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Protein

Peroxisomal targeting signal 2 receptor

Gene

PEX7

Organism
Komagataella pastoris (Yeast) (Pichia pastoris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 2 receptor
Short name:
PTS2 receptor
Alternative name(s):
Peroxin-7
Gene namesi
Name:PEX7
OrganismiKomagataella pastoris (Yeast) (Pichia pastoris)
Taxonomic identifieri4922 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511181 – 376Peroxisomal targeting signal 2 receptorAdd BLAST376

Interactioni

Subunit structurei

Interacts with PEX5.By similarity

Protein-protein interaction databases

STRINGi644223.XP_002490564.1.

Structurei

3D structure databases

ProteinModelPortaliO59894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 98WD 1Add BLAST41
Repeati102 – 142WD 2Add BLAST41
Repeati182 – 222WD 3Add BLAST41
Repeati226 – 267WD 4Add BLAST42
Repeati279 – 319WD 5Add BLAST41
Repeati339 – 375WD 6Add BLAST37

Sequence similaritiesi

Belongs to the WD repeat peroxin-7 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0277. Eukaryota.
ENOG410XNVU. LUCA.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKFQTNGFS GYAVRYSPFY DNKIAVATSA NYGLVGNGRL YVLSIMDDGN
60 70 80 90 100
IITDISYDTQ DGLFGVAWSE TNENHVLTSS GDGCVSLFDT TLKDYPVMKF
110 120 130 140 150
TEHQREVFSV DWSNIDKNLF CSASWDGSVK VWSPGSNRNT SLLTLRSLAS
160 170 180 190 200
REEKTGRIEK PIPVVQPSQV PMSKTRPNIR NDNNDCVYDA KFSFHDPNII
210 220 230 240 250
MSCNSDSHLQ LWDTRLPNPL FMDFVAHNGL EALSCDFNRY RPFVVASAGV
260 270 280 290 300
DKLAKVWDTR MIQPNVHSRP PRALNKFMGH EFAIRKLAWS PHGPTQLLTC
310 320 330 340 350
SYDMTVRVWN DSPSPTSRVG LLDGASQPHA PPCSKIFSAH TEFVMGCDWS
360 370
LWGEPGWVVT TGWDEMVYVW NTQRLQ
Length:376
Mass (Da):42,422
Last modified:August 1, 1998 - v1
Checksum:i3FE1279920E2CAA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021797 Genomic DNA. Translation: AAC08303.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021797 Genomic DNA. Translation: AAC08303.1.

3D structure databases

ProteinModelPortaliO59894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi644223.XP_002490564.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0277. Eukaryota.
ENOG410XNVU. LUCA.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX7_PICPA
AccessioniPrimary (citable) accession number: O59894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.