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O59921 (TPS1_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

EC=2.4.1.15
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene names
Name:tpsA
ORF Names:AN5523
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Sequence similarities

Belongs to the glycosyltransferase 20 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
PRO_0000122497

Sequences

Sequence LengthMass (Da)Tools
O59921 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 2CC239AF768BCA94

FASTA50456,801
        10         20         30         40         50         60 
MPGVEKSSQN ESRLLLVSNR LPITIKRSED GKYDFSMSSG GLVSGLSGLS KTTTFQWYGW 

        70         80         90        100        110        120 
PGLEVPEEEI PTLKNRLKEE YNAIPVFIDD ELADRHYNGF SNSILWPLFH YHPGEITFDE 

       130        140        150        160        170        180 
SAWEAYKEAN RLFAQAVASQ VQDGDLIWVH DYHLMLLPEM LREEIGNTKK NIKIGFFLHT 

       190        200        210        220        230        240 
PFPSSEIYRI LPVRNELLLG LLHCDLIGFH TYDYTRHFLS ACSRLLGLPT TPNGIEFQGK 

       250        260        270        280        290        300 
IIACGAFPIG IDPEKFKEGL KKEKVQKRIA TLEQKFQGVK LMVGVDRLDY IKGVPQKLHA 

       310        320        330        340        350        360 
LEVFLSDHPE WVGKVVLVQV AVPSRQDVEE YQNLRAVVNE LVGRINGKFG TVEFMPIHFL 

       370        380        390        400        410        420 
HKSVNFDELI ALYAVSDACV VSSTRDGMNL VSYEYIATQE KRHGSLVLSE FAGAAQSLNG 

       430        440        450        460        470        480 
SIIVNPWNTE ELAAAYHEAV TMSDEQRALN FSKLDKYVNK YTSAFWGQSF VTELTRISEQ 

       490        500 
AAGKLPTKET PVNGETSKLE TSSQ 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the Aspergillus nidulans tpsA gene encoding trehalose-6-phosphate synthase."
d'Enfert C., Wolschek M., Kubicek C.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF043230 Genomic DNA. Translation: AAC18060.1.
AACD01000094 Genomic DNA. Translation: EAA62683.1.
BN001305 Genomic DNA. Translation: CBF81745.1.
RefSeqXP_663127.1. XM_658035.1.

3D structure databases

ProteinModelPortalO59921.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING162425.CADANIAP00003562.

Protein family/group databases

CAZyGT20. Glycosyltransferase Family 20.

Proteomic databases

PRIDEO59921.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00003562; CADANIAP00003562; CADANIAG00003562.
GeneID2871815.
KEGGani:AN5523.2.

Phylogenomic databases

eggNOGCOG0380.
HOGENOMHOG000191477.
KOK00697.
OMAIEFMPIH.
OrthoDBEOG76QFS6.

Family and domain databases

InterProIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsTIGR02400. trehalose_OtsA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTPS1_EMENI
AccessionPrimary (citable) accession number: O59921
Secondary accession number(s): C8VG92, Q5B1Q7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families