HOG000191477.
KO	K00697.
OMA	EYGRKEM.
OrthoDB	EOG4KPXK7.
Family and domain databases
InterPro	IPR001830. Glyco_trans_20. IPR012766. Trehalose_OtsA. [Graphical view]
Pfam	PF00982. Glyco_transf_20. 1 hit. [Graphical view]
TIGRFAMs	TIGR02400. trehalose_OtsA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPS1_EMENI

Accession

Primary (citable) accession number: O59921
Secondary accession number(s): C8VG92, Q5B1Q7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	August 1, 1998
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program