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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

tpsA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: AspGD
  • phosphatase activity Source: GO_Central

GO - Biological processi

  • cellular carbohydrate metabolic process Source: AspGD
  • cellular response to heat Source: AspGD
  • cellular response to hydrogen peroxide Source: AspGD
  • trehalose biosynthetic process Source: AspGD
  • trehalose metabolism in response to stress Source: GO_Central

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:tpsA
ORF Names:AN5523
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome V
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) Source: AspGD
  • cytoplasm Source: GO_Central

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224971 – 504Alpha,alpha-trehalose-phosphate synthase [UDP-forming]Add BLAST504

Proteomic databases

PRIDEiO59921.

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00003562.

Structurei

3D structure databases

ProteinModelPortaliO59921.
SMRiO59921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

HOGENOMiHOG000191477.
InParanoidiO59921.
KOiK00697.
OMAiIEFMPIH.
OrthoDBiEOG092C0LDC.

Family and domain databases

CDDicd03788. GT1_TPS. 1 hit.
InterProiView protein in InterPro
IPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
PfamiView protein in Pfam
PF00982. Glyco_transf_20. 1 hit.
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

O59921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVEKSSQN ESRLLLVSNR LPITIKRSED GKYDFSMSSG GLVSGLSGLS
60 70 80 90 100
KTTTFQWYGW PGLEVPEEEI PTLKNRLKEE YNAIPVFIDD ELADRHYNGF
110 120 130 140 150
SNSILWPLFH YHPGEITFDE SAWEAYKEAN RLFAQAVASQ VQDGDLIWVH
160 170 180 190 200
DYHLMLLPEM LREEIGNTKK NIKIGFFLHT PFPSSEIYRI LPVRNELLLG
210 220 230 240 250
LLHCDLIGFH TYDYTRHFLS ACSRLLGLPT TPNGIEFQGK IIACGAFPIG
260 270 280 290 300
IDPEKFKEGL KKEKVQKRIA TLEQKFQGVK LMVGVDRLDY IKGVPQKLHA
310 320 330 340 350
LEVFLSDHPE WVGKVVLVQV AVPSRQDVEE YQNLRAVVNE LVGRINGKFG
360 370 380 390 400
TVEFMPIHFL HKSVNFDELI ALYAVSDACV VSSTRDGMNL VSYEYIATQE
410 420 430 440 450
KRHGSLVLSE FAGAAQSLNG SIIVNPWNTE ELAAAYHEAV TMSDEQRALN
460 470 480 490 500
FSKLDKYVNK YTSAFWGQSF VTELTRISEQ AAGKLPTKET PVNGETSKLE

TSSQ
Length:504
Mass (Da):56,801
Last modified:August 1, 1998 - v1
Checksum:i2CC239AF768BCA94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043230 Genomic DNA. Translation: AAC18060.1.
AACD01000094 Genomic DNA. Translation: EAA62683.1.
BN001305 Genomic DNA. Translation: CBF81745.1.
RefSeqiXP_663127.1. XM_658035.1.

Genome annotation databases

EnsemblFungiiCADANIAT00003562; CADANIAP00003562; CADANIAG00003562.
EAA62683; EAA62683; AN5523.2.
GeneIDi2871815.
KEGGiani:AN5523.2.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTPS1_EMENI
AccessioniPrimary (citable) accession number: O59921
Secondary accession number(s): C8VG92, Q5B1Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: August 1, 1998
Last modified: July 5, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families