Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-transporting ATPase 1

Gene

pmr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports calcium and manganese ions into the cell. Regulates cell morphogenesis through control of manganese and calcium homeostasis.2 Publications

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei329 – 32914-aspartylphosphate intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

  • calcium ion transmembrane transport Source: PomBase
  • Golgi calcium ion export Source: PomBase
  • manganese ion transmembrane transport Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Manganese, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.2.34. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 1 (EC:3.6.3.8)
Alternative name(s):
Golgi Ca(2+)-ATPase
Gene namesi
Name:pmr1
Synonyms:pgak2
ORF Names:SPBC31E1.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC31E1.02c.
PomBaseiSPBC31E1.02c. pmr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Transmembranei688 – 70821HelicalSequence analysisAdd
BLAST
Transmembranei757 – 77721HelicalSequence analysisAdd
BLAST
Transmembranei827 – 84721HelicalSequence analysisAdd
BLAST
Transmembranei854 – 87421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: PomBase
  • endoplasmic reticulum membrane Source: PomBase
  • integral component of endoplasmic reticulum membrane Source: PomBase
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 899899Calcium-transporting ATPase 1PRO_0000046229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei892 – 8921Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO59868.

PTM databases

iPTMnetiO59868.

Interactioni

Protein-protein interaction databases

BioGridi276912. 41 interactions.
MINTiMINT-4676692.

Structurei

3D structure databases

ProteinModelPortaliO59868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000265621.
InParanoidiO59868.
KOiK01537.
OMAiERNNIAF.
OrthoDBiEOG092C12IX.
PhylomeDBiO59868.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF217. PTHR24093:SF217. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQYDAFSV EQTCADLETD MYNGLSSLQE ITRRNKVHGD NDLKVEDEEN
60 70 80 90 100
MVVQFLKQFV KDPLILLLFA SSAISVTLGN IDDAISIALA IVIVVTVGFV
110 120 130 140 150
QEYRSEQSLK ALNNLVPHYC NVIRSGKTEH IVASKLVPGD LVILQIGDRV
160 170 180 190 200
PADLRIVEAT ELEIDESNLT GENSPRKKSS EAISSNISLT ERNNIAFMGT
210 220 230 240 250
LVRHGHGRGI VVATGSDTEF GRVFLTMQQT EKPKTPLQNS MDDLGKQLSL
260 270 280 290 300
ISLIGIAVIV LVGFFQGKNW LEMLTIGVSL AVAAIPEGLP IIVTVTLALG
310 320 330 340 350
VLRMSKKRAI IRRLPSVETL GSVNVICSDK TGTLTMNHMT VTKIYTCGML
360 370 380 390 400
AAFSLPESEH IELSVRRTVG IEKALLAAAL CNNSKVHNKA DSILDTTCPW
410 420 430 440 450
AGFPVDVALI ECSERFGLKD PRETYSRISE VSFSSERKYM SVAVQYNSSK
460 470 480 490 500
MNFMKGATEQ VLSSCAYFSD QDGVQHELTA EMKENIQRNE FEMAASGLRI
510 520 530 540 550
IAVASGINTN KLVFHGLFGI NDPPRPQVRE SVQYLMTGGV RVIMITGDSV
560 570 580 590 600
VTAISIARSL GMAIPSNDEE AIRNYALTGA QLDDLDSSSL RDAVSRVVVF
610 620 630 640 650
ARTTPQHKMK IVEALQSLGD VVAMTGDGVN DAPALKLADI GIAMGRQGTD
660 670 680 690 700
VAKEAADMIL TDDSFATILS AVEEGKGIFN NIKNFITFQL STSVAALSLI
710 720 730 740 750
AISSVFGFQN PLNAMQILWI NILMDGPPAQ SLGVESVDED VMMKPPRPRN
760 770 780 790 800
APIISVQLLQ RVLLSAFIIV TVTIVVFRVQ MQDGNVTARD TTMTFTCFVF
810 820 830 840 850
FDMFNALACR SETKSVFKLG IFSNRMFNIA VGGSLIGQAL VVYASPFQRI
860 870 880 890
FQTEAIGLKD VLILLACTSS VLWVDEIRKW YRRRKGLVRT KSNYLLRNV
Length:899
Mass (Da):98,359
Last modified:August 1, 1998 - v1
Checksum:i7E45E9180F36FD44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004698 Genomic DNA. Translation: AAC16669.1.
CU329671 Genomic DNA. Translation: CAB39136.1.
PIRiT40199.
RefSeqiNP_595098.1. NM_001021005.2.

Genome annotation databases

EnsemblFungiiSPBC31E1.02c.1; SPBC31E1.02c.1:pep; SPBC31E1.02c.
GeneIDi2540383.
KEGGispo:SPBC31E1.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004698 Genomic DNA. Translation: AAC16669.1.
CU329671 Genomic DNA. Translation: CAB39136.1.
PIRiT40199.
RefSeqiNP_595098.1. NM_001021005.2.

3D structure databases

ProteinModelPortaliO59868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276912. 41 interactions.
MINTiMINT-4676692.

Protein family/group databases

TCDBi3.A.3.2.34. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiO59868.

Proteomic databases

MaxQBiO59868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC31E1.02c.1; SPBC31E1.02c.1:pep; SPBC31E1.02c.
GeneIDi2540383.
KEGGispo:SPBC31E1.02c.

Organism-specific databases

EuPathDBiFungiDB:SPBC31E1.02c.
PomBaseiSPBC31E1.02c. pmr1.

Phylogenomic databases

HOGENOMiHOG000265621.
InParanoidiO59868.
KOiK01537.
OMAiERNNIAF.
OrthoDBiEOG092C12IX.
PhylomeDBiO59868.

Enzyme and pathway databases

ReactomeiR-SPO-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiO59868.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF217. PTHR24093:SF217. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATC1_SCHPO
AccessioniPrimary (citable) accession number: O59868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.